|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 906 for Ndrg2

<< First    < Previous  |  Next >    Last >>
0.039s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: N-myc downstream regulated gene (NDRG) family members are characterised by an alpha/beta hydrolase-fold motif. NDRG proteins may function as tumour suppressors and may also play important roles in the development of neurological and electrophysiological diseases [, ]. This entry represents NDRG2. NDRG2 is expressed during dendritic cell (DC) differentiation, and silencing NDRG2 in DCs reduces the ability to induce T-cell proliferation [, ]. NDRG2 is also expressed in the central nervous system and may function in neural differentiation, synapse formation, and axon survival in response to glucocorticoids []. NDRG2 is associated with Alzheimer's disease []. The down-regulation of NDRG2 has been shown in a variety of human cancer cell lines and primary tumours []. The structure of NDRG2 has been solved [].
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Mitchelmore C
Year: 2004
Journal: Neurobiol Dis
Title: NDRG2: a novel Alzheimer's disease associated protein.
Volume: 16
Issue: 1
Pages: 48-58
Protein
Organism: Mus musculus/domesticus
Length: 63  
Fragment?: true
Publication
First Author: Choi SC
Year: 2003
Journal: FEBS Lett
Title: Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells.
Volume: 553
Issue: 3
Pages: 413-8
Protein
Organism: Mus musculus/domesticus
Length: 371  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 273  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
Publication
First Author: Choi SC
Year: 2008
Journal: J Leukoc Biol
Title: Expression of human NDRG2 by myeloid dendritic cells inhibits down-regulation of activated leukocyte cell adhesion molecule (ALCAM) and contributes to maintenance of T cell stimulatory activity.
Volume: 83
Issue: 1
Pages: 89-98
Publication
First Author: Hwang J
Year: 2011
Journal: J Biol Chem
Title: Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor.
Volume: 286
Issue: 14
Pages: 12450-60
Publication
First Author: Nichols NR
Year: 2005
Journal: Brain Res Brain Res Rev
Title: Glucocorticoid regulation of glial responses during hippocampal neurodegeneration and regeneration.
Volume: 48
Issue: 2
Pages: 287-301
GXD Expression  
Probe: MGI:5306965
Assay Type: RNA in situ
Annotation Date: 2012-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5307013
Age: embryonic day 14.5
Image: S4 Ndrg2 ISH
Specimen Label: S4 Ndrg2 ISH
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3507258
Assay Type: RNA in situ
Annotation Date: 2021-03-30
Strength: Present
Sex: Female
Emaps: EMAPS:3152723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6513176
Age: embryonic day 15.5
Image: 6 - Ndrg2
Note: Restricted expression is observed.
Specimen Label: 6 - Ndrg2
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:4416462
Assay Type: RNA in situ
Annotation Date: 2021-03-31
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3152722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6514160
Age: embryonic day 14.5
Image: 8D - Ndrg2
Note: Expression is seen in proximity to the nephric duct and ureter insertions sites where the bladder neck joins the urethra.
Specimen Label: 8D - Ndrg2
Detected: true
Specimen Num: 1
Publication
First Author: Hu XL
Year: 2006
Journal: Cell Tissue Res
Title: Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues.
Volume: 325
Issue: 1
Pages: 67-76
Publication
First Author: Melotte V
Year: 2010
Journal: FASEB J
Title: The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications.
Volume: 24
Issue: 11
Pages: 4153-66
Publication
First Author: Zhu H
Year: 2012
Journal: Dev Biol
Title: Ndrg2 regulates vertebral specification in differentiating somites.
Volume: 369
Issue: 2
Pages: 308-18
Publication
First Author: Le TM
Year: 2018
Journal: J Neurochem
Title: Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis.
Volume: 145
Issue: 2
Pages: 139-153
Publication  
First Author: Wei M
Year: 2020
Journal: EBioMedicine
Title: NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis.
Volume: 61
Pages: 103068
Publication
First Author: Zhu J
Year: 2020
Journal: Mol Med Rep
Title: NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1.
Volume: 22
Issue: 4
Pages: 3103-3110
Publication
First Author: Yin A
Year: 2020
Journal: Transl Stroke Res
Title: NDRG2 Protects the Brain from Excitotoxicity by Facilitating Interstitial Glutamate Uptake.
Volume: 11
Issue: 2
Pages: 214-227
Publication  
First Author: Nakahata S
Year: 2014
Journal: Nat Commun
Title: Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.
Volume: 5
Pages: 3393
Publication
First Author: Zhang M
Year: 2017
Journal: FEBS Lett
Title: NDRG2 acts as a PERK co-factor to facilitate PERK branch and ERS-induced cell death.
Volume: 591
Issue: 21
Pages: 3670-3681
Publication
First Author: Tamura T
Year: 2017
Journal: Cancer Res
Title: Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential.
Volume: 77
Issue: 9
Pages: 2363-2374
Publication
First Author: Li Y
Year: 2017
Journal: J Clin Invest
Title: Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior.
Volume: 127
Issue: 12
Pages: 4270-4284
Publication
First Author: Liu S
Year: 2010
Journal: Biochim Biophys Acta
Title: NDRG2 induced by oxidized LDL in macrophages antagonizes growth factor productions via selectively inhibiting ERK activation.
Volume: 1801
Issue: 2
Pages: 106-13
Publication
First Author: Xu J
Year: 2022
Journal: J Neuroinflammation
Title: Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen-glucose deprivation conditions.
Volume: 19
Issue: 1
Pages: 314
Publication
First Author: Li M
Year: 2018
Journal: Cell Death Dis
Title: Loss of NDRG2 in liver microenvironment inhibits cancer liver metastasis by regulating tumor associate macrophages polarization.
Volume: 9
Issue: 2
Pages: 248
Publication
First Author: Liu L
Year: 2012
Journal: J Mol Histol
Title: Ndrg2 expression in neurogenic germinal zones of embryonic and postnatal mouse brain.
Volume: 43
Issue: 1
Pages: 27-35
Publication  
First Author: Zhou J
Year: 2020
Journal: Brain Res
Title: Suppression of NDRG2 alleviates brain injury after intracerebral hemorrhage through mitigating astrocyte-drived glutamate neurotoxicity via NF-κB/GLT1 signaling.
Volume: 1729
Pages: 146600
Publication
First Author: Foletta VC
Year: 2013
Journal: Biochim Biophys Acta
Title: Ndrg2 is a PGC-1α/ERRα target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes.
Volume: 1833
Issue: 12
Pages: 3112-3123
Publication
First Author: Li T
Year: 2012
Journal: Biochim Biophys Acta
Title: Up-regulation of NDRG2 through nuclear factor-kappa B is required for Leydig cell apoptosis in both human and murine infertile testes.
Volume: 1822
Issue: 2
Pages: 301-13
Publication  
First Author: Gu Y
Year: 2015
Journal: Reprod Biol Endocrinol
Title: Uterine NDRG2 expression is increased at implantation sites during early pregnancy in mice, and its down-regulation inhibits decidualization of mouse endometrial stromal cells.
Volume: 13
Pages: 49
Publication
First Author: Okuda T
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc.
Volume: 266
Issue: 1
Pages: 208-15
UniProt Feature
Begin: 2
Description: Protein NDRG2
Type: chain
End: 371
Publication
First Author: Takarada-Iemata M
Year: 2014
Journal: J Neurochem
Title: Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury.
Volume: 130
Issue: 3
Pages: 374-87
Publication  
First Author: Tao L
Year: 2020
Journal: Behav Brain Res
Title: N-myc downstream-regulated gene 2 deficiency aggravates memory impairment in Alzheimer's disease.
Volume: 379
Pages: 112384
Publication
First Author: Takarada-Iemata M
Year: 2018
Journal: Glia
Title: N-myc downstream-regulated gene 2 protects blood-brain barrier integrity following cerebral ischemia.
Volume: 66
Issue: 7
Pages: 1432-1446
Publication  
First Author: Takarada-Iemata M
Year: 2021
Journal: Neurosci Lett
Title: Abnormal social behavior and altered gene expression in mice lacking NDRG2.
Volume: 743
Pages: 135563
Publication
First Author: Foletta VC
Year: 2009
Journal: J Physiol
Title: NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors.
Volume: 587
Issue: Pt 7
Pages: 1619-34
Publication
First Author: Zhang Z
Year: 2019
Journal: J Cell Physiol
Title: N-myc downstream-regulated gene 2 controls astrocyte morphology via Rho-GTPase signaling.
Volume: 234
Issue: 11
Pages: 20847-20858
Publication
First Author: Qu X
Year: 2002
Journal: Mol Cell Biochem
Title: Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family.
Volume: 229
Issue: 1-2
Pages: 35-44
Publication
First Author: Mokhonova EI
Year: 2015
Journal: Hum Mol Genet
Title: The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2.
Volume: 24
Issue: 10
Pages: 2873-83
Publication
First Author: Okuda T
Year: 2008
Journal: J Histochem Cytochem
Title: Differential expression patterns of NDRG family proteins in the central nervous system.
Volume: 56
Issue: 2
Pages: 175-82
Protein
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Liu Z
Year: 2019
Journal: Sci Adv
Title: NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages.
Volume: 5
Issue: 2
Pages: eaav0163
GXD Expression      
Probe: MGI:3701085
Assay Type: RT-PCR
Annotation Date: 2007-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610514
Stage: TS14
Assay Id: MGI:3701200
Age: embryonic day 8.5,9.5
Specimen Label: Not shown
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5306940
Assay Type: RT-PCR
Annotation Date: 2012-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Stage: TS22
Assay Id: MGI:5307080
Age: embryonic day 14.5
Image: S4
Specimen Label: CP
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5306940
Assay Type: RT-PCR
Annotation Date: 2012-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:5307080
Age: embryonic day 14.5
Image: S4
Specimen Label: SVZ-IZ
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5306940
Assay Type: RT-PCR
Annotation Date: 2012-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271222
Stage: TS22
Assay Id: MGI:5307080
Age: embryonic day 14.5
Image: S4
Specimen Label: SVZ-IZ
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5306940
Assay Type: RT-PCR
Annotation Date: 2012-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Stage: TS22
Assay Id: MGI:5307080
Age: embryonic day 14.5
Image: S4
Specimen Label: VZ
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5696136
Assay Type: Northern blot
Annotation Date: 2015-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:5696143
Age: embryonic day 11.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5696136
Assay Type: Northern blot
Annotation Date: 2015-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:5696143
Age: embryonic day 11.5
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5696136
Assay Type: Northern blot
Annotation Date: 2015-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:5696143
Age: embryonic day 11.5
Specimen Label: -/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5696136
Assay Type: Northern blot
Annotation Date: 2015-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:5696146
Age: embryonic day 9.5
Specimen Label: 9.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5696136
Assay Type: Northern blot
Annotation Date: 2015-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5696146
Age: embryonic day 10.5
Specimen Label: 10.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5696136
Assay Type: Northern blot
Annotation Date: 2015-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:5696146
Age: embryonic day 11.5
Specimen Label: 11.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5696136
Assay Type: Northern blot
Annotation Date: 2015-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5696146
Age: embryonic day 12.5
Specimen Label: 12.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5696136
Assay Type: Northern blot
Annotation Date: 2015-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:5696146
Age: embryonic day 13.5
Specimen Label: 13.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5696136
Assay Type: Northern blot
Annotation Date: 2015-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:5696146
Age: embryonic day 15.5
Specimen Label: 15.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5780429
Assay Type: RT-PCR
Annotation Date: 2016-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:5780447
Age: embryonic day 8.5
Specimen Label: E8.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5780429
Assay Type: RT-PCR
Annotation Date: 2016-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:5780447
Age: embryonic day 9.5
Specimen Label: E9.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5780429
Assay Type: RT-PCR
Annotation Date: 2016-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5780447
Age: embryonic day 10.5
Specimen Label: E10.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5780429
Assay Type: RT-PCR
Annotation Date: 2016-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5780447
Age: embryonic day 12.5
Specimen Label: E12.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5780429
Assay Type: RT-PCR
Annotation Date: 2016-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:5780447
Age: embryonic day 13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5780429
Assay Type: RT-PCR
Annotation Date: 2016-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:5780447
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5780429
Assay Type: RT-PCR
Annotation Date: 2016-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:5780447
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5780429
Assay Type: RT-PCR
Annotation Date: 2016-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:5780447
Age: embryonic day 17.5
Specimen Label: E17.5
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5780427
Assay Type: Western blot
Annotation Date: 2016-07-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5780448
Age: postnatal adult
Specimen Label: Heart
Detected: true
Specimen Num: 1