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Search results 1 to 100 out of 125 for Myo9a

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
4649 | MYO9A
Type: gene
Organism: human
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Gene
100216086 | myo9a
Type: gene
Organism: frog, western clawed
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Gene
171296 | Myo9a
Type: gene
Organism: rat
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Gene
453556 | MYO9A
Type: gene
Organism: chimpanzee
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Gene
487630 | MYO9A
Type: gene
Organism: dog, domestic
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Gene
515330 | MYO9A
Type: gene
Organism: cattle
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Gene
701520 | MYO9A
Type: gene
Organism: macaque, rhesus
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Gene
101748321 | MYO9A
Type: gene
Organism: chicken
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Protein Domain
IPR028558 | MYO9A
Type: Family
Description: Unconventional myosin-IXa (MYO9A) belongs to class IX myosin that contains an extra Rho-specific GAP (GTPase-activating protein) domain in the tail region []. In mice, MYO9A homologue, Myr7 regulates Rho by stimulating it's GTPase activity in neurons and has a role in the regulation of neuronal morphology and function []. In humans, there are two proteins in class IX, MYO9A and MYO9B. Class IX myosins may carry its own Rho-GAP tail using its motor head domain to sites that require down-regulation of Rho-dependent signalling [].Myosin constitutes a large superfamily of actin-dependent molecular motors. Myosin binds to actins and moves along actin filaments by using the energy from ATP hydrolysis. Myosin is involved in muscular contraction, cytokinesis, membrane trafficking and signal transduction [, ]. Myosins are typically composed of three functional domains:Motor head domain whose core sequence is highly conserved in all the myosin classes. This domain binds to actin and uses ATP hydrolysis to generate force to move along actin filaments. Neck domain composed of a long helix of variable length depending on the number of IQ motifs (has a consensus sequence of IQXXXRGXXXR) []. This domain acts as a linker and as a lever arm. The neck domain also serves as a binding site for moysin light chains, which are calmodulin-like proteins that have regulatory functions. Tail domain is the most diverse domain and vary in length and in sequence. Many myosin tails form coiled-coil structure that allow the molecules to dimerise and produce two-headed molecules. This domain mediates interaction with cargo molecules and/or other myosin subunits.
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Protein Coding Gene
MGI:107735 | Myo9a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
27259756 | J:273536
First Author: O'Connor E
Year: 2016
Journal: Brain
Title: Identification of mutations in the MYO9A gene in patients with congenital myasthenic syndrome.
Volume: 139
Issue: Pt 8
Pages: 2143-53
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Publication
33412162 | J:302901
     
First Author: Li Q
Year: 2021
Journal: Kidney Int
Title: Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis.
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Publication
29462312 | J:260494
First Author: O'Connor E
Year: 2018
Journal: Hum Mol Genet
Title: MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion.
Volume: 27
Issue: 8
Pages: 1434-1446
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Publication
9819351 | -
 
First Author: Chieregatti E
Year: 1998
Journal: J Cell Sci
Title: Myr 7 is a novel myosin IX-RhoGAP expressed in rat brain.
Volume: 111 ( Pt 24)
Pages: 3597-608
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Publication
20566876 | J:162326
First Author: Hanley PJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility.
Volume: 107
Issue: 27
Pages: 12145-50
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Publication
11801597 | -
First Author: Post PL
Year: 2002
Journal: J Biol Chem
Title: Myosin-IXb is a single-headed and processive motor.
Volume: 277
Issue: 14
Pages: 11679-83
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Publication
1558751 | -
First Author: Cheney RE
Year: 1992
Journal: Curr Opin Cell Biol
Title: Unconventional myosins.
Volume: 4
Issue: 1
Pages: 27-35
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Publication
8689571 | -
 
First Author: Mooseker MS
Year: 1995
Journal: Annu Rev Cell Dev Biol
Title: Unconventional myosins.
Volume: 11
Pages: 633-75
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Publication
10722873 | J:61347
First Author: Sellers JR
Year: 2000
Journal: Biochim Biophys Acta
Title: Myosins: a diverse superfamily.
Volume: 1496
Issue: 1
Pages: 3-22
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Protein
Q8C170
Organism: Mus musculus/domesticus
Length: 2542  
Fragment?: false
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Protein
D3Z3A8
Organism: Mus musculus/domesticus
Length: 2631  
Fragment?: false
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Publication
26834556 | J:244201
 
First Author: Folci A
Year: 2016
Journal: Front Mol Neurosci
Title: Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function.
Volume: 9
Pages: 1
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Publication
26136556 | J:256663
First Author: Thelen S
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: Rho GAP myosin IXa is a regulator of kidney tubule function.
Volume: 309
Issue: 6
Pages: F501-13
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Publication
19828736 | J:251454
First Author: Abouhamed M
Year: 2009
Journal: Mol Biol Cell
Title: Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus.
Volume: 20
Issue: 24
Pages: 5074-85
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Protein Coding Gene
MGP_CAROLIEiJ_G0032310 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034907 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034887 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034817 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034880 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034590 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107735 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035399 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033911 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034561 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034720 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034662 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034803 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034705 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035421 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033615 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034024 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015176 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033448 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10409426 | J:56684
First Author: Gorman SW
Year: 1999
Journal: Genomics
Title: The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23.
Volume: 59
Issue: 2
Pages: 150-60
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741221
Stage: TS21
Assay Id: MGI:4429634
Age: embryonic day 13.5
Specimen Label: d. 13.5 forelimb
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1745821
Stage: TS21
Assay Id: MGI:4429634
Age: embryonic day 13.5
Specimen Label: d. 13.5 hindlimb
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Specimen Label: Adult eye
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Specimen Label: Adult lung
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Specimen Label: Adult liver
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Specimen Label: Adult brain
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Specimen Label: Adult heart
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Specimen Label: Skeletal muscle
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Specimen Label: Adult spleen
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:4429635
Age: embryonic day 7.0
Specimen Label: 7
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:4429635
Age: embryonic day 11.0
Specimen Label: 11
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:4429635
Age: embryonic day 15.0
Specimen Label: 15
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:4429635
Age: embryonic day 17.0
Specimen Label: 17
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:4429639
Age: postnatal adult
Specimen Label: Adult testis
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760024
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Specimen Label: 6D,L
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1665924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Specimen Label: Not shown, E16.5
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Specimen Label: 7B,H
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:4422770
Assay Type: RNA in situ
Annotation Date: 2019-01-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3271122
Stage: TS22
Assay Id: MGI:6274712
Age: embryonic day 14.5
Specimen Label: Table S1
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3272021
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:4429637
Age: embryonic day 13.5
Specimen Label: Not shown, E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Specimen Label: 6B,J
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Specimen Label: 6C,K
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289524
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Note: Expression is in ameloblasts.
Specimen Label: 7C,I
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Note: The inner nuclear layer has higher expression than the outer layer.
Specimen Label: 6A,I
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1927924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Specimen Label: 7A,G
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3568628
Stage: TS28
Assay Id: MGI:4429636
Age: postnatal adult
Specimen Label: 5A,B
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3573928
Pattern: Single cells
Stage: TS28
Assay Id: MGI:4429636
Age: postnatal adult
Note: Expression is in a subset of retinal ganglion cells.
Specimen Label: 5A,B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757724
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Specimen Label: Not shown, E16.5
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Specimen Label: 6B,J
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Specimen Label: 6D,L
Detected: true
Specimen Num: 5
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Publication
11212352 | J:58855
First Author: Oliver TN
Year: 1999
Journal: Cell Mol Life Sci
Title: Tails of unconventional myosins.
Volume: 56
Issue: 3-4
Pages: 243-57
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Publication
8884266 | J:35477
First Author: Hasson T
Year: 1996
Journal: Genomics
Title: Mapping of unconventional myosins in mouse and human.
Volume: 36
Issue: 3
Pages: 431-9
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Publication
- | J:239583
     
First Author: Mouse Genome Informatics and the Consortium: Deciphering the Mechanisms of Developmental Disorders (DMDD)
Year: 2017
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Deciphering the Mechanisms of Developmental Disorders (DMDD)
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Publication
21862448 | J:198109
First Author: Oeschger FM
Year: 2012
Journal: Cereb Cortex
Title: Gene expression analysis of the embryonic subplate.
Volume: 22
Issue: 6
Pages: 1343-59
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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