|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 27 out of 27 for Mrvi1

0.019s

Categories

Hits by Pathway

Hits by Category

Type Details Score
Protein Domain
IPR008677 | MRVI1
Type: Family
Description: This family consists of mammalian MRVI1 proteins which are related to the lymphoid-restricted membrane protein (JAW1) and the IP3 receptor associated cGMP kinase substrates A and B (IRAGA and IRAGB). The function of MRVI1 is unknown although mutations in the Mrvi1 gene induces myeloid leukaemia by altering the expression of a gene important for myeloid cell growth and/or differentiation so it has been speculated that Mrvi1 is a tumour suppressor gene []. IRAG is very similar in sequence to MRVI1 and is an essential NO/cGKI-dependent regulator of IP3-induced calcium release. Activation of cGKI decreases IP3-stimulated elevations in intracellular calcium, induces smooth muscle relaxation and contributes to the antiproliferative and pro-apoptotic effects of NO/cGMP [, []. Jaw1 is a member of a class of proteins with COOH-terminal hydrophobic membrane anchors and is structurally similar to proteins involved in vesicle targeting and fusion. This suggests that the function and/or the structure of the ER in lymphocytes may be modified by lymphoid-restricted resident ER proteins [].
•
•
•
•
•
Gene
100331961 | mrvi1
Type: gene
Organism: zebrafish
•
•
•
•
•
Protein
D3YUG8
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true
•
•
•
•
•
Protein
Q3UR44
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: true
•
•
•
•
•
Protein
G5E8V5
Organism: Mus musculus/domesticus
Length: 921  
Fragment?: false
•
•
•
•
•
Protein
Q9WUX5
Organism: Mus musculus/domesticus
Length: 899  
Fragment?: false
•
•
•
•
•
Publication
10321731 | J:54295
First Author: Shaughnessy JD Jr
Year: 1999
Journal: Oncogene
Title: Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1.
Volume: 18
Issue: 12
Pages: 2069-84
•
•
•
•
•
Publication
16990611 | J:180467
First Author: Antl M
Year: 2007
Journal: Blood
Title: IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.
Volume: 109
Issue: 2
Pages: 552-9
•
•
•
•
•
Publication
8021504 | J:35633
First Author: Behrens TW
Year: 1994
Journal: J Immunol
Title: Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulum.
Volume: 153
Issue: 2
Pages: 682-90
•
•
•
•
•
Protein
Q60664
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
•
•
•
•
•
Protein
E9Q2C8
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
•
•
•
•
•
Protein
G5E880
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
•
•
•
•
•
Protein
Q3TGD7
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: false
•
•
•
•
•
Protein
Q3TL84
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: true
•
•
•
•
•
Protein
Q3V325
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
•
•
•
•
•
Protein
Q3U583
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
•
•
•
•
•
Protein
Q8BNX8
Organism: Mus musculus/domesticus
Length: 227  
Fragment?: true
•
•
•
•
•
Protein
Q675B6
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
•
•
•
•
•
Protein
F6WLY0
Organism: Mus musculus/domesticus
Length: 504  
Fragment?: true
•
•
•
•
•
Protein
F6VUK8
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
•
•
•
•
•
Protein
Q3U560
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
•
•
•
•
•
Protein
Q3TVR1
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
•
•
•
•
•
Protein
Q3V3H7
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: true
•
•
•
•
•
Publication
10724174 | -
First Author: Schlossmann J
Year: 2000
Journal: Nature
Title: Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta.
Volume: 404
Issue: 6774
Pages: 197-201
•
•
•
•
•
Protein
Q3TNQ7
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
•
•
•
•
•
Protein Coding Gene
MGI:1338023 | Irag1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q9WUX5-2
Organism: Mus musculus/domesticus
Length: 856  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom