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Search results 1 to 100 out of 254 for Nck1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: Cytoplasmic protein NCK1 (NCK1) is a non-enzymatic adaptor protein composed of three SH3 (Src homology 3) domains and a C-terminal SH2 domain []. There aretwo vertebrate NCK proteins, NCK1 and NCK2.NCK1 mediates receptor tyrosine kinase signalling and modulates eIF2alphaSer51 phosphorylation by a subset of eIF2alpha kinases [, ]. NCK1 also mediates signalling from the ER membrane compartment [].
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Kebache S
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Modulation of protein translation by Nck-1.
Volume: 99
Issue: 8
Pages: 5406-11
Publication
First Author: Kebache S
Year: 2004
Journal: J Biol Chem
Title: Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation.
Volume: 279
Issue: 10
Pages: 9662-71
Gene
Type: gene
Organism: human
Protein
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
Publication
First Author: Cardin E
Year: 2007
Journal: FEBS J
Title: Nck-1 selectively modulates eIF2alphaSer51 phosphorylation by a subset of eIF2alpha-kinases.
Volume: 274
Issue: 22
Pages: 5865-75
Publication
First Author: Aryal AC
Year: 2013
Journal: J Cell Physiol
Title: Nck1 deficiency accelerates unloading-induced bone loss.
Volume: 228
Issue: 7
Pages: 1397-403
Protein
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true
Publication
First Author: Alfaidi M
Year: 2020
Journal: J Clin Invest
Title: Selective role of Nck1 in atherogenic inflammation and plaque formation.
Volume: 130
Issue: 8
Pages: 4331-4347
Publication
First Author: Round JE
Year: 2011
Journal: Mol Cell Neurosci
Title: The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology.
Volume: 47
Issue: 4
Pages: 265-73
Publication  
First Author: Diab A
Year: 2020
Journal: Neuroscience
Title: NCK1 Regulates Amygdala Activity to Control Context-dependent Stress Responses and Anxiety in Male Mice.
Volume: 448
Pages: 107-125
Publication
First Author: Latreille M
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Deletion of Nck1 attenuates hepatic ER stress signaling and improves glucose tolerance and insulin signaling in liver of obese mice.
Volume: 300
Issue: 3
Pages: E423-34
Publication
First Author: Ruusala A
Year: 2008
Journal: J Biol Chem
Title: Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.
Volume: 283
Issue: 44
Pages: 30034-44
Publication
First Author: Stylli SS
Year: 2009
Journal: J Cell Sci
Title: Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.
Volume: 122
Issue: Pt 15
Pages: 2727-40
Publication
First Author: Fawcett JP
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Nck adaptor proteins control the organization of neuronal circuits important for walking.
Volume: 104
Issue: 52
Pages: 20973-8
Publication
First Author: Alfaidi M
Year: 2020
Journal: J Am Heart Assoc
Title: Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability.
Volume: 9
Issue: 11
Pages: e016099
Publication
First Author: Hu T
Year: 2009
Journal: Biochemistry
Title: Regulation of process retraction and cell migration by EphA3 is mediated by the adaptor protein Nck1.
Volume: 48
Issue: 27
Pages: 6369-78
Publication  
First Author: Bywaters BC
Year: 2022
Journal: Front Cardiovasc Med
Title: Endothelial NCK2 promotes atherosclerosis progression in male but not female Nck1-null atheroprone mice.
Volume: 9
Pages: 955027
Publication
First Author: Aryal A C S
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Nck influences preosteoblastic/osteoblastic migration and bone mass.
Volume: 112
Issue: 50
Pages: 15432-7
Publication      
First Author: Bywaters BC
Year: 2022
Journal: bioRxiv
Title: Endothelial NCK2 Promotes Atherosclerosis Progression in Male but not Female Nck1-null Atheroprone Mice.
Publication
First Author: Lapetina S
Year: 2009
Journal: J Cell Biol
Title: Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion.
Volume: 185
Issue: 3
Pages: 503-19
Publication
First Author: Bladt F
Year: 2003
Journal: Mol Cell Biol
Title: The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network.
Volume: 23
Issue: 13
Pages: 4586-97
Publication
First Author: Lane C
Year: 2015
Journal: J Neurochem
Title: NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits.
Volume: 134
Issue: 6
Pages: 1008-14
Publication
First Author: Dubrac A
Year: 2016
Journal: Circulation
Title: Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization.
Volume: 133
Issue: 4
Pages: 409-21
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Park D
Year: 1997
Journal: Mol Cells
Title: Cloning, sequencing, and overexpression of SH2/SH3 adaptor protein Nck from mouse thymus.
Volume: 7
Issue: 2
Pages: 231-6
Publication
First Author: Nguyên DT
Year: 2004
Journal: Mol Biol Cell
Title: Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress.
Volume: 15
Issue: 9
Pages: 4248-60
Publication
First Author: Ditlev JA
Year: 2012
Journal: J Cell Biol
Title: Stoichiometry of Nck-dependent actin polymerization in living cells.
Volume: 197
Issue: 5
Pages: 643-58
Publication
First Author: Pauls SD
Year: 2020
Journal: Biochem Biophys Res Commun
Title: SHIP interacts with adaptor protein Nck and restricts actin turnover in B cells.
Volume: 527
Issue: 1
Pages: 207-212
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3663593
Age: postnatal week 6-8
Specimen Label: Spleen
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3663593
Age: postnatal week 6-8
Specimen Label: Thymus
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3663593
Age: postnatal week 6-8
Specimen Label: Brain
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3663593
Age: postnatal week 6-8
Specimen Label: Kidney
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3663593
Age: postnatal week 6-8
Specimen Label: Lung
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3663593
Age: postnatal week 6-8
Specimen Label: Heart
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3663593
Age: postnatal week 6-8
Specimen Label: Muscle
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3663596
Age: postnatal week 6-8
Specimen Label: wt Spleen
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3663596
Age: postnatal week 6-8
Specimen Label: wt Thymus
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3663596
Age: postnatal week 6-8
Specimen Label: wt Brain
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3663596
Age: postnatal week 6-8
Specimen Label: wt Kidney
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3663596
Age: postnatal week 6-8
Specimen Label: wt Lung
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3663596
Age: postnatal week 6-8
Specimen Label: wt Heart
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3663596
Age: postnatal week 6-8
Specimen Label: wt Muscle
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3663596
Age: postnatal week 6-8
Specimen Label: wt Liver
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3663592
Assay Type: Western blot
Annotation Date: 2006-10-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3663593
Age: postnatal week 6-8
Specimen Label: Liver
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1329113
Assay Type: Northern blot
Annotation Date: 2008-10-02
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3809267
Age: postnatal adult
Image: 1
Specimen Label: H
Specimen Num: 1
GXD Expression      
Probe: MGI:1329113
Assay Type: Northern blot
Annotation Date: 2008-10-02
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3809267
Age: postnatal adult
Image: 1
Specimen Label: B
Specimen Num: 2
GXD Expression      
Probe: MGI:1329113
Assay Type: Northern blot
Annotation Date: 2008-10-02
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3809267
Age: postnatal adult
Image: 1
Specimen Label: S
Specimen Num: 3
GXD Expression      
Probe: MGI:1329113
Assay Type: Northern blot
Annotation Date: 2008-10-02
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3809267
Age: postnatal adult
Image: 1
Specimen Label: L
Specimen Num: 4
GXD Expression      
Probe: MGI:1329113
Assay Type: Northern blot
Annotation Date: 2008-10-02
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3809267
Age: postnatal adult
Image: 1
Specimen Label: Li
Specimen Num: 5
GXD Expression      
Probe: MGI:1329113
Assay Type: Northern blot
Annotation Date: 2008-10-02
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3809267
Age: postnatal adult
Image: 1
Specimen Label: Sk
Specimen Num: 6
GXD Expression      
Probe: MGI:1329113
Assay Type: Northern blot
Annotation Date: 2008-10-02
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3809267
Age: postnatal adult
Image: 1
Specimen Label: K
Specimen Num: 7
GXD Expression      
Probe: MGI:1329113
Assay Type: Northern blot
Annotation Date: 2008-10-02
Strength: Not Specified
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3809267
Age: postnatal adult
Image: 1
Specimen Label: T
Specimen Num: 8
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691189
Age: postnatal adult
Image: UC Davis_1885740
Note: kidney
Specimen Label: UC Davis_1885740
Detected: true
Specimen Num: 1
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691189
Age: postnatal adult
Image: UC Davis_1885741
Note: kidney
Specimen Label: UC Davis_1885741
Detected: true
Specimen Num: 2
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691189
Age: postnatal adult
Image: UC Davis_1885746
Note: kidney
Specimen Label: UC Davis_1885746
Detected: true
Specimen Num: 6
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1619828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691189
Age: postnatal adult
Image: UC Davis_1885747
Specimen Label: UC Davis_1885747
Detected: true
Specimen Num: 7
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1634217
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3663632
Age: embryonic day 10.5
Specimen Label: 6c
Detected: true
Specimen Num: 7
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-10-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1616617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3663632
Age: embryonic day 10.5
Note: Expression is in motorneurons.
Specimen Label: 6a
Detected: true
Specimen Num: 5
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691189
Age: postnatal adult
Image: UC Davis_1885755
Note: vas deferens
Specimen Label: UC Davis_1885755
Detected: true
Specimen Num: 14
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1686017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3663632
Age: embryonic day 10.5
Specimen Label: 6b
Detected: true
Specimen Num: 6
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-10-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3663632
Age: embryonic day 10.5
Specimen Label: 6a
Detected: true
Specimen Num: 5
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-10-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1608513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3663632
Age: embryonic day 8.5
Specimen Label: 4b
Detected: true
Specimen Num: 2
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-10-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1608513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3663632
Age: embryonic day 8.5
Specimen Label: 4c
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-10-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3663632
Age: embryonic day 8.5
Note: Staining is throughout the embryo.
Specimen Label: 5j
Detected: true
Specimen Num: 4
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-10-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603911
Pattern: Uniform
Stage: TS11
Assay Id: MGI:3663632
Age: embryonic day 7.5
Specimen Label: 4a
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-10-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3663632
Age: embryonic day 8.5
Note: Expression is weak throughout the embryo.
Specimen Label: 4b
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-10-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3663632
Age: embryonic day 8.5
Note: Expression is weak throughout the embryo.
Specimen Label: 4c
Detected: true
Specimen Num: 3
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2006-10-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1604211
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:3663632
Age: embryonic day 7.5
Specimen Label: 4a
Detected: true
Specimen Num: 1