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Search results 1 to 100 out of 2105 for Ncam1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
4684 | NCAM1
Type: gene
Organism: human
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Gene
100038291 | ncam1
Type: gene
Organism: frog, western clawed
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Gene
281941 | NCAM1
Type: gene
Organism: cattle
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Gene
24586 | Ncam1
Type: gene
Organism: rat
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Gene
479435 | NCAM1
Type: gene
Organism: dog, domestic
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Gene
466782 | NCAM1
Type: gene
Organism: chimpanzee
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Gene
428253 | NCAM1
Type: gene
Organism: chicken
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Gene
693789 | NCAM1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR033019 | Ncam1
Type: Family
Description: The neural cell adhesion molecule (NCAM) is a member of the immunoglobulin (Ig) superfamily of adhesion molecules []that plays a crucial role in neurite outgrowth [, ]and synaptic plasticity [, ]. It is a multifunctional regulator that not only mediates cell-cell adhesion, but also induces activation of a complex network of intracellular signalling cascades []. NCAM is able to bind itself and to series of receptors, other adhesion molecules and extracellular matrix components. Abnormal NCAM signalling is associated with psychiatric disorders including depression [, ].NCAM can be polysialylated (PSA-NCAM) which reduces the adhesive properties of NCAM and increases intermembrane repulsion []. Polysialylation of NCAM is required during development to dampen the activity of NCAM []and in adult life is restricted to regions of the brain where cell migration, axonal outgrowth, or synaptic plasticity are ongoing [].
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Protein Coding Gene
MGI:97281 | Ncam1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
100288346 | NCAM1-AS1
Type: gene
Organism: human
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Gene
101928847 | NCAM1-AS2
Type: gene
Organism: human
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Publication
17000882 | J:114704
First Author: Sytnyk V
Year: 2006
Journal: J Cell Biol
Title: NCAM promotes assembly and activity-dependent remodeling of the postsynaptic signaling complex.
Volume: 174
Issue: 7
Pages: 1071-85
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Publication
16267048 | J:105899
First Author: Weinhold B
Year: 2005
Journal: J Biol Chem
Title: Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule.
Volume: 280
Issue: 52
Pages: 42971-7
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Publication
21389209 | J:170083
First Author: Chernyshova Y
Year: 2011
Journal: J Neurosci
Title: The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones.
Volume: 31
Issue: 10
Pages: 3522-35
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Protein
Q3V1M4
Organism: Mus musculus/domesticus
Length: 401  
Fragment?: false
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Protein
P13595
Organism: Mus musculus/domesticus
Length: 1115  
Fragment?: false
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Publication
28098160 | J:333976
 
First Author: Brethour D
Year: 2017
Journal: Sci Rep
Title: A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.
Volume: 7
Pages: 40313
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Publication
29346771 | J:271302
First Author: Ko HG
Year: 2018
Journal: Cell Rep
Title: Rapid Turnover of Cortical NCAM1 Regulates Synaptic Reorganization after Peripheral Nerve Injury.
Volume: 22
Issue: 3
Pages: 748-759
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Protein
Q61945
Organism: Mus musculus/domesticus
Length: 49  
Fragment?: false
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Protein
A0A0A6YY47
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
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Protein
A0A0A6YY91
Organism: Mus musculus/domesticus
Length: 1089  
Fragment?: true
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Protein
E9QB01
Organism: Mus musculus/domesticus
Length: 849  
Fragment?: false
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Protein
Q6LBT4
Organism: Mus musculus/domesticus
Length: 41  
Fragment?: true
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Protein
O08909
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: true
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Protein
O88682
Organism: Mus musculus/domesticus
Length: 31  
Fragment?: true
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Protein
A0A0A6YWU2
Organism: Mus musculus/domesticus
Length: 605  
Fragment?: false
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Protein
E9Q589
Organism: Mus musculus/domesticus
Length: 725  
Fragment?: false
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Publication
17975827 | -
First Author: Ditlevsen DK
Year: 2008
Journal: J Neurosci Res
Title: NCAM-induced intracellular signaling revisited.
Volume: 86
Issue: 4
Pages: 727-43
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Publication
18791849 | -
First Author: Hansen SM
Year: 2008
Journal: Cell Mol Life Sci
Title: Signaling mechanisms of neurite outgrowth induced by the cell adhesion molecules NCAM and N-cadherin.
Volume: 65
Issue: 23
Pages: 3809-21
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Publication
3576199 | -
First Author: Cunningham BA
Year: 1987
Journal: Science
Title: Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing.
Volume: 236
Issue: 4803
Pages: 799-806
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Publication
11783716 | -
First Author: Kiss JZ
Year: 2001
Journal: Rev Neurosci
Title: Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity.
Volume: 12
Issue: 4
Pages: 297-310
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Publication
20017030 | -
 
First Author: Brennaman LH
Year: 2010
Journal: Adv Exp Med Biol
Title: NCAM in neuropsychiatric and neurodegenerative disorders.
Volume: 663
Pages: 299-317
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Publication
26499173 | -
First Author: Aonurm-Helm A
Year: 2015
Journal: Eur Neuropsychopharmacol
Title: NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline.
Volume: 25
Issue: 12
Pages: 2394-403
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Publication
15504723 | -
First Author: Johnson CP
Year: 2005
Journal: J Biol Chem
Title: Direct evidence that neural cell adhesion molecule (NCAM) polysialylation increases intermembrane repulsion and abrogates adhesion.
Volume: 280
Issue: 1
Pages: 137-45
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Publication
11690614 | -
First Author: Kiss JZ
Year: 2001
Journal: Brain Res Brain Res Rev
Title: The role of neural cell adhesion molecules in plasticity and repair.
Volume: 36
Issue: 2-3
Pages: 175-84
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Publication
16952347 | J:115961
First Author: Fu M
Year: 2006
Journal: Dev Biol
Title: BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition.
Volume: 299
Issue: 1
Pages: 137-50
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190844
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Ncam1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190844
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Ncam1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190844
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Ncam1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190844
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Ncam1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190844
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Ncam1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190844
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Ncam1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6178775
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190844
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Ncam1
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:6303801
Assay Type: Immunohistochemistry
Annotation Date: 2019-05-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3284221
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6303885
Age: embryonic day 13.5
Note: Ncam1 immunoreactivity in the frontal cortex appeared less intense.
Specimen Label: not shown
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:6303801
Assay Type: Immunohistochemistry
Annotation Date: 2019-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6303885
Age: embryonic day 15.5
Note: Ncam1 immunoreactivity in the frontal cortex appeared less intense.
Specimen Label: not shown
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:1934887
Assay Type: Immunohistochemistry
Annotation Date: 2019-06-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3648124
Stage: TS24
Assay Id: MGI:6307796
Age: embryonic day 16.0
Note: The awl placodes were usually negative for Ncam1 staining. One sample with premature stratification exhibited positively stained placodal cells.
Specimen Label: 2G
Detected: false
Specimen Num: 3
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Publication
35148379 | J:338997
First Author: Jennings MJ
Year: 2022
Journal: Brain
Title: NCAM1 and GDF15 are biomarkers of Charcot-Marie-Tooth disease in patients and mice.
Volume: 145
Issue: 11
Pages: 3999-4015
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Pathway
R-MMU-419037 | NCAM1 interactions
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Publication
16006137 | J:104654
First Author: Mirnics ZK
Year: 2005
Journal: Neurobiol Dis
Title: P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1.
Volume: 20
Issue: 3
Pages: 969-85
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Publication
26153130 | J:341164
First Author: Röckle I
Year: 2016
Journal: Dev Neurobiol
Title: Deficits of olfactory interneurons in polysialyltransferase- and NCAM-deficient mice.
Volume: 76
Issue: 4
Pages: 421-33
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Publication
25384980 | J:319124
First Author: Kondoh D
Year: 2014
Journal: J Biol Chem
Title: Molecular clock regulates daily α1-2-fucosylation of the neural cell adhesion molecule (NCAM) within mouse secondary olfactory neurons.
Volume: 289
Issue: 52
Pages: 36158-65
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Publication
28870505 | J:256839
 
First Author: Ackermann MA
Year: 2017
Journal: J Mol Cell Cardiol
Title: TGF-β1 affects cell-cell adhesion in the heart in an NCAM1-dependent mechanism.
Volume: 112
Pages: 49-57
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Publication
35126044 | J:320248
 
First Author: Shabanipour S
Year: 2021
Journal: Front Neurosci
Title: Upregulation of Neural Cell Adhesion Molecule 1 and Excessive Migration of Purkinje Cells in Cerebellar Cortex.
Volume: 15
Pages: 804402
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Publication
16247769 | J:102850
First Author: Singh U
Year: 2005
Journal: Dev Dyn
Title: Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1.
Volume: 234
Issue: 4
Pages: 1034-45
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Protein Coding Gene
MGP_CAROLIEiJ_G0032180 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034774 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034755 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034683 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034747 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034457 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_97281 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035267 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033779 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034429 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034588 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034529 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034669 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034573 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035288 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033484 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033892 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015048 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033319 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
3595563 | J:8745
First Author: Barthels D
Year: 1987
Journal: EMBO J
Title: Isolation and nucleotide sequence of mouse NCAM cDNA that codes for a Mr 79,000 polypeptide without a membrane-spanning region.
Volume: 6
Issue: 4
Pages: 907-14
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Publication
2721486 | J:21651
First Author: Santoni MJ
Year: 1989
Journal: EMBO J
Title: Differential exon usage involving an unusual splicing mechanism generates at least eight types of NCAM cDNA in mouse brain.
Volume: 8
Issue: 2
Pages: 385-92
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Publication
3684567 | J:8943
First Author: Santoni MJ
Year: 1987
Journal: Nucleic Acids Res
Title: Analysis of cDNA clones that code for the transmembrane forms of the mouse neural cell adhesion molecule (NCAM) and are generated by alternative RNA splicing.
Volume: 15
Issue: 21
Pages: 8621-41
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Publication
3396534 | J:25665
First Author: Barbas JA
Year: 1988
Journal: EMBO J
Title: Differential splicing and alternative polyadenylation generates distinct NCAM transcripts and proteins in the mouse.
Volume: 7
Issue: 3
Pages: 625-32
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Publication
2454455 | J:9219
First Author: Barthels D
Year: 1988
Journal: Nucleic Acids Res
Title: NCAM-180, the large isoform of the neural cell adhesion molecule of the mouse, is encoded by an alternatively spliced transcript.
Volume: 16
Issue: 10
Pages: 4217-25
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Publication
9582442 | J:48396
First Author: Kawahigashi H
Year: 1998
Journal: Biochim Biophys Acta
Title: A cis-acting regulatory element that affects the alternative splicing of a muscle-specific exon in the mouse NCAM gene.
Volume: 1397
Issue: 3
Pages: 305-15
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Publication
1716358 | J:51724
First Author: Hamshere M
Year: 1991
Journal: Nucleic Acids Res
Title: The muscle specific domain of mouse N-CAM: structure and alternative splicing patterns.
Volume: 19
Issue: 17
Pages: 4709-16
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Publication
6577452 | J:37897
First Author: Hoffman S
Year: 1983
Journal: Proc Natl Acad Sci U S A
Title: Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule.
Volume: 80
Issue: 18
Pages: 5762-6
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Publication
8107803 | J:16590
First Author: Cremer H
Year: 1994
Journal: Nature
Title: Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning.
Volume: 367
Issue: 6462
Pages: 455-9
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Publication
11738028 | J:73253
First Author: Polo-Parada L
Year: 2001
Journal: Neuron
Title: Alterations in transmission, vesicle dynamics, and transmitter release machinery at NCAM-deficient neuromuscular junctions.
Volume: 32
Issue: 5
Pages: 815-28
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Publication
27661859 | J:257444
First Author: Luke MP
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: Polysialylated Neural Cell Adhesion Molecule Protects Against Light-Induced Retinal Degeneration.
Volume: 57
Issue: 11
Pages: 5066-5075
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Publication
22361116 | J:181837
 
First Author: Jürgenson M
Year: 2012
Journal: Brain Res
Title: Partial reduction in neural cell adhesion molecule (NCAM) in heterozygous mice induces depression-related behaviour without cognitive impairment.
Volume: 1447
Pages: 106-18
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Publication
22683856 | J:187071
First Author: Shi Y
Year: 2012
Journal: Exp Cell Res
Title: Neural cell adhesion molecule modulates mesenchymal stromal cell migration via activation of MAPK/ERK signaling.
Volume: 318
Issue: 17
Pages: 2257-67
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Publication
11860275 | J:75427
First Author: Decker L
Year: 2002
Journal: Mol Cell Neurosci
Title: Loss of polysialic residues accelerates CNS neural precursor differentiation in pathological conditions.
Volume: 19
Issue: 2
Pages: 225-38
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Publication
20530553 | J:162648
First Author: Zumsteg A
Year: 2010
Journal: Carcinogenesis
Title: A bioluminescent mouse model of pancreatic {beta}-cell carcinogenesis.
Volume: 31
Issue: 8
Pages: 1465-74
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Publication
27236020 | J:260987
 
First Author: Westphal N
Year: 2016
Journal: Mol Cell Neurosci
Title: Polysialic acid enters the cell nucleus attached to a fragment of the neural cell adhesion molecule NCAM to regulate the circadian rhythm in mouse brain.
Volume: 74
Pages: 114-27
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Publication
29175953 | J:258469
First Author: Hata K
Year: 2018
Journal: J Neurosci
Title: Distinct Roles of Different Presynaptic and Postsynaptic NCAM Isoforms in Early Motoneuron-Myotube Interactions Required for Functional Synapse Formation.
Volume: 38
Issue: 2
Pages: 498-510
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Publication
10440734 | J:57426
First Author: Stork O
Year: 1999
Journal: J Neurobiol
Title: Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice.
Volume: 40
Issue: 3
Pages: 343-55
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Publication
15728848 | J:97409
First Author: Franz CK
Year: 2005
Journal: J Neurosci
Title: Polysialylated neural cell adhesion molecule is necessary for selective targeting of regenerating motor neurons.
Volume: 25
Issue: 8
Pages: 2081-91
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Publication
26999607 | J:234709
First Author: Deborde S
Year: 2016
Journal: J Clin Invest
Title: Schwann cells induce cancer cell dispersion and invasion.
Volume: 126
Issue: 4
Pages: 1538-54
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Publication
18329813 | J:135413
First Author: Potschka H
Year: 2008
Journal: Neuroscience
Title: Deficiency of neural cell adhesion molecule or its polysialylation modulates pharmacological effects of the AMPA receptor antagonist NBQX.
Volume: 152
Issue: 4
Pages: 1093-8
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Publication
9789073 | J:50572
First Author: Cremer H
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Long-term but not short-term plasticity at mossy fiber synapses is impaired in neural cell adhesion molecule-deficient mice.
Volume: 95
Issue: 22
Pages: 13242-7
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Publication
15574770 | J:94451
First Author: Crnic I
Year: 2004
Journal: Cancer Res
Title: Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis.
Volume: 64
Issue: 23
Pages: 8630-8
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Publication
14754871 | J:106318
First Author: Troncoso E
Year: 2004
Journal: Cereb Cortex
Title: Recovery of evoked potentials, metabolic activity and behavior in a mouse model of somatosensory cortex lesion: role of the neural cell adhesion molecule (NCAM).
Volume: 14
Issue: 3
Pages: 332-41
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Publication
17971410 | J:130267
First Author: Diestel S
Year: 2007
Journal: J Cell Sci
Title: NCAM is ubiquitylated, endocytosed and recycled in neurons.
Volume: 120
Issue: Pt 22
Pages: 4035-49
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Publication
12351709 | J:79210
First Author: Rolf B
Year: 2002
Journal: J Neurosci
Title: Pathfinding errors of corticospinal axons in neural cell adhesion molecule-deficient mice.
Volume: 22
Issue: 19
Pages: 8357-62
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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