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Search results 1 to 27 out of 27 for Mrvi1

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Type Details Score
Protein Domain
IPR008677 | MRVI1
Type: Family
Description: This family consists of mammalian MRVI1 proteins which are related to the lymphoid-restricted membrane protein (JAW1) and the IP3 receptor associated cGMP kinase substrates A and B (IRAGA and IRAGB). The function of MRVI1 is unknown although mutations in the Mrvi1 gene induces myeloid leukaemia by altering the expression of a gene important for myeloid cell growth and/or differentiation so it has been speculated that Mrvi1 is a tumour suppressor gene []. IRAG is very similar in sequence to MRVI1 and is an essential NO/cGKI-dependent regulator of IP3-induced calcium release. Activation of cGKI decreases IP3-stimulated elevations in intracellular calcium, induces smooth muscle relaxation and contributes to the antiproliferative and pro-apoptotic effects of NO/cGMP [, []. Jaw1 is a member of a class of proteins with COOH-terminal hydrophobic membrane anchors and is structurally similar to proteins involved in vesicle targeting and fusion. This suggests that the function and/or the structure of the ER in lymphocytes may be modified by lymphoid-restricted resident ER proteins [].
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Gene
100331961 | mrvi1
Type: gene
Organism: zebrafish
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Protein
D3YUG8
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true
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Protein
Q3UR44
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: true
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Protein
G5E8V5
Organism: Mus musculus/domesticus
Length: 921  
Fragment?: false
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Protein
Q9WUX5
Organism: Mus musculus/domesticus
Length: 899  
Fragment?: false
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Publication
10321731 | J:54295
First Author: Shaughnessy JD Jr
Year: 1999
Journal: Oncogene
Title: Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1.
Volume: 18
Issue: 12
Pages: 2069-84
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Publication
16990611 | J:180467
First Author: Antl M
Year: 2007
Journal: Blood
Title: IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.
Volume: 109
Issue: 2
Pages: 552-9
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Publication
8021504 | J:35633
First Author: Behrens TW
Year: 1994
Journal: J Immunol
Title: Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulum.
Volume: 153
Issue: 2
Pages: 682-90
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Protein
Q60664
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
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Protein
E9Q2C8
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
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Protein
G5E880
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
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Protein
Q3TGD7
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: false
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Protein
Q3TL84
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: true
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Protein
Q3V325
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Protein
Q3U583
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
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Protein
Q8BNX8
Organism: Mus musculus/domesticus
Length: 227  
Fragment?: true
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Protein
Q675B6
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
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Protein
F6WLY0
Organism: Mus musculus/domesticus
Length: 504  
Fragment?: true
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Protein
F6VUK8
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
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Protein
Q3U560
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
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Protein
Q3TVR1
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
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Protein
Q3V3H7
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: true
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Publication
10724174 | -
First Author: Schlossmann J
Year: 2000
Journal: Nature
Title: Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta.
Volume: 404
Issue: 6774
Pages: 197-201
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Protein
Q3TNQ7
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
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Protein Coding Gene
MGI:1338023 | Irag1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9WUX5-2
Organism: Mus musculus/domesticus
Length: 856  
Fragment?: false
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