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Search results 1 to 100 out of 1277 for Myh6

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
key_980019 | Myh6
Type: gene
Organism: Not Specified
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Gene
4624 | MYH6
Type: gene
Organism: human
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Gene
452801 | MYH6
Type: gene
Organism: chimpanzee
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Gene
100296004 | MYH6
Type: gene
Organism: cattle
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Gene
386711 | myh6
Type: gene
Organism: zebrafish
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Gene
713471 | MYH6
Type: gene
Organism: macaque, rhesus
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Gene
100216059 | myh6
Type: gene
Organism: frog, western clawed
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Gene
119872812 | MYH6
Type: gene
Organism: dog, domestic
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Gene
key_41054 | MYH6
Type: gene
Organism: rabbit, European
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Gene
29556 | Myh6
Type: gene
Organism: rat
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Protein Coding Gene
MGI:97255 | Myh6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24092743 | J:201121
First Author: Jiang J
Year: 2013
Journal: Science
Title: Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy.
Volume: 342
Issue: 6154
Pages: 111-4
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Publication
26952936 | J:251477
First Author: Han P
Year: 2016
Journal: Biochim Biophys Acta
Title: Epigenetic response to environmental stress: Assembly of BRG1-G9a/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts.
Volume: 1863
Issue: 7 Pt B
Pages: 1772-81
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GXD Expression
GXD Expression
Probe: MGI:4830302
Assay Type: In situ reporter (knock in)
Annotation Date: 2023-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7511417
Age: embryonic day 12.5
Image: S1a/b
Note: Co-localized with MYH6 in TNNI3+ cardiomyocytes.
Specimen Label: S1a/b
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:4830302
Assay Type: In situ reporter (knock in)
Annotation Date: 2023-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7511417
Age: embryonic day 12.5
Image: S1a/b
Note: Co-localized with MYH6 in TNNI3+ cardiomyocytes.
Specimen Label: S1a/b
Detected: true
Specimen Num: 1
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Publication
23580644 | J:199626
First Author: Lowey S
Year: 2013
Journal: J Biol Chem
Title: Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences.
Volume: 288
Issue: 21
Pages: 14780-7
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Publication
18480046 | J:138748
First Author: Lowey S
Year: 2008
Journal: J Biol Chem
Title: Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone.
Volume: 283
Issue: 29
Pages: 20579-89
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Protein
Q5BKR0
Organism: Mus musculus/domesticus
Length: 1003  
Fragment?: true
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Protein
Q6P8P3
Organism: Mus musculus/domesticus
Length: 1004  
Fragment?: true
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Publication
26204265 | J:233991
First Author: Yan J
Year: 2015
Journal: PLoS One
Title: A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction.
Volume: 10
Issue: 7
Pages: e0133472
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Publication
34542814 | J:337240
First Author: Huang X
Year: 2021
Journal: Transgenic Res
Title: Generation and characterization of a Myh6-driven Cre knockin mouse line.
Volume: 30
Issue: 6
Pages: 821-835
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Publication
32792557 | J:293789
First Author: Kuwabara Y
Year: 2020
Journal: Commun Biol
Title: Lionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload.
Volume: 3
Issue: 1
Pages: 434
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ncRNA Gene
MGI:6476998 | Lnhrt
Type: ncRNA_gene
Organism: mouse, laboratory
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Publication
37115627 | J:335533
First Author: Andreassen K
Year: 2023
Journal: Am J Physiol Heart Circ Physiol
Title: Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice.
Volume: 324
Issue: 6
Pages: H881-H892
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Publication
20656787 | J:164454
First Author: Granados-Riveron JT
Year: 2010
Journal: Hum Mol Genet
Title: Alpha-cardiac myosin heavy chain (MYH6) mutations affecting myofibril formation are associated with congenital heart defects.
Volume: 19
Issue: 20
Pages: 4007-16
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Publication
21436590 | J:171993
First Author: Lv H
Year: 2011
Journal: J Clin Invest
Title: Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans.
Volume: 121
Issue: 4
Pages: 1561-73
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Publication
17379774 | J:120908
First Author: van Rooij E
Year: 2007
Journal: Science
Title: Control of stress-dependent cardiac growth and gene expression by a microRNA.
Volume: 316
Issue: 5824
Pages: 575-9
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Publication
29325795 | J:339014
First Author: Kraev A
Year: 2018
Journal: J Card Fail
Title: Insertional Mutagenesis Confounds the Mechanism of the Morbid Phenotype of a PLN(R9C) Transgenic Mouse Line.
Volume: 24
Issue: 2
Pages: 115-125
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Publication
19922871 | J:155756
First Author: van Rooij E
Year: 2009
Journal: Dev Cell
Title: A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.
Volume: 17
Issue: 5
Pages: 662-73
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Publication
27266388 | J:253740
 
First Author: Yan J
Year: 2016
Journal: J Mol Cell Cardiol
Title: A series of robust genetic indicators for definitive identification of cardiomyocytes.
Volume: 97
Pages: 278-85
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Publication
17322895 | J:121697
First Author: Trivedi CM
Year: 2007
Journal: Nat Med
Title: Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
Volume: 13
Issue: 3
Pages: 324-31
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Publication
31688894 | J:302922
First Author: Piroddi N
Year: 2020
Journal: Cardiovasc Res
Title: Myocardial overexpression of ANKRD1 causes sinus venosus defects and progressive diastolic dysfunction.
Volume: 116
Issue: 8
Pages: 1458-1472
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Publication
2026617 | J:11155
First Author: Gulick J
Year: 1991
Journal: J Biol Chem
Title: Isolation and characterization of the mouse cardiac myosin heavy chain genes.
Volume: 266
Issue: 14
Pages: 9180-5
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Publication
18755891 | J:139125
First Author: Pandya K
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.
Volume: 105
Issue: 35
Pages: 13063-8
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Publication
1722208 | J:30465
First Author: Subramaniam A
Year: 1991
Journal: J Biol Chem
Title: Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.
Volume: 266
Issue: 36
Pages: 24613-20
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Publication
36715298 | J:337007
First Author: Yang YS
Year: 2023
Journal: Stem Cells
Title: FAM122A Is Required for Mesendodermal and Cardiac Differentiation of Embryonic Stem Cells.
Volume: 41
Issue: 4
Pages: 354-367
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Publication
30428088 | J:285853
First Author: Zhang S
Year: 2019
Journal: Cardiovasc Res
Title: WD40 repeat and FYVE domain containing 3 is essential for cardiac development.
Volume: 115
Issue: 8
Pages: 1320-1331
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Protein Coding Gene
MGP_CAROLIEiJ_G0019282 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021334 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021293 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021269 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021297 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021077 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_97255 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021735 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020596 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021044 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021165 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021147 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021239 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021171 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021762 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020343 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020649 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030300 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020171 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
1577481 | J:514
First Author: Quinn-Laquer BK
Year: 1992
Journal: Genomics
Title: Characterization of the allelic differences in the mouse cardiac alpha-myosin heavy chain coding sequence.
Volume: 13
Issue: 1
Pages: 176-88
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Publication
19715700 | J:308169
First Author: Lam L
Year: 2010
Journal: J Mol Cell Cardiol
Title: Differential protein expression profiling of myocardial tissue in a mouse model of hypertrophic cardiomyopathy.
Volume: 48
Issue: 5
Pages: 1014-22
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Publication
26141530 | J:225830
 
First Author: Pugach EK
Year: 2015
Journal: J Mol Cell Cardiol
Title: Prolonged Cre expression driven by the α-myosin heavy chain promoter can be cardiotoxic.
Volume: 86
Pages: 54-61
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Publication
28009297 | J:241967
First Author: Hinson JT
Year: 2016
Journal: Cell Rep
Title: Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.
Volume: 17
Issue: 12
Pages: 3292-3304
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Publication
24829265 | J:247162
First Author: Blankenburg R
Year: 2014
Journal: Circ Res
Title: β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.
Volume: 115
Issue: 2
Pages: 227-37
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Publication
16983074 | J:114549
First Author: Schmitt JP
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.
Volume: 103
Issue: 39
Pages: 14525-30
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Publication
17351073 | J:126062
First Author: Debold EP
Year: 2007
Journal: Am J Physiol Heart Circ Physiol
Title: Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.
Volume: 293
Issue: 1
Pages: H284-91
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Publication
23313350 | J:213259
 
First Author: Palmer BM
Year: 2013
Journal: J Mol Cell Cardiol
Title: Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy.
Volume: 57
Pages: 23-31
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Publication
8614836 | J:32960
First Author: Geisterfer-Lowrance AA
Year: 1996
Journal: Science
Title: A mouse model of familial hypertrophic cardiomyopathy.
Volume: 272
Issue: 5262
Pages: 731-4
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Publication
15001446 | J:95600
First Author: Palmer BM
Year: 2004
Journal: Am J Physiol Heart Circ Physiol
Title: Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium.
Volume: 287
Issue: 1
Pages: H91-9
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Publication
16332958 | J:104363
First Author: Wolf CM
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.
Volume: 102
Issue: 50
Pages: 18123-8
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Publication
31424496 | J:307881
First Author: Huang Y
Year: 2020
Journal: Cardiovasc Res
Title: Fropofol prevents disease progression in mice with hypertrophic cardiomyopathy.
Volume: 116
Issue: 6
Pages: 1175-1185
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Publication
12925456 | J:113440
First Author: Schmitt JP
Year: 2003
Journal: Circulation
Title: Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomyopathy.
Volume: 108
Issue: 9
Pages: 1133-8
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Publication
18281382 | J:135581
First Author: Palmer BM
Year: 2008
Journal: Am J Physiol Heart Circ Physiol
Title: Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex.
Volume: 294
Issue: 4
Pages: H1939-47
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Publication
11956238 | J:76093
First Author: Semsarian C
Year: 2002
Journal: J Clin Invest
Title: The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model.
Volume: 109
Issue: 8
Pages: 1013-20
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Publication
22735528 | J:308171
First Author: Chuan P
Year: 2012
Journal: Biophys J
Title: Cell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy.
Volume: 102
Issue: 12
Pages: 2782-90
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Publication
10074482 | J:53392
First Author: Gao WD
Year: 1999
Journal: J Clin Invest
Title: Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy.
Volume: 103
Issue: 5
Pages: 661-6
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Publication
11827928 | J:128575
First Author: Hardt SE
Year: 2002
Journal: Circulation
Title: Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain.
Volume: 105
Issue: 5
Pages: 614-20
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Publication
9045856 | J:112966
First Author: Berul CI
Year: 1997
Journal: J Clin Invest
Title: Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice.
Volume: 99
Issue: 4
Pages: 570-6
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Publication
10066683 | J:53848
First Author: Blanchard E
Year: 1999
Journal: Circ Res
Title: Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.
Volume: 84
Issue: 4
Pages: 475-83
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Publication
10231857 | J:57223
First Author: Bevilacqua LM
Year: 1999
Journal: Pediatr Res
Title: QT dispersion in alpha-myosin heavy-chain familial hypertrophic cardiomyopathy mice.
Volume: 45
Issue: 5 Pt 1
Pages: 643-7
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Publication
10086390 | J:308281
First Author: Georgakopoulos D
Year: 1999
Journal: Nat Med
Title: The pathogenesis of familial hypertrophic cardiomyopathy: early and evolving effects from an alpha-cardiac myosin heavy chain missense mutation.
Volume: 5
Issue: 3
Pages: 327-30
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Publication
11708849 | J:89230
First Author: Semsarian C
Year: 2001
Journal: J Mol Cell Cardiol
Title: A polymorphic modifier gene alters the hypertrophic response in a murine model of familial hypertrophic cardiomyopathy.
Volume: 33
Issue: 11
Pages: 2055-60
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Publication
31983222 | J:307857
First Author: Toepfer CN
Year: 2020
Journal: Circulation
Title: Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
Volume: 141
Issue: 10
Pages: 828-842
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Publication
28089740 | J:253945
 
First Author: Hueneke R
Year: 2017
Journal: J Mol Cell Cardiol
Title: Early remodeling of repolarizing K+ currents in the αMHC403/+ mouse model of familial hypertrophic cardiomyopathy.
Volume: 103
Pages: 93-101
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Publication
30167506 | J:307854
First Author: Viola HM
Year: 2016
Journal: JACC Basic Transl Sci
Title: The Role of the L-Type Ca2+ Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy.
Volume: 1
Issue: 1-2
Pages: 61-72
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Publication
26912705 | J:308104
First Author: Green EM
Year: 2016
Journal: Science
Title: A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.
Volume: 351
Issue: 6273
Pages: 617-21
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Publication
17556586 | J:122171
First Author: Kim JB
Year: 2007
Journal: Science
Title: Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic cardiomyopathy.
Volume: 316
Issue: 5830
Pages: 1481-4
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Publication
10330263 | J:307767
First Author: Kim SJ
Year: 1999
Journal: Am J Physiol
Title: An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes.
Volume: 276
Issue: 5
Pages: H1780-7
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Publication
11104788 | J:307813
First Author: Fatkin D
Year: 2000
Journal: J Clin Invest
Title: An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy.
Volume: 106
Issue: 11
Pages: 1351-9
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Publication
8878443 | J:36089
First Author: Jones WK
Year: 1996
Journal: J Clin Invest
Title: Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart.
Volume: 98
Issue: 8
Pages: 1906-17
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Publication
8898372 | J:36522
First Author: Vikstrom KL
Year: 1996
Journal: Mol Med
Title: Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy.
Volume: 2
Issue: 5
Pages: 556-67
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Publication
8449897 | J:4164
First Author: Adolph EA
Year: 1993
Journal: J Biol Chem
Title: Role of myocyte-specific enhancer-binding factor (MEF-2) in transcriptional regulation of the alpha-cardiac myosin heavy chain gene.
Volume: 268
Issue: 8
Pages: 5349-52
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Publication
11123229 | J:68052
First Author: Freeman K
Year: 2001
Journal: Am J Physiol Heart Circ Physiol
Title: Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene.
Volume: 280
Issue: 1
Pages: H151-9
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Publication
16395406 | J:105362
First Author: Stauffer BL
Year: 2006
Journal: J Clin Invest
Title: Soy diet worsens heart disease in mice.
Volume: 116
Issue: 1
Pages: 209-16
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Publication
25318870 | J:308122
First Author: Luo HC
Year: 2014
Journal: J Huazhong Univ Sci Technolog Med Sci
Title: Age-related changes in familial hypertrophic cardiomyopathy phenotype in transgenic mice and humans.
Volume: 34
Issue: 5
Pages: 634-639
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Publication
11179057 | J:67857
First Author: Olsson MC
Year: 2001
Journal: Am J Physiol Heart Circ Physiol
Title: Gender and aging in a transgenic mouse model of hypertrophic cardiomyopathy.
Volume: 280
Issue: 3
Pages: H1136-44
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Publication
2144212 | J:48221
First Author: Tanigawa G
Year: 1990
Journal: Cell
Title: A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene.
Volume: 62
Issue: 5
Pages: 991-8
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Publication
15364804 | J:135389
First Author: Garnier A
Year: 2004
Journal: Circulation
Title: Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice.
Volume: 110
Issue: 13
Pages: 1819-25
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Publication
25677315 | J:308100
First Author: Cannon L
Year: 2015
Journal: J Am Coll Cardiol
Title: Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period.
Volume: 65
Issue: 6
Pages: 560-9
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GXD Expression
GXD Expression
   
Probe: MGI:1327126
Assay Type: RT-PCR
Annotation Date: 1999-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:1327301
Age: embryonic day 8.7
Image: 7
Specimen Label: +/+; 10X
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1327126
Assay Type: RT-PCR
Annotation Date: 1999-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:1327301
Age: embryonic day 8.7
Image: 7
Specimen Label: +/+; 1.0X
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1327126
Assay Type: RT-PCR
Annotation Date: 1999-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:1327301
Age: embryonic day 8.7
Image: 7
Specimen Label: +/+; 0.1X
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1327126
Assay Type: RT-PCR
Annotation Date: 1999-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:1327301
Age: embryonic day 8.7
Image: 7
Specimen Label: +/+; 0.01X
Detected: true
Specimen Num: 4
•
•
•
•
•




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