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Search results 1 to 100 out of 111 for Myo9a

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0.035s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Unconventional myosin-IXa (MYO9A) belongs to class IX myosin that contains an extra Rho-specific GAP (GTPase-activating protein) domain in the tail region []. In mice, MYO9A homologue, Myr7 regulates Rho by stimulating it's GTPase activity in neurons and has a role in the regulation of neuronal morphology and function []. In humans, there are two proteins in class IX, MYO9A and MYO9B. Class IX myosins may carry its own Rho-GAP tail using its motor head domain to sites that require down-regulation of Rho-dependent signalling [].Myosin constitutes a large superfamily of actin-dependent molecular motors. Myosin binds to actins and moves along actin filaments by using the energy from ATP hydrolysis. Myosin is involved in muscular contraction, cytokinesis, membrane trafficking and signal transduction [, ]. Myosins are typically composed of three functional domains:Motor head domain whose core sequence is highly conserved in all the myosin classes. This domain binds to actin anduses ATP hydrolysis to generate force to move along actin filaments. Neck domain composed of a long helix of variable length depending on the number of IQ motifs (has a consensus sequence of IQXXXRGXXXR) []. This domain acts as a linker and as a lever arm. The neck domain also serves as a binding site for moysin light chains, which are calmodulin-like proteins that have regulatory functions. Tail domain is the most diverse domain and vary in length and in sequence. Many myosin tails form coiled-coil structure that allow the molecules to dimerise and produce two-headed molecules. This domain mediates interaction with cargo molecules and/or other myosin subunits.
Publication
First Author: O'Connor E
Year: 2016
Journal: Brain
Title: Identification of mutations in the MYO9A gene in patients with congenital myasthenic syndrome.
Volume: 139
Issue: Pt 8
Pages: 2143-53
Publication
First Author: O'Connor E
Year: 2018
Journal: Hum Mol Genet
Title: MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion.
Volume: 27
Issue: 8
Pages: 1434-1446
Publication  
First Author: Chieregatti E
Year: 1998
Journal: J Cell Sci
Title: Myr 7 is a novel myosin IX-RhoGAP expressed in rat brain.
Volume: 111 ( Pt 24)
Pages: 3597-608
Publication
First Author: Hanley PJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility.
Volume: 107
Issue: 27
Pages: 12145-50
Publication
First Author: Post PL
Year: 2002
Journal: J Biol Chem
Title: Myosin-IXb is a single-headed and processive motor.
Volume: 277
Issue: 14
Pages: 11679-83
Publication
First Author: Cheney RE
Year: 1992
Journal: Curr Opin Cell Biol
Title: Unconventional myosins.
Volume: 4
Issue: 1
Pages: 27-35
Publication  
First Author: Mooseker MS
Year: 1995
Journal: Annu Rev Cell Dev Biol
Title: Unconventional myosins.
Volume: 11
Pages: 633-75
Publication
First Author: Sellers JR
Year: 2000
Journal: Biochim Biophys Acta
Title: Myosins: a diverse superfamily.
Volume: 1496
Issue: 1
Pages: 3-22
Protein
Organism: Mus musculus
Length: 2542  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2631  
Fragment?: false
Publication  
First Author: Folci A
Year: 2016
Journal: Front Mol Neurosci
Title: Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function.
Volume: 9
Pages: 1
Publication
First Author: Thelen S
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: Rho GAP myosin IXa is a regulator of kidney tubule function.
Volume: 309
Issue: 6
Pages: F501-13
Publication
First Author: Abouhamed M
Year: 2009
Journal: Mol Biol Cell
Title: Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus.
Volume: 20
Issue: 24
Pages: 5074-85
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Gorman SW
Year: 1999
Journal: Genomics
Title: The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23.
Volume: 59
Issue: 2
Pages: 150-60
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:4429635
Age: embryonic day 17.0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:4429635
Age: embryonic day 15.0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:4429635
Age: embryonic day 11.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:4429635
Age: embryonic day 7.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1745821
Stage: TS21
Assay Id: MGI:4429634
Age: embryonic day 13.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:4429634
Age: postnatal adult
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:4429639
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4429633
Assay Type: Northern blot
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741221
Stage: TS21
Assay Id: MGI:4429634
Age: embryonic day 13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3573928
Pattern: Single cells
Stage: TS28
Assay Id: MGI:4429636
Age: postnatal adult
Note: Expression is in a subset of retinal ganglion cells.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289524
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Note: Expression is in ameloblasts.
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3272021
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:4429637
Age: embryonic day 13.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1927924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:4422770
Assay Type: RNA in situ
Annotation Date: 2019-01-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3271122
Stage: TS22
Assay Id: MGI:6274712
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757724
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1729524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760024
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Note: The inner nuclear layer has higher expression than the outer layer.
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1665924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4429637
Age: embryonic day 16.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4429633
Assay Type: RNA in situ
Annotation Date: 2010-02-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3568628
Stage: TS28
Assay Id: MGI:4429636
Age: postnatal adult
Detected: false
Specimen Num: 1
Publication
First Author: Oliver TN
Year: 1999
Journal: Cell Mol Life Sci
Title: Tails of unconventional myosins.
Volume: 56
Issue: 3-4
Pages: 243-57
Publication
First Author: Hasson T
Year: 1996
Journal: Genomics
Title: Mapping of unconventional myosins in mouse and human.
Volume: 36
Issue: 3
Pages: 431-9
Publication      
First Author: Mouse Genome Informatics and the Consortium: Deciphering the Mechanisms of Developmental Disorders (DMDD)
Year: 2017
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Deciphering the Mechanisms of Developmental Disorders (DMDD)
Publication
First Author: Oeschger FM
Year: 2012
Journal: Cereb Cortex
Title: Gene expression analysis of the embryonic subplate.
Volume: 22
Issue: 6
Pages: 1343-59
Publication
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations