Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents the DNA mismatch repair protein Msh2 (homologous to bacterial MutS) from eukaryotes. Msh2-Msh6 complex recognises base pair mismatches and small insertion/deletions in DNA and initiates repair []. Human Msh2-Msh6 complex has been shown to regulate BLM helicase in response tothe damaged DNA forks during double-stranded break repair []. Mismatch repair (MMR) is one of five major DNA repair pathways. The mismatch repair system recognises and repairs mispaired or unpaired nucleotides that result from errors in DNA replication. The most extensively studied general MMR system is the MutHLS pathway of the bacterium Escherichia coli. In the first step of the MutHLS pathway, the MutS protein (in the form of a dimer) binds to the site of a mismatch in double-stranded DNA. Through a complex interaction between MutS, MutL and MutH, a section of the newly replicated DNA strand (and thus the strand with the replication error) at the location of the mismatch bound by MutS is targeted for removal []. Homologues of MutS have been found in many species including eukaryotes, Archaea and other bacteria, and together these proteins have been grouped into the MutS family. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
210
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
935
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Antony E |
Year: |
2003 |
Journal: |
Biochemistry |
Title: |
Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair. |
Volume: |
42 |
Issue: |
25 |
Pages: |
7682-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang Q |
Year: |
2004 |
Journal: |
Oncogene |
Title: |
The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase. |
Volume: |
23 |
Issue: |
21 |
Pages: |
3749-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Varlet I |
Year: |
1994 |
Journal: |
Nucleic Acids Res |
Title: |
Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch repair genes. |
Volume: |
22 |
Issue: |
25 |
Pages: |
5723-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
275
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wielders E |
Year: |
2017 |
Journal: |
Fam Cancer |
Title: |
Truncation of the MSH2 C-terminal 60 amino acids disrupts effective DNA mismatch repair and is causative for Lynch syndrome. |
Volume: |
16 |
Issue: |
2 |
Pages: |
221-229 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zienolddiny S |
Year: |
2006 |
Journal: |
Int J Cancer |
Title: |
Msh2 deficiency increases susceptibility to benzo[a]pyrene-induced lymphomagenesis. |
Volume: |
118 |
Issue: |
11 |
Pages: |
2899-902 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
935
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
935
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Eisen JA |
Year: |
1998 |
Journal: |
Nucleic Acids Res |
Title: |
A phylogenomic study of the MutS family of proteins. |
Volume: |
26 |
Issue: |
18 |
Pages: |
4291-300 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reitmair AH |
Year: |
1995 |
Journal: |
Nat Genet |
Title: |
MSH2 deficient mice are viable and susceptible to lymphoid tumours. |
Volume: |
11 |
Issue: |
1 |
Pages: |
64-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reitmair AH |
Year: |
1996 |
Journal: |
Cancer Res |
Title: |
MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis. |
Volume: |
56 |
Issue: |
13 |
Pages: |
2922-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin DP |
Year: |
2004 |
Journal: |
Cancer Res |
Title: |
An Msh2 point mutation uncouples DNA mismatch repair and apoptosis. |
Volume: |
64 |
Issue: |
2 |
Pages: |
517-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chalastanis A |
Year: |
2010 |
Journal: |
J Natl Cancer Inst |
Title: |
Azathioprine-induced carcinogenesis in mice according to Msh2 genotype. |
Volume: |
102 |
Issue: |
22 |
Pages: |
1731-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kolodner RD |
Year: |
1994 |
Journal: |
Genomics |
Title: |
Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations. |
Volume: |
24 |
Issue: |
3 |
Pages: |
516-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang M |
Year: |
2014 |
Journal: |
Mol Cell |
Title: |
HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. |
Volume: |
55 |
Issue: |
1 |
Pages: |
31-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martinez P |
Year: |
2009 |
Journal: |
Aging Cell |
Title: |
MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres. |
Volume: |
8 |
Issue: |
1 |
Pages: |
2-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tomé S |
Year: |
2009 |
Journal: |
PLoS Genet |
Title: |
MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice. |
Volume: |
5 |
Issue: |
5 |
Pages: |
e1000482 |
|
•
•
•
•
•
|
Publication |
First Author: |
Claij N |
Year: |
2004 |
Journal: |
Oncogene |
Title: |
Msh2 deficiency does not contribute to cisplatin resistance in mouse embryonic stem cells. |
Volume: |
23 |
Issue: |
1 |
Pages: |
260-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kucherlapati MH |
Year: |
2010 |
Journal: |
Gastroenterology |
Title: |
An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. |
Volume: |
138 |
Issue: |
3 |
Pages: |
993-1002.e1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burr KL |
Year: |
2007 |
Journal: |
Mutat Res |
Title: |
The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline. |
Volume: |
617 |
Issue: |
1-2 |
Pages: |
147-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leduc C |
Year: |
2010 |
Journal: |
Eur J Immunol |
Title: |
Combined deficiency of MSH2 and Sμ region abolishes class switch recombination. |
Volume: |
40 |
Issue: |
10 |
Pages: |
2925-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cranston A |
Year: |
1997 |
Journal: |
Nat Genet |
Title: |
Female embryonic lethality in mice nullizygous for both Msh2 and p53. |
Volume: |
17 |
Issue: |
1 |
Pages: |
114-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toft NJ |
Year: |
2002 |
Journal: |
Oncogene |
Title: |
Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background. |
Volume: |
21 |
Issue: |
41 |
Pages: |
6299-306 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sohn KJ |
Year: |
2003 |
Journal: |
Carcinogenesis |
Title: |
Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice. |
Volume: |
24 |
Issue: |
2 |
Pages: |
217-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meira LB |
Year: |
2002 |
Journal: |
DNA Repair (Amst) |
Title: |
Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer. |
Volume: |
1 |
Issue: |
11 |
Pages: |
929-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eso Y |
Year: |
2016 |
Journal: |
Cancer Res |
Title: |
MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development. |
Volume: |
76 |
Issue: |
15 |
Pages: |
4383-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshino M |
Year: |
2002 |
Journal: |
DNA Repair (Amst) |
Title: |
Additive roles of XPA and MSH2 genes in UVB-induced skin tumorigenesis in mice. |
Volume: |
1 |
Issue: |
11 |
Pages: |
935-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrew SE |
Year: |
1997 |
Journal: |
Oncogene |
Title: |
Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice. |
Volume: |
15 |
Issue: |
2 |
Pages: |
123-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jenab-Wolcott J |
Year: |
2000 |
Journal: |
Mol Cell Biol |
Title: |
The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation. |
Volume: |
20 |
Issue: |
22 |
Pages: |
8373-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
He D |
Year: |
2012 |
Journal: |
Mutat Res |
Title: |
Role of the Msh2 gene in genome maintenance and development in mouse fetuses. |
Volume: |
734 |
Issue: |
1-2 |
Pages: |
50-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Larijani M |
Year: |
2005 |
Journal: |
Nucleic Acids Res |
Title: |
Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events. |
Volume: |
33 |
Issue: |
21 |
Pages: |
6733-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Wind N |
Year: |
1995 |
Journal: |
Cell |
Title: |
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. |
Volume: |
82 |
Issue: |
2 |
Pages: |
321-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manley K |
Year: |
1999 |
Journal: |
Nat Genet |
Title: |
Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice. |
Volume: |
23 |
Issue: |
4 |
Pages: |
471-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wheeler VC |
Year: |
2003 |
Journal: |
Hum Mol Genet |
Title: |
Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum. |
Volume: |
12 |
Issue: |
3 |
Pages: |
273-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frieder D |
Year: |
2009 |
Journal: |
Mol Cell Biol |
Title: |
The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs. |
Volume: |
29 |
Issue: |
18 |
Pages: |
5148-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lv L |
Year: |
2013 |
Journal: |
Nucleic Acids Res |
Title: |
Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. |
Volume: |
41 |
Issue: |
22 |
Pages: |
10312-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Russo MT |
Year: |
2009 |
Journal: |
Cancer Res |
Title: |
Role of MUTYH and MSH2 in the control of oxidative DNA damage, genetic instability, and tumorigenesis. |
Volume: |
69 |
Issue: |
10 |
Pages: |
4372-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Oosten M |
Year: |
2005 |
Journal: |
DNA Repair (Amst) |
Title: |
Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes. |
Volume: |
4 |
Issue: |
1 |
Pages: |
81-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toft NJ |
Year: |
1999 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine. |
Volume: |
96 |
Issue: |
7 |
Pages: |
3911-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sansom OJ |
Year: |
2002 |
Journal: |
Oncogene |
Title: |
The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice. |
Volume: |
21 |
Issue: |
38 |
Pages: |
5934-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang S |
Year: |
2002 |
Journal: |
Mutat Res |
Title: |
Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum. |
Volume: |
500 |
Issue: |
1-2 |
Pages: |
67-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ehrenstein MR |
Year: |
1999 |
Journal: |
EMBO J |
Title: |
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. |
Volume: |
18 |
Issue: |
12 |
Pages: |
3484-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martin A |
Year: |
2003 |
Journal: |
J Exp Med |
Title: |
Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination. |
Volume: |
198 |
Issue: |
8 |
Pages: |
1171-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang S |
Year: |
2001 |
Journal: |
Oncogene |
Title: |
Msh2 DNA mismatch repair gene deficiency and the food-borne mutagen 2-amino-1-methy1-6-phenolimidazo [4,5-b] pyridine (PhIP) synergistically affect mutagenesis in mouse colon. |
Volume: |
20 |
Issue: |
42 |
Pages: |
6066-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fishel R |
Year: |
1993 |
Journal: |
Cell |
Title: |
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. |
Volume: |
75 |
Issue: |
5 |
Pages: |
1027-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ellison AR |
Year: |
2001 |
Journal: |
Hum Mol Genet |
Title: |
Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae. |
Volume: |
10 |
Issue: |
18 |
Pages: |
1889-900 |
|
•
•
•
•
•
|
Publication |
First Author: |
Phung QH |
Year: |
1998 |
Journal: |
J Exp Med |
Title: |
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. |
Volume: |
187 |
Issue: |
11 |
Pages: |
1745-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Egashira A |
Year: |
2002 |
Journal: |
DNA Repair (Amst) |
Title: |
Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes. |
Volume: |
1 |
Issue: |
11 |
Pages: |
881-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toft NJ |
Year: |
1998 |
Journal: |
Nat Genet |
Title: |
No female embryonic lethality in mice nullizygous for Msh2 and p53. |
Volume: |
18 |
Issue: |
1 |
Pages: |
17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Winter JM |
Year: |
2014 |
Journal: |
J Nutrigenet Nutrigenomics |
Title: |
Role of Red Meat and Resistant Starch in Promutagenic Adduct Formation, MGMT Repair, Thymic Lymphoma and Intestinal Tumourigenesis in Msh2 -Deficient Mice. |
Volume: |
7 |
Issue: |
4-6 |
Pages: |
299-313 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kovalenko M |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e44273 |
|
•
•
•
•
•
|
Publication |
First Author: |
Franchitto A |
Year: |
2003 |
Journal: |
Oncogene |
Title: |
The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. |
Volume: |
22 |
Issue: |
14 |
Pages: |
2110-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kongkanuntn R |
Year: |
1999 |
Journal: |
Oncogene |
Title: |
Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice. |
Volume: |
18 |
Issue: |
51 |
Pages: |
7219-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lowsky R |
Year: |
1997 |
Journal: |
Blood |
Title: |
Defects of the mismatch repair gene MSH2 are implicated in the development of murine and human lymphoblastic lymphomas and are associated with the aberrant expression of rhombotin-2 (Lmo-2) and Tal-1 (SCL). |
Volume: |
89 |
Issue: |
7 |
Pages: |
2276-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ranjit S |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected]. |
Volume: |
187 |
Issue: |
5 |
Pages: |
2464-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alabyev B |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice. |
Volume: |
169 |
Issue: |
7 |
Pages: |
3819-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peters AC |
Year: |
2003 |
Journal: |
DNA Repair (Amst) |
Title: |
Mammalian DNA mismatch repair protects cells from UVB-induced DNA damage by facilitating apoptosis and p53 activation. |
Volume: |
2 |
Issue: |
4 |
Pages: |
427-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vora KA |
Year: |
1999 |
Journal: |
J Exp Med |
Title: |
Severe attenuation of the B cell immune response in Msh2-deficient mice. |
Volume: |
189 |
Issue: |
3 |
Pages: |
471-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Min IM |
Year: |
2003 |
Journal: |
Immunity |
Title: |
The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2. |
Volume: |
19 |
Issue: |
4 |
Pages: |
515-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Min IM |
Year: |
2005 |
Journal: |
J Exp Med |
Title: |
Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2. |
Volume: |
201 |
Issue: |
12 |
Pages: |
1885-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rada C |
Year: |
1998 |
Journal: |
Immunity |
Title: |
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. |
Volume: |
9 |
Issue: |
1 |
Pages: |
135-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kovtun IV |
Year: |
2004 |
Journal: |
Hum Mol Genet |
Title: |
Somatic deletion events occur during early embryonic development and modify the extent of CAG expansion in subsequent generations. |
Volume: |
13 |
Issue: |
24 |
Pages: |
3057-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bruekner SR |
Year: |
2023 |
Journal: |
Nucleic Acids Res |
Title: |
Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding. |
Volume: |
51 |
Issue: |
3 |
Pages: |
1173-1188 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baross-Francis A |
Year: |
2000 |
Journal: |
Carcinogenesis |
Title: |
Tumors arising in DNA mismatch repair-deficient mice show a wide variation in mutation frequency as assessed by a transgenic reporter gene. |
Volume: |
21 |
Issue: |
6 |
Pages: |
1259-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qin J |
Year: |
2002 |
Journal: |
J Hered |
Title: |
Evidence for the lack of mismatch-repair directed antirecombination during mouse meiosis. |
Volume: |
93 |
Issue: |
3 |
Pages: |
201-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kabbarah O |
Year: |
2005 |
Journal: |
Int J Cancer |
Title: |
Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice. |
Volume: |
115 |
Issue: |
4 |
Pages: |
666-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wiesendanger M |
Year: |
2000 |
Journal: |
J Exp Med |
Title: |
Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. |
Volume: |
191 |
Issue: |
3 |
Pages: |
579-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oda S |
Year: |
2000 |
Journal: |
EMBO J |
Title: |
Efficient repair of A/C mismatches in mouse cells deficient in long-patch mismatch repair. |
Volume: |
19 |
Issue: |
7 |
Pages: |
1711-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Campbell MR |
Year: |
2000 |
Journal: |
Carcinogenesis |
Title: |
Candidate mutator genes in mismatch repair-deficient thymic lymphomas: no evidence of mutations in the DNA polymerase delta gene. |
Volume: |
21 |
Issue: |
12 |
Pages: |
2281-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Claij N |
Year: |
2003 |
Journal: |
Cancer Res |
Title: |
DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lymphomagenesis. |
Volume: |
63 |
Issue: |
9 |
Pages: |
2062-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sansom OJ |
Year: |
2001 |
Journal: |
Oncogene |
Title: |
Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner. |
Volume: |
20 |
Issue: |
27 |
Pages: |
3580-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elliott B |
Year: |
2001 |
Journal: |
Mol Cell Biol |
Title: |
Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells. |
Volume: |
21 |
Issue: |
8 |
Pages: |
2671-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Williams SA |
Year: |
2011 |
Journal: |
Hum Mol Genet |
Title: |
Functional and physical interaction between the mismatch repair and FA-BRCA pathways. |
Volume: |
20 |
Issue: |
22 |
Pages: |
4395-410 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aarts M |
Year: |
2006 |
Journal: |
Nucleic Acids Res |
Title: |
Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells. |
Volume: |
34 |
Issue: |
21 |
Pages: |
e147 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krijger PH |
Year: |
2009 |
Journal: |
J Exp Med |
Title: |
Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation. |
Volume: |
206 |
Issue: |
12 |
Pages: |
2603-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Green B |
Year: |
2011 |
Journal: |
Blood |
Title: |
The mismatch repair pathway functions normally at a non-AID target in germinal center B cells. |
Volume: |
118 |
Issue: |
11 |
Pages: |
3013-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu X |
Year: |
2016 |
Journal: |
Blood |
Title: |
AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma. |
Volume: |
127 |
Issue: |
1 |
Pages: |
102-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Downey CM |
Year: |
2015 |
Journal: |
Cancer Med |
Title: |
DNA mismatch repair deficiency accelerates lung neoplasm development in K-ras(LA1/+) mice: a brief report. |
Volume: |
4 |
Issue: |
6 |
Pages: |
897-902 |
|
•
•
•
•
•
|
Publication |
First Author: |
Colussi C |
Year: |
2001 |
Journal: |
J Natl Cancer Inst |
Title: |
1,2-Dimethylhydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice. |
Volume: |
93 |
Issue: |
20 |
Pages: |
1534-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hooker AM |
Year: |
2004 |
Journal: |
Mutat Res |
Title: |
Cancer-associated genes can affect somatic intrachromosomal recombination early in carcinogenesis. |
Volume: |
550 |
Issue: |
1-2 |
Pages: |
1-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kohonen-Corish MR |
Year: |
2002 |
Journal: |
Cancer Res |
Title: |
Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors. |
Volume: |
62 |
Issue: |
7 |
Pages: |
2092-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gebert J |
Year: |
2021 |
Journal: |
Gastroenterology |
Title: |
Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model. |
Volume: |
161 |
Issue: |
4 |
Pages: |
1288-1302.e13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kovtun IV |
Year: |
2011 |
Journal: |
Carcinogenesis |
Title: |
Increased incidence of endometrioid tumors caused by aberrations in E-cadherin promoter of mismatch repair-deficient mice. |
Volume: |
32 |
Issue: |
7 |
Pages: |
1085-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schrader CE |
Year: |
2003 |
Journal: |
J Exp Med |
Title: |
Mlh1 can function in antibody class switch recombination independently of Msh2. |
Volume: |
197 |
Issue: |
10 |
Pages: |
1377-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grigera F |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Complex relationship between mismatch repair proteins and MBD4 during immunoglobulin class switch recombination. |
Volume: |
8 |
Issue: |
10 |
Pages: |
e78370 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eccleston J |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats. |
Volume: |
183 |
Issue: |
2 |
Pages: |
1222-8 |
|
•
•
•
•
•
|