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Search results 1 to 100 out of 143 for Myoc

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0.05s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Liu P
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Efficient in vivo doxycycline and cre recombinase-mediated inducible transgene activation in the murine trabecular meshwork.
Volume: 52
Issue: 2
Pages: 969-74
Publication
First Author: Gould DB
Year: 2004
Journal: Mol Cell Biol
Title: Genetically increasing Myoc expression supports a necessary pathologic role of abnormal proteins in glaucoma.
Volume: 24
Issue: 20
Pages: 9019-25
Publication
First Author: Taniguchi F
Year: 2000
Journal: Invest Ophthalmol Vis Sci
Title: Molecular cloning of the bovine MYOC and induction of its expression in trabecular meshwork cells.
Volume: 41
Issue: 8
Pages: 2070-5
Allele
Name: myocilin; targeted mutation 3, Randy L Johnson
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Publication categories: ProxyCollection
Genotype
Symbol: Myoc/Myoc<+>
Background: involves: 129S6/SvEvTac * C57BL/6Brd * CD-1
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Swiderski RE
Year: 1999
Journal: Brain Res Mol Brain Res
Title: Expression pattern and in situ localization of the mouse homologue of the human MYOC (GLC1A) gene in adult brain.
Volume: 68
Issue: 1-2
Pages: 64-72
Publication
First Author: Lynch JM
Year: 2018
Journal: PLoS One
Title: Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle.
Volume: 13
Issue: 11
Pages: e0206801
Publication
First Author: Kasetti RB
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork.
Volume: 57
Issue: 14
Pages: 6058-6069
Publication
First Author: Zhou Y
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma.
Volume: 49
Issue: 5
Pages: 1932-9
Publication
First Author: Joe MK
Year: 2015
Journal: Hum Mol Genet
Title: Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma.
Volume: 24
Issue: 12
Pages: 3322-34
Publication
First Author: Kim BS
Year: 2001
Journal: Mol Cell Biol
Title: Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function.
Volume: 21
Issue: 22
Pages: 7707-13
Publication
First Author: Gould DB
Year: 2006
Journal: Mol Cell Biol
Title: Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
Volume: 26
Issue: 22
Pages: 8427-36
Publication
First Author: Senatorov V
Year: 2006
Journal: J Neurosci
Title: Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice.
Volume: 26
Issue: 46
Pages: 11903-14
Publication
First Author: Malyukova I
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: Mutated mouse and human myocilins have similar properties and do not block general secretory pathway.
Volume: 47
Issue: 1
Pages: 206-12
Publication
First Author: Joe MK
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: Myocilin Regulates Metalloprotease 2 Activity Through Interaction With TIMP3.
Volume: 58
Issue: 12
Pages: 5308-5318
Publication
First Author: Shepard AR
Year: 2007
Journal: Hum Mol Genet
Title: Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure.
Volume: 16
Issue: 6
Pages: 609-17
Publication
First Author: Torrado M
Year: 2002
Journal: Hum Mol Genet
Title: Optimedin: a novel olfactomedin-related protein that interacts with myocilin.
Volume: 11
Issue: 11
Pages: 1291-301
Publication
First Author: Lynch JM
Year: 2018
Journal: J Biol Chem
Title: Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells.
Volume: 293
Issue: 52
Pages: 20137-20156
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Tomarev SI
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Characterization of the mouse Myoc/Tigr gene.
Volume: 245
Issue: 3
Pages: 887-93
Publication
First Author: Takahashi H
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Mouse myocilin (Myoc) gene expression in ocular tissues.
Volume: 248
Issue: 1
Pages: 104-9
Publication
First Author: Fingert JH
Year: 1998
Journal: Genome Res
Title: Characterization and comparison of the human and mouse GLC1A glaucoma genes.
Volume: 8
Issue: 4
Pages: 377-84
Publication
First Author: Kwon HS
Year: 2013
Journal: J Biol Chem
Title: Myocilin stimulates osteogenic differentiation of mesenchymal stem cells through mitogen-activated protein kinase signaling.
Volume: 288
Issue: 23
Pages: 16882-94
Publication
First Author: Nagy I
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Expression and characterization of the olfactomedin domain of human myocilin.
Volume: 302
Issue: 3
Pages: 554-61
Publication
First Author: Joe MK
Year: 2014
Journal: J Biol Chem
Title: Myocilin regulates cell proliferation and survival.
Volume: 289
Issue: 14
Pages: 10155-67
Publication
First Author: Ortego J
Year: 1997
Journal: FEBS Lett
Title: Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin.
Volume: 413
Issue: 2
Pages: 349-53
Publication
First Author: Knaupp C
Year: 2004
Journal: Graefes Arch Clin Exp Ophthalmol
Title: The expression of myocilin during murine eye development.
Volume: 242
Issue: 4
Pages: 339-45
Publication
First Author: Zillig M
Year: 2005
Journal: Invest Ophthalmol Vis Sci
Title: Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice.
Volume: 46
Issue: 1
Pages: 223-34
Publication
First Author: Joe MK
Year: 2010
Journal: Am J Pathol
Title: Expression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: implication for glaucoma pathogenesis.
Volume: 176
Issue: 6
Pages: 2880-90
Publication  
First Author: Koch MA
Year: 2014
Journal: Exp Eye Res
Title: Myocilin modulates programmed cell death during retinal development.
Volume: 125
Pages: 41-52
Publication
First Author: Patel GC
Year: 2017
Journal: Am J Pathol
Title: Dexamethasone-Induced Ocular Hypertension in Mice: Effects of Myocilin and Route of Administration.
Volume: 187
Issue: 4
Pages: 713-723
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:4352570
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4352570
Age: postnatal adult
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:4352570
Age: postnatal adult
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:4352570
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:4352570
Age: postnatal adult
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:4352570
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:4352570
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:4352570
Age: postnatal adult
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:4352570
Age: postnatal adult
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4352570
Age: postnatal adult
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:4352572
Age: embryonic day 10.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:4352572
Age: embryonic day 13.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185817
Stage: TS17
Assay Id: MGI:4352572
Age: embryonic day 10.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:4352572
Age: embryonic day 13.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3852650
Assay Type: Northern blot
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4352572
Age: postnatal adult
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3852650
Assay Type: RNA in situ
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3518328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4352670
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3852650
Assay Type: RNA in situ
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3518328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4352670
Age: postnatal adult
Note: Expression is in the ependymal cells lining the third and fourth ventricles at the interface between the cerebrospinal fluid and the central nervous system.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3852650
Assay Type: RNA in situ
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4352670
Age: postnatal adult
Note: Expression is in the pia mater over the visual cortex.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3852650
Assay Type: RNA in situ
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3518328
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4352670
Age: postnatal adult
Note: Expression is in the ependymal cells lining the third and fourth ventricles at the interface between the cerebrospinal fluid and the central nervous system.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3852650
Assay Type: RNA in situ
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3538628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4352670
Age: postnatal adult
Note: Expression is in neurons in the rostral and caudal habenula.
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3852650
Assay Type: RNA in situ
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4352670
Age: postnatal adult
Note: Expression is in the choroid plexus of the third ventricle.
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:3852650
Assay Type: RNA in situ
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4352670
Age: postnatal adult
Note: Expression is in the outer zonal layer at the junction of the inferior and superiro colliculi.
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:3852650
Assay Type: RNA in situ
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4352670
Age: postnatal adult
Note: Expression is in the outer zonal layer at the junction of the inferior and superiro colliculi.
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3852650
Assay Type: RNA in situ
Annotation Date: 2009-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1924128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4352670
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3852652
Assay Type: RNA in situ
Annotation Date: 2009-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3554928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4353384
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3852652
Assay Type: RNA in situ
Annotation Date: 2009-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4353384
Age: postnatal adult
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3852652
Assay Type: RNA in situ
Annotation Date: 2009-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3561628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4353384
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3852652
Assay Type: RNA in situ
Annotation Date: 2009-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1924128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4353384
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3852652
Assay Type: RNA in situ
Annotation Date: 2009-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4353384
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3852652
Assay Type: RNA in situ
Annotation Date: 2009-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4353384
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3852652
Assay Type: RNA in situ
Annotation Date: 2009-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4353384
Age: postnatal adult
Note: Expression is in the outer zonal layer at the junction of the inferior and superiro colliculi.
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3852652
Assay Type: RNA in situ
Annotation Date: 2009-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4353384
Age: postnatal adult
Note: Expression is in the outer zonal layer at the junction of the inferior and superiro colliculi.
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3852652
Assay Type: RNA in situ
Annotation Date: 2009-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3538628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4353384
Age: postnatal adult
Note: Expression is in neurons in the rostral and caudal habenula.
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3852652
Assay Type: RNA in situ
Annotation Date: 2009-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3518328
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4353384
Age: postnatal adult
Note: Expression is in the ependymal cells lining the third and fourth ventricles at the interface between the cerebrospinal fluid and the central nervous system.
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6178657
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190839
Age: embryonic day 11.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6178657
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190839
Age: embryonic day 13.5
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6178657
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190839
Age: embryonic day 15.5
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:6178657
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190839
Age: embryonic day 18.5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6178657
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190839
Age: postnatal day 4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6178657
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190839
Age: postnatal day 14
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6178657
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190839
Age: postnatal day 28
Detected: true
Specimen Num: 7
Publication
First Author: Surgucheva I
Year: 2005
Journal: Cell Mol Neurobiol
Title: Interaction of myocilin with gamma-synuclein affects its secretion and aggregation.
Volume: 25
Issue: 6
Pages: 1009-33
Publication
First Author: Toutzaris D
Year: 2010
Journal: Free Radic Biol Med
Title: A novel giant peroxisomal superoxide dismutase motif-containing protein.
Volume: 48
Issue: 6
Pages: 811-20
Publication
First Author: Kwon HS
Year: 2009
Journal: Mol Cell Biol
Title: Myocilin is a modulator of Wnt signaling.
Volume: 29
Issue: 8
Pages: 2139-54
Publication
First Author: Abderrahim H
Year: 1998
Journal: Mamm Genome
Title: Characterization of the murine TIGR/myocilin gene.
Volume: 9
Issue: 8
Pages: 673-5
Publication
First Author: Kwon HS
Year: 2014
Journal: J Neurosci
Title: Myocilin is involved in NgR1/Lingo-1-mediated oligodendrocyte differentiation and myelination of the optic nerve.
Volume: 34
Issue: 16
Pages: 5539-51
Publication
First Author: Joe MK
Year: 2012
Journal: J Biol Chem
Title: Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex.
Volume: 287
Issue: 16
Pages: 13216-27