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Search results 1 to 100 out of 2028 for Ncam1

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4.681s

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Type Details Score
Gene
4684 | NCAM1
Type: gene
Organism: human
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Gene
466782 | NCAM1
Type: gene
Organism: chimpanzee
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Gene
428253 | NCAM1
Type: gene
Organism: chicken
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Gene
693789 | NCAM1
Type: gene
Organism: macaque, rhesus
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Gene
100038291 | ncam1
Type: gene
Organism: frog, western clawed
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Gene
281941 | NCAM1
Type: gene
Organism: cattle
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Gene
24586 | Ncam1
Type: gene
Organism: rat
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Gene
479435 | NCAM1
Type: gene
Organism: dog, domestic
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Protein Domain
IPR033019 | Ncam1
Type: Family
Description: The neural cell adhesion molecule (NCAM) is a member of the immunoglobulin (Ig) superfamily of adhesion molecules []that plays a crucial role in neurite outgrowth [, ]and synaptic plasticity [, ]. It is a multifunctional regulator that not only mediates cell-cell adhesion, but also induces activation of a complex network of intracellular signalling cascades []. NCAM is able to bind itself and to series of receptors, other adhesion molecules and extracellular matrix components. Abnormal NCAM signalling is associated with psychiatric disorders including depression [, ].NCAM can be polysialylated (PSA-NCAM) which reduces the adhesive properties of NCAM and increases intermembrane repulsion []. Polysialylation of NCAM is required during development to dampen the activity of NCAM []and in adult life is restricted to regions of the brain where cell migration, axonal outgrowth, or synaptic plasticity are ongoing [].
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Protein Coding Gene
MGI:97281 | Ncam1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
100288346 | NCAM1-AS1
Type: gene
Organism: human
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Publication
17000882 | J:114704
First Author: Sytnyk V
Year: 2006
Journal: J Cell Biol
Title: NCAM promotes assembly and activity-dependent remodeling of the postsynaptic signaling complex.
Volume: 174
Issue: 7
Pages: 1071-85
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Publication
16267048 | J:105899
First Author: Weinhold B
Year: 2005
Journal: J Biol Chem
Title: Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule.
Volume: 280
Issue: 52
Pages: 42971-7
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Publication
21389209 | J:170083
First Author: Chernyshova Y
Year: 2011
Journal: J Neurosci
Title: The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones.
Volume: 31
Issue: 10
Pages: 3522-35
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Protein
Q3V1M4
Organism: Mus musculus/domesticus
Length: 401  
Fragment?: false
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Protein
P13595
Organism: Mus musculus/domesticus
Length: 1115  
Fragment?: false
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Publication
28098160 | J:333976
 
First Author: Brethour D
Year: 2017
Journal: Sci Rep
Title: A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.
Volume: 7
Pages: 40313
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Publication
29346771 | J:271302
First Author: Ko HG
Year: 2018
Journal: Cell Rep
Title: Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury.
Volume: 22
Issue: 3
Pages: 748-759
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Protein
Q61945
Organism: Mus musculus/domesticus
Length: 49  
Fragment?: false
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Protein
A0A0A6YY47
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
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Protein
A0A0A6YY91
Organism: Mus musculus/domesticus
Length: 1089  
Fragment?: true
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Protein
E9QB01
Organism: Mus musculus/domesticus
Length: 849  
Fragment?: false
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Protein
Q6LBT4
Organism: Mus musculus/domesticus
Length: 41  
Fragment?: true
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Protein
O08909
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: true
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Protein
O88682
Organism: Mus musculus/domesticus
Length: 31  
Fragment?: true
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Protein
A0A0A6YWU2
Organism: Mus musculus/domesticus
Length: 605  
Fragment?: false
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Protein
E9Q589
Organism: Mus musculus/domesticus
Length: 725  
Fragment?: false
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Publication
17975827 | -
First Author: Ditlevsen DK
Year: 2008
Journal: J Neurosci Res
Title: NCAM-induced intracellular signaling revisited.
Volume: 86
Issue: 4
Pages: 727-43
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Publication
18791849 | -
First Author: Hansen SM
Year: 2008
Journal: Cell Mol Life Sci
Title: Signaling mechanisms of neurite outgrowth induced by the cell adhesion molecules NCAM and N-cadherin.
Volume: 65
Issue: 23
Pages: 3809-21
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Publication
3576199 | -
First Author: Cunningham BA
Year: 1987
Journal: Science
Title: Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing.
Volume: 236
Issue: 4803
Pages: 799-806
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Publication
11783716 | -
First Author: Kiss JZ
Year: 2001
Journal: Rev Neurosci
Title: Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity.
Volume: 12
Issue: 4
Pages: 297-310
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Publication
20017030 | -
 
First Author: Brennaman LH
Year: 2010
Journal: Adv Exp Med Biol
Title: NCAM in neuropsychiatric and neurodegenerative disorders.
Volume: 663
Pages: 299-317
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Publication
26499173 | -
First Author: Aonurm-Helm A
Year: 2015
Journal: Eur Neuropsychopharmacol
Title: NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline.
Volume: 25
Issue: 12
Pages: 2394-403
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Publication
15504723 | -
First Author: Johnson CP
Year: 2005
Journal: J Biol Chem
Title: Direct evidence that neural cell adhesion molecule (NCAM) polysialylation increases intermembrane repulsion and abrogates adhesion.
Volume: 280
Issue: 1
Pages: 137-45
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Publication
11690614 | -
First Author: Kiss JZ
Year: 2001
Journal: Brain Res Brain Res Rev
Title: The role of neural cell adhesion molecules in plasticity and repair.
Volume: 36
Issue: 2-3
Pages: 175-84
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Publication
16952347 | J:115961
First Author: Fu M
Year: 2006
Journal: Dev Biol
Title: BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition.
Volume: 299
Issue: 1
Pages: 137-50
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190844
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Ncam1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190844
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Ncam1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190844
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Ncam1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190844
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Ncam1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190844
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Ncam1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190844
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Ncam1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190844
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Ncam1
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:6303801
Assay Type: Immunohistochemistry
Annotation Date: 2019-05-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3284221
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6303885
Age: embryonic day 13.5
Note: Ncam1 immunoreactivity in the frontal cortex appeared less intense.
Specimen Label: not shown
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:6303801
Assay Type: Immunohistochemistry
Annotation Date: 2019-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6303885
Age: embryonic day 15.5
Note: Ncam1 immunoreactivity in the frontal cortex appeared less intense.
Specimen Label: not shown
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:1934887
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3648124
Stage: TS24
Assay Id: MGI:6307796
Age: embryonic day 16.0
Note: The awl placodes were usually negative for Ncam1 staining. One sample with premature stratification exhibited positively stained placodal cells.
Specimen Label: 2G
Detected: false
Specimen Num: 3
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Publication
35148379 | J:338997
First Author: Jennings MJ
Year: 2022
Journal: Brain
Title: NCAM1 and GDF15 are biomarkers of Charcot-Marie-Tooth disease in patients and mice.
Volume: 145
Issue: 11
Pages: 3999-4015
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Publication
16006137 | J:104654
First Author: Mirnics ZK
Year: 2005
Journal: Neurobiol Dis
Title: P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1.
Volume: 20
Issue: 3
Pages: 969-85
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Pathway
R-MMU-419037 | NCAM1 interactions
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Publication
25384980 | J:319124
First Author: Kondoh D
Year: 2014
Journal: J Biol Chem
Title: Molecular clock regulates daily α1-2-fucosylation of the neural cell adhesion molecule (NCAM) within mouse secondary olfactory neurons.
Volume: 289
Issue: 52
Pages: 36158-65
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Publication
26153130 | J:341164
First Author: Röckle I
Year: 2016
Journal: Dev Neurobiol
Title: Deficits of olfactory interneurons in polysialyltransferase- and NCAM-deficient mice.
Volume: 76
Issue: 4
Pages: 421-33
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Publication
28870505 | J:256839
 
First Author: Ackermann MA
Year: 2017
Journal: J Mol Cell Cardiol
Title: TGF-β1 affects cell-cell adhesion in the heart in an NCAM1-dependent mechanism.
Volume: 112
Pages: 49-57
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Publication
35126044 | J:320248
 
First Author: Shabanipour S
Year: 2021
Journal: Front Neurosci
Title: Upregulation of Neural Cell Adhesion Molecule 1 and Excessive Migration of Purkinje Cells in Cerebellar Cortex.
Volume: 15
Pages: 804402
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Publication
16247769 | J:102850
First Author: Singh U
Year: 2005
Journal: Dev Dyn
Title: Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1.
Volume: 234
Issue: 4
Pages: 1034-45
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Protein Coding Gene
MGP_CAROLIEiJ_G0032180 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034774 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034755 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034683 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034747 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034457 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_97281 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035267 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033779 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034429 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034588 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034529 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034669 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034573 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035288 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033484 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033892 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015048 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033319 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
3595563 | J:8745
First Author: Barthels D
Year: 1987
Journal: EMBO J
Title: Isolation and nucleotide sequence of mouse NCAM cDNA that codes for a Mr 79,000 polypeptide without a membrane-spanning region.
Volume: 6
Issue: 4
Pages: 907-14
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Publication
2721486 | J:21651
First Author: Santoni MJ
Year: 1989
Journal: EMBO J
Title: Differential exon usage involving an unusual splicing mechanism generates at least eight types of NCAM cDNA in mouse brain.
Volume: 8
Issue: 2
Pages: 385-92
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Publication
3684567 | J:8943
First Author: Santoni MJ
Year: 1987
Journal: Nucleic Acids Res
Title: Analysis of cDNA clones that code for the transmembrane forms of the mouse neural cell adhesion molecule (NCAM) and are generated by alternative RNA splicing.
Volume: 15
Issue: 21
Pages: 8621-41
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Publication
3396534 | J:25665
First Author: Barbas JA
Year: 1988
Journal: EMBO J
Title: Differential splicing and alternative polyadenylation generates distinct NCAM transcripts and proteins in the mouse.
Volume: 7
Issue: 3
Pages: 625-32
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Publication
2454455 | J:9219
First Author: Barthels D
Year: 1988
Journal: Nucleic Acids Res
Title: NCAM-180, the large isoform of the neural cell adhesion molecule of the mouse, is encoded by an alternatively spliced transcript.
Volume: 16
Issue: 10
Pages: 4217-25
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Publication
9582442 | J:48396
First Author: Kawahigashi H
Year: 1998
Journal: Biochim Biophys Acta
Title: A cis-acting regulatory element that affects the alternative splicing of a muscle-specific exon in the mouse NCAM gene.
Volume: 1397
Issue: 3
Pages: 305-15
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Publication
1716358 | J:51724
First Author: Hamshere M
Year: 1991
Journal: Nucleic Acids Res
Title: The muscle specific domain of mouse N-CAM: structure and alternative splicing patterns.
Volume: 19
Issue: 17
Pages: 4709-16
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Publication
6577452 | J:37897
First Author: Hoffman S
Year: 1983
Journal: Proc Natl Acad Sci U S A
Title: Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule.
Volume: 80
Issue: 18
Pages: 5762-6
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Publication
10086383 | J:53305
First Author: Perl AK
Year: 1999
Journal: Nat Med
Title: Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells.
Volume: 5
Issue: 3
Pages: 286-91
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Publication
8692830 | J:34293
First Author: Rabinowitz JE
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Targeted mutation of Ncam to produce a secreted molecule results in a dominant embryonic lethality.
Volume: 93
Issue: 13
Pages: 6421-4
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Publication
8107803 | J:16590
First Author: Cremer H
Year: 1994
Journal: Nature
Title: Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning.
Volume: 367
Issue: 6462
Pages: 455-9
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Publication
26999607 | J:234709
First Author: Deborde S
Year: 2016
Journal: J Clin Invest
Title: Schwann cells induce cancer cell dispersion and invasion.
Volume: 126
Issue: 4
Pages: 1538-54
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Publication
29175953 | J:258469
First Author: Hata K
Year: 2018
Journal: J Neurosci
Title: Distinct Roles of Different Presynaptic and Postsynaptic NCAM Isoforms in Early Motoneuron-Myotube Interactions Required for Functional Synapse Formation.
Volume: 38
Issue: 2
Pages: 498-510
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Publication
11738028 | J:73253
First Author: Polo-Parada L
Year: 2001
Journal: Neuron
Title: Alterations in transmission, vesicle dynamics, and transmitter release machinery at NCAM-deficient neuromuscular junctions.
Volume: 32
Issue: 5
Pages: 815-28
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Publication
18757519 | J:146691
First Author: Murphy JA
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Endogenous polysialylated neural cell adhesion molecule enhances the survival of retinal ganglion cells.
Volume: 50
Issue: 2
Pages: 861-9
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Publication
20843898 | J:183825
First Author: Gómez-Climent MÁ
Year: 2011
Journal: Cereb Cortex
Title: The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is expressed in a subpopulation of mature cortical interneurons characterized by reduced structural features and connectivity.
Volume: 21
Issue: 5
Pages: 1028-41
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Publication
10964958 | J:64212
First Author: Rafuse VF
Year: 2000
Journal: J Neurosci
Title: Structural and functional alterations of neuromuscular junctions in NCAM-deficient mice.
Volume: 20
Issue: 17
Pages: 6529-39
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Publication
19788570 | J:155440
First Author: Boutin C
Year: 2009
Journal: Eur J Neurosci
Title: NCAM expression induces neurogenesis in vivo.
Volume: 30
Issue: 7
Pages: 1209-18
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Publication
22683856 | J:187071
First Author: Shi Y
Year: 2012
Journal: Exp Cell Res
Title: Neural cell adhesion molecule modulates mesenchymal stromal cell migration via activation of MAPK/ERK signaling.
Volume: 318
Issue: 17
Pages: 2257-67
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Publication
15931078 | J:103566
First Author: Plappert CF
Year: 2005
Journal: Neuroreport
Title: Neural cell adhesion molecule-null mice are not deficient in prepulse inhibition of the startle response.
Volume: 16
Issue: 9
Pages: 1009-12
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Publication
12177211 | J:128160
First Author: Delling M
Year: 2002
Journal: J Neurosci
Title: The neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid rafts.
Volume: 22
Issue: 16
Pages: 7154-64
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Publication
17301083 | J:118866
First Author: Gascon E
Year: 2007
Journal: Development
Title: PSA-NCAM in postnatally generated immature neurons of the olfactory bulb: a crucial role in regulating p75 expression and cell survival.
Volume: 134
Issue: 6
Pages: 1181-90
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Publication
16436188 | J:118083
First Author: Plappert CF
Year: 2006
Journal: Genes Brain Behav
Title: Neural cell adhesion molecule (NCAM-/-) null mice show impaired sensitization of the startle response.
Volume: 5
Issue: 1
Pages: 46-52
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Publication
22361116 | J:181837
 
First Author: Jürgenson M
Year: 2012
Journal: Brain Res
Title: Partial reduction in neural cell adhesion molecule (NCAM) in heterozygous mice induces depression-related behaviour without cognitive impairment.
Volume: 1447
Pages: 106-18
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Publication
20530553 | J:162648
First Author: Zumsteg A
Year: 2010
Journal: Carcinogenesis
Title: A bioluminescent mouse model of pancreatic {beta}-cell carcinogenesis.
Volume: 31
Issue: 8
Pages: 1465-74
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Publication
11399310 | J:96708
First Author: Shen H
Year: 2001
Journal: Physiol Behav
Title: Genetic deletions of NCAM and PSA impair circadian function in the mouse.
Volume: 73
Issue: 1-2
Pages: 185-93
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Publication
14985425 | J:96999
First Author: Polo-Parada L
Year: 2004
Journal: J Neurosci
Title: Distinct roles of different neural cell adhesion molecule (NCAM) isoforms in synaptic maturation revealed by analysis of NCAM 180 kDa isoform-deficient mice.
Volume: 24
Issue: 8
Pages: 1852-64
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