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Search results 1 to 92 out of 92 for Mul1

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Hits by Strain

Type Details Score
Gene
79594 | MUL1
Type: gene
Organism: human
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Gene
116412398 | mul1
Type: gene
Organism: frog, western clawed
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Gene
298576 | Mul1
Type: gene
Organism: rat
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Gene
487394 | MUL1
Type: gene
Organism: dog, domestic
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Gene
456590 | MUL1
Type: gene
Organism: chimpanzee
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Gene
508406 | MUL1
Type: gene
Organism: cattle
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Gene
426969 | MUL1
Type: gene
Organism: chicken
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Gene
100004181 | mul1
Type: gene
Organism: zebrafish
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Gene
705429 | MUL1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1915600 | Mul1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31409786 | J:281088
First Author: Puri R
Year: 2019
Journal: Nat Commun
Title: Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts.
Volume: 10
Issue: 1
Pages: 3645
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Publication
24898855 | J:219122
 
First Author: Yun J
Year: 2014
Journal: Elife
Title: MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin.
Volume: 3
Pages: e01958
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Publication
26321632 | J:264396
First Author: Tang FL
Year: 2015
Journal: Cell Rep
Title: VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function.
Volume: 12
Issue: 10
Pages: 1631-43
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Publication
28763789 | J:257308
 
First Author: Ni G
Year: 2017
Journal: Sci Immunol
Title: Ubiquitination of STING at lysine 224 controls IRF3 activation.
Volume: 2
Issue: 11
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Publication
27852436 | J:239181
   
First Author: Rojansky R
Year: 2016
Journal: Elife
Title: Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1.
Volume: 5
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Publication
32184272 | J:293018
First Author: Zhao H
Year: 2020
Journal: Diabetes
Title: Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling.
Volume: 69
Issue: 6
Pages: 1164-1177
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Protein Coding Gene
MGP_CAROLIEiJ_G0026692 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028997 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028956 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028908 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028980 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028694 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1915600 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0029421 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028126 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028659 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028808 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028775 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028907 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028801 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0029459 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027847 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028204 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029023 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027672 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
37962001 | J:343276
First Author: Goyon V
Year: 2023
Journal: EMBO Rep
Title: MAPL loss dysregulates bile and liver metabolism in mice.
Volume: 24
Issue: 12
Pages: e57972
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Publication
28273895 | J:336080
First Author: Doiron K
Year: 2017
Journal: Sci Rep
Title: The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity.
Volume: 7
Issue: 1
Pages: 107
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Publication
41083601 | J:383201
First Author: Nguyen M
Year: 2025
Journal: Nat Cell Biol
Title: MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death.
Volume: 27
Issue: 10
Pages: 1708-1724
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Publication
18082624 | J:381741
First Author: Zhang H
Year: 2008
Journal: Biochem Biophys Res Commun
Title: 0610009K11Rik, a testis-specific and germ cell nuclear receptor-interacting protein.
Volume: 366
Issue: 4
Pages: 898-904
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Publication
24709290 | J:212461
First Author: Cilenti L
Year: 2014
Journal: Biochim Biophys Acta
Title: Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy.
Volume: 1843
Issue: 7
Pages: 1295-307
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Publication
36394958 | J:336020
 
First Author: Roque PS
Year: 2023
Journal: J Clin Invest
Title: Parvalbumin interneuron loss mediates repeated anesthesia-induced memory deficits in mice.
Volume: 133
Issue: 2
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:384794
     
First Author: MGI and IMPC
Year: 2026
Journal: Database Release
Title: MGI Load of Molecular Notes for Endonuclease-Mediated (CRISPR) Alleles from the International Mouse Phenotyping Consortium (IMPC)
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342609
       
First Author: UniProt
Year: 2021
Title: Electronic Gene Ontology annotations created by ARBA machine learning models
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Protein Domain
IPR051652 | MDM2_MDM4_MUL1
Type: Family
Description: The MDM2/MDM4 and MUL1 family includes proteins that regulate cell cycle arrest and apoptosis, as well as mitochondrial morphology and localization. Members of the family, such as MDM4, inhibit TP53 and TP73, preventing cell cycle arrest and apoptosis by binding their transcriptional activation domains. They also inhibit the degradation of MDM2 and can reverse MDM2-targeted degradation of TP53, while suppressing TP53 transactivation and apoptotic functions. MUL1 proteins, on the other hand, exhibit E3 ubiquitin-protein ligase activity, accepting ubiquitin from E2 enzymes and transferring it to substrates. They play roles in mitochondrial dynamics, promoting fragmentation and influencing localization. MUL1 proteins also ubiquitinate and regulate proteins like AKT1 and TP53, and are involved in immune defense by modulating antiviral responses. The family is characterized by the presence of zinc finger domains and, in some members, RING finger domains that mediate specific protein interactions.
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Protein
Q8VCM5
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
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Publication
23140641 | J:197115
First Author: Lokireddy S
Year: 2012
Journal: Cell Metab
Title: The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli.
Volume: 16
Issue: 5
Pages: 613-24
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Publication
23399697 | -
First Author: Jenkins K
Year: 2013
Journal: Immunol Cell Biol
Title: Mitochondrially localised MUL1 is a novel modulator of antiviral signaling.
Volume: 91
Issue: 4
Pages: 321-30
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Protein
Q8VCM5-3
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
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Protein
Q8VCM5-2
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: false
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Publication
18591963 | -
First Author: Zhang B
Year: 2008
Journal: Cell Res
Title: GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth.
Volume: 18
Issue: 9
Pages: 900-10
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Publication
18207745 | -
First Author: Neuspiel M
Year: 2008
Journal: Curr Biol
Title: Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers.
Volume: 18
Issue: 2
Pages: 102-8
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Publication
27034206 | -
 
First Author: Peng J
Year: 2016
Journal: Mitochondrion
Title: Mitochondrial E3 ubiquitin ligase 1: A key enzyme in regulation of mitochondrial dynamics and functions.
Volume: 28
Pages: 49-53
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Protein Domain
IPR022170 | MUL1-like
Type: Domain
Description: This domain is found in mitochondrial ubiquitin ligase activator of NFKB 1 (MULAN, also known as MUL1) from animals and ubiquitin E3 Ligase SP1/SP2/SPL1/SPL2 from Arabidopsis.MUL1 is a multifunctional E3 ubiquitin ligase anchored in the outer mitochondrial membrane with its RING finger domain facing the cytoplasm. Mul1 functions as a ubiquitin ligase to ubiquitinate molecules such as mitofusin2 (Mfn2), Akt, p53 and ULK1, through its RING finger domain, leading to proteins degradation. Moreover, Mul1 can also act as a small ubiquitin-like modifiers (SUMO) E3 ligase to sumoylate proteins such as dynamin-related protein 1 (Drp1), enhancing protein stabilization []. It playsa role in the control of mitochondrial morphology, promotes mitochondrial fragmentation and influences mitochondrial localisation []. When over-expressed in human cells, it activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis []. MUL1 has also been shown to regulate RIG-I mediated antiviral response [].
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Publication
26387714 | -
First Author: Ling Q
Year: 2015
Journal: Curr Biol
Title: Regulation of Chloroplast Protein Import by the Ubiquitin E3 Ligase SP1 Is Important for Stress Tolerance in Plants.
Volume: 25
Issue: 19
Pages: 2527-34
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Publication
23118188 | -
First Author: Ling Q
Year: 2012
Journal: Science
Title: Chloroplast biogenesis is regulated by direct action of the ubiquitin-proteasome system.
Volume: 338
Issue: 6107
Pages: 655-9
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Publication
38480688 | J:374692
First Author: Chen CW
Year: 2024
Journal: Nat Commun
Title: NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia.
Volume: 15
Issue: 1
Pages: 2264
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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