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Search results 1 to 94 out of 94 for Mtmr14

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
64419 | MTMR14
Type: gene
Organism: human
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Gene
460149 | MTMR14
Type: gene
Organism: chimpanzee
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Gene
514596 | MTMR14
Type: gene
Organism: cattle
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Gene
416048 | MTMR14
Type: gene
Organism: chicken
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Gene
323929 | mtmr14
Type: gene
Organism: zebrafish
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Gene
703936 | MTMR14
Type: gene
Organism: macaque, rhesus
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Gene
100036693 | mtmr14
Type: gene
Organism: frog, western clawed
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Gene
312634 | Mtmr14
Type: gene
Organism: rat
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Gene
484668 | MTMR14
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1916075 | Mtmr14
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR039802 | MTMR14
Type: Family
Description: Myotubularin-related protein 14 (MTMR14, also known as Jumpy) belongs to the myotubularin family, whose members are dual-specificity phosphatases that act primarily to dephosphorylate phosphoinositides (PIs). They act specifically on PI3P and PI3,5P2, dephosphorylating them to form PIP and PI5P, respectively []. MTMR14 interacts with early autophagosomes and negatively regulates progression through the steps of autophagy []. It has been linked to the a congenital muscle disorder known as myopathy, centronuclear, 1 (CNM1) [].
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Publication
30412589 | J:267733
First Author: Wen N
Year: 2018
Journal: PLoS One
Title: Deficiency of MTMR14 impairs male fertility in Mus musculus.
Volume: 13
Issue: 11
Pages: e0206224
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Publication
32768948 | J:302855
 
First Author: Li S
Year: 2020
Journal: Biomed Pharmacother
Title: MTMR14 protects against hepatic ischemia-reperfusion injury through interacting with AKT signaling in vivo and in vitro.
Volume: 129
Pages: 110455
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Protein
F7BA73
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
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Publication
17008356 | -
First Author: Tosch V
Year: 2006
Journal: Hum Mol Genet
Title: A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy.
Volume: 15
Issue: 21
Pages: 3098-106
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Publication
19590496 | -
First Author: Vergne I
Year: 2009
Journal: EMBO J
Title: Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy.
Volume: 28
Issue: 15
Pages: 2244-58
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Protein
D6RDS6
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: false
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Protein
D3Z1C1
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
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Protein
D6RFN8
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
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Protein
F6W741
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: true
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Protein
Q9D0W0
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: true
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Protein
Q8VEL2
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
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Protein
Q3TTC5
Organism: Mus musculus/domesticus
Length: 274  
Fragment?: false
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Protein
F6RV41
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: true
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Protein
F6SBM1
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Publication
16828287 | -
First Author: Robinson FL
Year: 2006
Journal: Trends Cell Biol
Title: Myotubularin phosphatases: policing 3-phosphoinositides.
Volume: 16
Issue: 8
Pages: 403-12
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Publication
32080168 | J:285453
First Author: Zhang JL
Year: 2020
Journal: Cell Death Dis
Title: Myotubularin-related protein 14 suppresses cardiac hypertrophy by inhibiting Akt.
Volume: 11
Issue: 2
Pages: 140
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Publication
27807764 | J:310513
First Author: Yin L
Year: 2017
Journal: J Physiol Biochem
Title: Mice lacking myotubularin-related protein 14 show accelerated high-fat diet-induced lipid accumulation and inflammation.
Volume: 73
Issue: 1
Pages: 17-28
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Protein Coding Gene
MGP_CAROLIEiJ_G0028717 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0031114 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0031083 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0031014 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0031094 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030614 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1916075 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0031553 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0030201 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030780 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030933 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030887 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0031013 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030921 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0031580 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029917 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0030285 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022468 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029745 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
19465920 | J:155068
First Author: Shen J
Year: 2009
Journal: Nat Cell Biol
Title: Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis.
Volume: 11
Issue: 6
Pages: 769-76
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Publication
21930146 | J:309837
First Author: Hnia K
Year: 2012
Journal: Adv Biol Regul
Title: Primary T-tubule and autophagy defects in the phosphoinositide phosphatase Jumpy/MTMR14 knockout mice muscle.
Volume: 52
Issue: 1
Pages: 98-107
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GXD Expression
GXD Expression
     
Probe: MGI:6444353
Assay Type: RT-PCR
Annotation Date: 2020-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6446197
Age: postnatal week 5
Specimen Label: wild type control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6444353
Assay Type: RT-PCR
Annotation Date: 2020-07-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6446197
Age: postnatal week 5
Specimen Label: miR-183C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1518971
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Pattern: Scattered
Stage: TS22
Assay Id: MGI:4354967
Age: embryonic day 14.5
Specimen Label: Table S5 - 1110061O0Rik
Detected: true
Specimen Num: 1
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Publication
23341629 | J:193822
First Author: Lumayag S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Volume: 110
Issue: 6
Pages: E507-16
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Publication
19521500 | J:149737
First Author: Sansom SN
Year: 2009
Journal: PLoS Genet
Title: The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume: 5
Issue: 6
Pages: e1000511
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Allele
Mtmr14<em2Smoc> | MGI:7291180
Name: myotubularin related protein 14; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6770961 | C57BL/6-Mtmr14<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Mtmr14<em1Smoc> | MGI:7291179
Name: myotubularin related protein 14; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6475832 | C57BL/6J-Mtmr14<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein Domain
IPR039803 | MTMR14_PH-GRAM
Type: Domain
Description: Myotubularin-related protein 14 (MTMR14, also known as Jumpy) belongs to the myotubularin family, whose members are dual-specificity phosphatases that act primarily to dephosphorylate phosphoinositides (PIs). They act specifically on PI3P and PI3,5P2, dephosphorylating them to form PIP and PI5P, respectively []. MTMR14 interacts with early autophagosomes and negatively regulates progression through the steps of autophagy []. It has been linked to the a congenital muscle disorder known as myopathy, centronuclear, 1 (CNM1) [].MTMR14 contain a N-terminal PH-GRAM domain, a Rac-induced recruitment domain (RID) domain, an active PTP domain, a SET-interaction domain (SID), a coiled-coil region, and a C-terminal PDZ domain. This entry represents the PH-GRAM domain that binds to phosphoinositide lipid [].
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Publication
11050430 | -
First Author: Doerks T
Year: 2000
Journal: Trends Biochem Sci
Title: GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins.
Volume: 25
Issue: 10
Pages: 483-5
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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