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Search results 1 to 100 out of 219 for Mylk

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0.079s
Type Details Score
Gene
Type: gene
Organism: Not Specified
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
GXD Expression    
Probe: MGI:6178625
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190838
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Mylk
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6178625
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190838
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Mylk
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6178625
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190838
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Mylk
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6178625
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190838
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Mylk
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6178625
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190838
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Mylk
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6178625
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190838
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Mylk
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6178625
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190838
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Mylk
Detected: true
Specimen Num: 7
Publication
First Author: Xu J
Year: 2008
Journal: Nat Immunol
Title: Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins.
Volume: 9
Issue: 8
Pages: 880-6
Publication
First Author: Chen M
Year: 2013
Journal: J Biol Chem
Title: Regulation of 130-kDa smooth muscle myosin light chain kinase expression by an intronic CArG element.
Volume: 288
Issue: 48
Pages: 34647-57
Publication
First Author: Giorgi D
Year: 2001
Journal: Genomics
Title: The myosin light chain kinase gene is not duplicated in mouse: partial structure and chromosomal localization of Mylk.
Volume: 75
Issue: 1-3
Pages: 49-56
Publication
First Author: Huang YJ
Year: 2021
Journal: Carcinogenesis
Title: A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis.
Volume: 42
Issue: 7
Pages: 961-974
Publication
First Author: Wang T
Year: 2014
Journal: Am J Respir Cell Mol Biol
Title: Nonmuscle myosin light chain kinase regulates murine asthmatic inflammation.
Volume: 50
Issue: 6
Pages: 1129-35
Publication
First Author: Srivastava N
Year: 2020
Journal: FASEB J
Title: Noncanonical function of long myosin light chain kinase in increasing ER-PM junctions and augmentation of SOCE.
Volume: 34
Issue: 9
Pages: 12805-12819
Publication
First Author: Mirzapoiazova T
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury.
Volume: 44
Issue: 1
Pages: 40-52
Publication
First Author: Wang L
Year: 2010
Journal: Am J Hum Genet
Title: Mutations in myosin light chain kinase cause familial aortic dissections.
Volume: 87
Issue: 5
Pages: 701-7
Publication
First Author: Beard RS Jr
Year: 2014
Journal: J Cell Sci
Title: Non-muscle Mlck is required for β-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1β-mediated barrier dysfunction in brain endothelial cells.
Volume: 127
Issue: Pt 8
Pages: 1840-53
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Ohlmann P
Year: 2005
Journal: Am J Physiol Heart Circ Physiol
Title: Deletion of MLCK210 induces subtle changes in vascular reactivity but does not affect cardiac function.
Volume: 289
Issue: 6
Pages: H2342-9
Publication
First Author: Wainwright MS
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment.
Volume: 100
Issue: 10
Pages: 6233-8
Publication
First Author: Rossi JL
Year: 2007
Journal: Am J Physiol Lung Cell Mol Physiol
Title: MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice.
Volume: 292
Issue: 6
Pages: L1327-34
Publication
First Author: Ralay Ranaivo H
Year: 2007
Journal: Am J Pathol
Title: Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice.
Volume: 170
Issue: 2
Pages: 439-46
Publication
First Author: Drolia R
Year: 2018
Journal: Cell Host Microbe
Title: Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation.
Volume: 23
Issue: 4
Pages: 470-484.e7
Publication
First Author: Recoquillon S
Year: 2017
Journal: Sci Rep
Title: Non-muscular myosin light chain kinase triggers intermittent hypoxia-induced interleukin-6 release, endothelial dysfunction and permeability.
Volume: 7
Issue: 1
Pages: 13664
Publication
First Author: Yu LC
Year: 2014
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Enteric dysbiosis promotes antibiotic-resistant bacterial infection: systemic dissemination of resistant and commensal bacteria through epithelial transcytosis.
Volume: 307
Issue: 8
Pages: G824-35
Publication
First Author: Nalle SC
Year: 2019
Journal: J Clin Invest
Title: Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability.
Volume: 129
Issue: 2
Pages: 902-914
Publication
First Author: Yu Y
Year: 2012
Journal: FEBS J
Title: Deletion of myosin light chain kinase in endothelial cells has a minor effect on the lipopolysaccharide-induced increase in microvascular endothelium permeability in mice.
Volume: 279
Issue: 8
Pages: 1485-94
Publication
First Author: Bu Y
Year: 2015
Journal: J Biol Chem
Title: Myosin IIb-dependent Regulation of Actin Dynamics Is Required for N-Methyl-D-aspartate Receptor Trafficking during Synaptic Plasticity.
Volume: 290
Issue: 42
Pages: 25395-410
Publication
First Author: Zhu GJ
Year: 2012
Journal: PLoS One
Title: Myosin light-chain kinase is necessary for membrane homeostasis in cochlear inner hair cells.
Volume: 7
Issue: 4
Pages: e34894
Publication
First Author: Khromov AS
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation.
Volume: 103
Issue: 7
Pages: 2440-5
Publication
First Author: Gallagher PJ
Year: 1995
Journal: J Biol Chem
Title: Expression of a novel myosin light chain kinase in embryonic tissues and cultured cells.
Volume: 270
Issue: 49
Pages: 29090-5
Publication
First Author: Kabir N
Year: 1996
Journal: J Exp Zool
Title: Regulation of preimplantation development of mouse embryos: effects of inhibition of myosin light-chain kinase, a Ca2+/calmodulin-dependent enzyme.
Volume: 274
Issue: 2
Pages: 101-10
Publication
First Author: Kabir N
Year: 1997
Journal: J Exp Zool
Title: Immunocytochemical detection and spatial distribution of myosin light-chain kinase in preimplantation mouse embryos.
Volume: 278
Issue: 3
Pages: 147-55
Publication
First Author: Zhang WC
Year: 2008
Journal: FEBS J
Title: Identification and functional characterization of an aggregation domain in long myosin light chain kinase.
Volume: 275
Issue: 10
Pages: 2489-500
Publication
First Author: Su L
Year: 2009
Journal: Gastroenterology
Title: Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.
Volume: 136
Issue: 2
Pages: 551-63
Publication
First Author: Zhang J
Year: 2010
Journal: Am J Physiol Heart Circ Physiol
Title: In vivo assessment of artery smooth muscle [Ca2+]i and MLCK activation in FRET-based biosensor mice.
Volume: 299
Issue: 3
Pages: H946-56
Publication
First Author: Yao H
Year: 2013
Journal: FASEB J
Title: Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: involvement of β1 integrins.
Volume: 27
Issue: 4
Pages: 1532-48
Publication
First Author: Lossie J
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Molecular mechanism regulating myosin and cardiac functions by ELC.
Volume: 450
Issue: 1
Pages: 464-9
Publication  
First Author: Wu J
Year: 2024
Journal: Biomed Pharmacother
Title: Inhibition of non-muscular myosin light chain kinase accelerates the clearance of inflammatory cells by promoting the lysosome-mediated cell death.
Volume: 170
Pages: 115986
GXD Expression    
Probe: MGI:2660667
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603912
Stage: TS12
Assay Id: MGI:2660671
Age: embryonic day 8.0
Image: 5
Specimen Label: E8
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2660667
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2660671
Age: embryonic day 12.0
Image: 5
Specimen Label: E12
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2660667
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610523
Stage: TS23
Assay Id: MGI:2660671
Age: embryonic day 15.0
Image: 5
Specimen Label: E15
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2660667
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:2660671
Age: postnatal newborn
Image: 5
Specimen Label: N0
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2660667
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2660671
Age: postnatal day 5
Image: 5
Specimen Label: N5
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:2660667
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2660671
Age: postnatal adult
Image: 5
Specimen Label: Adult
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:2660667
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:2660671
Age: embryonic day 15.0
Image: 5
Specimen Label: E15
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:2660667
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2660671
Age: postnatal day 1
Image: 5
Specimen Label: N1
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:2660667
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2660671
Age: postnatal adult
Image: 5
Specimen Label: Adult
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:2660669
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603912
Stage: TS12
Assay Id: MGI:2660672
Age: embryonic day 8.0
Image: 5
Specimen Label: E8
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2660669
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2660672
Age: embryonic day 12.0
Image: 5
Specimen Label: E12
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2660669
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610523
Stage: TS23
Assay Id: MGI:2660672
Age: embryonic day 15.0
Image: 5
Specimen Label: E15
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2660669
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:2660672
Age: postnatal newborn
Image: 5
Specimen Label: N0
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2660669
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2660672
Age: postnatal day 5
Image: 5
Specimen Label: N5
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:2660669
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2660672
Age: postnatal adult
Image: 5
Specimen Label: Adult
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:2660669
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:2660672
Age: embryonic day 15.0
Image: 5
Specimen Label: E15
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:2660669
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2660672
Age: postnatal day 1
Image: 5
Specimen Label: N1
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:2660669
Assay Type: Western blot
Annotation Date: 2003-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2660672
Age: postnatal adult
Image: 5
Specimen Label: Adult
Detected: true
Specimen Num: 11
GXD Expression
Probe: MGI:3834423
Assay Type: RNA in situ
Annotation Date: 2009-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:3834890
Age: postnatal adult
Image: S4 wt
Note: Expression was detected throughout the outer nuclear layer at greater levels in cones than in rods.
Specimen Label: S4 wt
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3834423
Assay Type: RNA in situ
Annotation Date: 2009-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:3834890
Age: postnatal adult
Image: S4 Nr2e3-/-
Note: Expression was detected throughout the outer nuclear layer, consistent with expression in all photoreceptors.
Specimen Label: S4 Nr2e3-/-
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884765
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945520
Age: embryonic day 11.5
Image: g01049 E11.5
Specimen Label: g01049 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4884765
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945520
Age: embryonic day 11.5
Image: g01049 E11.5
Specimen Label: g01049 E11.5
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:4884765
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1697419
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4945520
Age: embryonic day 11.5
Image: g01049 E11.5
Note: Expression was region specific and scattered.
Specimen Label: g01049 E11.5
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:4884765
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4945520
Age: embryonic day 11.5
Image: g01049 E11.5
Note: Expression was region specific and scattered.
Specimen Label: g01049 E11.5
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:4884765
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4945520
Age: embryonic day 11.5
Image: g01049 E11.5
Note: Expression was region specific and scattered.
Specimen Label: g01049 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4884765
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778723
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945520
Age: embryonic day 15.5
Image: g01049 E15.5
Specimen Label: g01049 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884765
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945520
Age: embryonic day 15.5
Image: g01049 E15.5
Specimen Label: g01049 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884765
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945520
Age: embryonic day 15.5
Image: g01049 E15.5
Specimen Label: g01049 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884765
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945520
Age: embryonic day 15.5
Image: g01049 E15.5
Specimen Label: g01049 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884765
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945520
Age: embryonic day 15.5
Image: g01049 E15.5
Specimen Label: g01049 E15.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:4884765
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1753623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945520
Age: embryonic day 15.5
Image: g01049 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01049 E15.5
Detected: true
Specimen Num: 2