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Search results 1 to 100 out of 435 for Myocd

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0.069s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: Myocardin (Myocd) is a coactivator of serum response factor (SRF), which is a key regulator of the expression of smooth and cardiac muscle genes. Myocardin plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) [, ]. It contains the RPEL repeats, which are monomeric globular actin (G-actin) binding elements. However, it binds to actin-related protein 5 (Arp5) instead of conventional actin, resulting in a significant suppression of Myocd activity [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 948  
Fragment?: false
Publication
First Author: Du KL
Year: 2003
Journal: Mol Cell Biol
Title: Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation.
Volume: 23
Issue: 7
Pages: 2425-37
Gene
Type: gene
Organism: human
GXD Expression      
Probe: MGI:4949079
Assay Type: RT-PCR
Annotation Date: 2011-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603912
Stage: TS12
Assay Id: MGI:4949210
Age: embryonic day 8.25
Specimen Label: Myocd Sox17-/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4949079
Assay Type: RT-PCR
Annotation Date: 2011-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603912
Stage: TS12
Assay Id: MGI:4949210
Age: embryonic day 8.25
Specimen Label: Myocd Sox17+/+
Detected: true
Specimen Num: 1
Publication
First Author: Yang Q
Year: 2023
Journal: J Pathol
Title: Myocd regulates airway smooth muscle cell remodeling in response to chronic asthmatic injury.
Volume: 259
Issue: 3
Pages: 331-341
Gene
Type: gene
Organism: human
Publication  
First Author: Kurz J
Year: 2022
Journal: Development
Title: GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter.
Volume: 149
Issue: 15
Protein
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: true
Publication
First Author: Long X
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Myocardin: new therapeutic agent in vascular disease?
Volume: 33
Issue: 10
Pages: 2284-5
Publication
First Author: Morita T
Year: 2014
Journal: J Cell Biol
Title: Arp5 is a key regulator of myocardin in smooth muscle cells.
Volume: 204
Issue: 5
Pages: 683-96
Publication  
First Author: Katano W
Year: 2023
Journal: Development
Title: Sall1 and Sall4 cooperatively interact with Myocd and SRF to promote cardiomyocyte proliferation by regulating CDK and cyclin genes.
Volume: 150
Issue: 24
Protein
Organism: Mus musculus/domesticus
Length: 935  
Fragment?: false
Publication
First Author: Long X
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation.
Volume: 104
Issue: 42
Pages: 16570-5
Publication
First Author: Houweling AC
Year: 2019
Journal: J Clin Invest
Title: Loss-of-function variants in myocardin cause congenital megabladder in humans and mice.
Volume: 129
Issue: 12
Pages: 5374-5380
Publication
First Author: Thomas S
Year: 2021
Journal: Physiol Rep
Title: miR-145 transgenic mice develop cardiopulmonary complications leading to postnatal death.
Volume: 9
Issue: 17
Pages: e15013
Publication
First Author: Baeten JT
Year: 2015
Journal: J Biol Chem
Title: Differential Regulation of NOTCH2 and NOTCH3 Contribute to Their Unique Functions in Vascular Smooth Muscle Cells.
Volume: 290
Issue: 26
Pages: 16226-37
Publication
First Author: Zhou Q
Year: 2021
Journal: Theranostics
Title: Targeting hyperactive TGFBR2 for treating MYOCD deficient lung cancer.
Volume: 11
Issue: 13
Pages: 6592-6606
Publication
First Author: Baeten JT
Year: 2015
Journal: Genesis
Title: Loss of Notch2 and Notch3 in vascular smooth muscle causes patent ductus arteriosus.
Volume: 53
Issue: 12
Pages: 738-48
Publication
First Author: Huang J
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development.
Volume: 112
Issue: 14
Pages: 4447-52
Publication
First Author: Lyu Q
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: CRISPR-Cas9-Mediated Epitope Tagging Provides Accurate and Versatile Assessment of Myocardin-Brief Report.
Volume: 38
Issue: 9
Pages: 2184-2190
Publication
First Author: Morita T
Year: 2023
Journal: FEBS Open Bio
Title: Actin-related protein 5 suppresses the cooperative activation of cardiac gene transcription by myocardin and MEF2.
Volume: 13
Issue: 2
Pages: 363-379
Publication
First Author: Imamura M
Year: 2010
Journal: Gene
Title: Expression and functional activity of four myocardin isoforms.
Volume: 464
Issue: 1-2
Pages: 1-10
Publication
First Author: Huang J
Year: 2008
Journal: J Clin Invest
Title: Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice.
Volume: 118
Issue: 2
Pages: 515-25
Publication
First Author: DeSouza KR
Year: 2013
Journal: PLoS One
Title: Analysis of the Sonic Hedgehog signaling pathway in normal and abnormal bladder development.
Volume: 8
Issue: 1
Pages: e53675
Publication
First Author: Huang J
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Myocardin is required for cardiomyocyte survival and maintenance of heart function.
Volume: 106
Issue: 44
Pages: 18734-9
Publication
First Author: Xia XD
Year: 2021
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
Title: Myocardin suppression increases lipid retention and atherosclerosis via downregulation of ABCA1 in vascular smooth muscle cells.
Volume: 1866
Issue: 4
Pages: 158824
Publication
First Author: Kwon C
Year: 2009
Journal: Nat Cell Biol
Title: A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate.
Volume: 11
Issue: 8
Pages: 951-7
Publication
First Author: Chow N
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.
Volume: 104
Issue: 3
Pages: 823-8
Publication
First Author: Sun Q
Year: 2009
Journal: J Biol Chem
Title: Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein.
Volume: 284
Issue: 47
Pages: 32582-90
Publication
First Author: Qiu P
Year: 2005
Journal: Circ Res
Title: Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo.
Volume: 97
Issue: 10
Pages: 983-91
Publication
First Author: Martin E
Year: 2013
Journal: PLoS One
Title: TSHZ3 and SOX9 regulate the timing of smooth muscle cell differentiation in the ureter by reducing myocardin activity.
Volume: 8
Issue: 5
Pages: e63721
Publication
First Author: Huang J
Year: 2012
Journal: J Clin Invest
Title: Myocardin regulates BMP10 expression and is required for heart development.
Volume: 122
Issue: 10
Pages: 3678-91
Publication  
First Author: Kurz J
Year: 2022
Journal: Development
Title: Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter.
Volume: 149
Issue: 4
Publication  
First Author: Koenig SN
Year: 2017
Journal: JCI Insight
Title: Notch1 haploinsufficiency causes ascending aortic aneurysms in mice.
Volume: 2
Issue: 21
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Hoofnagle MH
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes.
Volume: 300
Issue: 5
Pages: H1707-21
Publication  
First Author: Heidersbach A
Year: 2013
Journal: Elife
Title: microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart.
Volume: 2
Pages: e01323
Publication  
First Author: Li H
Year: 2017
Journal: Gene
Title: Myocardin inhibited the gap protein connexin 43 via promoted miR-206 to regulate vascular smooth muscle cell phenotypic switch.
Volume: 616
Pages: 22-30
Publication
First Author: Li HJ
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation.
Volume: 104
Issue: 10
Pages: 4065-70
Publication
First Author: Vengrenyuk Y
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Cholesterol loading reprograms the microRNA-143/145-myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotype.
Volume: 35
Issue: 3
Pages: 535-46
Publication
First Author: Creemers EE
Year: 2006
Journal: Development
Title: Myocardin is a direct transcriptional target of Mef2, Tead and Foxo proteins during cardiovascular development.
Volume: 133
Issue: 21
Pages: 4245-56
Publication
First Author: Milyavsky M
Year: 2007
Journal: Cancer Cell
Title: Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect.
Volume: 11
Issue: 2
Pages: 133-46
Publication
First Author: Luo Y
Year: 2019
Journal: Biochem Biophys Res Commun
Title: MiR-466h-5p induces expression of myocardin with complementary promoter sequences.
Volume: 514
Issue: 1
Pages: 187-193
Publication
First Author: Ackers-Johnson M
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Myocardin regulates vascular smooth muscle cell inflammatory activation and disease.
Volume: 35
Issue: 4
Pages: 817-28
GXD Expression      
Probe: MGI:3054910
Assay Type: RT-PCR
Annotation Date: 2004-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3054928
Age: embryonic day 9.5
Specimen Label: + S/S
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3054910
Assay Type: RT-PCR
Annotation Date: 2004-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3054928
Age: embryonic day 9.5
Specimen Label: - S/S
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3054910
Assay Type: RT-PCR
Annotation Date: 2004-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185715
Stage: TS15
Assay Id: MGI:3054928
Age: embryonic day 9.5
Specimen Label: + S/S
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3054910
Assay Type: RT-PCR
Annotation Date: 2004-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185815
Stage: TS15
Assay Id: MGI:3054928
Age: embryonic day 9.5
Specimen Label: + S/S
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3054910
Assay Type: RT-PCR
Annotation Date: 2004-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185715
Stage: TS15
Assay Id: MGI:3054928
Age: embryonic day 9.5
Specimen Label: - S/S
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3054910
Assay Type: RT-PCR
Annotation Date: 2004-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185815
Stage: TS15
Assay Id: MGI:3054928
Age: embryonic day 9.5
Specimen Label: - S/S
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:1860126
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: aorta
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:1860126
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: aorta
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:1860126
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: aorta
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:1832126
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: bladder
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:1832126
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: bladder
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:1832126
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: bladder
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:1702126
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: stomach
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:1702126
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: stomach
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:1702126
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: stomach
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: intestine
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: intestine
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: intestine
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: heart
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: heart
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Present
Sex: Female
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: heart
Detected: true
Specimen Num: 15
GXD Expression        
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: brain
Specimen Num: 16
GXD Expression        
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: brain
Specimen Num: 17
GXD Expression        
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: brain
Specimen Num: 18
GXD Expression        
Probe: MGI:3805888
Assay Type: RT-PCR
Annotation Date: 2008-09-15
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:3805923
Age: embryonic day 18.5
Specimen Label: liver
Specimen Num: 19