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Search results 1 to 96 out of 96 for Mrs2

0.034s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Madaris TR
Year: 2023
Journal: Cell Rep
Title: Limiting Mrs2-dependent mitochondrial Mg(2+) uptake induces metabolic programming in prolonged dietary stress.
Volume: 42
Issue: 3
Pages: 112155
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Daw CC
Year: 2020
Journal: Cell
Title: Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism.
Volume: 183
Issue: 2
Pages: 474-489.e17
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Zsurka G
Year: 2001
Journal: Genomics
Title: The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter.
Volume: 72
Issue: 2
Pages: 158-68
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: frog, African clawed
UniProt Feature
Begin: 54
Description: Magnesium transporter MRS2 homolog, mitochondrial
Type: chain
End: 434
Protein
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: false
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: macaque, rhesus
Allele    
Name: MRS2 magnesium transporter; wild type
Allele
Name: MRS2 magnesium transporter; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: MRS2 magnesium transporter; endonuclease-mediated mutation 1, Muniswamy Madesh
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: MRS2 magnesium transporter; endonuclease-mediated mutation 1, Baylor College of Medicine
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: MRS2 magnesium transporter; endonuclease-mediated mutation 5, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: MRS2 magnesium transporter; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele
Name: MRS2 magnesium transporter; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Strain
Attribute String: mutant strain, endonuclease-mediated mutation, congenic
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: coisogenic, targeted mutation
Genotype
Symbol: Mrs2/Mrs2
Background: B6.Cg-Mrs2
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Mrs2/Mrs2
Background: C57BL/6N-Mrs2/BayMmucd
Zygosity: hm
Has Mutant Allele: true
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication
First Author: Chen J
Year: 2009
Journal: Cell Res
Title: Magnesium transporter AtMGT9 is essential for pollen development in Arabidopsis.
Volume: 19
Issue: 7
Pages: 887-98
Protein Domain
Type: Family
Description: This entry includes prokaryotic magnesium transport protein CorA and its related protein, zinc transport protein ZntB []. This entry also includes eukaryotic magnesium transporters, such as mitochondrial inner membrane magnesium transporter Mrs2 and magnesium transporter Alr1 and Alr2. These proteins are characterised by the conserved GMN motif at the end of the first of twoconserved transmembrane (TM) domains near the C terminus []. Thermotoga maritima CorA (TmCorA) has been reported to be an efflux system. It only has 2 TM domains,TM1 and TM2 [, , ]. The loop connecting TM1 and TM2 contains the conserved CorA signature motifs YGMNF and MPEL. With its N- and C-terminal ends face the cytosol and its similarity to the class II CorA (a CorA group lacking the MPEL motif and may transport divalent cations out of the cell), TmCorA is predicted to be primarily involved in ion efflux []. It forms a pentameric membrane protein channel featuring a possible ion discriminating aspartate ring at the cytoplasmic entrance of the pore and two distinct cytoplasmic metal binding sites per monomer, which could have regulatory roles [, ]. It has been suggested that eukaryotic CorA homologues have the same topology and overall structure as T. maritima CorA []. In budding yeasts, Mrs2 is an essential component of the major electrophoretic Mg2+ influx system in mitochondria []. Overexpression of Alr1 or Alr2 increases tolerance to Al3+ and Ga3+ ions []. Despite generally low sequence similarity, both human Mrs2 (also known as LPE10) and S. typhimurium CorA can restore Mg2+ uptake activity in Saccharomyces cerevisiae with inactive Mrs2 [].
Protein Domain
Type: Homologous_superfamily
Description: This superfamily represents the transmembrane region (including TM1 and TM2) of the Mg2 transporter protein CorA. Thermotoga maritima CorA is an efflux system that forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains []. This domain can also be found in zinc transport protein ZntB []and plant magnesium transporter MRS2 [].Thermotoga maritima CorA (TmCorA) has 2 TM domains,TM1 and TM2 [, , ]. The loop connecting TM1 and TM2 contains the conserved CorA signature motifs YGMNF and MPEL. With its N- and C-terminal ends face the cytosol and its similarity to the class II CorA (a CorA group lacking the MPEL motif and may transport divalent cations out of the cell), TmCorA is predicted to be primarily involved in ion efflux []. It forms a pentameric membrane protein channel featuring a possible ion discriminating aspartate ring at the cytoplasmic entrance of the pore and two distinct cytoplasmic metal binding sites per monomer, which could have regulatory roles [, ]. It has been suggested that eukaryotic CorA homologues have the same topology and overall structure as T. maritima CorA []. In budding yeasts, Mrs2 is an essential component of the major electrophoretic Mg2+ influx system in mitochondria []. Overexpression of Alr1 or Alr2 increases tolerance to Al3+ and Ga3+ ions []. Despite generally low sequence similarity, both human Mrs2 (also known as LPE10) and S. typhimurium CorA can restore Mg2+ uptake activity in Saccharomyces cerevisiae with inactive Mrs2 [].
Protein Domain
Type: Homologous_superfamily
Description: This superfamily represents the N-terminal cytoplasmic domain of the Mg2+ transporter protein CorA. Thermotoga maritima CorA is an efflux system that forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains []. This domain can also be found in zinc transport protein ZntB [].Thermotoga maritima CorA (TmCorA) has 2 TM domains,TM1 and TM2 [, , ]. The loop connecting TM1 and TM2 contains the conserved CorA signature motifs YGMNF and MPEL. With its N- and C-terminal ends face the cytosol and its similarity to the class II CorA (a CorA group lacking the MPEL motif and may transport divalent cations out of the cell), TmCorA is predicted to be primarily involved in ion efflux []. It forms a pentameric membrane protein channel featuring a possible ion discriminating aspartate ring at the cytoplasmic entrance of the pore and two distinct cytoplasmic metal binding sites per monomer, which could have regulatory roles [, ]. It has been suggested that eukaryotic CorA homologues have the same topology and overall structure as T. maritima CorA []. In budding yeasts, Mrs2 is an essential component of the major electrophoretic Mg2+ influx system in mitochondria []. Overexpression of Alr1 or Alr2 increases tolerance to Al3+ and Ga3+ ions []. Despite generally low sequence similarity, both human Mrs2 (also known as LPE10) and S. typhimurium CorA can restore Mg2+ uptake activity in Saccharomyces cerevisiae with inactive Mrs2 [].
Publication
First Author: Eshaghi S
Year: 2006
Journal: Science
Title: Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution.
Volume: 313
Issue: 5785
Pages: 354-7
Publication
First Author: Worlock AJ
Year: 2002
Journal: J Bacteriol
Title: ZntB is a novel Zn2+ transporter in Salmonella enterica serovar Typhimurium.
Volume: 184
Issue: 16
Pages: 4369-73
Publication
First Author: Nordin N
Year: 2013
Journal: Biochem J
Title: Exploring the structure and function of Thermotoga maritima CorA reveals the mechanism of gating and ion selectivity in Co2+/Mg2+ transport.
Volume: 451
Issue: 3
Pages: 365-74
Publication
First Author: Kehres DG
Year: 2002
Journal: Biometals
Title: Structure, properties and regulation of magnesium transport proteins.
Volume: 15
Issue: 3
Pages: 261-70
Publication
First Author: Niegowski D
Year: 2007
Journal: Cell Mol Life Sci
Title: The CorA family: structure and function revisited.
Volume: 64
Issue: 19-20
Pages: 2564-74
Publication
First Author: MacDiarmid CW
Year: 1998
Journal: J Biol Chem
Title: Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion.
Volume: 273
Issue: 3
Pages: 1727-32
Publication
First Author: Kolisek M
Year: 2003
Journal: EMBO J
Title: Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria.
Volume: 22
Issue: 6
Pages: 1235-44
Publication
First Author: Lunin VV
Year: 2006
Journal: Nature
Title: Crystal structure of the CorA Mg2+ transporter.
Volume: 440
Issue: 7085
Pages: 833-7
Publication
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112