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Search results 1 to 100 out of 1836 for Nedd4

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
100496333 | nedd4
Type: gene
Organism: frog, western clawed
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Gene
4734 | NEDD4
Type: gene
Organism: human
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Gene
25489 | Nedd4
Type: gene
Organism: rat
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Gene
467689 | NEDD4
Type: gene
Organism: chimpanzee
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Gene
608738 | NEDD4
Type: gene
Organism: dog, domestic
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Gene
507781 | NEDD4
Type: gene
Organism: cattle
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Gene
415406 | NEDD4
Type: gene
Organism: chicken
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Gene
699550 | NEDD4
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:97297 | Nedd4
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:3821167
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3564522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825728
Age: embryonic day 14.5
Image: Additional file 4 Nedd4
Specimen Label: Additional file 4 Nedd4
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5306966
Assay Type: RNA in situ
Annotation Date: 2012-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5307027
Age: embryonic day 14.5
Image: S4 Nedd4 ISH
Specimen Label: S4 Nedd4 ISH
Detected: true
Specimen Num: 1
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Publication
11748237 | J:75315
First Author: Harvey KF
Year: 2002
Journal: J Biol Chem
Title: N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.
Volume: 277
Issue: 11
Pages: 9307-17
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Publication
11717310 | J:164713
First Author: Murillas R
Year: 2002
Journal: J Biol Chem
Title: Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase.
Volume: 277
Issue: 4
Pages: 2897-907
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Publication
24036464 | J:201824
 
First Author: Goh CP
Year: 2013
Journal: Neurosci Lett
Title: Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development.
Volume: 555
Pages: 225-30
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Publication
24280120 | J:315318
 
First Author: Camera D
Year: 2014
Journal: Behav Brain Res
Title: Subtle gait abnormalities in Nedd4 heterozygous mice.
Volume: 260
Pages: 15-24
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GXD Expression
GXD Expression
     
Probe: MGI:4354352
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354836
Age: embryonic day 14.5
Specimen Label: Table S5 - Nedd4
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4354352
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:4354836
Age: embryonic day 14.5
Note: Expression is present in the upper, but not the lower, cortical plate.
Specimen Label: Table S5 - Nedd4
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4354352
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354836
Age: embryonic day 14.5
Specimen Label: Table S5 - Nedd4
Detected: true
Specimen Num: 1
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Gene
9683 | N4BP1
Type: gene
Organism: human
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Gene
55728 | N4BP2
Type: gene
Organism: human
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Gene
23138 | N4BP3
Type: gene
Organism: human
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Publication
18812566 | J:207675
First Author: Cao XR
Year: 2008
Journal: Sci Signal
Title: Nedd4 controls animal growth by regulating IGF-1 signaling.
Volume: 1
Issue: 38
Pages: ra5
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Publication
27086928 | J:309340
First Author: Lu C
Year: 2016
Journal: Oncogene
Title: Intestinal knockout of Nedd4 enhances growth of Apcmin tumors.
Volume: 35
Issue: 45
Pages: 5839-5849
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Publication
36732831 | J:344550
First Author: Sun W
Year: 2023
Journal: Cell Commun Signal
Title: NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis.
Volume: 21
Issue: 1
Pages: 29
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Publication
17544362 | J:122283
First Author: Sanchez-Perez A
Year: 2007
Journal: Biochem Biophys Res Commun
Title: GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.
Volume: 359
Issue: 3
Pages: 611-5
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Publication
26681395 | J:229488
First Author: Wiszniak S
Year: 2016
Journal: Dev Biol
Title: Cell autonomous roles of Nedd4 in craniofacial bone formation.
Volume: 410
Issue: 1
Pages: 98-107
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Publication
15060076 | J:159070
First Author: Murdaca J
Year: 2004
Journal: J Biol Chem
Title: Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation.
Volume: 279
Issue: 25
Pages: 26754-61
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Publication
10842081 | J:63185
First Author: Weston AD
Year: 2000
Journal: Mech Dev
Title: Analysis of Nedd4 expression during skeletal development in the mouse limb.
Volume: 94
Issue: 1-2
Pages: 247-50
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Publication
15123669 | J:333673
First Author: Fotia AB
Year: 2004
Journal: J Biol Chem
Title: Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.
Volume: 279
Issue: 28
Pages: 28930-5
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Publication
30816303 | J:298413
First Author: Liu Q
Year: 2019
Journal: Cell Death Differ
Title: E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation.
Volume: 26
Issue: 11
Pages: 2386-2399
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Publication
30125728 | J:267962
 
First Author: Jeon SA
Year: 2018
Journal: Bone
Title: E3-ubiquitin ligase NEDD4 enhances bone formation by removing TGFβ1-induced pSMAD1 in immature osteoblast.
Volume: 116
Pages: 248-258
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Publication
9073511 | J:39362
First Author: Kumar S
Year: 1997
Journal: Genomics
Title: cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene.
Volume: 40
Issue: 3
Pages: 435-43
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Publication
26854353 | J:314101
First Author: Noyes NC
Year: 2016
Journal: Biochemistry
Title: Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.
Volume: 55
Issue: 8
Pages: 1204-13
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Publication
28585553 | J:249718
 
First Author: Zhou Z
Year: 2017
Journal: Nat Commun
Title: NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes.
Volume: 8
Pages: 15662
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Publication
11779188 | J:73954
First Author: Flasza M
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.
Volume: 290
Issue: 1
Pages: 431-7
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Publication
35075134 | J:320185
First Author: Windley SP
Year: 2022
Journal: Cell Death Dis
Title: Loss of NEDD4 causes complete XY gonadal sex reversal in mice.
Volume: 13
Issue: 1
Pages: 75
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Publication
18931680 | J:143560
First Author: Yang B
Year: 2008
Journal: Nat Immunol
Title: Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells.
Volume: 9
Issue: 12
Pages: 1356-63
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Publication
11149908 | J:66806
First Author: Kamynina E
Year: 2001
Journal: FASEB J
Title: A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.
Volume: 15
Issue: 1
Pages: 204-214
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Publication
28029182 | J:274506
First Author: Lee JH
Year: 2017
Journal: J Bone Miner Res
Title: Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1.
Volume: 32
Issue: 5
Pages: 927-938
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Publication
33484199 | J:329578
First Author: Hirata H
Year: 2021
Journal: FASEB J
Title: PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking.
Volume: 35
Issue: 2
Pages: e21281
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Publication
21920314 | J:178643
First Author: Van Campenhout CA
Year: 2011
Journal: Dev Cell
Title: Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases.
Volume: 21
Issue: 3
Pages: 479-91
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Publication
23964096 | J:201065
First Author: Sun J
Year: 2013
Journal: Genes Dev
Title: E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells.
Volume: 27
Issue: 16
Pages: 1821-33
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Publication
32450490 | J:320539
 
First Author: Manning J
Year: 2020
Journal: J Proteomics
Title: Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis.
Volume: 223
Pages: 103830
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Publication
8665844 | J:33228
First Author: Staub O
Year: 1996
Journal: EMBO J
Title: WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.
Volume: 15
Issue: 10
Pages: 2371-80
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Publication
22763434 | J:196025
First Author: Guo H
Year: 2012
Journal: Cell Rep
Title: E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity.
Volume: 1
Issue: 5
Pages: 472-82
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Publication
39511974 | J:361256
First Author: Fimiani C
Year: 2025
Journal: Glia
Title: The E3 ubiquitin ligase Nedd4 fosters developmental myelination in the mouse central and peripheral nervous system.
Volume: 73
Issue: 2
Pages: 422-444
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Publication
10212229 | J:54531
First Author: Harvey KF
Year: 1999
Journal: J Biol Chem
Title: All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+.
Volume: 274
Issue: 18
Pages: 12525-30
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Publication
19706893 | J:153079
First Author: Howitt J
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.
Volume: 106
Issue: 36
Pages: 15489-94
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Publication
36002265 | J:352718
First Author: Gorla M
Year: 2022
Journal: J Neurosci
Title: A Nedd4 E3 Ubiquitin Ligase Pathway Inhibits Robo1 Repulsion and Promotes Commissural Axon Guidance across the Midline.
Volume: 42
Issue: 40
Pages: 7547-7561
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Publication
24080509 | J:203994
First Author: Wiszniak S
Year: 2013
Journal: Dev Biol
Title: The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties.
Volume: 383
Issue: 2
Pages: 186-200
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Gene
80762 | NDFIP1
Type: gene
Organism: human
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Gene
54602 | NDFIP2
Type: gene
Organism: human
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Protein
Q8R0W6
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
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Gene
23327 | NEDD4L
Type: gene
Organism: human
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Gene
146227 | BEAN1
Type: gene
Organism: human
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Gene
90634 | N4BP2L1
Type: gene
Organism: human
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Gene
10443 | N4BP2L2
Type: gene
Organism: human
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Gene
100420792 | NDFIP1P1
Type: gene
Organism: human
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Gene
108281179 | LOC108281179
Type: gene
Organism: human
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Publication
20962770 | J:244459
First Author: Ramon HE
Year: 2011
Journal: Mucosal Immunol
Title: The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility.
Volume: 4
Issue: 3
Pages: 314-24
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Publication
11042109 | J:65663
 
First Author: Jolliffe CN
Year: 2000
Journal: Biochem J
Title: Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4.
Volume: 351 Pt 3
Pages: 557-65
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Publication
9182527 | J:41090
First Author: Hatakeyama S
Year: 1997
Journal: J Biol Chem
Title: Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases.
Volume: 272
Issue: 24
Pages: 15085-92
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Publication
1378265 | J:1344
First Author: Kumar S
Year: 1992
Journal: Biochem Biophys Res Commun
Title: Identification of a set of genes with developmentally down-regulated expression in the mouse brain.
Volume: 185
Issue: 3
Pages: 1155-61
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Publication
20159449 | J:164745
First Author: Kawabe H
Year: 2010
Journal: Neuron
Title: Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.
Volume: 65
Issue: 3
Pages: 358-72
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Protein
Q91ZP6
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: true
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Publication
25631046 | J:222650
First Author: Low LH
Year: 2015
Journal: J Biol Chem
Title: Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.
Volume: 290
Issue: 11
Pages: 7141-50
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Publication
28784777 | J:244072
First Author: Li S
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.
Volume: 114
Issue: 34
Pages: E7111-E7120
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Publication
24520172 | J:206813
First Author: Altin JA
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells.
Volume: 111
Issue: 6
Pages: 2067-74
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Publication
10322449 | J:54651
First Author: Harvey KF
Year: 1999
Journal: Trends Cell Biol
Title: Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions.
Volume: 9
Issue: 5
Pages: 166-9
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Publication
28051111 | J:243853
 
First Author: Layman AAK
Year: 2017
Journal: Sci Rep
Title: Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production.
Volume: 7
Pages: 39649
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Publication
9407065 | J:44866
First Author: Ermekova KS
Year: 1997
Journal: J Biol Chem
Title: The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.
Volume: 272
Issue: 52
Pages: 32869-77
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Publication
25344756 | J:217694
First Author: Fang NN
Year: 2014
Journal: Nat Cell Biol
Title: Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress.
Volume: 16
Issue: 12
Pages: 1227-37
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Publication
10037602 | J:140385
First Author: Lu PJ
Year: 1999
Journal: Science
Title: Function of WW domains as phosphoserine- or phosphothreonine-binding modules.
Volume: 283
Issue: 5406
Pages: 1325-8
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Publication
12559917 | J:81924
First Author: Timmins J
Year: 2003
Journal: J Mol Biol
Title: Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4.
Volume: 326
Issue: 2
Pages: 493-502
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Publication
12460120 | J:82861
First Author: Gormley K
Year: 2003
Journal: Biochem J
Title: Regulation of the epithelial sodium channel by accessory proteins.
Volume: 371
Issue: Pt 1
Pages: 1-14
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Protein
Q91ZP6-2
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: true
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Publication
33993186 | J:319820
First Author: Zheng HL
Year: 2021
Journal: Cell Death Dis
Title: Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination.
Volume: 12
Issue: 5
Pages: 497
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Publication
32792353 | J:299106
First Author: Ding X
Year: 2020
Journal: Genes Dev
Title: The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation.
Volume: 34
Issue: 17-18
Pages: 1177-1189
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Publication
23897647 | J:226892
First Author: Hammond VE
Year: 2014
Journal: Cereb Cortex
Title: Ndfip1 is required for the development of pyramidal neuron dendrites and spines in the neocortex.
Volume: 24
Issue: 12
Pages: 3289-300
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Publication
22768111 | J:187910
First Author: Terabayashi T
Year: 2012
Journal: PLoS One
Title: Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development.
Volume: 7
Issue: 6
Pages: e39714
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Publication
10446181 | J:56881
First Author: Morrione A
Year: 1999
Journal: J Biol Chem
Title: mGrb10 interacts with Nedd4.
Volume: 274
Issue: 34
Pages: 24094-9
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Publication
19193720 | -
First Author: Zeng F
Year: 2009
Journal: FASEB J
Title: Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells.
Volume: 23
Issue: 6
Pages: 1935-45
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Publication
18819914 | -
First Author: Putz U
Year: 2008
Journal: J Biol Chem
Title: Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins.
Volume: 283
Issue: 47
Pages: 32621-7
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Publication
26319551 | -
First Author: Beck A
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells.
Volume: 465
Issue: 4
Pages: 851-6
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Publication
20026598 | J:159895
First Author: Fouladkou F
Year: 2010
Journal: J Biol Chem
Title: The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.
Volume: 285
Issue: 9
Pages: 6770-80
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Publication
19345204 | J:149227
First Author: Liu Y
Year: 2009
Journal: Dev Biol
Title: Abnormal development of the neuromuscular junction in Nedd4-deficient mice.
Volume: 330
Issue: 1
Pages: 153-66
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Publication
28106071 | J:255082
 
First Author: Kurogi S
Year: 2017
Journal: Sci Rep
Title: Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.
Volume: 7
Pages: 40692
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Publication
17137798 | J:116617
First Author: Oliver PM
Year: 2006
Journal: Immunity
Title: Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation.
Volume: 25
Issue: 6
Pages: 929-40
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UniProt Feature
UniProt Feature
Begin: 1
Description: E3 ubiquitin-protein ligase NEDD4
Type: chain
End: 887
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UniProt Feature
UniProt Feature
Begin: 1
Description: NEDD4 family-interacting protein 2
Type: chain
End: 311
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UniProt Feature
UniProt Feature
Begin: 2
Description: NEDD4 family-interacting protein 1
Type: chain
End: 221
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Protein Coding Gene
MGP_CAROLIEiJ_G0032420 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035017 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034998 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034990 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034699 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_97297 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035509 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034021 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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