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Search results 1 to 100 out of 246 for Ndufs4

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Type Details Score
Gene
4724 | NDUFS4
Type: gene
Organism: human
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Gene
461878 | NDUFS4
Type: gene
Organism: chimpanzee
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Gene
374122 | NDUFS4
Type: gene
Organism: chicken
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Gene
573689 | ndufs4
Type: gene
Organism: zebrafish
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Gene
704137 | NDUFS4
Type: gene
Organism: macaque, rhesus
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Gene
100125122 | ndufs4
Type: gene
Organism: frog, western clawed
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Gene
327680 | NDUFS4
Type: gene
Organism: cattle
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Gene
499529 | Ndufs4
Type: gene
Organism: rat
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Gene
479335 | NDUFS4
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1343135 | Ndufs4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
34040028 | J:306701
First Author: Shil SK
Year: 2021
Journal: Sci Rep
Title: Ndufs4 ablation decreases synaptophysin expression in hippocampus.
Volume: 11
Issue: 1
Pages: 10969
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Publication
29136012 | J:250850
First Author: Ramadasan-Nair R
Year: 2017
Journal: PLoS One
Title: Regional knockdown of NDUFS4 implicates a thalamocortical circuit mediating anesthetic sensitivity.
Volume: 12
Issue: 11
Pages: e0188087
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Publication
22430089 | J:188096
First Author: Valsecchi F
Year: 2012
Journal: Biochim Biophys Acta
Title: Metabolic consequences of NDUFS4 gene deletion in immortalized mouse embryonic fibroblasts.
Volume: 1817
Issue: 10
Pages: 1925-36
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Publication
35770802 | J:334596
First Author: Aguilar K
Year: 2022
Journal: Glia
Title: Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome.
Volume: 70
Issue: 11
Pages: 2032-2044
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Publication
21965299 | J:178864
First Author: Calvaruso MA
Year: 2012
Journal: Hum Mol Genet
Title: Mitochondrial complex III stabilizes complex I in the absence of NDUFS4 to provide partial activity.
Volume: 21
Issue: 1
Pages: 115-20
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Publication
25652399 | J:220851
First Author: Yu AK
Year: 2015
Journal: Hum Mol Genet
Title: Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse.
Volume: 24
Issue: 10
Pages: 2848-60
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Publication
32918239 | J:310481
First Author: Miller HC
Year: 2021
Journal: Mol Neurobiol
Title: Metallothionein 1 Overexpression Does Not Protect Against Mitochondrial Disease Pathology in Ndufs4 Knockout Mice.
Volume: 58
Issue: 1
Pages: 243-262
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Publication
28327638 | J:260020
 
First Author: Choi WS
Year: 2017
Journal: Sci Rep
Title: Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson's disease-like non-motor symptoms without loss of dopamine neurons.
Volume: 7
Pages: 44989
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Publication
24705922 | J:215018
First Author: Chouchani ET
Year: 2014
Journal: PLoS One
Title: Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy.
Volume: 9
Issue: 4
Pages: e94157
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Publication
11165261 | J:67810
First Author: Papa S
Year: 2001
Journal: FEBS Lett
Title: Mutation in the NDUFS4 gene of complex I abolishes cAMP-dependent activation of the complex in a child with fatal neurological syndrome.
Volume: 489
Issue: 2-3
Pages: 259-62
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Publication
32335026 | J:297197
First Author: Adjobo-Hermans MJW
Year: 2020
Journal: Biochim Biophys Acta Bioenerg
Title: NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4-/- mice and Leigh syndrome patients: A stabilizing role for NDUFAF2.
Volume: 1861
Issue: 8
Pages: 148213
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Publication
20534480 | J:161393
First Author: Quintana A
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome.
Volume: 107
Issue: 24
Pages: 10996-1001
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Publication
29501746 | J:271477
First Author: Kuksal N
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Partial loss of complex I due to NDUFS4 deficiency augments myocardial reperfusion damage by increasing mitochondrial superoxide/hydrogen peroxide production.
Volume: 498
Issue: 1
Pages: 214-220
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Publication
28883788 | J:289720
 
First Author: Chen B
Year: 2017
Journal: Front Mol Neurosci
Title: Loss of Mitochondrial Ndufs4 in Striatal Medium Spiny Neurons Mediates Progressive Motor Impairment in a Mouse Model of Leigh Syndrome.
Volume: 10
Pages: 265
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Publication
19460290 | J:192154
First Author: Ingraham CA
Year: 2009
Journal: Mitochondrion
Title: NDUFS4: creation of a mouse model mimicking a Complex I disorder.
Volume: 9
Issue: 3
Pages: 204-10
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Publication
25594180 | J:219580
First Author: Liu L
Year: 2015
Journal: Cell
Title: Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration.
Volume: 160
Issue: 1-2
Pages: 177-90
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Publication
23931755 | J:200989
First Author: Karamanlidis G
Year: 2013
Journal: Cell Metab
Title: Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure.
Volume: 18
Issue: 2
Pages: 239-50
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Publication
21383081 | J:170099
First Author: Choi WS
Year: 2011
Journal: J Cell Biol
Title: Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model.
Volume: 192
Issue: 5
Pages: 873-82
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Publication
24231806 | J:205114
First Author: Johnson SC
Year: 2013
Journal: Science
Title: mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome.
Volume: 342
Issue: 6165
Pages: 1524-8
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Publication
25446449 | J:218592
 
First Author: Song L
Year: 2015
Journal: Brain Res
Title: Mitochondrial complex I defects increase ubiquitin in substantia nigra.
Volume: 1594
Pages: 82-91
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Publication
18812510 | J:143381
First Author: Choi WS
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.
Volume: 105
Issue: 39
Pages: 15136-41
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Publication
35171275 | J:325628
 
First Author: Choi KM
Year: 2022
Journal: Endocrinology
Title: Adipose Mitochondrial Complex I Deficiency Modulates Inflammation and Glucose Homeostasis in a Sex-Dependent Manner.
Volume: 163
Issue: 4
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Publication
32488052 | J:326310
First Author: Emmerzaal TL
Year: 2020
Journal: Transl Psychiatry
Title: Impaired mitochondrial complex I function as a candidate driver in the biological stress response and a concomitant stress-induced brain metabolic reprogramming in male mice.
Volume: 10
Issue: 1
Pages: 176
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Publication
37883842 | J:342904
 
First Author: Piroli GG
Year: 2023
Journal: Redox Biol
Title: Defective function of α-ketoglutarate dehydrogenase exacerbates mitochondrial ATP deficits during complex I deficiency.
Volume: 67
Pages: 102932
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Publication
28483998 | J:242202
First Author: Ferrari M
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.
Volume: 114
Issue: 21
Pages: E4241-E4250
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Publication
26363424 | J:227501
 
First Author: de Haas R
Year: 2016
Journal: Behav Brain Res
Title: Gait analysis in a mouse model resembling Leigh disease.
Volume: 296
Pages: 191-8
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Publication
22912761 | J:189977
First Author: Quintana A
Year: 2012
Journal: PLoS One
Title: Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I.
Volume: 7
Issue: 8
Pages: e42904
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Publication
31248988 | J:281143
First Author: Gospe SM 3rd
Year: 2019
Journal: J Biol Chem
Title: Photoreceptors in a mouse model of Leigh syndrome are capable of normal light-evoked signaling.
Volume: 294
Issue: 33
Pages: 12432-12443
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Publication
33486097 | J:304102
First Author: Terburgh K
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Aberrant BCAA and glutamate metabolism linked to regional neurodegeneration in a mouse model of Leigh syndrome.
Volume: 1867
Issue: 5
Pages: 166082
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Publication
22653057 | J:190475
First Author: Quintana A
Year: 2012
Journal: J Clin Invest
Title: Fatal breathing dysfunction in a mouse model of Leigh syndrome.
Volume: 122
Issue: 7
Pages: 2359-68
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Publication
22535952 | J:186512
First Author: Leong DW
Year: 2012
Journal: J Biol Chem
Title: Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene.
Volume: 287
Issue: 24
Pages: 20652-63
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Publication
30520688 | J:272109
First Author: Schleifer G
Year: 2019
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Impaired hypoxic pulmonary vasoconstriction in a mouse model of Leigh syndrome.
Volume: 316
Issue: 2
Pages: L391-L399
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Publication
32331968 | J:305627
First Author: Johnson SC
Year: 2020
Journal: Mol Genet Metab
Title: Regional metabolic signatures in the Ndufs4(KO) mouse brain implicate defective glutamate/α-ketoglutarate metabolism in mitochondrial disease.
Volume: 130
Issue: 2
Pages: 118-132
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Publication
28916769 | J:255567
First Author: de Haas R
Year: 2017
Journal: Sci Rep
Title: Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease.
Volume: 7
Issue: 1
Pages: 11733
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Publication
31403401 | J:279128
   
First Author: Bolea I
Year: 2019
Journal: Elife
Title: Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome.
Volume: 8
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Publication
33004958 | J:297447
First Author: Wang L
Year: 2020
Journal: Sci Rep
Title: Progressive optic atrophy in a retinal ganglion cell-specific mouse model of complex I deficiency.
Volume: 10
Issue: 1
Pages: 16326
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Publication
18396137 | J:134334
First Author: Kruse SE
Year: 2008
Journal: Cell Metab
Title: Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy.
Volume: 7
Issue: 4
Pages: 312-20
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Publication
26039449 | J:226126
First Author: Civiletto G
Year: 2015
Journal: Cell Metab
Title: Opa1 overexpression ameliorates the phenotype of two mitochondrial disease mouse models.
Volume: 21
Issue: 6
Pages: 845-54
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Publication
25130399 | J:215568
First Author: Jin Z
Year: 2014
Journal: Cell Metab
Title: Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization.
Volume: 20
Issue: 3
Pages: 483-98
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Publication
37704057 | J:340761
 
First Author: Manning A
Year: 2023
Journal: Neurobiol Dis
Title: Elevated susceptibility to exogenous seizure triggers and impaired interneuron excitability in a mouse model of Leigh syndrome epilepsy.
Volume: 187
Pages: 106288
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Publication
22090423 | J:180604
First Author: Sterky FH
Year: 2012
Journal: Hum Mol Genet
Title: Altered dopamine metabolism and increased vulnerability to MPTP in mice with partial deficiency of mitochondrial complex I in dopamine neurons.
Volume: 21
Issue: 5
Pages: 1078-89
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Publication
32828307 | J:304246
First Author: Kagawa Y
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Mitochondrial dysfunction in GnRH neurons impaired GnRH production.
Volume: 530
Issue: 1
Pages: 329-335
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Publication
26070241 | J:226288
First Author: Kim HW
Year: 2015
Journal: Neurobiol Aging
Title: Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivo.
Volume: 36
Issue: 9
Pages: 2617-27
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Protein Coding Gene
MGP_CAROLIEiJ_G0018910 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020905 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020880 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020905 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020694 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1343135 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021341 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020656 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020779 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020763 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020855 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020791 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021377 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019966 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020271 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015980 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019788 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
32574562 | J:296588
First Author: McElroy GS
Year: 2020
Journal: Cell Metab
Title: NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction.
Volume: 32
Issue: 2
Pages: 301-308.e6
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Publication
35688155 | J:327615
First Author: Jung S
Year: 2022
Journal: Curr Biol
Title: Isoflurane inhibition of endocytosis is an anesthetic mechanism of action.
Volume: 32
Issue: 14
Pages: 3016-3032.e3
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Publication
30979712 | J:290745
 
First Author: Indrieri A
Year: 2019
Journal: EMBO Mol Med
Title: miR-181a/b downregulation exerts a protective action on mitochondrial disease models.
Volume: 11
Issue: 5
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Publication
34270929 | J:321686
First Author: Liu S
Year: 2021
Journal: Cell Metab
Title: Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease.
Volume: 33
Issue: 10
Pages: 1974-1987.e9
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Publication
23911619 | J:205304
 
First Author: Lee KK
Year: 2013
Journal: Free Radic Biol Med
Title: Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes.
Volume: 65
Pages: 584-94
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Publication
26276820 | J:230681
First Author: Gong G
Year: 2015
Journal: Am J Physiol Heart Circ Physiol
Title: Mitochondrial flash as a novel biomarker of mitochondrial respiration in the heart.
Volume: 309
Issue: 7
Pages: H1166-77
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Publication
26712463 | J:232864
First Author: Logan A
Year: 2016
Journal: Cell Metab
Title: Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry.
Volume: 23
Issue: 2
Pages: 379-85
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Publication
25687896 | J:234578
First Author: Alam MT
Year: 2015
Journal: Biochim Biophys Acta
Title: Skeletal muscle mitochondria of NDUFS4-/- mice display normal maximal pyruvate oxidation and ATP production.
Volume: 1847
Issue: 6-7
Pages: 526-33
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Publication
30391276 | J:270767
First Author: Terburgh K
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Metabolomics of Ndufs4-/- skeletal muscle: Adaptive mechanisms converge at the ubiquinone-cycle.
Volume: 1865
Issue: 1
Pages: 98-106
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Publication
34254587 | J:308505
   
First Author: Stokes J
Year: 2021
Journal: Elife
Title: Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics.
Volume: 10
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Publication
32070771 | J:293965
First Author: Frambach SJCM
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice.
Volume: 1866
Issue: 6
Pages: 165727
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Publication
26917594 | J:231513
First Author: Jain IH
Year: 2016
Journal: Science
Title: Hypoxia as a therapy for mitochondrial disease.
Volume: 352
Issue: 6281
Pages: 54-61
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Publication
30917721 | J:313276
First Author: Fernandez-Mosquera L
Year: 2019
Journal: Autophagy
Title: Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.
Volume: 15
Issue: 9
Pages: 1572-1591
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Publication
24508508 | J:210644
First Author: Li J
Year: 2014
Journal: Cell Metab
Title: Rapamycin: one drug, many effects.
Volume: 19
Issue: 3
Pages: 373-9
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Publication
26824698 | J:248742
First Author: Kayser EB
Year: 2016
Journal: PLoS One
Title: Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain.
Volume: 11
Issue: 1
Pages: e0148219
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Publication
32187526 | J:287118
First Author: Yang L
Year: 2020
Journal: Cell Metab
Title: Serine Catabolism Feeds NADH when Respiration Is Impaired.
Volume: 31
Issue: 4
Pages: 809-821.e6
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Publication
32483148 | J:295358
First Author: Balsa E
Year: 2020
Journal: Nat Commun
Title: Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.
Volume: 11
Issue: 1
Pages: 2714
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Publication
10747996 | J:62752
First Author: Scacco S
Year: 2000
Journal: J Biol Chem
Title: cAMP-dependent phosphorylation of the nuclear encoded 18-kDa (IP) subunit of respiratory complex I and activation of the complex in serum-starved mouse fibroblast cultures.
Volume: 275
Issue: 23
Pages: 17578-82
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Publication
25853418 | J:233404
First Author: Mayer J
Year: 2015
Journal: PLoS One
Title: Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants.
Volume: 10
Issue: 4
Pages: e0123863
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GXD Expression
GXD Expression
   
Probe: MGI:3710849
Assay Type: RT-PCR
Annotation Date: 2007-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:3710884
Age: embryonic day 2.0
Image: 3
Specimen Label: 4C
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3710849
Assay Type: RT-PCR
Annotation Date: 2007-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3710884
Age: embryonic day 3.0
Image: 3
Specimen Label: MO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3710849
Assay Type: RT-PCR
Annotation Date: 2007-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3710884
Age: embryonic day 3.5
Image: 3
Specimen Label: BL
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5310110
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5423434
Age: embryonic day 14.5
Specimen Label: EB1105; Specimen B472
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5310110
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5423434
Age: embryonic day 14.5
Specimen Label: EB1105; Specimen B472
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5310110
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423434
Age: embryonic day 14.5
Image: EB1105; Specimen B472
Specimen Label: EB1105; Specimen B472
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5310110
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423434
Age: embryonic day 14.5
Image: EB1105; Specimen B472
Specimen Label: EB1105; Specimen B472
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5310110
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423434
Age: embryonic day 14.5
Image: EB1105; Specimen B472
Specimen Label: EB1105; Specimen B472
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5310110
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:5423434
Age: embryonic day 14.5
Specimen Label: EB1105; Specimen B472
Detected: false
Specimen Num: 1
•
•
•
•
•




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