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Search results 1 to 100 out of 368 for Nalcn

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
259232 | NALCN
Type: gene
Organism: human
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Gene
100492286 | nalcn
Type: gene
Organism: frog, western clawed
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Gene
106994360 | NALCN
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028823 | NALCN
Type: Family
Description: Sodium leak channel non-selective protein (NALCN) was first described as a voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions [], however, it was recently reported to be selective only for monovalent cations and to be blocked by extracellular divalent cations []. Coexpression of NALCN, UNC79, UNC80, and NALF1 results in voltage-dependent NALCN currents [, ]. It is responsible for the background sodium ion leak current in neurons and controls neuronal excitability. It is activated either by neuropeptides substance P or neurotensin []. NALCN is required for normal respiratory rhythm and neonatal survival [].
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Gene
266760 | Nalcn
Type: gene
Organism: rat
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Gene
485535 | NALCN
Type: gene
Organism: dog, domestic
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Gene
452643 | NALCN
Type: gene
Organism: chimpanzee
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Gene
536103 | NALCN
Type: gene
Organism: cattle
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Gene
418770 | NALCN
Type: gene
Organism: chicken
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Gene
548345 | nalcn
Type: gene
Organism: zebrafish
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Protein Coding Gene
MGI:2444306 | Nalcn
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17448995 | J:141581
First Author: Lu B
Year: 2007
Journal: Cell
Title: The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm.
Volume: 129
Issue: 2
Pages: 371-83
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Publication
19092807 | J:145000
First Author: Lu B
Year: 2009
Journal: Nature
Title: Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.
Volume: 457
Issue: 7230
Pages: 741-4
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Publication
31409833 | -
First Author: Bouasse M
Year: 2019
Journal: Sci Rep
Title: Functional expression of CLIFAHDD and IHPRF pathogenic variants of the NALCN channel in neuronal cells reveals both gain- and loss-of-function properties.
Volume: 9
Issue: 1
Pages: 11791
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Publication
32620897 | J:291847
First Author: Wie J
Year: 2020
Journal: Nat Commun
Title: Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.
Volume: 11
Issue: 1
Pages: 3351
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Publication
19575010 | J:233576
First Author: Swayne LA
Year: 2009
Journal: EMBO Rep
Title: The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line.
Volume: 10
Issue: 8
Pages: 873-80
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Publication
27177420 | J:234021
   
First Author: Lutas A
Year: 2016
Journal: Elife
Title: The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.
Volume: 5
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Publication
32494638 | -
First Author: Chua HC
Year: 2020
Journal: Sci Adv
Title: The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium.
Volume: 6
Issue: 17
Pages: eaaz3154
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Publication
21177381 | J:171768
First Author: Sinke AP
Year: 2011
Journal: Physiol Genomics
Title: Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation.
Volume: 43
Issue: 5
Pages: 265-70
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Publication
21040849 | J:167858
First Author: Lu B
Year: 2010
Journal: Neuron
Title: Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.
Volume: 68
Issue: 3
Pages: 488-99
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Protein
Q8BXR5
Organism: Mus musculus/domesticus
Length: 1738  
Fragment?: false
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Protein
E9QLE4
Organism: Mus musculus/domesticus
Length: 1739  
Fragment?: false
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Publication
36175792 | J:333728
First Author: Rahrmann EP
Year: 2022
Journal: Nat Genet
Title: The NALCN channel regulates metastasis and nonmalignant cell dissemination.
Volume: 54
Issue: 12
Pages: 1827-1838
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Publication
34409942 | J:349866
   
First Author: Um KB
Year: 2021
Journal: Elife
Title: TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons.
Volume: 10
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Gene
100885778 | NALCN-AS1
Type: gene
Organism: human
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Publication
27488637 | J:234622
First Author: Shi Y
Year: 2016
Journal: J Neurosci
Title: Nalcn Is a "Leak" Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing.
Volume: 36
Issue: 31
Pages: 8174-87
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Publication
31601786 | J:280701
First Author: Lee SY
Year: 2019
Journal: Exp Mol Med
Title: Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells.
Volume: 51
Issue: 10
Pages: 1-14
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Publication
38197879 | J:349019
   
First Author: Ngodup T
Year: 2024
Journal: Elife
Title: The Na(+) leak channel NALCN controls spontaneous activity and mediates synaptic modulation by ?2-adrenergic receptors in auditory neurons.
Volume: 12
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Publication
37640554 | J:346238
First Author: Cobb-Lewis DE
Year: 2023
Journal: J Neurosci
Title: Contributions of the Sodium Leak Channel NALCN to Pacemaking of Medial Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons.
Volume: 43
Issue: 41
Pages: 6841-6853
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Gene
27112 | NALF2
Type: gene
Organism: human
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Gene
728215 | NALF1
Type: gene
Organism: human
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Gene
285175 | UNC80
Type: gene
Organism: human
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Gene
57578 | UNC79
Type: gene
Organism: human
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Publication
20714347 | J:163308
 
First Author: Speca DJ
Year: 2010
Journal: PLoS Genet
Title: Conserved role of unc-79 in ethanol responses in lightweight mutant mice.
Volume: 6
Issue: 8
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Publication
33766679 | J:303571
 
First Author: Zhang D
Year: 2021
Journal: Prog Neurobiol
Title: Sodium leak channel contributes to neuronal sensitization in neuropathic pain.
Volume: 202
Pages: 102041
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Publication
33176139 | J:299229
First Author: Do J
Year: 2020
Journal: Cell Rep
Title: A Leptin-Mediated Neural Mechanism Linking Breathing to Metabolism.
Volume: 33
Issue: 6
Pages: 108358
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Publication
30556810 | J:271472
   
First Author: Philippart F
Year: 2018
Journal: Elife
Title: G(i/o) protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN.
Volume: 7
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Publication
27806374 | J:236598
First Author: Funato H
Year: 2016
Journal: Nature
Title: Forward-genetics analysis of sleep in randomly mutagenized mice.
Volume: 539
Issue: 7629
Pages: 378-383
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Publication
36796706 | J:352450
 
First Author: Wang J
Year: 2023
Journal: Brain Behav Immun
Title: Loss of sodium leak channel (NALCN) in the ventral dentate gyrus impairs neuronal activity of the glutamatergic neurons for inflammation-induced depression in male mice.
Volume: 110
Pages: 13-29
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Publication
28392070 | J:241562
First Author: Yeh SY
Year: 2017
Journal: Neuron
Title: Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn.
Volume: 94
Issue: 2
Pages: 294-303.e4
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Publication
40839605 | J:377316
First Author: de la Pe?a JB
Year: 2025
Journal: Pain
Title: Ribosome profiling reveals that post-transcriptional control of Nalf1 by heterogeneous nuclear ribonucleoprotein L is required for paclitaxel-induced neuropathic pain.
Volume: 166
Issue: 9
Pages: 2091-2102
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Protein Coding Gene
MGP_CAROLIEiJ_G0019621 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
ENSMUSG00200009523 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00195030760 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00220007497 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00180027894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00175001948 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2444306 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00215022245 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSTCUG00005008271 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00210026533 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00185013561 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00205007135 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00230011456 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSUMUG00000020584 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00190024730 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00225029093 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSLUMG00010028639 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSIUOG00005030658 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030637 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
ENSMSPG00010014330 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
26276633 | J:238767
First Author: Flourakis M
Year: 2015
Journal: Cell
Title: A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability.
Volume: 162
Issue: 4
Pages: 836-48
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GXD Expression
GXD Expression
     
Probe: MGI:3840289
Assay Type: RT-PCR
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3840292
Age: embryonic day 18.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3840289
Assay Type: RT-PCR
Annotation Date: 2009-04-17
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3840292
Age: embryonic day 18.5
Specimen Label: -/-
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3840289
Assay Type: RT-PCR
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3840292
Age: embryonic day 18.5
Specimen Label: +/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Specimen Label: 1C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3579428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Specimen Label: Not shown
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3579028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Specimen Label: Not shown
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3840288
Assay Type: RNA in situ
Annotation Date: 2009-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3840291
Age: postnatal
Note: Expression is in all neurons.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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Publication
37339878 | J:353455
First Author: Yang ND
Year: 2023
Journal: J Neurosci
Title: Effects of NALCN-Encoded Na(+) Leak Currents on the Repetitive Firing Properties of SCN Neurons Depend on K(+)-Driven Rhythmic Changes in Input Resistance.
Volume: 43
Issue: 28
Pages: 5132-5141
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:384794
     
First Author: MGI and IMPC
Year: 2026
Journal: Database Release
Title: MGI Load of Molecular Notes for Endonuclease-Mediated (CRISPR) Alleles from the International Mouse Phenotyping Consortium (IMPC)
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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