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Search results 1 to 100 out of 256 for Muc2

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0.039s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Protein
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: true
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: Mucin-2 (MUC2) belongs to the mucin family. They are high molecular weight proteins that are components of mucus and are synthesised and secreted by specialised cells of the epithelium (goblet cells, cells of mucous glands) or non mucin-secreting cells []. There are two main mucin subfamilies: secreted mucins or gel-forming mucins (MUC2, MUC5AC, MUC5B, MUC6) and membrane-bound mucins (MUC1, MUC3, MUC4, MUC12, MUC17) []. In colon epithelium, MUC2 forms a net-like disulfide-bonded polymer structure that organise the two mucus layer of colon []. The colon inner layer is adherent to intestinal epithelial cells (IECs) and does not allow bacteria to penetrate, while the outer layer is inhabited by the microbiota []. In the small intestine, MUC2 modulates inflammatory responses and delivers tolerogenic signal to antigen-sampling dendritic cells (DCs) []. It plays an important role in gut homeostasis and promotes oral tolerance [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Johansson ME
Year: 2009
Journal: J Proteome Res
Title: Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein.
Volume: 8
Issue: 7
Pages: 3549-57
Publication
First Author: Shan M
Year: 2013
Journal: Science
Title: Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.
Volume: 342
Issue: 6157
Pages: 447-53
GXD Expression  
Probe: MGI:5576882
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7463994
Age: postnatal adult
Image: S12E - Muc2
Specimen Label: S12E - Muc2
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4453820
Assay Type: RT-PCR
Annotation Date: 2010-06-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1880928
Stage: TS28
Assay Id: MGI:4453842
Age: postnatal adult
Specimen Label: Muc2
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:4453820
Assay Type: RT-PCR
Annotation Date: 2010-06-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1880927
Stage: TS27
Assay Id: MGI:4453842
Age: postnatal newborn
Specimen Label: Muc2
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:4453820
Assay Type: RT-PCR
Annotation Date: 2010-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276428
Stage: TS28
Assay Id: MGI:4453842
Age: postnatal
Specimen Label: Muc2
Detected: true
Specimen Num: 13
Protein
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
Publication
First Author: Borchers MT
Year: 1999
Journal: Am J Physiol
Title: Regulation of human airway mucins by acrolein and inflammatory mediators.
Volume: 276
Issue: 4 Pt 1
Pages: L549-55
Publication
First Author: Yu T
Year: 2016
Journal: Cell Death Dis
Title: KLF4 deletion alters gastric cell lineage and induces MUC2 expression.
Volume: 7
Issue: 6
Pages: e2255
Publication
First Author: Feofanova NA
Year: 2022
Journal: PLoS One
Title: L-fucose reduces gut inflammation due to T-regulatory response in Muc2 null mice.
Volume: 17
Issue: 12
Pages: e0278714
Publication
First Author: Birchenough GM
Year: 2016
Journal: Science
Title: A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.
Volume: 352
Issue: 6293
Pages: 1535-42
Publication
First Author: Johansson ME
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.
Volume: 105
Issue: 39
Pages: 15064-9
Publication
First Author: Van der Sluis M
Year: 2006
Journal: Gastroenterology
Title: Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.
Volume: 131
Issue: 1
Pages: 117-29
Publication
First Author: Bergstrom KS
Year: 2010
Journal: PLoS Pathog
Title: Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa.
Volume: 6
Issue: 5
Pages: e1000902
Publication
First Author: Kumar M
Year: 2017
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Probiotic mixture VSL#3 reduces colonic inflammation and improves intestinal barrier function in Muc2 mucin-deficient mice.
Volume: 312
Issue: 1
Pages: G34-G45
Publication
First Author: Leon-Coria A
Year: 2021
Journal: Cell Mol Gastroenterol Hepatol
Title: Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic Injury.
Volume: 11
Issue: 1
Pages: 77-98
GXD Expression  
Probe: MGI:3799241
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3577828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7463976
Age: postnatal adult
Image: S12E - Muc2
Specimen Label: S12E - Muc2
Detected: true
Specimen Num: 7
Publication
First Author: Zarepour M
Year: 2013
Journal: Infect Immun
Title: The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis.
Volume: 81
Issue: 10
Pages: 3672-83
Publication
First Author: Liso M
Year: 2020
Journal: Inflamm Bowel Dis
Title: A Specific Mutation in Muc2 Determines Early Dysbiosis in Colitis-Prone Winnie Mice.
Volume: 26
Issue: 4
Pages: 546-556
Publication
First Author: Stahl M
Year: 2018
Journal: Am J Physiol Gastrointest Liver Physiol
Title: The Muc2 mucin coats murine Paneth cell granules and facilitates their content release and dispersion.
Volume: 315
Issue: 2
Pages: G195-G205
Publication
First Author: Bao Y
Year: 2014
Journal: PLoS One
Title: MicroRNA profiling in Muc2 knockout mice of colitis-associated cancer model reveals epigenetic alterations during chronic colitis malignant transformation.
Volume: 9
Issue: 6
Pages: e99132
Publication
First Author: Lu P
Year: 2013
Journal: PLoS One
Title: High beta-palmitate fat controls the intestinal inflammatory response and limits intestinal damage in mucin Muc2 deficient mice.
Volume: 8
Issue: 6
Pages: e65878
Publication
First Author: Aslam F
Year: 2001
Journal: Cancer Res
Title: The Sp family of transcription factors in the regulation of the human and mouse MUC2 gene promoters.
Volume: 61
Issue: 2
Pages: 570-6
Publication
First Author: Tawiah A
Year: 2018
Journal: Am J Pathol
Title: High MUC2 Mucin Expression and Misfolding Induce Cellular Stress, Reactive Oxygen Production, and Apoptosis in Goblet Cells.
Volume: 188
Issue: 6
Pages: 1354-1373
Publication
First Author: Porchet N
Year: 2004
Journal: Med Sci (Paris)
Title: [MUC genes: mucin or not mucin? That is the question].
Volume: 20
Issue: 5
Pages: 569-74
Publication      
First Author: Brandl K
Year: 2010
Journal: MGI Direct Data Submission
Title: Muskatenwein is an allele of Muc2 and confers susceptibility to DSS-induced colitis
Publication
First Author: Yang K
Year: 2008
Journal: Cancer Res
Title: Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation.
Volume: 68
Issue: 18
Pages: 7313-22
Publication
First Author: Burger-van Paassen N
Year: 2012
Journal: PLoS One
Title: Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4.
Volume: 7
Issue: 6
Pages: e38798
Publication
First Author: van der Sluis M
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells.
Volume: 369
Issue: 4
Pages: 1108-13
Protein
Organism: Mus musculus/domesticus
Length: 2680  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 4576  
Fragment?: false
Publication
First Author: van der Sluis M
Year: 2004
Journal: Biochem Biophys Res Commun
Title: The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells.
Volume: 325
Issue: 3
Pages: 952-60
Publication
First Author: Schütte A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.
Volume: 111
Issue: 34
Pages: 12396-401
Publication
First Author: Tashiro M
Year: 2017
Journal: PLoS One
Title: The N-terminal region of serum amyloid A3 protein activates NF-κB and up-regulates MUC2 mucin mRNA expression in mouse colonic epithelial cells.
Volume: 12
Issue: 7
Pages: e0181796
Publication  
First Author: Wu M
Year: 2018
Journal: Int J Mol Sci
Title: The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice.
Volume: 19
Issue: 9
Publication
First Author: Tsai K
Year: 2020
Journal: J Immunol
Title: Cutting Edge: Intestinal Mucus Limits the Clonal Deletion of Developing T Cells Specific for an Oral Antigen.
Volume: 205
Issue: 2
Pages: 329-334
Publication
First Author: Velcich A
Year: 2002
Journal: Science
Title: Colorectal cancer in mice genetically deficient in the mucin Muc2.
Volume: 295
Issue: 5560
Pages: 1726-9
Publication
First Author: Tsuru A
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Negative feedback by IRE1β optimizes mucin production in goblet cells.
Volume: 110
Issue: 8
Pages: 2864-9
Publication
First Author: Bergstrom K
Year: 2020
Journal: Science
Title: Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota.
Volume: 370
Issue: 6515
Pages: 467-472
Publication
First Author: Morozova MV
Year: 2022
Journal: Sci Rep
Title: Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice.
Volume: 12
Issue: 1
Pages: 16345
Publication
First Author: Borisova MA
Year: 2020
Journal: Sci Rep
Title: Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium.
Volume: 10
Issue: 1
Pages: 21135
Publication
First Author: Amat CB
Year: 2017
Journal: Am J Pathol
Title: Cysteine Protease-Dependent Mucous Disruptions and Differential Mucin Gene Expression in Giardia duodenalis Infection.
Volume: 187
Issue: 11
Pages: 2486-2498
Publication
First Author: Moutin EB
Year: 2024
Journal: Cell Mol Gastroenterol Hepatol
Title: Extracellular Matrix Orchestration of Tissue Remodeling in the Chronically Inflamed Mouse Colon.
Volume: 17
Issue: 4
Pages: 639-656
Publication  
First Author: Ephraim R
Year: 2023
Journal: Cancers (Basel)
Title: Differential Gene Expression of Checkpoint Markers and Cancer Markers in Mouse Models of Spontaneous Chronic Colitis.
Volume: 15
Issue: 19
Publication
First Author: Das I
Year: 2013
Journal: J Exp Med
Title: Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins.
Volume: 210
Issue: 6
Pages: 1201-16
Publication
First Author: Han C
Year: 2022
Journal: Am J Pathol
Title: Activation of 5-Hydroxytryptamine 4 Receptor Improves Colonic Barrier Function by Triggering Mucin 2 Production in a Mouse Model of Type 1 Diabetes.
Volume: 192
Issue: 6
Pages: 876-886
Publication
First Author: Birchenough GMH
Year: 2023
Journal: Cell Rep
Title: Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection.
Volume: 42
Issue: 2
Pages: 112084
Publication
First Author: van Klinken BJ
Year: 1999
Journal: Am J Physiol
Title: Gastrointestinal expression and partial cDNA cloning of murine Muc2.
Volume: 276
Issue: 1 Pt 1
Pages: G115-24
Publication
First Author: Burger-van Paassen N
Year: 2011
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Colitis development during the suckling-weaning transition in mucin Muc2-deficient mice.
Volume: 301
Issue: 4
Pages: G667-78
Publication
First Author: Ehrencrona E
Year: 2021
Journal: J Biol Chem
Title: The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds.
Volume: 297
Issue: 1
Pages: 100871
Publication
First Author: Schneider H
Year: 2018
Journal: Sci Rep
Title: Study of mucin turnover in the small intestine by in vivo labeling.
Volume: 8
Issue: 1
Pages: 5760
Publication
First Author: Heazlewood CK
Year: 2008
Journal: PLoS Med
Title: Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.
Volume: 5
Issue: 3
Pages: e54
Publication
First Author: van der Sluis M
Year: 2008
Journal: Lab Invest
Title: Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice.
Volume: 88
Issue: 6
Pages: 634-42
Publication
First Author: Wallace JL
Year: 2011
Journal: Am J Pathol
Title: Muc-2-deficient mice display a sex-specific, COX-2-related impairment of gastric mucosal repair.
Volume: 178
Issue: 3
Pages: 1126-33
Publication
First Author: Yang W
Year: 2005
Journal: Am J Pathol
Title: Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice.
Volume: 166
Issue: 4
Pages: 1239-46
Publication  
First Author: Znalesniak EB
Year: 2017
Journal: Int J Mol Sci
Title: Transcriptional Responses in the Murine Spleen after Toxoplasma gondii Infection: Inflammasome and Mucus-Associated Genes.
Volume: 18
Issue: 6
Publication
First Author: Escande F
Year: 2004
Journal: Biochim Biophys Acta
Title: The mouse secreted gel-forming mucin gene cluster.
Volume: 1676
Issue: 3
Pages: 240-50
Publication
First Author: Taniguchi M
Year: 2023
Journal: Mucosal Immunol
Title: Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon.
Volume: 16
Issue: 5
Pages: 624-641
Publication
First Author: Khatri IA
Year: 2001
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Characteristics of rodent intestinal mucin Muc3 and alterations in a mouse model of human cystic fibrosis.
Volume: 280
Issue: 6
Pages: G1321-30
Publication  
First Author: Gonzalez-Perez V
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice.
Volume: 118
Issue: 3
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Publication
First Author: Wenzel UA
Year: 2014
Journal: PLoS One
Title: Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis.
Volume: 9
Issue: 6
Pages: e100217
Publication
First Author: Hamano S
Year: 2008
Journal: Genes Immun
Title: Gender and genetic control of resistance to intestinal amebiasis in inbred mice.
Volume: 9
Issue: 5
Pages: 452-61
Publication
First Author: Hecht AL
Year: 2017
Journal: Cell Host Microbe
Title: A Two-Component System Regulates Bacteroides fragilis Toxin to Maintain Intestinal Homeostasis and Prevent Lethal Disease.
Volume: 22
Issue: 4
Pages: 443-448.e5
Publication
First Author: Ye J
Year: 2021
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Deletion of mucin 2 induces colitis with concomitant metabolic abnormalities in mice.
Volume: 320
Issue: 5
Pages: G791-G803
Publication
First Author: Bao Y
Year: 2014
Journal: PLoS One
Title: Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2.
Volume: 9
Issue: 8
Pages: e105991
Publication
First Author: Wenzel TJ
Year: 2022
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Dietary fats modulate neuroinflammation in mucin 2 knock out mice model of spontaneous colitis.
Volume: 1868
Issue: 3
Pages: 166336
Publication
First Author: Wenzel UA
Year: 2015
Journal: PLoS One
Title: CD103+ CD11b+ Dendritic Cells Induce Th17 T Cells in Muc2-Deficient Mice with Extensively Spread Colitis.
Volume: 10
Issue: 6
Pages: e0130750
Publication
First Author: Kissoon-Singh V
Year: 2013
Journal: Am J Pathol
Title: Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.
Volume: 182
Issue: 3
Pages: 852-65
Publication      
First Author: Brandl K
Year: 2009
Journal: MGI Direct Data Submission
Title: Record for "Schlendrian", updated July 1st, 2009
Publication
First Author: Robinson AM
Year: 2017
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Alterations of colonic function in the Winnie mouse model of spontaneous chronic colitis.
Volume: 312
Issue: 1
Pages: G85-G102
Publication      
First Author: McAlpine W
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for nomoco
GXD Expression      
Probe: MGI:4357895
Assay Type: RT-PCR
Annotation Date: 2009-09-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702125
Stage: TS25
Assay Id: MGI:4358225
Age: embryonic day 17.5
Specimen Label: St
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4357895
Assay Type: RT-PCR
Annotation Date: 2009-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287425
Stage: TS25
Assay Id: MGI:4358225
Age: embryonic day 17.5
Specimen Label: Int
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6368572
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368577
Age: embryonic day 18.5
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6368572
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368577
Age: embryonic day 18.5
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6368572
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368577
Age: embryonic day 18.5
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6368572
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368577
Age: embryonic day 18.5
Specimen Label: 5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6368572
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368577
Age: embryonic day 18.5
Specimen Label: 6
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6368572
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368577
Age: embryonic day 18.5
Specimen Label: 7
Detected: true
Specimen Num: 7