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Search results 1 to 100 out of 198 for Muc2

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0.022s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein
Organism: Mus musculus
Length: 311  
Fragment?: true
Protein Domain
Type: Family
Description: Mucin-2 (MUC2) belongs to the mucin family. They are high molecular weight proteins that are components of mucus and are synthesised and secreted by specialised cells of the epithelium (goblet cells, cells of mucous glands) or non mucin-secreting cells []. There are two main mucin subfamilies: secreted mucins or gel-forming mucins (MUC2, MUC5AC, MUC5B, MUC6) and membrane-bound mucins (MUC1, MUC3, MUC4, MUC12, MUC17) []. In colon epithelium, MUC2 forms a net-like disulfide-bonded polymer structure that organise the two mucus layer of colon []. The colon inner layer is adherent to intestinal epithelial cells (IECs) and does not allow bacteria to penetrate, while the outer layer is inhabited by the microbiota []. In the small intestine, MUC2 modulates inflammatory responses and delivers tolerogenic signal to antigen-sampling dendritic cells (DCs) []. It plays an important role in gut homeostasis and promotes oral tolerance [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Johansson ME
Year: 2009
Journal: J Proteome Res
Title: Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein.
Volume: 8
Issue: 7
Pages: 3549-57
Publication
First Author: Shan M
Year: 2013
Journal: Science
Title: Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.
Volume: 342
Issue: 6157
Pages: 447-53
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Protein
Organism: Mus musculus
Length: 132  
Fragment?: true
Allele
Name: mucin 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase, Reporter
Publication categories: ProxyCollection
Publication
First Author: Borchers MT
Year: 1999
Journal: Am J Physiol
Title: Regulation of human airway mucins by acrolein and inflammatory mediators.
Volume: 276
Issue: 4 Pt 1
Pages: L549-55
Publication
First Author: Yu T
Year: 2016
Journal: Cell Death Dis
Title: KLF4 deletion alters gastric cell lineage and induces MUC2 expression.
Volume: 7
Issue: 6
Pages: e2255
Publication
First Author: Johansson ME
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.
Volume: 105
Issue: 39
Pages: 15064-9
Publication
First Author: Van der Sluis M
Year: 2006
Journal: Gastroenterology
Title: Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.
Volume: 131
Issue: 1
Pages: 117-29
Publication
First Author: Birchenough GM
Year: 2016
Journal: Science
Title: A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.
Volume: 352
Issue: 6293
Pages: 1535-42
Publication
First Author: Bergstrom KS
Year: 2010
Journal: PLoS Pathog
Title: Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa.
Volume: 6
Issue: 5
Pages: e1000902
Publication
First Author: Kumar M
Year: 2017
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Probiotic mixture VSL#3 reduces colonic inflammation and improves intestinal barrier function in Muc2 mucin-deficient mice.
Volume: 312
Issue: 1
Pages: G34-G45
Publication
First Author: Zarepour M
Year: 2013
Journal: Infect Immun
Title: The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis.
Volume: 81
Issue: 10
Pages: 3672-83
Publication
First Author: Liso M
Year: 2020
Journal: Inflamm Bowel Dis
Title: A Specific Mutation in Muc2 Determines Early Dysbiosis in Colitis-Prone Winnie Mice.
Volume: 26
Issue: 4
Pages: 546-556
Publication
First Author: Stahl M
Year: 2018
Journal: Am J Physiol Gastrointest Liver Physiol
Title: The Muc2 mucin coats murine Paneth cell granules and facilitates their content release and dispersion.
Volume: 315
Issue: 2
Pages: G195-G205
Publication
First Author: Lu P
Year: 2013
Journal: PLoS One
Title: High beta-palmitate fat controls the intestinal inflammatory response and limits intestinal damage in mucin Muc2 deficient mice.
Volume: 8
Issue: 6
Pages: e65878
Publication
First Author: Bao Y
Year: 2014
Journal: PLoS One
Title: MicroRNA profiling in Muc2 knockout mice of colitis-associated cancer model reveals epigenetic alterations during chronic colitis malignant transformation.
Volume: 9
Issue: 6
Pages: e99132
Publication
First Author: Aslam F
Year: 2001
Journal: Cancer Res
Title: The Sp family of transcription factors in the regulation of the human and mouse MUC2 gene promoters.
Volume: 61
Issue: 2
Pages: 570-6
Publication
First Author: Yang K
Year: 2008
Journal: Cancer Res
Title: Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation.
Volume: 68
Issue: 18
Pages: 7313-22
Publication
First Author: Tawiah A
Year: 2018
Journal: Am J Pathol
Title: High MUC2 Mucin Expression and Misfolding Induce Cellular Stress, Reactive Oxygen Production, and Apoptosis in Goblet Cells.
Volume: 188
Issue: 6
Pages: 1354-1373
Publication      
First Author: Brandl K
Year: 2010
Journal: MGI Direct Data Submission
Title: Muskatenwein is an allele of Muc2 and confers susceptibility to DSS-induced colitis
Publication
First Author: Burger-van Paassen N
Year: 2012
Journal: PLoS One
Title: Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4.
Volume: 7
Issue: 6
Pages: e38798
Publication
First Author: van der Sluis M
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells.
Volume: 369
Issue: 4
Pages: 1108-13
Publication
First Author: van der Sluis M
Year: 2004
Journal: Biochem Biophys Res Commun
Title: The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells.
Volume: 325
Issue: 3
Pages: 952-60
Publication
First Author: Schütte A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.
Volume: 111
Issue: 34
Pages: 12396-401
Publication
First Author: Porchet N
Year: 2004
Journal: Med Sci (Paris)
Title: [MUC genes: mucin or not mucin? That is the question].
Volume: 20
Issue: 5
Pages: 569-74
Publication
First Author: Tashiro M
Year: 2017
Journal: PLoS One
Title: The N-terminal region of serum amyloid A3 protein activates NF-κB and up-regulates MUC2 mucin mRNA expression in mouse colonic epithelial cells.
Volume: 12
Issue: 7
Pages: e0181796
Protein
Organism: Mus musculus
Length: 2680  
Fragment?: true
Protein
Organism: Mus musculus
Length: 4576  
Fragment?: false
Publication  
First Author: Wu M
Year: 2018
Journal: Int J Mol Sci
Title: The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice.
Volume: 19
Issue: 9
Publication
First Author: Tsai K
Year: 2020
Journal: J Immunol
Title: Cutting Edge: Intestinal Mucus Limits the Clonal Deletion of Developing T Cells Specific for an Oral Antigen.
Volume: 205
Issue: 2
Pages: 329-334
Publication
First Author: Velcich A
Year: 2002
Journal: Science
Title: Colorectal cancer in mice genetically deficient in the mucin Muc2.
Volume: 295
Issue: 5560
Pages: 1726-9
Publication
First Author: Tsuru A
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Negative feedback by IRE1β optimizes mucin production in goblet cells.
Volume: 110
Issue: 8
Pages: 2864-9
Publication
First Author: Borisova MA
Year: 2020
Journal: Sci Rep
Title: Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium.
Volume: 10
Issue: 1
Pages: 21135
Publication
First Author: Amat CB
Year: 2017
Journal: Am J Pathol
Title: Cysteine Protease-Dependent Mucous Disruptions and Differential Mucin Gene Expression in Giardia duodenalis Infection.
Volume: 187
Issue: 11
Pages: 2486-2498
Publication
First Author: Das I
Year: 2013
Journal: J Exp Med
Title: Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins.
Volume: 210
Issue: 6
Pages: 1201-16
Publication
First Author: Schneider H
Year: 2018
Journal: Sci Rep
Title: Study of mucin turnover in the small intestine by in vivo labeling.
Volume: 8
Issue: 1
Pages: 5760
Publication
First Author: van Klinken BJ
Year: 1999
Journal: Am J Physiol
Title: Gastrointestinal expression and partial cDNA cloning of murine Muc2.
Volume: 276
Issue: 1 Pt 1
Pages: G115-24
Publication
First Author: Burger-van Paassen N
Year: 2011
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Colitis development during the suckling-weaning transition in mucin Muc2-deficient mice.
Volume: 301
Issue: 4
Pages: G667-78
Publication
First Author: Heazlewood CK
Year: 2008
Journal: PLoS Med
Title: Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.
Volume: 5
Issue: 3
Pages: e54
Publication
First Author: Yang W
Year: 2005
Journal: Am J Pathol
Title: Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice.
Volume: 166
Issue: 4
Pages: 1239-46
Publication
First Author: van der Sluis M
Year: 2008
Journal: Lab Invest
Title: Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice.
Volume: 88
Issue: 6
Pages: 634-42
Publication
First Author: Wallace JL
Year: 2011
Journal: Am J Pathol
Title: Muc-2-deficient mice display a sex-specific, COX-2-related impairment of gastric mucosal repair.
Volume: 178
Issue: 3
Pages: 1126-33
Publication
First Author: Khatri IA
Year: 2001
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Characteristics of rodent intestinal mucin Muc3 and alterations in a mouse model of human cystic fibrosis.
Volume: 280
Issue: 6
Pages: G1321-30
Publication
First Author: Escande F
Year: 2004
Journal: Biochim Biophys Acta
Title: The mouse secreted gel-forming mucin gene cluster.
Volume: 1676
Issue: 3
Pages: 240-50
Publication  
First Author: Gonzalez-Perez V
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice.
Volume: 118
Issue: 3
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Publication
First Author: Wenzel UA
Year: 2014
Journal: PLoS One
Title: Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis.
Volume: 9
Issue: 6
Pages: e100217
Publication
First Author: Hamano S
Year: 2008
Journal: Genes Immun
Title: Gender and genetic control of resistance to intestinal amebiasis in inbred mice.
Volume: 9
Issue: 5
Pages: 452-61
Publication
First Author: Bao Y
Year: 2014
Journal: PLoS One
Title: Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2.
Volume: 9
Issue: 8
Pages: e105991
Publication
First Author: Hecht AL
Year: 2017
Journal: Cell Host Microbe
Title: A Two-Component System Regulates Bacteroides fragilis Toxin to Maintain Intestinal Homeostasis and Prevent Lethal Disease.
Volume: 22
Issue: 4
Pages: 443-448.e5
Publication
First Author: Ye J
Year: 2021
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Deletion of mucin 2 induces colitis with concomitant metabolic abnormalities in mice.
Volume: 320
Issue: 5
Pages: G791-G803
Publication
First Author: Wenzel UA
Year: 2015
Journal: PLoS One
Title: CD103+ CD11b+ Dendritic Cells Induce Th17 T Cells in Muc2-Deficient Mice with Extensively Spread Colitis.
Volume: 10
Issue: 6
Pages: e0130750
Publication      
First Author: Brandl K
Year: 2009
Journal: MGI Direct Data Submission
Title: Record for "Schlendrian", updated July 1st, 2009
Publication
First Author: Robinson AM
Year: 2017
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Alterations of colonic function in the Winnie mouse model of spontaneous chronic colitis.
Volume: 312
Issue: 1
Pages: G85-G102
Publication      
First Author: McAlpine W
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for nomoco
Publication
First Author: Mastrodonato M
Year: 2020
Journal: J Histochem Cytochem
Title: High-fat Diet Alters the Glycosylation Patterns of Duodenal Mucins in a Murine Model.
Volume: 68
Issue: 4
Pages: 279-294
GXD Expression      
Probe: MGI:6368572
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368577
Age: embryonic day 18.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6368572
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368577
Age: embryonic day 18.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6368572
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368577
Age: embryonic day 18.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6368572
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368577
Age: embryonic day 18.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6368572
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368577
Age: embryonic day 18.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6368572
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368577
Age: embryonic day 18.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:4453820
Assay Type: RT-PCR
Annotation Date: 2010-06-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1880928
Stage: TS28
Assay Id: MGI:4453842
Age: postnatal adult
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:4453820
Assay Type: RT-PCR
Annotation Date: 2010-06-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1880927
Stage: TS27
Assay Id: MGI:4453842
Age: postnatal newborn
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:4357895
Assay Type: RT-PCR
Annotation Date: 2009-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287425
Stage: TS25
Assay Id: MGI:4358225
Age: embryonic day 17.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4357895
Assay Type: RT-PCR
Annotation Date: 2009-09-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702125
Stage: TS25
Assay Id: MGI:4358225
Age: embryonic day 17.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4453820
Assay Type: RT-PCR
Annotation Date: 2010-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276428
Stage: TS28
Assay Id: MGI:4453842
Age: postnatal
Detected: true
Specimen Num: 13
GXD Expression
Probe: MGI:5576882
Assay Type: Immunohistochemistry
Annotation Date: 2014-08-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1894128
Pattern: Single cells
Stage: TS28
Assay Id: MGI:5577151
Age: postnatal
Image: 3C
Note: Expression is present in goblet cells.
Detected: true
Specimen Num: 1
Publication
First Author: Hsu CC
Year: 2021
Journal: Int Immunol
Title: Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel disease.
Volume: 33
Issue: 7
Pages: 359-372
Publication
First Author: Wei X
Year: 2012
Journal: Cell Host Microbe
Title: Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2.
Volume: 11
Issue: 2
Pages: 140-52
Publication
First Author: Nyström EEL
Year: 2019
Journal: J Biol Chem
Title: Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing properties.
Volume: 294
Issue: 45
Pages: 17075-17089
Publication
First Author: Qadura M
Year: 2009
Journal: Blood
Title: Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice.
Volume: 114
Issue: 4
Pages: 871-80
Publication
First Author: Petersson J
Year: 2011
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Importance and regulation of the colonic mucus barrier in a mouse model of colitis.
Volume: 300
Issue: 2
Pages: G327-33
Publication
First Author: Pysz MA
Year: 2009
Journal: Exp Cell Res
Title: PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.
Volume: 315
Issue: 8
Pages: 1415-28
Publication
First Author: Yang K
Year: 2008
Journal: Cancer Res
Title: Dietary induction of colonic tumors in a mouse model of sporadic colon cancer.
Volume: 68
Issue: 19
Pages: 7803-10
Publication
First Author: Kumar M
Year: 2020
Journal: Nat Commun
Title: Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling.
Volume: 11
Issue: 1
Pages: 483
Publication
First Author: Garg P
Year: 2007
Journal: Gastroenterology
Title: Matrix metalloproteinase-9 regulates MUC-2 expression through its effect on goblet cell differentiation.
Volume: 132
Issue: 5
Pages: 1877-89
Publication
First Author: Desseyn JL
Year: 2003
Journal: Genomics
Title: Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.
Volume: 81
Issue: 4
Pages: 433-6
Publication
First Author: Prokhortchouk A
Year: 2006
Journal: Mol Cell Biol
Title: Kaiso-deficient mice show resistance to intestinal cancer.
Volume: 26
Issue: 1
Pages: 199-208
Publication
First Author: Leclaire C
Year: 2018
Journal: FASEB J
Title: Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins.
Volume: 32
Issue: 6
Pages: 3301-3320
Publication
First Author: Tomasetto C
Year: 2000
Journal: Gastroenterology
Title: pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins.
Volume: 118
Issue: 1
Pages: 70-80
Publication  
First Author: Tang AT
Year: 2019
Journal: Sci Transl Med
Title: Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.
Volume: 11
Issue: 520
Publication
First Author: Das B
Year: 2009
Journal: J Histochem Cytochem
Title: Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.
Volume: 57
Issue: 4
Pages: 383-96
Publication
First Author: Reynolds SD
Year: 2008
Journal: Stem Cells
Title: Conditional stabilization of beta-catenin expands the pool of lung stem cells.
Volume: 26
Issue: 5
Pages: 1337-46
Publication
First Author: Kosinsky RL
Year: 2015
Journal: Oncotarget
Title: Usp22 deficiency impairs intestinal epithelial lineage specification in vivo.
Volume: 6
Issue: 35
Pages: 37906-18