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Search results 1 to 88 out of 88 for Myo18b

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Unconventional myosin-XVIII A/B (MYO18A/B) belongs to class XIII myosin that contains two large domains of unknown function at the N and C-termini []. MYO18B appears to be expressed mainly in human cardiac and skeletal muscles and is involved in the regulation of muscle specific genes []. Its inactivation is involved in lung cancer progression [].Myosin constitutes a large superfamily of actin-dependent molecular motors. Myosin binds to actins and moves along actin filaments by using the energy from ATP hydrolysis. Myosin is involved in muscular contraction, cytokinesis, membrane trafficking and signal transduction [, ]. Myosins are typically composed of three functional domains:Motor head domain whose core sequence is highly conserved in all the myosin classes. This domain binds to actin and uses ATP hydrolysis to generate force to move along actin filaments. Neck domain composed of a long helix of variable length depending on the number of IQ motifs (has a consensus sequence of IQXXXRGXXXR) []. This domain acts as a linker and as a lever arm. The neck domain also serves as a binding site for moysin light chains, which are calmodulin-like proteins that have regulatory functions. Tail domain is the most diverse domain and vary in length and in sequence. Many myosin tails form coiled-coil structure that allow the molecules to dimerise and produce two-headed molecules. This domain mediates interaction with cargo molecules and/or other myosin subunits.
Publication
First Author: Salamon M
Year: 2003
Journal: J Mol Biol
Title: Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation.
Volume: 326
Issue: 1
Pages: 137-49
Protein
Organism: Mus musculus
Length: 1357  
Fragment?: true
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Ajima R
Year: 2008
Journal: Genes Cells
Title: Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations.
Volume: 13
Issue: 10
Pages: 987-99
Publication
First Author: Nishioka M
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer.
Volume: 99
Issue: 19
Pages: 12269-74
Protein
Organism: Mus musculus
Length: 745  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2605  
Fragment?: false
Publication
First Author: Cheney RE
Year: 1992
Journal: Curr Opin Cell Biol
Title: Unconventional myosins.
Volume: 4
Issue: 1
Pages: 27-35
Publication  
First Author: Mooseker MS
Year: 1995
Journal: Annu Rev Cell Dev Biol
Title: Unconventional myosins.
Volume: 11
Pages: 633-75
Publication
First Author: Sellers JR
Year: 2000
Journal: Biochim Biophys Acta
Title: Myosins: a diverse superfamily.
Volume: 1496
Issue: 1
Pages: 3-22
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:2664318
Assay Type: Northern blot
Annotation Date: 2003-07-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2664325
Age: postnatal
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:2664318
Assay Type: Northern blot
Annotation Date: 2003-07-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2664325
Age: postnatal
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:2664312
Assay Type: RT-PCR
Annotation Date: 2003-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1770128
Stage: TS28
Assay Id: MGI:2664327
Age: postnatal adult
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2664312
Assay Type: RT-PCR
Annotation Date: 2003-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268828
Stage: TS28
Assay Id: MGI:2664327
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:2664318
Assay Type: Northern blot
Annotation Date: 2003-07-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2664325
Age: postnatal
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:2664318
Assay Type: Northern blot
Annotation Date: 2003-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2664325
Age: postnatal
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2664318
Assay Type: Northern blot
Annotation Date: 2003-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2664325
Age: postnatal
Detected: true
Specimen Num: 8
GXD Expression        
Probe: MGI:2664312
Assay Type: RT-PCR
Annotation Date: 2003-07-02
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:2664345
Age: embryonic day 10.0-12.0
Specimen Num: 1
GXD Expression        
Probe: MGI:2664312
Assay Type: RT-PCR
Annotation Date: 2003-07-02
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2664345
Age: embryonic day 10.0-12.0
Specimen Num: 1
GXD Expression      
Probe: MGI:2664312
Assay Type: RT-PCR
Annotation Date: 2003-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:2664345
Age: embryonic day 16.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2664318
Assay Type: Northern blot
Annotation Date: 2003-07-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2664325
Age: postnatal
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:2664318
Assay Type: Northern blot
Annotation Date: 2003-07-02
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2664325
Age: postnatal
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:2664312
Assay Type: RT-PCR
Annotation Date: 2003-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3567028
Stage: TS28
Assay Id: MGI:2664327
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2664312
Assay Type: RT-PCR
Annotation Date: 2003-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3586728
Stage: TS28
Assay Id: MGI:2664327
Age: postnatal adult
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2664312
Assay Type: RT-PCR
Annotation Date: 2003-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3578628
Stage: TS28
Assay Id: MGI:2664327
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2664312
Assay Type: RT-PCR
Annotation Date: 2003-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3537528
Stage: TS28
Assay Id: MGI:2664327
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2664312
Assay Type: RT-PCR
Annotation Date: 2003-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:2664327
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2664312
Assay Type: RT-PCR
Annotation Date: 2003-07-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:2664345
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2664318
Assay Type: Northern blot
Annotation Date: 2003-07-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2664325
Age: postnatal
Detected: false
Specimen Num: 7
Publication
First Author: Tonelli Gombalov√° Z
Year: 2020
Journal: J Comp Neurol
Title: Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.
Volume: 528
Issue: 15
Pages: 2523-2550
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
DO Term
Publication
First Author: Furusawa T
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Isolation of a novel PDZ-containing myosin from hematopoietic supportive bone marrow stromal cell lines.
Volume: 270
Issue: 1
Pages: 67-75
Publication
First Author: Mori K
Year: 2003
Journal: J Biochem
Title: Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A).
Volume: 133
Issue: 4
Pages: 405-13
Publication
First Author: Mori K
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Subcellular localization and dynamics of MysPDZ (Myo18A) in live mammalian cells.
Volume: 326
Issue: 2
Pages: 491-8
Publication
First Author: Guzik-Lendrum S
Year: 2011
Journal: J Biol Chem
Title: Drosophila melanogaster myosin-18 represents a highly divergent motor with actin tethering properties.
Volume: 286
Issue: 24
Pages: 21755-66
Protein Domain
Type: Domain
Description: Many members of myosin class XVIII contain an N-terminal PDZ domain which is commonly found in proteins establishing molecular complexes. Mammals express a second isoform, Myo18B, that lacks the PDZ domain []. They also contain a motor domain which does not exhibit ATPase activity, suggesting that these myosins function as an actin tether protein [, ]. They also have two IQ domains that probably bind light chains or related calmodulins and a C-terminal tail with two sections of coiled-coil domains, which are thought to mediate homodimerization []. Myo18A has been implicated in stromal cell differentiation []and Myo18B in tumor suppression [].This entry represents the motor domain.
Publication
First Author: Isogawa Y
Year: 2005
Journal: Biochemistry
Title: The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site.
Volume: 44
Issue: 16
Pages: 6190-6
Protein
Organism: Mus musculus
Length: 1722  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2409  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1642  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1700  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2050  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2047  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2083  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2036  
Fragment?: false
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7