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Search results 1 to 100 out of 102 for Mrs2

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Hits by Strain

Type Details Score
Gene
57380 | MRS2
Type: gene
Organism: human
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Gene
100493829 | mrs2
Type: gene
Organism: frog, western clawed
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Gene
79032 | Mrs2
Type: gene
Organism: rat
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Gene
488245 | MRS2
Type: gene
Organism: dog, domestic
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Gene
462472 | MRS2
Type: gene
Organism: chimpanzee
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Gene
508554 | MRS2
Type: gene
Organism: cattle
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Gene
565251 | mrs2
Type: gene
Organism: zebrafish
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Gene
707676 | MRS2
Type: gene
Organism: macaque, rhesus
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Gene
420820 | MRS2
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:2685748 | Mrs2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
38878275 | J:351333
 
First Author: Powell DR
Year: 2024
Journal: Endocrinology
Title: Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and Thin When Maintained on a High-Fat Diet.
Volume: 165
Issue: 8
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Publication
36857182 | J:334126
First Author: Madaris TR
Year: 2023
Journal: Cell Rep
Title: Limiting Mrs2-dependent mitochondrial Mg(2+) uptake induces metabolic programming in prolonged dietary stress.
Volume: 42
Issue: 3
Pages: 112155
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Gene
729633 | MRS2P2
Type: gene
Organism: human
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Gene
100130448 | MRS2P1
Type: gene
Organism: human
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Publication
38513662 | J:347153
First Author: Vishnu N
Year: 2024
Journal: Mol Cell
Title: ERMA (TMEM94) is a P-type ATPase transporter for Mg(2+) uptake in the endoplasmic reticulum.
Volume: 84
Issue: 7
Pages: 1321-1337.e11
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Publication
33035451 | J:298361
First Author: Daw CC
Year: 2020
Journal: Cell
Title: Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism.
Volume: 183
Issue: 2
Pages: 474-489.e17
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Protein Coding Gene
MGP_129S1SvImJ_G0020386 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020315 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020137 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020091 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020201 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020228 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019408 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019421 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_CAROLIEiJ_G0018358 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_AJ_G0020335 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020333 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2685748 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019654 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020217 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020290 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020812 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019714 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_SPRETEiJ_G0019224 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
38599304 | J:350505
 
First Author: Ponnusamy T
Year: 2024
Journal: Mitochondrion
Title: Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca(2+) uptake and viability.
Volume: 76
Pages: 101877
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
11401429 | -
First Author: Zsurka G
Year: 2001
Journal: Genomics
Title: The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter.
Volume: 72
Issue: 2
Pages: 158-68
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Gene
104001630 | LOC104001630
Type: gene
Organism: chimpanzee
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Gene
104007759 | LOC104007759
Type: gene
Organism: chimpanzee
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Gene
108719154 | mrs2.L
Type: gene
Organism: frog, African clawed
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UniProt Feature
UniProt Feature
Begin: 54
Description: Magnesium transporter MRS2 homolog, mitochondrial
Type: chain
End: 434
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Protein
Q5NCE8
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: false
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Gene
100428132 | LOC100428132
Type: gene
Organism: macaque, rhesus
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Gene
107000931 | LOC107000931
Type: gene
Organism: macaque, rhesus
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Gene
106992448 | LOC106992448
Type: gene
Organism: macaque, rhesus
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Allele
Mrs2<+> | MGI:3049034
   
Name: MRS2 magnesium transporter; wild type
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Allele
Mrs2<tm1e(KOMP)Wtsi> | MGI:5299680
Name: MRS2 magnesium transporter; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Mrs2<tm1a(KOMP)Wtsi> | MGI:5299681
Name: MRS2 magnesium transporter; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Mrs2<em1(IMPC)Bay> | MGI:6414516
Name: MRS2 magnesium transporter; endonuclease-mediated mutation 1, Baylor College of Medicine
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Mrs2<em1Muma> | MGI:6514834
Name: MRS2 magnesium transporter; endonuclease-mediated mutation 1, Muniswamy Madesh
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Mrs2<em1Gpt> | MGI:7302511
Name: MRS2 magnesium transporter; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Mrs2<em5Gpt> | MGI:7302512
Name: MRS2 magnesium transporter; endonuclease-mediated mutation 5, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7607565 | C57BL/6NJ-Mrs2<em1(IMPC)Bay>/Mmnc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7266896 | C57BL/6N-Mrs2<em1(IMPC)Bay>/BayMmucd
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6514891 | B6.Cg-Mrs2<em1Muma>
Attribute String: mutant strain, endonuclease-mediated mutation, congenic
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Genotype
Genotype
Symbol: Mrs2/Mrs2
Background: B6.Cg-Mrs2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mrs2/Mrs2
Background: C57BL/6N-Mrs2/BayMmucd
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE216538 | Limiting Mrs2-Dependent Mg2+ Uptake Induces Metabolic Programming in Prolonged Dietary Stress
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
19436262 | -
First Author: Chen J
Year: 2009
Journal: Cell Res
Title: Magnesium transporter AtMGT9 is essential for pollen development in Arabidopsis.
Volume: 19
Issue: 7
Pages: 887-98
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Protein Domain
IPR002523 | MgTranspt_CorA/ZnTranspt_ZntB
Type: Family
Description: This entry includes prokaryotic magnesium transport protein CorA and its related protein, zinc transport protein ZntB []. This entry also includes eukaryotic magnesium transporters, such as mitochondrial inner membrane magnesium transporter Mrs2 and magnesium transporter Alr1 and Alr2. These proteins are characterised by the conserved GMN motif at the end of the first of twoconserved transmembrane (TM) domains near the C terminus []. Thermotoga maritima CorA (TmCorA) has been reported to be an efflux system. It only has 2 TM domains,TM1 and TM2 [, , ]. The loop connecting TM1 and TM2 contains the conserved CorA signature motifs YGMNF and MPEL. With its N- and C-terminal ends face the cytosol and its similarity to the class II CorA (a CorA group lacking the MPEL motif and may transport divalent cations out of the cell), TmCorA is predicted to be primarily involved in ion efflux []. It forms a pentameric membrane protein channel featuring a possible ion discriminating aspartate ring at the cytoplasmic entrance of the pore and two distinct cytoplasmic metal binding sites per monomer, which could have regulatory roles [, ]. It has been suggested that eukaryotic CorA homologues have the same topology and overall structure as T. maritima CorA []. In budding yeasts, Mrs2 is an essential component of the major electrophoretic Mg2+ influx system in mitochondria []. Overexpression of Alr1 or Alr2 increases tolerance to Al3+ and Ga3+ ions []. Despite generally low sequence similarity, both human Mrs2 (also known as LPE10) and S. typhimurium CorA can restore Mg2+ uptake activity in Saccharomyces cerevisiae with inactive Mrs2 [].
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Protein Domain
IPR045863 | CorA_TM1_TM2
Type: Homologous_superfamily
Description: This superfamily represents the transmembrane region (including TM1 and TM2) of the Mg2 transporter protein CorA. Thermotoga maritima CorA is an efflux system that forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains []. This domain can also be found in zinc transport protein ZntB []and plant magnesium transporter MRS2 [].Thermotoga maritima CorA (TmCorA) has 2 TM domains,TM1 and TM2 [, , ]. The loop connecting TM1 and TM2 contains the conserved CorA signature motifs YGMNF and MPEL. With its N- and C-terminal ends face the cytosol and its similarity to the class II CorA (a CorA group lacking the MPEL motif and may transport divalent cations out of the cell), TmCorA is predicted to be primarily involved in ion efflux []. It forms a pentameric membrane protein channel featuring a possible ion discriminating aspartate ring at the cytoplasmic entrance of the pore and two distinct cytoplasmic metal binding sites per monomer, which could have regulatory roles [, ]. It has been suggested that eukaryotic CorA homologues have the same topology and overall structure as T. maritima CorA []. In budding yeasts, Mrs2 is an essential component of the major electrophoretic Mg2+ influx system in mitochondria []. Overexpression of Alr1 or Alr2 increases tolerance to Al3+ and Ga3+ ions []. Despite generally low sequence similarity, both human Mrs2 (also known as LPE10) and S. typhimurium CorA can restore Mg2+ uptake activity in Saccharomyces cerevisiae with inactive Mrs2 [].
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Protein Domain
IPR045861 | CorA_cytoplasmic_dom
Type: Homologous_superfamily
Description: This superfamily represents the N-terminal cytoplasmic domain of the Mg2+ transporter protein CorA. Thermotoga maritima CorA is an efflux system that forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains []. This domain can also be found in zinc transport protein ZntB [].Thermotoga maritima CorA (TmCorA) has 2 TM domains,TM1 and TM2 [, , ]. The loop connecting TM1 and TM2 contains the conserved CorA signature motifs YGMNF and MPEL. With its N- and C-terminal ends face the cytosol and its similarity to the class II CorA (a CorA group lacking the MPEL motif and may transport divalent cations out of the cell), TmCorA is predicted to be primarily involved in ion efflux []. It forms a pentameric membrane protein channel featuring a possible ion discriminating aspartate ring at the cytoplasmic entrance of the pore and two distinct cytoplasmic metal binding sites per monomer, which could have regulatory roles [, ]. It has been suggested that eukaryotic CorA homologues have the same topology and overall structure as T. maritima CorA []. In budding yeasts, Mrs2 is an essential component of the major electrophoretic Mg2+ influx system in mitochondria []. Overexpression of Alr1 or Alr2 increases tolerance to Al3+ and Ga3+ ions []. Despite generally low sequence similarity, both human Mrs2 (also known as LPE10) and S. typhimurium CorA can restore Mg2+ uptake activity in Saccharomyces cerevisiae with inactive Mrs2 [].
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Publication
16857941 | -
First Author: Eshaghi S
Year: 2006
Journal: Science
Title: Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution.
Volume: 313
Issue: 5785
Pages: 354-7
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Publication
12142406 | -
First Author: Worlock AJ
Year: 2002
Journal: J Bacteriol
Title: ZntB is a novel Zn2+ transporter in Salmonella enterica serovar Typhimurium.
Volume: 184
Issue: 16
Pages: 4369-73
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Publication
23425532 | -
First Author: Nordin N
Year: 2013
Journal: Biochem J
Title: Exploring the structure and function of Thermotoga maritima CorA reveals the mechanism of gating and ion selectivity in Co2+/Mg2+ transport.
Volume: 451
Issue: 3
Pages: 365-74
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Publication
12206392 | -
First Author: Kehres DG
Year: 2002
Journal: Biometals
Title: Structure, properties and regulation of magnesium transport proteins.
Volume: 15
Issue: 3
Pages: 261-70
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Publication
17619822 | -
First Author: Niegowski D
Year: 2007
Journal: Cell Mol Life Sci
Title: The CorA family: structure and function revisited.
Volume: 64
Issue: 19-20
Pages: 2564-74
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Publication
9430719 | -
First Author: MacDiarmid CW
Year: 1998
Journal: J Biol Chem
Title: Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion.
Volume: 273
Issue: 3
Pages: 1727-32
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Publication
12628916 | -
First Author: Kolisek M
Year: 2003
Journal: EMBO J
Title: Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria.
Volume: 22
Issue: 6
Pages: 1235-44
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