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Search results 1 to 100 out of 162 for Nalcn

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0.036s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Sodium leak channel non-selective protein (NALCN) is a voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. It is responsible for the background sodium ion leak current in neurons and controls neuronal excitability. It is activated either by neuropeptides substance P or neurotensin []. NALCN is required for normal respiratory rhythm and neonatal survival [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Lu B
Year: 2009
Journal: Nature
Title: Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.
Volume: 457
Issue: 7230
Pages: 741-4
Publication
First Author: Lu B
Year: 2007
Journal: Cell
Title: The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm.
Volume: 129
Issue: 2
Pages: 371-83
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Lu B
Year: 2010
Journal: Neuron
Title: Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.
Volume: 68
Issue: 3
Pages: 488-99
Publication
First Author: Swayne LA
Year: 2009
Journal: EMBO Rep
Title: The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line.
Volume: 10
Issue: 8
Pages: 873-80
Publication
First Author: Shi Y
Year: 2016
Journal: J Neurosci
Title: Nalcn Is a "Leak" Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing.
Volume: 36
Issue: 31
Pages: 8174-87
Publication    
First Author: Lutas A
Year: 2016
Journal: Elife
Title: The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.
Volume: 5
Publication
First Author: Sinke AP
Year: 2011
Journal: Physiol Genomics
Title: Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation.
Volume: 43
Issue: 5
Pages: 265-70
Protein
Organism: Mus musculus
Length: 1738  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1739  
Fragment?: false
Allele
Name: sodium leak channel, non-selective; targeted mutation 2, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Inducible, Recombinase, Reporter
Publication categories: ProxyCollection
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication    
First Author: Philippart F
Year: 2018
Journal: Elife
Title: Gi/o protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN.
Volume: 7
Publication
First Author: Funato H
Year: 2016
Journal: Nature
Title: Forward-genetics analysis of sleep in randomly mutagenized mice.
Volume: 539
Issue: 7629
Pages: 378-383
Publication
First Author: Yeh SY
Year: 2017
Journal: Neuron
Title: Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn.
Volume: 94
Issue: 2
Pages: 294-303.e4
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Flourakis M
Year: 2015
Journal: Cell
Title: A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability.
Volume: 162
Issue: 4
Pages: 836-48
GXD Expression      
Probe: MGI:3840289
Assay Type: RT-PCR
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3840292
Age: embryonic day 18.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3840289
Assay Type: RT-PCR
Annotation Date: 2009-04-17
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3840292
Age: embryonic day 18.5
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3840289
Assay Type: RT-PCR
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3840292
Age: embryonic day 18.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3579428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3579028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Detected: true
Specimen Num: 3
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Allele    
Name: unc-80, NALCN activator; wild type
Allele Type: Not Specified
ProxyCollection
Publication
First Author: Lee SY
Year: 2019
Journal: Exp Mol Med
Title: Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells.
Volume: 51
Issue: 10
Pages: 119
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus