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Search results 1 to 100 out of 105 for Muc4

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication    
First Author: Bartman AE
Year: 2000
Journal: GenBank Submission
Title: Mus musculus mucin Muc4 mRNA, partial cds
Pages: AF218265
Publication
First Author: Das S
Year: 2016
Journal: Oncogene
Title: Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer.
Volume: 35
Issue: 20
Pages: 2645-54
Publication
First Author: Rowson-Hodel AR
Year: 2018
Journal: Oncogene
Title: Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer.
Volume: 37
Issue: 2
Pages: 197-207
Publication
First Author: Vasseur R
Year: 2015
Journal: Biochim Biophys Acta
Title: The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways.
Volume: 1849
Issue: 12
Pages: 1375-84
Publication      
First Author: Plante JA
Year: 2020
Journal: bioRxiv
Title: Mucin 4 Protects Female Mice from Coronavirus Pathogenesis.
Publication
First Author: Desseyn JL
Year: 2002
Journal: Eur J Biochem
Title: Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4.
Volume: 269
Issue: 13
Pages: 3150-9
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:6368574
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368578
Age: embryonic day 18.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6368574
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368578
Age: embryonic day 18.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6368574
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368578
Age: embryonic day 18.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6368574
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368578
Age: embryonic day 18.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6368574
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368578
Age: embryonic day 18.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6368574
Assay Type: RT-PCR
Annotation Date: 2019-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893926
Stage: TS26
Assay Id: MGI:6368578
Age: embryonic day 18.5
Detected: true
Specimen Num: 2
Protein
Organism: Mus musculus
Length: 1403  
Fragment?: true
Publication  
First Author: Wang IJ
Year: 2009
Journal: Mol Vis
Title: Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice.
Volume: 15
Pages: 108-19
Publication
First Author: Tréhoux S
Year: 2015
Journal: Biochim Biophys Acta
Title: Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells.
Volume: 1853
Issue: 10 Pt A
Pages: 2392-403
Publication
First Author: Lee CG
Year: 2002
Journal: J Biol Chem
Title: Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways.
Volume: 277
Issue: 38
Pages: 35466-74
Publication
First Author: Wang X
Year: 2011
Journal: Cell
Title: Residual embryonic cells as precursors of a Barrett's-like metaplasia.
Volume: 145
Issue: 7
Pages: 1023-35
Publication
First Author: Metwalli KA
Year: 2018
Journal: J Dent Res
Title: Interferon Regulatory Factor 6 Is Necessary for Salivary Glands and Pancreas Development.
Volume: 97
Issue: 2
Pages: 226-236
Publication
First Author: Bondow BJ
Year: 2012
Journal: Dev Biol
Title: E-cadherin is required for intestinal morphogenesis in the mouse.
Volume: 371
Issue: 1
Pages: 1-12
Publication
First Author: Garrison WD
Year: 2006
Journal: Gastroenterology
Title: Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon.
Volume: 130
Issue: 4
Pages: 1207-20
Publication  
First Author: Timmermans S
Year: 2018
Journal: JCI Insight
Title: Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.
Volume: 3
Issue: 13
Publication
First Author: Kuo TL
Year: 2016
Journal: Oncogene
Title: APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice.
Volume: 35
Issue: 17
Pages: 2223-34
Publication
First Author: Nagamachi A
Year: 2013
Journal: Cancer Cell
Title: Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Volume: 24
Issue: 3
Pages: 305-17
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication  
First Author: Naba A
Year: 2017
Journal: Sci Rep
Title: Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Volume: 7
Pages: 40495
Publication      
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication
First Author: Mejías-Luque R
Year: 2010
Journal: Oncogene
Title: Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors.
Volume: 29
Issue: 12
Pages: 1753-62
Publication
First Author: Lahdaoui F
Year: 2015
Journal: Oncogene
Title: miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer.
Volume: 34
Issue: 6
Pages: 780-8
Publication
First Author: Price-Schiavi SA
Year: 2000
Journal: Biochem J
Title: Cloning and characterization of the 5' flanking region of the sialomucin complex/rat Muc4 gene: promoter activity in cultured cells.
Volume: 349
Issue: Pt 2
Pages: 641-9
Publication  
First Author: Duraisamy S
Year: 2006
Journal: Gene
Title: Distinct evolution of the human carcinoma-associated transmembrane mucins, MUC1, MUC4 AND MUC16.
Volume: 373
Pages: 28-34
Allele  
Name: mucin 4; PWK/PhJ
Attribute String: Hypomorph
Publication categories: ProxyCollection
Genotype
Symbol: Muc4/Muc4
Background: PWK/PhJ
Zygosity: hm
Has Mutant Allele: true
Protein
Organism: Mus musculus
Length: 185  
Fragment?: false
Publication
First Author: Carraway KL
Year: 2003
Journal: Bioessays
Title: Cell signaling through membrane mucins.
Volume: 25
Issue: 1
Pages: 66-71
Publication  
First Author: Carraway KL
Year: 2002
Journal: Prog Nucleic Acid Res Mol Biol
Title: Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive.
Volume: 71
Pages: 149-85
Publication
First Author: Jepson S
Year: 2002
Journal: Oncogene
Title: Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways.
Volume: 21
Issue: 49
Pages: 7524-32
Protein Domain
Type: family
Description: Mucins are high-molecular-weight glycoproteins present on all mucosal surfaces. Mucins are characterised by the presence of tandemly repeated amino acid sequences, the mucin domains that contain high amounts of serine and threonine and thus create an attachment point for O-linked glycosylation [].Mucin-4 (Muc4) is a cell surface glycoprotein implicated in the protection and lubrication of epithelia []. Muc4 also functions as a modulator of cell signaling. It is an intramembrane ligand for the receptor tyrosine kinase ErbB, triggering phosphorylation of ErbB2 and potentiating signaling through the ErbB2/ErbB3 receptor complex []. The Muc4 complex, also known as sialomucin complex (SMC) in rats, is a heterodimeric complex of two subunits, alpha (ASGP-1) and beta (ASGP-2), that result from the cleavage of the Muc4 gene product. The Muc4 complex has been shown to repress apoptosis in transfected tumour cells [].
Strain
Attribute String: inbred strain, wild-derived
Publication
First Author: van Putten JPM
Year: 2017
Journal: J Innate Immun
Title: Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer.
Volume: 9
Issue: 3
Pages: 281-299
Protein Domain
Type: domain
Description: The AMOP domain (for adhesion-associated domain in MUC4 and other proteins) isan ~100-residue long extracellular domain that occurs in putative celladhesion molecules and in some splice variants of MUC4. It contains eightinvariant cysteines residues that are predicted to be involved in disulfidebonds. The AMOP domain is found associated with extracellular domains involvedin cell adhesion, such as NIDO, sushi, somatomedin B, VWFD, EGF, IPT, or TSP1. Thepresence of the AMOP domain in cell adhesion molecules could be indicative ofa role for this domain in adhesion [].Secondary structure prediction indicates an initial region rich in alpha helixfollowed by four beta strands, suggesting a beta-sheet organisation for the C-terminus of the AMOP domain [].
HT Experiment
Series Id: GSE23373
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Protein
Organism: Mus musculus
Length: 3443  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1401  
Fragment?: true
Protein
Organism: Mus musculus
Length: 3470  
Fragment?: false
Publication
First Author: Xiang W
Year: 2011
Journal: J Cell Mol Med
Title: Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice.
Volume: 15
Issue: 2
Pages: 359-74
Publication
First Author: Ciccarelli FD
Year: 2002
Journal: Trends Biochem Sci
Title: AMOP, a protein module alternatively spliced in cancer cells.
Volume: 27
Issue: 3
Pages: 113-5
Publication
First Author: van der Sluis M
Year: 2008
Journal: Lab Invest
Title: Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice.
Volume: 88
Issue: 6
Pages: 634-42
Publication
First Author: Wang HH
Year: 2004
Journal: J Lipid Res
Title: Targeted disruption of the murine mucin gene 1 decreases susceptibility to cholesterol gallstone formation.
Volume: 45
Issue: 3
Pages: 438-47
Publication
First Author: Wang HH
Year: 2004
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Lack of the intestinal Muc1 mucin impairs cholesterol uptake and absorption but not fatty acid uptake in Muc1-/- mice.
Volume: 287
Issue: 3
Pages: G547-54
Publication
First Author: Kumar S
Year: 2015
Journal: Oncogene
Title: NCOA3-mediated upregulation of mucin expression via transcriptional and post-translational changes during the development of pancreatic cancer.
Volume: 34
Issue: 37
Pages: 4879-89
Publication
First Author: Schmitz JM
Year: 2009
Journal: J Histochem Cytochem
Title: Gastric mucus alterations associated with murine Helicobacter infection.
Volume: 57
Issue: 5
Pages: 457-67
Publication
First Author: Osório L
Year: 2014
Journal: Cell Cycle
Title: Distinct spatiotemporal expression of ISM1 during mouse and chick development.
Volume: 13
Issue: 10
Pages: 1571-82
Publication
First Author: Danjo Y
Year: 2000
Journal: Invest Ophthalmol Vis Sci
Title: C57BL/6 mice lacking Muc1 show no ocular surface phenotype.
Volume: 41
Issue: 13
Pages: 4080-4
Publication
First Author: Thiagarajah JR
Year: 2014
Journal: PLoS One
Title: Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease.
Volume: 9
Issue: 6
Pages: e99944
Publication
First Author: Kunert KS
Year: 2001
Journal: Invest Ophthalmol Vis Sci
Title: Alteration in goblet cell numbers and mucin gene expression in a mouse model of allergic conjunctivitis.
Volume: 42
Issue: 11
Pages: 2483-9