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Search results 1 to 100 out of 107 for Mysm1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
114803 | MYSM1
Type: gene
Organism: human
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Gene
100126685 | mysm1
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR033497 | MYSM1
Type: Family
Description: MYSM1 (MEROPS identifier M67.005) is a deubiquitinase specific for monoubiquitinated histone H2A (uH2A). It is a positive regulator of androgen receptor (AR) activity on an AR responsive element (ARE)-containing reporter gene []. It plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response []. It has been shown to represses innate immunity and autoimmunity through suppressing the cGAS-STING Pathway [].
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Gene
298247 | Mysm1
Type: gene
Organism: rat
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Gene
489568 | MYSM1
Type: gene
Organism: dog, domestic
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Gene
456892 | MYSM1
Type: gene
Organism: chimpanzee
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Gene
515332 | MYSM1
Type: gene
Organism: cattle
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Gene
424671 | MYSM1
Type: gene
Organism: chicken
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Gene
561225 | mysm1
Type: gene
Organism: zebrafish
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Gene
718013 | MYSM1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2444584 | Mysm1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
33086059 | J:299946
First Author: Tian M
Year: 2020
Journal: Cell Rep
Title: MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway.
Volume: 33
Issue: 3
Pages: 108297
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Protein
Q69Z66
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
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Publication
17707232 | -
First Author: Zhu P
Year: 2007
Journal: Mol Cell
Title: A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.
Volume: 27
Issue: 4
Pages: 609-21
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Publication
26220525 | -
First Author: Le Guen T
Year: 2015
Journal: J Allergy Clin Immunol
Title: An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation.
Volume: 136
Issue: 6
Pages: 1619-1626.e5
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Publication
26474655 | J:233920
First Author: Panda S
Year: 2015
Journal: Immunity
Title: Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes.
Volume: 43
Issue: 4
Pages: 647-59
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Publication
30405132 | J:267514
First Author: Panda S
Year: 2018
Journal: Nat Commun
Title: The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex.
Volume: 9
Issue: 1
Pages: 4654
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Publication
29203593 | J:271371
First Author: Haffner-Luntzer M
Year: 2018
Journal: FASEB J
Title: Loss of p53 compensates osteopenia in murine Mysm1 deficiency.
Volume: 32
Issue: 4
Pages: 1957-1968
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Publication
25217698 | J:218684
First Author: Won H
Year: 2014
Journal: Blood
Title: Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1.
Volume: 124
Issue: 17
Pages: 2647-56
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Publication
26348977 | J:251591
 
First Author: Jiang XX
Year: 2015
Journal: Sci Rep
Title: Epigenetic Regulation of Antibody Responses by the Histone H2A Deubiquitinase MYSM1.
Volume: 5
Pages: 13755
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Publication
22169041 | J:179287
First Author: Jiang XX
Year: 2011
Journal: Immunity
Title: Control of B cell development by the histone H2A deubiquitinase MYSM1.
Volume: 35
Issue: 6
Pages: 883-96
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Publication
24062447 | J:202315
First Author: Nandakumar V
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1.
Volume: 110
Issue: 41
Pages: E3927-36
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Publication
27895164 | J:302873
First Author: Förster M
Year: 2017
Journal: J Leukoc Biol
Title: MYSM1-dependent checkpoints in B cell lineage differentiation and B cell-mediated immune response.
Volume: 101
Issue: 3
Pages: 643-654
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Publication
22184403 | J:181727
First Author: Nijnik A
Year: 2012
Journal: Blood
Title: The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.
Volume: 119
Issue: 6
Pages: 1370-9
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Publication
25710881 | J:222019
First Author: Belle JI
Year: 2015
Journal: Blood
Title: p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency.
Volume: 125
Issue: 15
Pages: 2344-8
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Publication
34114734 | J:314225
First Author: Lin YH
Year: 2021
Journal: J Cell Mol Med
Title: Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma.
Volume: 25
Issue: 14
Pages: 7089-7094
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Publication
36611064 | J:332556
First Author: Liang Y
Year: 2023
Journal: Sci Rep
Title: Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development.
Volume: 13
Issue: 1
Pages: 338
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Publication
26915790 | J:251160
 
First Author: Li P
Year: 2016
Journal: Sci Rep
Title: Deubiquitinase MYSM1 Is Essential for Normal Bone Formation and Mesenchymal Stem Cell Differentiation.
Volume: 6
Pages: 22211
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Publication
28066899 | J:246416
First Author: Förster M
Year: 2017
Journal: Immunology
Title: A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells.
Volume: 151
Issue: 1
Pages: 110-121
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Publication
32641579 | J:295178
 
First Author: Belle JI
Year: 2020
Journal: JCI Insight
Title: MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopoietic dysfunction.
Volume: 5
Issue: 13
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Publication
26125289 | J:252503
First Author: Förster M
Year: 2015
Journal: Stem Cells Dev
Title: Deubiquitinase MYSM1 Is Essential for Normal Fetal Liver Hematopoiesis and for the Maintenance of Hematopoietic Stem Cells in Adult Bone Marrow.
Volume: 24
Issue: 16
Pages: 1865-77
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Publication
26768662 | J:235706
First Author: Belle JI
Year: 2016
Journal: Cell Death Differ
Title: Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.
Volume: 23
Issue: 5
Pages: 759-75
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Publication
24014243 | J:203809
First Author: Wang T
Year: 2013
Journal: Blood
Title: The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation.
Volume: 122
Issue: 16
Pages: 2812-22
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Publication
32466590 | J:292174
 
First Author: Kroeger C
Year: 2020
Journal: Int J Mol Sci
Title: Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors.
Volume: 21
Issue: 11
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Publication
28978033 | J:256442
First Author: Wilms C
Year: 2017
Journal: Oncotarget
Title: MYSM1/2A-DUB is an epigenetic regulator in human melanoma and contributes to tumor cell growth.
Volume: 8
Issue: 40
Pages: 67287-67299
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Publication
25613381 | J:232680
First Author: Gatzka M
Year: 2015
Journal: Cell Death Differ
Title: Interplay of H2A deubiquitinase 2A-DUB/Mysm1 and the p19(ARF)/p53 axis in hematopoiesis, early T-cell development and tissue differentiation.
Volume: 22
Issue: 9
Pages: 1451-62
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Protein Coding Gene
MGP_CAROLIEiJ_G0026169 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028455 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028418 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028365 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028436 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028149 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2444584 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028875 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027589 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028118 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028268 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028235 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028368 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028263 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028913 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027314 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027667 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028506 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027135 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:5140912
Assay Type: RT-PCR
Annotation Date: 2011-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:5141032
Age: embryonic day 14.5
Image: 5
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5140912
Assay Type: RT-PCR
Annotation Date: 2011-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:5141032
Age: embryonic day 14.5
Image: 5
Specimen Label: Pkd1-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7464959
Assay Type: RT-PCR
Annotation Date: 2023-04-24
Strength: Present
Sex: Female
Emaps: EMAPS:3570528
Stage: TS28
Assay Id: MGI:7465050
Age: postnatal adult
Image: S5
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7464959
Assay Type: RT-PCR
Annotation Date: 2023-04-24
Strength: Present
Sex: Female
Emaps: EMAPS:3570528
Stage: TS28
Assay Id: MGI:7465050
Age: postnatal adult
Image: S5
Specimen Label: fl/fl:Cre
Detected: true
Specimen Num: 2
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Publication
29495602 | J:264657
 
First Author: Wilms C
Year: 2018
Journal: Int J Mol Sci
Title: 2A-DUB/Mysm1 Regulates Epidermal Development in Part by Suppressing p53-Mediated Programs.
Volume: 19
Issue: 3
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UniProt Feature
UniProt Feature
Begin: 1
Description: Deubiquitinase MYSM1
Type: chain
End: 819
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Publication
20799038 | J:167648
First Author: Karp NA
Year: 2010
Journal: Mamm Genome
Title: Optimising experimental design for high-throughput phenotyping in mice: a case study.
Volume: 21
Issue: 9-10
Pages: 467-76
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Publication
33660780 | J:304858
First Author: Olthof AM
Year: 2021
Journal: Nucleic Acids Res
Title: Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns.
Volume: 49
Issue: 6
Pages: 3524-3545
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Publication
25340873 | J:232539
First Author: DiTommaso T
Year: 2014
Journal: PLoS Genet
Title: Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.
Volume: 10
Issue: 10
Pages: e1004705
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Publication
21518438 | J:173488
 
First Author: Pandey P
Year: 2011
Journal: BMC Syst Biol
Title: Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease.
Volume: 5
Pages: 56
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Publication
35640597 | J:325355
First Author: Rong Y
Year: 2022
Journal: Nucleic Acids Res
Title: USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation.
Volume: 50
Issue: 10
Pages: 5599-5616
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Publication
24721909 | J:209956
 
First Author: Liakath-Ali K
Year: 2014
Journal: Nat Commun
Title: Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.
Volume: 5
Pages: 3540
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q69Z66-2
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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