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Search results 1 to 100 out of 344 for Mthfr

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
4524 | MTHFR
Type: gene
Organism: human
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Gene
100125082 | mthfr
Type: gene
Organism: frog, western clawed
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Gene
362657 | Mthfr
Type: gene
Organism: rat
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Gene
478230 | MTHFR
Type: gene
Organism: dog, domestic
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Gene
469800 | MTHFR
Type: gene
Organism: chimpanzee
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Gene
497032 | MTHFR
Type: gene
Organism: cattle
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Gene
419489 | MTHFR
Type: gene
Organism: chicken
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Gene
567547 | mthfr
Type: gene
Organism: zebrafish
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Gene
714840 | MTHFR
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:106639 | Mthfr
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24384392 | J:205587
First Author: Wlodarczyk BJ
Year: 2014
Journal: Toxicol Appl Pharmacol
Title: Mthfr gene ablation enhances susceptibility to arsenic prenatal toxicity.
Volume: 275
Issue: 1
Pages: 22-7
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Publication
23896051 | J:202104
 
First Author: Kezurer N
Year: 2013
Journal: Behav Brain Res
Title: Increased susceptibility to mild neonatal stress in MTHFR deficient mice.
Volume: 253
Pages: 240-52
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Publication
14630804 | J:89039
First Author: Devlin AM
Year: 2004
Journal: Blood
Title: Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice.
Volume: 103
Issue: 7
Pages: 2624-9
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Publication
21697299 | J:173752
First Author: Chew TW
Year: 2011
Journal: J Nutr
Title: Folate intake, MTHFR genotype, and sex modulate choline metabolism in mice.
Volume: 141
Issue: 8
Pages: 1475-81
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Publication
30288696 | J:284761
First Author: Bahous RH
Year: 2019
Journal: Mol Neurobiol
Title: Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency.
Volume: 56
Issue: 6
Pages: 4175-4191
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Publication
34128976 | J:324053
 
First Author: Karahan G
Year: 2021
Journal: Development
Title: Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations.
Volume: 148
Issue: 13
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Publication
29360980 | J:260788
First Author: Aarabi M
Year: 2018
Journal: Hum Mol Genet
Title: Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation.
Volume: 27
Issue: 7
Pages: 1123-1135
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Publication
21769670 | J:178814
First Author: Pickell L
Year: 2011
Journal: Mamm Genome
Title: Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation.
Volume: 22
Issue: 11-12
Pages: 635-47
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Publication
26646559 | J:279813
 
First Author: Markand S
Year: 2016
Journal: Exp Eye Res
Title: Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice.
Volume: 145
Pages: 164-172
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Publication
24048573 | J:204010
First Author: Garner JL
Year: 2013
Journal: Biol Reprod
Title: Stability of DNA methylation patterns in mouse spermatogonia under conditions of MTHFR deficiency and methionine supplementation.
Volume: 89
Issue: 5
Pages: 125
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Publication
20813139 | J:166168
First Author: Levav-Rabkin T
Year: 2011
Journal: Behav Brain Res
Title: Sex-dependent behavioral effects of Mthfr deficiency and neonatal GABA potentiation in mice.
Volume: 216
Issue: 2
Pages: 505-13
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Publication
21169404 | J:170362
First Author: Lemarié CA
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1.
Volume: 300
Issue: 3
Pages: H745-53
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Publication
26235956 | J:290576
First Author: Zuckerman C
Year: 2015
Journal: Eur Neuropsychopharmacol
Title: Glutamatergic synapse protein composition of wild-type mice is sensitive to in utero MTHFR genotype and the timing of neonatal vigabatrin exposure.
Volume: 25
Issue: 10
Pages: 1787-802
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Publication
25956258 | J:224489
 
First Author: Jadavji NM
Year: 2015
Journal: Neuroscience
Title: MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring.
Volume: 300
Pages: 1-9
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Protein
Q497H7
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: true
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Publication
26937386 | J:290577
 
First Author: Jadavji NM
Year: 2015
Journal: Mol Genet Metab Rep
Title: Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue.
Volume: 3
Pages: 1-4
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Publication
14637162 | J:86746
First Author: Takeya C
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Multiple single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase and its truncated pseudogene of 23 inbred strains of mice.
Volume: 312
Issue: 2
Pages: 480-6
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Publication
11181567 | J:67779
First Author: Chen Z
Year: 2001
Journal: Hum Mol Genet
Title: Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.
Volume: 10
Issue: 5
Pages: 433-43
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Publication
20444942 | J:169509
First Author: Chan D
Year: 2010
Journal: Endocrinology
Title: Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice.
Volume: 151
Issue: 7
Pages: 3363-73
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Publication
37449270 | J:337821
 
First Author: Sadigurschi N
Year: 2023
Journal: Front Neurosci
Title: Genetic impairment of folate metabolism regulates cortical interneurons and social behavior.
Volume: 17
Pages: 1203262
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Publication
15979267 | J:100044
First Author: Chen Z
Year: 2005
Journal: Int J Dev Neurosci
Title: Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase.
Volume: 23
Issue: 5
Pages: 465-74
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Publication
30552741 | J:290509
First Author: Sadigurschi N
Year: 2019
Journal: Genes Brain Behav
Title: Maternal and offspring methylenetetrahydrofolate-reductase genotypes interact in a mouse model to induce autism spectrum disorder-like behavior.
Volume: 18
Issue: 1
Pages: e12547
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Publication
15548731 | J:104636
First Author: Kelly TL
Year: 2005
Journal: Biol Reprod
Title: Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation.
Volume: 72
Issue: 3
Pages: 667-77
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Publication
30055159 | J:268395
 
First Author: Jadavji NM
Year: 2018
Journal: Exp Neurol
Title: A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke.
Volume: 309
Pages: 14-22
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Publication
22521626 | J:184437
First Author: Jadavji NM
Year: 2012
Journal: Mol Genet Metab
Title: Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus.
Volume: 106
Issue: 2
Pages: 149-59
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Publication
12551843 | J:118489
First Author: Schwahn BC
Year: 2003
Journal: FASEB J
Title: Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency.
Volume: 17
Issue: 3
Pages: 512-4
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Publication
16772436 | J:115049
First Author: Li D
Year: 2006
Journal: J Nutr
Title: Maternal folate deficiency affects proliferation, but not apoptosis, in embryonic mouse heart.
Volume: 136
Issue: 7
Pages: 1774-8
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Publication
15514261 | J:102203
First Author: Ghandour H
Year: 2004
Journal: J Nutr
Title: Mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates.
Volume: 134
Issue: 11
Pages: 2975-8
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Publication
25202269 | J:284734
 
First Author: Sontag JM
Year: 2014
Journal: Front Aging Neurosci
Title: Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice.
Volume: 6
Pages: 214
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Publication
31133774 | J:284334
 
First Author: Orenbuch A
Year: 2019
Journal: Front Neurosci
Title: Prenatal Nutritional Intervention Reduces Autistic-Like Behavior Rates Among Mthfr-Deficient Mice.
Volume: 13
Pages: 383
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Publication
17079455 | J:114921
First Author: Knock E
Year: 2006
Journal: Cancer Res
Title: Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.
Volume: 66
Issue: 21
Pages: 10349-56
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Publication
36050860 | J:341560
First Author: Reagan AM
Year: 2022
Journal: J Cereb Blood Flow Metab
Title: The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice.
Volume: 42
Issue: 12
Pages: 2333-2350
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Publication
9680386 | J:48976
First Author: Goyette P
Year: 1998
Journal: Mamm Genome
Title: Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)
Volume: 9
Issue: 8
Pages: 652-6
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Publication
29329322 | J:257871
First Author: Eyring KR
Year: 2018
Journal: PLoS One
Title: Methylene-tetrahydrofolate reductase contributes to allergic airway disease.
Volume: 13
Issue: 1
Pages: e0190916
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Publication
15097236 | J:105560
First Author: Neves MF
Year: 2004
Journal: J Hypertens
Title: Small artery mechanics in hyperhomocysteinemic mice: effects of angiotensin II.
Volume: 22
Issue: 5
Pages: 959-66
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Publication
25766590 | J:230967
First Author: Markand S
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia.
Volume: 56
Issue: 4
Pages: 2684-95
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Publication
25733650 | J:290573
First Author: Christensen KE
Year: 2015
Journal: Am J Clin Nutr
Title: High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.
Volume: 101
Issue: 3
Pages: 646-58
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Publication
11080594 | J:65860
First Author: Gaughan DJ
Year: 2000
Journal: Gene
Title: The human and mouse methylenetetrahydrofolate reductase (MTHFR) genes: genomic organization, mRNA structure and linkage to the CLCN6 gene.
Volume: 257
Issue: 2
Pages: 279-89
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Publication
14577615 | J:86338
First Author: Leclerc D
Year: 2003
Journal: Mol Cell Biochem
Title: Characterization of a pseudogene for murine methylenetetrahydrofolate reductase.
Volume: 252
Issue: 1-2
Pages: 391-5
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Publication
29141214 | J:254241
First Author: Leung KY
Year: 2017
Journal: Cell Rep
Title: Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure.
Volume: 21
Issue: 7
Pages: 1795-1808
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Publication
28396257 | J:259599
 
First Author: Jadavji NM
Year: 2017
Journal: Neurobiol Dis
Title: B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke.
Volume: 103
Pages: 89-100
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Publication
35652653 | J:332923
First Author: Young K
Year: 2022
Journal: Zygote
Title: 5,10-Methylenetetrahydrofolate reductase becomes phosphorylated during meiotic maturation in mouse oocytes.
Volume: 30
Issue: 5
Pages: 674-688
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Publication
15217352 | J:93942
First Author: Schwahn BC
Year: 2004
Journal: Biochem J
Title: Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.
Volume: 382
Issue: Pt 3
Pages: 831-40
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Publication
16397891 | J:112763
First Author: Li D
Year: 2006
Journal: Birth Defects Res A Clin Mol Teratol
Title: Impact of methylenetetrahydrofolate reductase deficiency and low dietary folate on the development of neural tube defects in splotch mice.
Volume: 76
Issue: 1
Pages: 55-9
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Publication
19560954 | J:152562
First Author: Mikael LG
Year: 2009
Journal: Mol Genet Metab
Title: Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency.
Volume: 98
Issue: 1-2
Pages: 187-94
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Publication
9188671 | J:40811
First Author: Finnell RH
Year: 1997
Journal: Am J Med Genet
Title: Strain-dependent alterations in the expression of folate pathway genes following teratogenic exposure to valproic acid in a mouse model.
Volume: 70
Issue: 3
Pages: 303-11
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Publication
12370778 | J:78737
First Author: Tran P
Year: 2002
Journal: Mamm Genome
Title: Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms.
Volume: 13
Issue: 9
Pages: 483-92
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Publication
30345292 | J:290507
 
First Author: Borowczyk K
Year: 2018
Journal: Int J Genomics
Title: Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice.
Volume: 2018
Pages: 7570850
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Publication
16274753 | J:104059
First Author: Pickell L
Year: 2005
Journal: Biochim Biophys Acta
Title: Regulatory studies of murine methylenetetrahydrofolate reductase reveal two major promoters and NF-kappaB sensitivity.
Volume: 1731
Issue: 2
Pages: 104-14
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Publication
22259189 | J:181924
First Author: Mikael LG
Year: 2012
Journal: J Nutr
Title: Disturbed one-carbon metabolism causing adverse reproductive outcomes in mice is associated with altered expression of apolipoprotein AI and inflammatory mediators PPARα, interferon-γ, and interleukin-10.
Volume: 142
Issue: 3
Pages: 411-8
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Protein Coding Gene
MGP_CAROLIEiJ_G0026791 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029115 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029080 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029028 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028817 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_106639 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0029545 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028230 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028779 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028892 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029018 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028919 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0029577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027950 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028310 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029139 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027784 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
21193302 | J:285696
First Author: Knock E
Year: 2011
Journal: J Nutr Biochem
Title: Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair.
Volume: 22
Issue: 11
Pages: 1022-9
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Publication
19176749 | J:146287
First Author: Garcia-Crespo D
Year: 2009
Journal: J Nutr
Title: Intestinal neoplasia induced by low dietary folate is associated with altered tumor expression profiles and decreased apoptosis in mouse normal intestine.
Volume: 139
Issue: 3
Pages: 488-94
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Publication
28087280 | J:250290
 
First Author: Dam K
Year: 2017
Journal: Behav Brain Res
Title: Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment.
Volume: 321
Pages: 201-208
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Publication
37942134 | J:342420
 
First Author: Gal A
Year: 2023
Journal: Front Neurosci
Title: Temporal dynamics of isolation calls emitted by pups in environmental and genetic mouse models of autism spectrum disorder.
Volume: 17
Pages: 1274039
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Publication
18356316 | J:138499
First Author: Knock E
Year: 2008
Journal: J Nutr
Title: Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.
Volume: 138
Issue: 4
Pages: 653-8
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Publication
23449672 | J:196380
First Author: Hoffmann L
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Osmotic regulation of hepatic betaine metabolism.
Volume: 304
Issue: 9
Pages: G835-46
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Publication
34880723 | J:333606
 
First Author: Shekel I
Year: 2021
Journal: Front Neurosci
Title: Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism.
Volume: 15
Pages: 769670
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Publication
31525435 | J:284627
 
First Author: Jadavji NM
Year: 2019
Journal: Neurobiol Dis
Title: One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice.
Volume: 132
Pages: 104613
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Publication
25188266 | J:284735
First Author: Fowler AK
Year: 2014
Journal: PLoS One
Title: Differential sensitivity of prefrontal cortex and hippocampus to alcohol-induced toxicity.
Volume: 9
Issue: 9
Pages: e106945
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Publication
12829522 | J:103033
First Author: Virdis A
Year: 2003
Journal: Arterioscler Thromb Vasc Biol
Title: Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice.
Volume: 23
Issue: 8
Pages: 1352-7
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Publication
24169962 | J:290566
First Author: Leclerc D
Year: 2013
Journal: Cancer Prev Res (Phila)
Title: Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients.
Volume: 6
Issue: 11
Pages: 1171-81
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Publication
8875901 | J:37152
First Author: Frosst P
Year: 1996
Journal: Mamm Genome
Title: The methylenetetrahydrofolate reductase (Mthfr) gene maps to distal mouse chromosome 4.
Volume: 7
Issue: 11
Pages: 864-5
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GXD Expression
GXD Expression
     
Probe: MGI:3846712
Assay Type: RT-PCR
Annotation Date: 2009-06-05
Strength: Present
Sex: Male
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3846859
Age: postnatal
Specimen Label: WTM
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3846712
Assay Type: RT-PCR
Annotation Date: 2009-06-05
Strength: Present
Sex: Male
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3846859
Age: postnatal
Specimen Label: KOM
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3846712
Assay Type: RT-PCR
Annotation Date: 2009-06-05
Strength: Present
Sex: Female
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3846859
Age: postnatal
Specimen Label: WTF
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3846712
Assay Type: RT-PCR
Annotation Date: 2009-06-05
Strength: Present
Sex: Female
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3846859
Age: postnatal
Specimen Label: KOF
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7435373
Assay Type: RT-PCR
Annotation Date: 2023-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:7435400
Age: embryonic day 12.5
Image: S2
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7435373
Assay Type: RT-PCR
Annotation Date: 2023-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:7435400
Age: embryonic day 12.5
Image: S2
Specimen Label: KO
Detected: true
Specimen Num: 2
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•
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GXD Expression
GXD Expression
   
Probe: MGI:7516725
Assay Type: RT-PCR
Annotation Date: 2023-08-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684714
Stage: TS14
Assay Id: MGI:7516766
Age: embryonic day 9.0
Image: 3
Specimen Label: E9
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7516725
Assay Type: RT-PCR
Annotation Date: 2023-08-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684618
Stage: TS18
Assay Id: MGI:7516766
Age: embryonic day 11.0
Image: 3
Specimen Label: E11
Detected: true
Specimen Num: 2
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•
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•
GXD Expression
GXD Expression
   
Probe: MGI:7516725
Assay Type: RT-PCR
Annotation Date: 2023-08-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7516766
Age: embryonic day 13.0
Image: 3
Specimen Label: E13
Detected: true
Specimen Num: 3
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•
•
•
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