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Search results 1 to 66 out of 66 for Muc6

0.049s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Mucin-6 (MUC6) is a secretory mucin found at high levels in the normal stomach, where it has a protective function [, ]. It is aberrantly expressed in gastric cancer and other types of carcinomas [, , , ]. MUC6, like other glycosylated mucins, could represent a target for the development of efficient immunotherapies [].The mucin (MUC) family members are high molecular weight proteins that are components of mucus and are synthesised and secreted by specialised cells of the epithelium (goblet cells, cells of mucous glands) or non mucin-secreting cells []. There are two main mucin subfamilies: secreted mucins or gel-forming mucins (MUC2, MUC5AC, MUC5B, MUC6) and membrane-bound mucins (MUC1, MUC3, MUC4, MUC12, MUC17) []. They were thought to have the unique function of protecting and lubricating the epithelial surfaces. However, they also possess other important functions, such as growth, direct implication in the fetal development, the epithelial renewal and differentiation, the epithelial integrity, carcinogenesis, and metastasis [].
Publication
First Author: Desseyn JL
Year: 2003
Journal: Genomics
Title: Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.
Volume: 81
Issue: 4
Pages: 433-6
Publication
First Author: Hamamoto A
Year: 2005
Journal: Int J Oncol
Title: Aberrant expression of the gastric mucin MUC6 in human pulmonary adenocarcinoma xenografts.
Volume: 26
Issue: 4
Pages: 891-6
Publication
First Author: Zheng H
Year: 2006
Journal: J Cancer Res Clin Oncol
Title: MUC6 down-regulation correlates with gastric carcinoma progression and a poor prognosis: an immunohistochemical study with tissue microarrays.
Volume: 132
Issue: 12
Pages: 817-23
Publication
First Author: de Bolòs C
Year: 1998
Journal: Int J Cancer
Title: MUC6 expression in breast tissues and cultured cells: abnormal expression in tumors and regulation by steroid hormones.
Volume: 77
Issue: 2
Pages: 193-9
Publication
First Author: Kim GE
Year: 2002
Journal: Gastroenterology
Title: Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas.
Volume: 123
Issue: 4
Pages: 1052-60
Publication
First Author: Freire T
Year: 2011
Journal: J Biol Chem
Title: Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses.
Volume: 286
Issue: 10
Pages: 7797-811
Publication
First Author: Reis CA
Year: 2000
Journal: J Histochem Cytochem
Title: Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas.
Volume: 48
Issue: 3
Pages: 377-88
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:4453822
Assay Type: RT-PCR
Annotation Date: 2010-06-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1880927
Stage: TS27
Assay Id: MGI:4453846
Age: postnatal newborn
Detected: false
Specimen Num: 11
GXD Expression      
Probe: MGI:4453822
Assay Type: RT-PCR
Annotation Date: 2010-06-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1880928
Stage: TS28
Assay Id: MGI:4453846
Age: postnatal adult
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:4453822
Assay Type: RT-PCR
Annotation Date: 2010-06-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:4453846
Age: postnatal
Detected: true
Specimen Num: 16
Protein
Organism: Mus musculus
Length: 2850  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1437  
Fragment?: false
Protein
Organism: Mus musculus
Length: 499  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1674  
Fragment?: true
Protein
Organism: Mus musculus
Length: 313  
Fragment?: true
Protein
Organism: Mus musculus
Length: 2918  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2853  
Fragment?: false
Publication
First Author: Porchet N
Year: 2004
Journal: Med Sci (Paris)
Title: [MUC genes: mucin or not mucin? That is the question].
Volume: 20
Issue: 5
Pages: 569-74
Publication
First Author: Toribara NW
Year: 1993
Journal: J Biol Chem
Title: Human gastric mucin. Identification of a unique species by expression cloning.
Volume: 268
Issue: 8
Pages: 5879-85
Publication  
First Author: Moniaux N
Year: 2001
Journal: Front Biosci
Title: Structural organization and classification of the human mucin genes.
Volume: 6
Pages: D1192-206
Publication
First Author: Escande F
Year: 2004
Journal: Biochim Biophys Acta
Title: The mouse secreted gel-forming mucin gene cluster.
Volume: 1676
Issue: 3
Pages: 240-50
Publication
First Author: Gavanescu I
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.
Volume: 104
Issue: 11
Pages: 4583-7
Publication
First Author: Stringer EJ
Year: 2012
Journal: Development
Title: Cdx2 determines the fate of postnatal intestinal endoderm.
Volume: 139
Issue: 3
Pages: 465-74
Publication
First Author: Das B
Year: 2009
Journal: J Histochem Cytochem
Title: Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.
Volume: 57
Issue: 4
Pages: 383-96
Publication        
First Author: Mouse Genome Informatics Scientfic Curators
Year: 2013
Title: Curated associations of genes in MGI and UniProt sequence records
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication
First Author: Kuver R
Year: 2006
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Absence of CFTR is associated with pleiotropic effects on mucins in mouse gallbladder epithelial cells.
Volume: 291
Issue: 6
Pages: G1148-54
Publication
First Author: Van der Sluis M
Year: 2006
Journal: Gastroenterology
Title: Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.
Volume: 131
Issue: 1
Pages: 117-29
Publication
First Author: Horst D
Year: 2010
Journal: J Biol Chem
Title: Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum.
Volume: 285
Issue: 45
Pages: 35047-55
Publication
First Author: Kang W
Year: 2005
Journal: Lab Invest
Title: Interferon gamma induction of gastric mucous neck cell hypertrophy.
Volume: 85
Issue: 5
Pages: 702-15