|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 396 for Msh2

<< First    < Previous  |  Next >    Last >>
0.034s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: This entry represents the DNA mismatch repair protein Msh2 (homologous to bacterial MutS) from eukaryotes. Msh2-Msh6 complex recognises base pair mismatches and small insertion/deletions in DNA and initiates repair []. Human Msh2-Msh6 complex has been shown to regulate BLM helicase in response to the damaged DNA forks during double-stranded break repair []. Mismatch repair (MMR) is one of five major DNA repair pathways. The mismatch repair system recognises and repairs mispaired or unpaired nucleotides that result from errors in DNA replication. The most extensively studied general MMR system is the MutHLS pathway of the bacterium Escherichia coli. In the first step of the MutHLS pathway, the MutS protein (in the form of a dimer) binds to the site of a mismatch in double-stranded DNA. Through a complex interaction between MutS, MutL and MutH, a section of the newly replicated DNA strand (and thus the strand with the replication error) at the location of the mismatch bound by MutS is targeted for removal []. Homologues of MutS have been found in many species including eukaryotes, Archaea and other bacteria, and together these proteins have been grouped into the MutS family.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 210  
Fragment?: true
Gene
Type: gene
Organism: Homo sapiens
Protein
Organism: Mus musculus
Length: 935  
Fragment?: false
Publication
First Author: Antony E
Year: 2003
Journal: Biochemistry
Title: Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair.
Volume: 42
Issue: 25
Pages: 7682-93
Publication
First Author: Yang Q
Year: 2004
Journal: Oncogene
Title: The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.
Volume: 23
Issue: 21
Pages: 3749-56
Publication
First Author: Varlet I
Year: 1994
Journal: Nucleic Acids Res
Title: Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch repair genes.
Volume: 22
Issue: 25
Pages: 5723-8
Protein
Organism: Mus musculus
Length: 275  
Fragment?: true
Publication
First Author: Zienolddiny S
Year: 2006
Journal: Int J Cancer
Title: Msh2 deficiency increases susceptibility to benzo[a]pyrene-induced lymphomagenesis.
Volume: 118
Issue: 11
Pages: 2899-902
Protein
Organism: Mus musculus
Length: 935  
Fragment?: false
Protein
Organism: Mus musculus
Length: 935  
Fragment?: false
Publication
First Author: Eisen JA
Year: 1998
Journal: Nucleic Acids Res
Title: A phylogenomic study of the MutS family of proteins.
Volume: 26
Issue: 18
Pages: 4291-300
Publication
First Author: Reitmair AH
Year: 1995
Journal: Nat Genet
Title: MSH2 deficient mice are viable and susceptible to lymphoid tumours.
Volume: 11
Issue: 1
Pages: 64-70
Publication
First Author: Reitmair AH
Year: 1996
Journal: Cancer Res
Title: MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis.
Volume: 56
Issue: 13
Pages: 2922-6
Publication
First Author: Lin DP
Year: 2004
Journal: Cancer Res
Title: An Msh2 point mutation uncouples DNA mismatch repair and apoptosis.
Volume: 64
Issue: 2
Pages: 517-22
Publication
First Author: Chalastanis A
Year: 2010
Journal: J Natl Cancer Inst
Title: Azathioprine-induced carcinogenesis in mice according to Msh2 genotype.
Volume: 102
Issue: 22
Pages: 1731-40
Publication
First Author: Kolodner RD
Year: 1994
Journal: Genomics
Title: Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations.
Volume: 24
Issue: 3
Pages: 516-26
Publication
First Author: Kucherlapati MH
Year: 2010
Journal: Gastroenterology
Title: An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.
Volume: 138
Issue: 3
Pages: 993-1002.e1
Publication
First Author: Tomé S
Year: 2009
Journal: PLoS Genet
Title: MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.
Volume: 5
Issue: 5
Pages: e1000482
Publication
First Author: Martinez P
Year: 2009
Journal: Aging Cell
Title: MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres.
Volume: 8
Issue: 1
Pages: 2-17
Publication
First Author: Zhang M
Year: 2014
Journal: Mol Cell
Title: HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα.
Volume: 55
Issue: 1
Pages: 31-46
Publication
First Author: Burr KL
Year: 2007
Journal: Mutat Res
Title: The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline.
Volume: 617
Issue: 1-2
Pages: 147-51
Publication
First Author: Leduc C
Year: 2010
Journal: Eur J Immunol
Title: Combined deficiency of MSH2 and Sμ region abolishes class switch recombination.
Volume: 40
Issue: 10
Pages: 2925-31
Publication
First Author: Toft NJ
Year: 2002
Journal: Oncogene
Title: Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background.
Volume: 21
Issue: 41
Pages: 6299-306
Publication
First Author: Cranston A
Year: 1997
Journal: Nat Genet
Title: Female embryonic lethality in mice nullizygous for both Msh2 and p53.
Volume: 17
Issue: 1
Pages: 114-8
Publication
First Author: Sohn KJ
Year: 2003
Journal: Carcinogenesis
Title: Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice.
Volume: 24
Issue: 2
Pages: 217-24
Publication
First Author: Eso Y
Year: 2016
Journal: Cancer Res
Title: MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development.
Volume: 76
Issue: 15
Pages: 4383-93
Publication
First Author: Meira LB
Year: 2002
Journal: DNA Repair (Amst)
Title: Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer.
Volume: 1
Issue: 11
Pages: 929-34
Publication
First Author: Jenab-Wolcott J
Year: 2000
Journal: Mol Cell Biol
Title: The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation.
Volume: 20
Issue: 22
Pages: 8373-81
Publication
First Author: Andrew SE
Year: 1997
Journal: Oncogene
Title: Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice.
Volume: 15
Issue: 2
Pages: 123-9
Publication
First Author: He D
Year: 2012
Journal: Mutat Res
Title: Role of the Msh2 gene in genome maintenance and development in mouse fetuses.
Volume: 734
Issue: 1-2
Pages: 50-5
Publication
First Author: Larijani M
Year: 2005
Journal: Nucleic Acids Res
Title: Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events.
Volume: 33
Issue: 21
Pages: 6733-42
Publication
First Author: de Wind N
Year: 1995
Journal: Cell
Title: Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer.
Volume: 82
Issue: 2
Pages: 321-30
Publication
First Author: Yoshino M
Year: 2002
Journal: DNA Repair (Amst)
Title: Additive roles of XPA and MSH2 genes in UVB-induced skin tumorigenesis in mice.
Volume: 1
Issue: 11
Pages: 935-40
Publication
First Author: Russo MT
Year: 2009
Journal: Cancer Res
Title: Role of MUTYH and MSH2 in the control of oxidative DNA damage, genetic instability, and tumorigenesis.
Volume: 69
Issue: 10
Pages: 4372-9
Publication
First Author: Frieder D
Year: 2009
Journal: Mol Cell Biol
Title: The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.
Volume: 29
Issue: 18
Pages: 5148-57
Publication
First Author: Manley K
Year: 1999
Journal: Nat Genet
Title: Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice.
Volume: 23
Issue: 4
Pages: 471-3
Publication
First Author: Wheeler VC
Year: 2003
Journal: Hum Mol Genet
Title: Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum.
Volume: 12
Issue: 3
Pages: 273-81
Publication
First Author: Lv L
Year: 2013
Journal: Nucleic Acids Res
Title: Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.
Volume: 41
Issue: 22
Pages: 10312-22
Publication
First Author: Toft NJ
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine.
Volume: 96
Issue: 7
Pages: 3911-5
Publication
First Author: van Oosten M
Year: 2005
Journal: DNA Repair (Amst)
Title: Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes.
Volume: 4
Issue: 1
Pages: 81-9
Publication
First Author: Ehrenstein MR
Year: 1999
Journal: EMBO J
Title: Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.
Volume: 18
Issue: 12
Pages: 3484-90
Publication
First Author: Martin A
Year: 2003
Journal: J Exp Med
Title: Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination.
Volume: 198
Issue: 8
Pages: 1171-8
Publication
First Author: Zhang S
Year: 2001
Journal: Oncogene
Title: Msh2 DNA mismatch repair gene deficiency and the food-borne mutagen 2-amino-1-methy1-6-phenolimidazo [4,5-b] pyridine (PhIP) synergistically affect mutagenesis in mouse colon.
Volume: 20
Issue: 42
Pages: 6066-72
Publication
First Author: Sansom OJ
Year: 2002
Journal: Oncogene
Title: The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice.
Volume: 21
Issue: 38
Pages: 5934-9
Publication
First Author: Zhang S
Year: 2002
Journal: Mutat Res
Title: Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum.
Volume: 500
Issue: 1-2
Pages: 67-74
Publication
First Author: Fishel R
Year: 1993
Journal: Cell
Title: The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
Volume: 75
Issue: 5
Pages: 1027-38
Publication
First Author: Ellison AR
Year: 2001
Journal: Hum Mol Genet
Title: Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae.
Volume: 10
Issue: 18
Pages: 1889-900
Publication
First Author: Phung QH
Year: 1998
Journal: J Exp Med
Title: Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein.
Volume: 187
Issue: 11
Pages: 1745-51
Publication
First Author: Egashira A
Year: 2002
Journal: DNA Repair (Amst)
Title: Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes.
Volume: 1
Issue: 11
Pages: 881-93
Publication
First Author: Toft NJ
Year: 1998
Journal: Nat Genet
Title: No female embryonic lethality in mice nullizygous for Msh2 and p53.
Volume: 18
Issue: 1
Pages: 17
Publication
First Author: Kovalenko M
Year: 2012
Journal: PLoS One
Title: Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.
Volume: 7
Issue: 9
Pages: e44273
Publication
First Author: Franchitto A
Year: 2003
Journal: Oncogene
Title: The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase.
Volume: 22
Issue: 14
Pages: 2110-20
Publication
First Author: Kongkanuntn R
Year: 1999
Journal: Oncogene
Title: Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice.
Volume: 18
Issue: 51
Pages: 7219-25
Publication
First Author: Lowsky R
Year: 1997
Journal: Blood
Title: Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL).
Volume: 89
Issue: 7
Pages: 2276-82
Publication
First Author: Ranjit S
Year: 2011
Journal: J Immunol
Title: AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].
Volume: 187
Issue: 5
Pages: 2464-75
Publication
First Author: Kovtun IV
Year: 2004
Journal: Hum Mol Genet
Title: Somatic deletion events occur during early embryonic development and modify the extent of CAG expansion in subsequent generations.
Volume: 13
Issue: 24
Pages: 3057-68
Publication
First Author: Vora KA
Year: 1999
Journal: J Exp Med
Title: Severe attenuation of the B cell immune response in Msh2-deficient mice.
Volume: 189
Issue: 3
Pages: 471-82
Publication
First Author: Peters AC
Year: 2003
Journal: DNA Repair (Amst)
Title: Mammalian DNA mismatch repair protects cells from UVB-induced DNA damage by facilitating apoptosis and p53 activation.
Volume: 2
Issue: 4
Pages: 427-35
Publication
First Author: Rada C
Year: 1998
Journal: Immunity
Title: Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting.
Volume: 9
Issue: 1
Pages: 135-41
Publication
First Author: Alabyev B
Year: 2002
Journal: J Immunol
Title: Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice.
Volume: 169
Issue: 7
Pages: 3819-24
Publication
First Author: Min IM
Year: 2003
Journal: Immunity
Title: The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2.
Volume: 19
Issue: 4
Pages: 515-24
Publication
First Author: Min IM
Year: 2005
Journal: J Exp Med
Title: Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2.
Volume: 201
Issue: 12
Pages: 1885-90
Publication
First Author: Baross-Francis A
Year: 2000
Journal: Carcinogenesis
Title: Tumors arising in DNA mismatch repair-deficient mice show a wide variation in mutation frequency as assessed by a transgenic reporter gene.
Volume: 21
Issue: 6
Pages: 1259-62
Publication
First Author: Qin J
Year: 2002
Journal: J Hered
Title: Evidence for the lack of mismatch-repair directed antirecombination during mouse meiosis.
Volume: 93
Issue: 3
Pages: 201-5
Publication
First Author: Campbell MR
Year: 2000
Journal: Carcinogenesis
Title: Candidate mutator genes in mismatch repair-deficient thymic lymphomas: no evidence of mutations in the DNA polymerase delta gene.
Volume: 21
Issue: 12
Pages: 2281-5
Publication
First Author: Claij N
Year: 2003
Journal: Cancer Res
Title: DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lymphomagenesis.
Volume: 63
Issue: 9
Pages: 2062-6
Publication
First Author: Sansom OJ
Year: 2001
Journal: Oncogene
Title: Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner.
Volume: 20
Issue: 27
Pages: 3580-4
Publication
First Author: Elliott B
Year: 2001
Journal: Mol Cell Biol
Title: Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells.
Volume: 21
Issue: 8
Pages: 2671-82
Publication
First Author: Williams SA
Year: 2011
Journal: Hum Mol Genet
Title: Functional and physical interaction between the mismatch repair and FA-BRCA pathways.
Volume: 20
Issue: 22
Pages: 4395-410
Publication
First Author: Kabbarah O
Year: 2005
Journal: Int J Cancer
Title: Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice.
Volume: 115
Issue: 4
Pages: 666-9
Publication
First Author: Oda S
Year: 2000
Journal: EMBO J
Title: Efficient repair of A/C mismatches in mouse cells deficient in long-patch mismatch repair.
Volume: 19
Issue: 7
Pages: 1711-8
Publication
First Author: Hooker AM
Year: 2004
Journal: Mutat Res
Title: Cancer-associated genes can affect somatic intrachromosomal recombination early in carcinogenesis.
Volume: 550
Issue: 1-2
Pages: 1-10
Publication
First Author: Colussi C
Year: 2001
Journal: J Natl Cancer Inst
Title: 1,2-Dimethylhydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice.
Volume: 93
Issue: 20
Pages: 1534-40
Publication
First Author: Kohonen-Corish MR
Year: 2002
Journal: Cancer Res
Title: Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors.
Volume: 62
Issue: 7
Pages: 2092-7
Publication
First Author: Wiesendanger M
Year: 2000
Journal: J Exp Med
Title: Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern.
Volume: 191
Issue: 3
Pages: 579-84
Publication
First Author: Gu X
Year: 2016
Journal: Blood
Title: AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma.
Volume: 127
Issue: 1
Pages: 102-12
Publication
First Author: Green B
Year: 2011
Journal: Blood
Title: The mismatch repair pathway functions normally at a non-AID target in germinal center B cells.
Volume: 118
Issue: 11
Pages: 3013-8
Publication
First Author: Aarts M
Year: 2006
Journal: Nucleic Acids Res
Title: Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells.
Volume: 34
Issue: 21
Pages: e147
Publication
First Author: Krijger PH
Year: 2009
Journal: J Exp Med
Title: Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.
Volume: 206
Issue: 12
Pages: 2603-11
Publication
First Author: Kovtun IV
Year: 2011
Journal: Carcinogenesis
Title: Increased incidence of endometrioid tumors caused by aberrations in E-cadherin promoter of mismatch repair-deficient mice.
Volume: 32
Issue: 7
Pages: 1085-92
Publication
First Author: Schrader CE
Year: 2003
Journal: J Exp Med
Title: Mlh1 can function in antibody class switch recombination independently of Msh2.
Volume: 197
Issue: 10
Pages: 1377-83
Publication
First Author: Kucherlapati MH
Year: 2013
Journal: PLoS One
Title: Genotype directed therapy in murine mismatch repair deficient tumors.
Volume: 8
Issue: 7
Pages: e68817
Publication
First Author: Aoi J
Year: 2014
Journal: Mol Cancer Res
Title: Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress.
Volume: 12
Issue: 2
Pages: 239-49
Publication
First Author: Nikitin AY
Year: 2002
Journal: Cancer Res
Title: Cell lineage-specific effects associated with multiple deficiencies of tumor susceptibility genes in Msh2(-/-)Rb(+/-) mice.
Volume: 62
Issue: 18
Pages: 5134-8
Publication
First Author: de Wind N
Year: 1998
Journal: Cancer Res
Title: Mouse models for hereditary nonpolyposis colorectal cancer.
Volume: 58
Issue: 2
Pages: 248-55
Publication
First Author: Sansom OJ
Year: 2003
Journal: DNA Repair (Amst)
Title: Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.
Volume: 2
Issue: 9
Pages: 1029-39
Publication
First Author: Schrader CE
Year: 2002
Journal: J Exp Med
Title: Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions.
Volume: 195
Issue: 3
Pages: 367-73
Publication
First Author: Eccleston J
Year: 2009
Journal: J Immunol
Title: Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats.
Volume: 183
Issue: 2
Pages: 1222-8
Publication
First Author: Grigera F
Year: 2013
Journal: PLoS One
Title: Complex relationship between mismatch repair proteins and MBD4 during immunoglobulin class switch recombination.
Volume: 8
Issue: 10
Pages: e78370
Publication
First Author: Andrew SE
Year: 2000
Journal: Carcinogenesis
Title: Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts.
Volume: 21
Issue: 7
Pages: 1291-5
Publication
First Author: de Wind N
Year: 1999
Journal: Nat Genet
Title: HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions.
Volume: 23
Issue: 3
Pages: 359-62
Publication
First Author: Eccleston J
Year: 2011
Journal: J Immunol
Title: Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.
Volume: 186
Issue: 4
Pages: 2336-43
Publication
First Author: Hegan DC
Year: 2006
Journal: Carcinogenesis
Title: Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6.
Volume: 27
Issue: 12
Pages: 2402-8
Publication
First Author: Bourn RL
Year: 2012
Journal: PLoS One
Title: Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues.
Volume: 7
Issue: 10
Pages: e47085