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Search results 1 to 100 out of 734 for Ndrg1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: N-myc downstream regulated gene (NDRG) family members are characterised by an alpha/beta hydrolase-fold motif. NDRG proteins may function as tumour suppressors and may also play important roles in the development of neurological and electrophysiological diseases [, ]. This entry represents NDRG1. The C-terminal region of NDRG1 contains three 10-aa (GTRSRSHTSE) tandem repeats, which are absent in the other family members and may be crucial for its function. NDRG1 is implicated in placentation and is involved in the development of the urinary and reproductive organs of the embryos. NDRG1 also functions in mast cell inflammatory processes []. NDRG1 is expressed in Purkinje cells in the cerebellum and in the cytoplasm of myelinating Schwann cells in peripheral nerves []. NDRG1 has been links to several diseases, such as hereditary motor and sensory neuropathy-Lom (HMSNL) []and Schwann cell dysfunction []. The expression of NDRG1 is down-regulated in certain cancer types, but up-regulated in other cancer types. This suggests that NDRG1 has tissue-specific functions in various cancer types []. NDRG1 is necessary for p53-dependent apoptosis []. It is also a Rab4a effector involved in vesicular recycling of the adhesion molecule E-cadherin [].
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Okuda T
Year: 2004
Journal: Mol Cell Biol
Title: Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves.
Volume: 24
Issue: 9
Pages: 3949-56
Protein
Organism: Mus musculus/domesticus
Length: 53  
Fragment?: true
Publication
First Author: Stein S
Year: 2004
Journal: J Biol Chem
Title: NDRG1 is necessary for p53-dependent apoptosis.
Volume: 279
Issue: 47
Pages: 48930-40
Protein
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
Publication
First Author: King RH
Year: 2011
Journal: Neurobiol Dis
Title: Ndrg1 in development and maintenance of the myelin sheath.
Volume: 42
Issue: 3
Pages: 368-80
GXD Expression  
Probe: MGI:3713684
Assay Type: RNA in situ
Annotation Date: 2007-07-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607511
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:3713795
Age: embryonic day 7.5
Image: 2 Ndrg1 E7.5
Specimen Label: 2 Ndrg1 E7.5
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:3713684
Assay Type: RNA in situ
Annotation Date: 2007-07-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160659
Pattern: Regionally restricted
Stage: TS09
Assay Id: MGI:3713795
Age: embryonic day 6.5
Image: 2 Ndrg1 E6.5
Note: Uniform expression throughout the extraembryonic ectoderm but more strongly expressed within the labyrinth of the ectoplacental cone.
Specimen Label: 2 Ndrg1 E6.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3713684
Assay Type: RNA in situ
Annotation Date: 2007-07-05
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1611311
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:3713795
Age: embryonic day 7.5
Image: 2 Ndrg1 E7.5
Specimen Label: 2 Ndrg1 E7.5
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:3713684
Assay Type: RNA in situ
Annotation Date: 2007-07-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160427
Pattern: Regionally restricted
Stage: TS07
Assay Id: MGI:3713795
Age: embryonic day 5.5
Image: 2 Ndrg1 E5.5
Note: Uniform expression throughout the extraembryonic ectoderm but more strongly expressed within the labyrinth of the ectoplacental cone.
Specimen Label: 2 Ndrg1 E5.5
Detected: true
Specimen Num: 1
Publication
First Author: Kalaydjieva L
Year: 2000
Journal: Am J Hum Genet
Title: N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom.
Volume: 67
Issue: 1
Pages: 47-58
Publication
First Author: Kachhap SK
Year: 2007
Journal: PLoS One
Title: The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin.
Volume: 2
Issue: 9
Pages: e844
Publication
First Author: Hwang J
Year: 2011
Journal: J Biol Chem
Title: Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor.
Volume: 286
Issue: 14
Pages: 12450-60
Publication
First Author: Melotte V
Year: 2010
Journal: FASEB J
Title: The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications.
Volume: 24
Issue: 11
Pages: 4153-66
Publication
First Author: Watari K
Year: 2020
Journal: Commun Biol
Title: NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells.
Volume: 3
Issue: 1
Pages: 107
Publication
First Author: Larkin J
Year: 2014
Journal: Endocrinology
Title: NDRG1 deficiency attenuates fetal growth and the intrauterine response to hypoxic injury.
Volume: 155
Issue: 3
Pages: 1099-106
Publication
First Author: Lin TM
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone.
Volume: 94
Issue: 10
Pages: 4988-93
Publication
First Author: Shimono A
Year: 1999
Journal: Mech Dev
Title: N-myc-dependent repression of ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant.
Volume: 83
Issue: 1-2
Pages: 39-52
Publication
First Author: Taketomi Y
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Identification of NDRG1 as an early inducible gene during in vitro maturation of cultured mast cells.
Volume: 306
Issue: 2
Pages: 339-46
Publication
First Author: Hodgson R
Year: 2022
Journal: Commun Biol
Title: NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance.
Volume: 5
Issue: 1
Pages: 1216
Publication  
First Author: Watari K
Year: 2016
Journal: Sci Rep
Title: Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.
Volume: 6
Pages: 19470
Publication  
First Author: Oh YM
Year: 2015
Journal: Nat Commun
Title: Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2.
Volume: 6
Pages: 8698
Publication
First Author: Hunter M
Year: 2005
Journal: Biochem Biophys Res Commun
Title: NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24.
Volume: 332
Issue: 4
Pages: 982-92
Publication
First Author: Meng N
Year: 2019
Journal: Mol Reprod Dev
Title: Decreased NDRG1 expression is associated with pregnancy loss in mice and attenuates the in vitro decidualization of endometrial stromal cells.
Volume: 86
Issue: 9
Pages: 1210-1223
UniProt Feature
Begin: 2
Description: Protein NDRG1
Type: chain
End: 394
Publication  
First Author: Chandler D
Year: 2013
Journal: F1000Res
Title: The stretcher spontaneous neurodegenerative mutation models Charcot-Marie-Tooth disease type 4D.
Volume: 2
Pages: 46
Publication
First Author: Marechal D
Year: 2022
Journal: Glia
Title: N-myc downstream regulated family member 1 (NDRG1) is enriched in myelinating oligodendrocytes and impacts myelin degradation in response to demyelination.
Volume: 70
Issue: 2
Pages: 321-336
Publication  
First Author: Futatsugi K
Year: 2016
Journal: Sci Rep
Title: Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules.
Volume: 6
Pages: 36533
Publication
First Author: Heller BA
Year: 2014
Journal: J Cell Biol
Title: Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system.
Volume: 204
Issue: 7
Pages: 1219-36
Publication
First Author: Taketomi Y
Year: 2007
Journal: J Immunol
Title: Impaired mast cell maturation and degranulation and attenuated allergic responses in Ndrg1-deficient mice.
Volume: 178
Issue: 11
Pages: 7042-53
Publication
First Author: Shrestha S
Year: 2018
Journal: Sci Rep
Title: Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption.
Volume: 8
Issue: 1
Pages: 16451
Publication
First Author: Sugahara S
Year: 2019
Journal: J Am Soc Nephrol
Title: Protein O-GlcNAcylation Is Essential for the Maintenance of Renal Energy Homeostasis and Function via Lipolysis during Fasting and Diabetes.
Volume: 30
Issue: 6
Pages: 962-978
Publication
First Author: Jiang LT
Year: 2022
Journal: Mol Cell Biol
Title: Aberrant Neuregulin 1/ErbB Signaling in Charcot-Marie-Tooth Type 4D Disease.
Volume: 42
Issue: 7
Pages: e0055921
Publication
First Author: Kawakami R
Year: 2021
Journal: J Pathol
Title: Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury.
Volume: 255
Issue: 4
Pages: 362-373
Publication
First Author: Okuda T
Year: 2008
Journal: J Histochem Cytochem
Title: Differential expression patterns of NDRG family proteins in the central nervous system.
Volume: 56
Issue: 2
Pages: 175-82
Publication
First Author: Endo T
Year: 2015
Journal: J Pathol
Title: Exploring the origin and limitations of kidney regeneration.
Volume: 236
Issue: 2
Pages: 251-63
Publication
First Author: Tomita I
Year: 2020
Journal: Cell Metab
Title: SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition.
Volume: 32
Issue: 3
Pages: 404-419.e6
Publication
First Author: Takeshita A
Year: 2018
Journal: Sci Rep
Title: Central role of the proximal tubular αKlotho/FGF receptor complex in FGF23-regulated phosphate and vitamin D metabolism.
Volume: 8
Issue: 1
Pages: 6917
Publication
First Author: Lim M
Year: 2019
Journal: Reprod Fertil Dev
Title: Haemoglobin expression in in vivo murine preimplantation embryos suggests a role in oxygen-regulated gene expression.
Volume: 31
Issue: 4
Pages: 724-734
Publication
First Author: Yamamoto T
Year: 2016
Journal: Autophagy
Title: Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule.
Volume: 12
Issue: 5
Pages: 801-13
Publication
First Author: Yamamoto T
Year: 2017
Journal: J Am Soc Nephrol
Title: High-Fat Diet-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney.
Volume: 28
Issue: 5
Pages: 1534-1551
Publication
First Author: Dominick G
Year: 2017
Journal: Aging Cell
Title: mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.
Volume: 16
Issue: 1
Pages: 52-60
Publication
First Author: Mori KP
Year: 2017
Journal: J Am Soc Nephrol
Title: Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.
Volume: 28
Issue: 1
Pages: 278-289
Publication
First Author: Choi J
Year: 2020
Journal: Cell Stem Cell
Title: Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration.
Volume: 27
Issue: 3
Pages: 366-382.e7
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:3037917
Assay Type: Northern blot
Annotation Date: 2004-04-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3037929
Age: embryonic day 9.5
Image: 4
Specimen Label: 9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3037917
Assay Type: Northern blot
Annotation Date: 2004-04-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3037929
Age: embryonic day 10.5
Image: 4
Specimen Label: 10.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3037917
Assay Type: Northern blot
Annotation Date: 2004-04-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3037929
Age: embryonic day 11.5
Image: 4
Specimen Label: 11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3037917
Assay Type: Northern blot
Annotation Date: 2004-04-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3037929
Age: embryonic day 12.5
Image: 4
Specimen Label: 12.5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3037917
Assay Type: Northern blot
Annotation Date: 2004-04-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3037929
Age: embryonic day 13.5
Image: 4
Specimen Label: 13.5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3037917
Assay Type: Northern blot
Annotation Date: 2004-04-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3037929
Age: embryonic day 15.5
Image: 4
Specimen Label: 15.5
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3037917
Assay Type: Northern blot
Annotation Date: 2004-04-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3037929
Age: embryonic day 17.5
Image: 4
Specimen Label: 17.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5288870
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289504
Age: embryonic day 1.5
Specimen Label: 2-cell-A1-1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5288870
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289504
Age: embryonic day 1.5
Specimen Label: 2-cell-A1-2
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:5288870
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289504
Age: embryonic day 1.5
Specimen Label: 2-cell-A2-1
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:5288870
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289504
Age: embryonic day 1.5
Specimen Label: 2-cell-A2-2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:5288870
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289504
Age: embryonic day 1.5
Specimen Label: 2-cell-B1-1
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:5288870
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289504
Age: embryonic day 1.5
Specimen Label: 2-cell-B1-2
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:5288870
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289504
Age: embryonic day 1.5
Specimen Label: 2-cell-B2-1
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:5288870
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289504
Age: embryonic day 1.5
Specimen Label: 2-cell-B2-2
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:5288870
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289504
Age: embryonic day 1.5
Specimen Label: 2-cell-C1-1
Detected: false
Specimen Num: 9
GXD Expression      
Probe: MGI:5288870
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289504
Age: embryonic day 1.5
Specimen Label: 2-cell-C1-2
Detected: false
Specimen Num: 10
GXD Expression      
Probe: MGI:5288870
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289504
Age: embryonic day 1.5
Specimen Label: 2-cell-C2-1
Detected: false
Specimen Num: 11
GXD Expression      
Probe: MGI:5288870
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:5289504
Age: embryonic day 1.5
Specimen Label: 2-cell-C2-2
Detected: false
Specimen Num: 12