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Search results 1 to 100 out of 186 for Ms4a2

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Type Details Score
Gene
2206 | MS4A2
Type: gene
Organism: human
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Gene
736459 | MS4A2
Type: gene
Organism: chimpanzee
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Gene
531987 | MS4A2
Type: gene
Organism: cattle
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Gene
697830 | MS4A2
Type: gene
Organism: macaque, rhesus
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Gene
25316 | Ms4a2
Type: gene
Organism: rat
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Gene
403799 | MS4A2
Type: gene
Organism: dog, domestic
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Protein Domain
IPR030420 | MS4A2
Type: Family
Description: The high affinity immunoglobulin epsilon (IgE) receptor (FceRI) binds to the Fc region of IgE. A typical FceRI is a tetrameric hetero-oligomer composed of an alpha chain, a beta chain, and two disulfide-linked gamma chains []. Interestingly, human monocytes, dendritic cells and Langerhans cells express FceRI without the beta subunit, employing an alphagamma2 FceRI trimeric receptor for antigen presentation []. It has been suggested that the inclusion of beta in the FceRI produces a powerful inflammatory IgE-binding tetramer restricted to mast cells and basophils, and this plays an important role in IgE-mediated allergic reaction [].This entry represents the subunit beta of the high affinity immunoglobulin epsilon (IgE) receptor (FceRI), also known as membrane-spanning 4-domains subfamily A member 2 (MS4A2). A coding variant of MS4A2 has been associated with asthma [, ].
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Protein Coding Gene
MGI:95495 | Ms4a2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31501274 | J:291300
 
First Author: Ohmori S
Year: 2019
Journal: Mol Cell Biol
Title: GATA2 and PU.1 Collaborate To Activate the Expression of the Mouse Ms4a2 Gene, Encoding FcεRIβ, through Distinct Mechanisms.
Volume: 39
Issue: 22
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Protein
A0A0B4J1P0
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
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Protein
P97890
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: true
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Publication
1535625 | -
First Author: Küster H
Year: 1992
Journal: J Biol Chem
Title: The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor.
Volume: 267
Issue: 18
Pages: 12782-7
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Publication
8817330 | -
First Author: Hill MR
Year: 1996
Journal: Hum Mol Genet
Title: A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness.
Volume: 5
Issue: 7
Pages: 959-62
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Publication
8842731 | -
First Author: Shirakawa T
Year: 1996
Journal: Hum Mol Genet
Title: Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population.
Volume: 5
Issue: 8
Pages: 1129-30
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Publication
22623922 | -
 
First Author: Ra C
Year: 2012
Journal: Front Immunol
Title: Fine-Tuning of Mast Cell Activation by FcεRIβ Chain.
Volume: 3
Pages: 112
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Publication
24447079 | -
First Author: Ryan JJ
Year: 2014
Journal: Clin Exp Allergy
Title: Too much of a good thing: beta-chain overexpression blocks FcεRI signalling by capturing Lyn in the cytosol.
Volume: 44
Issue: 2
Pages: 154-6
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Protein
P20490
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Protein
A0A087WPM9
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
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Protein
Q3UNT6
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
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Protein
B2RTF7
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Publication
16272347 | J:119693
First Author: Xiao W
Year: 2005
Journal: J Immunol
Title: Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.
Volume: 175
Issue: 10
Pages: 6885-92
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Protein Coding Gene
MGP_CAROLIEiJ_G0022725 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024879 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024853 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024853 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024619 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_95495 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025301 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024092 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024593 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024720 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024687 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024807 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024714 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025349 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023836 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024154 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014221 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023642 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10069418 | J:53106
First Author: Hiraoka S
Year: 1999
Journal: Int Immunol
Title: Fc receptor beta subunit is required for full activation of mast cells through Fc receptor engagement.
Volume: 11
Issue: 2
Pages: 199-207
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Publication
19741711 | J:159569
First Author: Kobayashi M
Year: 2010
Journal: J Invest Dermatol
Title: Abrogation of high-affinity IgE receptor-mediated mast cell activation at the effector phase prevents contact hypersensitivity to oxazolone.
Volume: 130
Issue: 3
Pages: 725-31
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Publication
15944196 | J:99534
First Author: Nunomura S
Year: 2005
Journal: Int Immunol
Title: Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE.
Volume: 17
Issue: 6
Pages: 685-94
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Publication
2970642 | J:39249
First Author: Kinet JP
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E.
Volume: 85
Issue: 17
Pages: 6483-7
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Publication
8188278 | J:16778
First Author: Szepetowski P
Year: 1994
Journal: Genomics
Title: FCER1B, a candidate gene for atopy, is located in 11q13 between CD20 and TCN1.
Volume: 19
Issue: 2
Pages: 399-400
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Publication
19741159 | J:155622
First Author: Brenzovich J
Year: 2009
Journal: J Leukoc Biol
Title: IgE signaling suppresses FcepsilonRIbeta expression.
Volume: 86
Issue: 6
Pages: 1351-8
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GXD Expression
GXD Expression
     
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:4360036
Age: embryonic day 17.5
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:4360036
Age: embryonic day 17.5
Specimen Label: None
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
       
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:4360036
Age: embryonic day 17.5
Specimen Label: None
Specimen Num: 3
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GXD Expression
GXD Expression
       
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:4360036
Age: embryonic day 17.5
Specimen Label: None
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:4360036
Age: embryonic day 17.5
Specimen Label: None
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
       
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:4360036
Age: embryonic day 17.5
Specimen Label: None
Specimen Num: 6
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GXD Expression
GXD Expression
       
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:4360036
Age: embryonic day 17.5
Specimen Label: None
Specimen Num: 7
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GXD Expression
GXD Expression
       
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752525
Stage: TS25
Assay Id: MGI:4360036
Age: embryonic day 17.5
Specimen Label: None
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360058
Age: postnatal day 5
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360058
Age: postnatal day 5
Specimen Label: None
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
       
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360058
Age: postnatal day 5
Specimen Label: None
Specimen Num: 3
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GXD Expression
GXD Expression
       
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360058
Age: postnatal day 5
Specimen Label: None
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360058
Age: postnatal day 5
Specimen Label: None
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
       
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360058
Age: postnatal day 5
Specimen Label: None
Specimen Num: 6
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GXD Expression
GXD Expression
       
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360058
Age: postnatal day 5
Specimen Label: None
Specimen Num: 7
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GXD Expression
GXD Expression
       
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360058
Age: postnatal day 5
Specimen Label: None
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360062
Age: postnatal day 150
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360062
Age: postnatal day 150
Specimen Label: None
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
       
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360062
Age: postnatal day 150
Specimen Label: None
Specimen Num: 3
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GXD Expression
GXD Expression
       
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360062
Age: postnatal day 150
Specimen Label: None
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360062
Age: postnatal day 150
Specimen Label: None
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360062
Age: postnatal day 150
Specimen Label: None
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360062
Age: postnatal day 150
Specimen Label: None
Detected: false
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:4360019
Assay Type: RT-PCR
Annotation Date: 2009-10-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4360062
Age: postnatal day 150
Specimen Label: None
Detected: false
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:6109998
Assay Type: RT-PCR
Annotation Date: 2018-01-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752520
Stage: TS20
Assay Id: MGI:6110000
Age: embryonic day 12.5
Specimen Label: Day 13pc
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6109998
Assay Type: RT-PCR
Annotation Date: 2018-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752521
Stage: TS21
Assay Id: MGI:6110000
Age: embryonic day 13.5
Specimen Label: Day 14pc
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6109998
Assay Type: RT-PCR
Annotation Date: 2018-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:6110000
Age: embryonic day 14.5
Specimen Label: Day 15pc
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6109998
Assay Type: RT-PCR
Annotation Date: 2018-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752523
Stage: TS23
Assay Id: MGI:6110000
Age: embryonic day 15.5
Specimen Label: Day 16pc
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6109998
Assay Type: RT-PCR
Annotation Date: 2018-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752524
Stage: TS24
Assay Id: MGI:6110000
Age: embryonic day 16.5
Specimen Label: Day 17pc
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6109998
Assay Type: RT-PCR
Annotation Date: 2018-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:6110000
Age: postnatal day 5
Specimen Label: Day 5
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:6109998
Assay Type: RT-PCR
Annotation Date: 2018-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:6110000
Age: postnatal day 10
Specimen Label: Day 10
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:6109998
Assay Type: RT-PCR
Annotation Date: 2018-01-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752527
Stage: TS27
Assay Id: MGI:6110000
Age: postnatal day 1
Specimen Label: W/W
Detected: false
Specimen Num: 9
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Publication
9586641 | J:47138
First Author: Dombrowicz D
Year: 1998
Journal: Immunity
Title: Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses.
Volume: 8
Issue: 4
Pages: 517-29
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Publication
2527850 | J:31359
First Author: Ra C
Year: 1989
Journal: J Biol Chem
Title: Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat-mouse-human) on transfected cells.
Volume: 264
Issue: 26
Pages: 15323-7
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Publication
25180604 | J:217638
First Author: Dahdah A
Year: 2014
Journal: J Clin Invest
Title: Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.
Volume: 124
Issue: 10
Pages: 4577-89
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Publication
28167630 | J:252693
First Author: Danelli L
Year: 2017
Journal: J Immunol
Title: Early Phase Mast Cell Activation Determines the Chronic Outcome of Renal Ischemia-Reperfusion Injury.
Volume: 198
Issue: 6
Pages: 2374-2382
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Publication
22430736 | J:184055
First Author: Nunomura S
Year: 2012
Journal: J Immunol
Title: The FcRβ- and γ-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEκ and Protein L.
Volume: 188
Issue: 8
Pages: 4052-64
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Publication
38055674 | J:343485
First Author: Loste A
Year: 2023
Journal: PLoS One
Title: Involvement of an IgE/Mast cell/B cell amplification loop in abdominal aortic aneurysm progression.
Volume: 18
Issue: 12
Pages: e0295408
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Publication
17371974 | J:145059
First Author: Ekoff M
Year: 2007
Journal: J Immunol
Title: FcepsilonRI aggregation promotes survival of connective tissue-like mast cells but not mucosal-like mast cells.
Volume: 178
Issue: 7
Pages: 4177-83
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Publication
17513616 | J:147024
First Author: Hong H
Year: 2007
Journal: Blood
Title: The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.
Volume: 110
Issue: 7
Pages: 2511-9
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