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Search results 1 to 100 out of 773 for Nfat5

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
10725 | NFAT5
Type: gene
Organism: human
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Gene
100495532 | nfat5
Type: gene
Organism: frog, western clawed
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Gene
key_48660 | NFAT5
Type: gene
Organism: pig, domestic
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Gene
307820 | Nfat5
Type: gene
Organism: rat
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Gene
489734 | NFAT5
Type: gene
Organism: dog, domestic
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Gene
454203 | NFAT5
Type: gene
Organism: chimpanzee
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Gene
538523 | NFAT5
Type: gene
Organism: cattle
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Gene
415866 | NFAT5
Type: gene
Organism: chicken
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Gene
705518 | NFAT5
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR015646 | NFAT5
Type: Family
Description: Nuclear factor of activated T-cells 5 (NFAT5) is a member of the nuclear factors of activated T cells (NFAT) of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. NFAT5, regulated by DDX5/DDX17, plays a role in the migratory capacity of breast cancer cells []. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Five transcript variants encoding three different isoforms have been identified for this gene [].NFAT proteins appear to be regulated primarily at the level of their subcellular localisation []. They are found exclusively in the cytoplasm of resting T cells, and consist of 2 components: a pre-existing cytoplasmic component that translocates into the nucleus on calcium mobilisation, and an inducible nuclear component comprising members of the activating protein-1 (AP-1) family of transcription factors. In response to antigen receptor signalling, the calcium-regulated phosphatase calcineurin acts directly to dephosphorylate NFAT proteins, causing their rapid translocation from the cytoplasm to the nucleus, where they cooperatively bind their target.
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Protein Coding Gene
MGI:1859333 | Nfat5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12438710 | J:80792
First Author: Dalski A
Year: 2002
Journal: Cytogenet Genome Res
Title: Complete cDNA sequence, expression, alternative splicing, and genomic organization of the mouse Nfat5 gene.
Volume: 97
Issue: 3-4
Pages: 179-82
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Publication
11060450 | J:65211
First Author: Hebinck A
Year: 2000
Journal: Cytogenet Cell Genet
Title: Assignment of transcription factor NFAT5 to human chromosome 16q22.1, murine chromosome 8D and porcine chromosome 6p1.4 and comparison of the polyglutamine domains.
Volume: 90
Issue: 1-2
Pages: 68-70
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Protein
Q8VHJ6
Organism: Mus musculus/domesticus
Length: 1458  
Fragment?: false
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Publication
34956208 | J:358495
 
First Author: Muhammad K
Year: 2021
Journal: Front Immunol
Title: NFAT5 Controls the Integrity of Epidermis.
Volume: 12
Pages: 780727
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Publication
23045390 | J:192726
First Author: Jang EJ
Year: 2012
Journal: Mol Cell Biol
Title: TAZ suppresses NFAT5 activity through tyrosine phosphorylation.
Volume: 32
Issue: 24
Pages: 4925-32
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Publication
12421923 | J:80066
First Author: Trama J
Year: 2002
Journal: J Immunol
Title: The osmoprotective function of the NFAT5 transcription factor in T cell development and activation.
Volume: 169
Issue: 10
Pages: 5477-88
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Protein
Q9WV30
Organism: Mus musculus/domesticus
Length: 1534  
Fragment?: false
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Publication
22266867 | -
First Author: Germann S
Year: 2012
Journal: Oncogene
Title: Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor.
Volume: 31
Issue: 42
Pages: 4536-49
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Publication
28192374 | J:242926
First Author: Choi S
Year: 2017
Journal: J Clin Invest
Title: Transcription factor NFAT5 promotes macrophage survival in rheumatoid arthritis.
Volume: 127
Issue: 3
Pages: 954-969
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Publication
31816635 | J:289860
 
First Author: Huerga Encabo H
Year: 2020
Journal: J Exp Med
Title: The transcription factor NFAT5 limits infection-induced type I interferon responses.
Volume: 217
Issue: 3
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Publication
33806698 | J:305523
 
First Author: Gwon DH
Year: 2021
Journal: Int J Mol Sci
Title: NFAT5 Deficiency Alleviates Formalin-Induced Inflammatory Pain Through mTOR.
Volume: 22
Issue: 5
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Publication
20937271 | J:167777
First Author: Fujiki T
Year: 2010
Journal: Exp Cell Res
Title: NFAT5 regulates transcription of the mouse telomerase reverse transcriptase gene.
Volume: 316
Issue: 20
Pages: 3342-50
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Publication
11528118 | -
First Author: Dalski A
Year: 2001
Journal: Cytogenet Cell Genet
Title: Genomic organization of the human NFAT5 gene: exon-intron structure of the 14-kb transcript and CpG-island analysis of the promoter region.
Volume: 93
Issue: 3-4
Pages: 239-41
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Publication
34383982 | J:310455
First Author: Kappert L
Year: 2021
Journal: FASEB J
Title: Loss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells.
Volume: 35
Issue: 9
Pages: e21831
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Publication
22934063 | J:290910
 
First Author: Halterman JA
Year: 2012
Journal: Front Physiol
Title: NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration.
Volume: 3
Pages: 313
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Publication
14983020 | J:88636
First Author: López-Rodríguez C
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression.
Volume: 101
Issue: 8
Pages: 2392-7
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Publication
17164296 | J:117463
First Author: O'Connor RS
Year: 2007
Journal: J Cell Sci
Title: A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis.
Volume: 120
Issue: Pt 1
Pages: 149-59
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Publication
25601839 | J:232839
 
First Author: Küper C
Year: 2014
Journal: Front Physiol
Title: Generation of a conditional knockout allele for the NFAT5 gene in mice.
Volume: 5
Pages: 507
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Publication
29794013 | J:264065
First Author: Lee S
Year: 2018
Journal: J Immunol
Title: Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2.
Volume: 201
Issue: 2
Pages: 359-370
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Publication
38153851 | J:359494
First Author: Ono M
Year: 2024
Journal: Am J Physiol Renal Physiol
Title: Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice.
Volume: 326
Issue: 3
Pages: F394-F410
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Publication
19369291 | J:148695
First Author: Hao S
Year: 2009
Journal: Am J Physiol Renal Physiol
Title: Expression and function of NFAT5 in medullary thick ascending limb (mTAL) cells.
Volume: 296
Issue: 6
Pages: F1494-503
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Publication
34031145 | J:320464
First Author: Lunazzi G
Year: 2021
Journal: J Immunol
Title: NFAT5 Amplifies Antipathogen Responses by Enhancing Chromatin Accessibility, H3K27 Demethylation, and Transcription Factor Recruitment.
Volume: 206
Issue: 11
Pages: 2652-2667
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Publication
21037089 | J:166144
First Author: Berga-Bolaños R
Year: 2010
Journal: J Immunol
Title: NFAT5 regulates T lymphocyte homeostasis and CD24-dependent T cell expansion under pathologic hypernatremia.
Volume: 185
Issue: 11
Pages: 6624-35
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Publication
21228109 | J:170644
First Author: Hao S
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Differential regulation of NFAT5 by NKCC2 isoforms in medullary thick ascending limb (mTAL) cells.
Volume: 300
Issue: 4
Pages: F966-75
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Publication
23269645 | J:193276
First Author: Hao S
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: NKCC2A and NFAT5 regulate renal TNF production induced by hypertonic NaCl intake.
Volume: 304
Issue: 5
Pages: F533-42
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Publication
30413537 | J:274742
First Author: Maeoka Y
Year: 2019
Journal: J Biol Chem
Title: NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells.
Volume: 294
Issue: 1
Pages: 101-115
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190870
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Nfat5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190870
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Nfat5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190870
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Nfat5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190870
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Nfat5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190870
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Nfat5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190870
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Nfat5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190870
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Nfat5
Detected: true
Specimen Num: 7
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Publication
24389345 | J:210024
First Author: Luo Y
Year: 2014
Journal: Biochim Biophys Acta
Title: Sfmbt2 10th intron-hosted miR-466(a/e)-3p are important epigenetic regulators of Nfat5 signaling, osmoregulation and urine concentration in mice.
Volume: 1839
Issue: 2
Pages: 97-106
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Publication
34601973 | J:359493
First Author: Hiramatsu A
Year: 2021
Journal: Hypertension
Title: Salt-Sensitive Hypertension of the Renal Tubular Cell-Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice.
Volume: 78
Issue: 5
Pages: 1335-1346
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Publication
19381288 | J:148271
First Author: Drews-Elger K
Year: 2009
Journal: PLoS One
Title: The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress.
Volume: 4
Issue: 4
Pages: e5245
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Publication
31970899 | J:305682
First Author: Madonna R
Year: 2020
Journal: J Cell Mol Med
Title: Co-expression of glycosylated aquaporin-1 and transcription factor NFAT5 contributes to aortic stiffness in diabetic and atherosclerosis-prone mice.
Volume: 24
Issue: 5
Pages: 2857-2865
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Publication
31067085 | J:276943
First Author: Serman Y
Year: 2019
Journal: Am J Physiol Cell Physiol
Title: Emerging new role of NFAT5 in inducible nitric oxide synthase in response to hypoxia in mouse embryonic fibroblast cells.
Volume: 317
Issue: 1
Pages: C31-C38
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Publication
23324178 | J:194347
First Author: Zhou X
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Inhibitory phosphorylation of GSK-3β by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP).
Volume: 304
Issue: 7
Pages: F908-17
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Protein
Q80TR0
Organism: Mus musculus/domesticus
Length: 1033  
Fragment?: true
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Protein
A0A1U6URG8
Organism: Mus musculus/domesticus
Length: 1458  
Fragment?: false
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Protein
Q9JIH4
Organism: Mus musculus/domesticus
Length: 669  
Fragment?: false
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Protein
Q9JIH5
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
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Protein
Q3UZ77
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: false
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Protein
F6VCW7
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: true
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Protein
Q8C778
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
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Protein
Q3UW17
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
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Protein
Q9QXF1
Organism: Mus musculus/domesticus
Length: 688  
Fragment?: true
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Protein
F6ZRF0
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Protein
D6RH40
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: false
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Publication
10652349 | -
First Author: Porter CM
Year: 2000
Journal: J Biol Chem
Title: Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization.
Volume: 275
Issue: 5
Pages: 3543-51
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Publication
15247420 | J:91482
First Author: Go WY
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment.
Volume: 101
Issue: 29
Pages: 10673-8
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Publication
30383452 | J:287994
First Author: Arnold C
Year: 2019
Journal: FASEB J
Title: Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice.
Volume: 33
Issue: 3
Pages: 3364-3377
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Publication
21757659 | J:191847
First Author: Halterman JA
Year: 2011
Journal: Arterioscler Thromb Vasc Biol
Title: Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation.
Volume: 31
Issue: 10
Pages: 2287-96
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Publication
36197017 | J:330062
First Author: Petrillo F
Year: 2022
Journal: FASEB J
Title: Genetic deletion of the nuclear factor of activated T cells 5 in collecting duct principal cells causes nephrogenic diabetes insipidus.
Volume: 36
Issue: 11
Pages: e22583
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Publication
38426494 | J:360544
 
First Author: Li M
Year: 2024
Journal: J Clin Invest
Title: Serum amyloid A expression in liver promotes synovial macrophage activation and chronic arthritis via NFAT5.
Volume: 134
Issue: 5
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Publication
31801906 | J:287896
 
First Author: Schröder A
Year: 2019
Journal: JCI Insight
Title: Osteoprotective action of low-salt diet requires myeloid cell-derived NFAT5.
Volume: 4
Issue: 23
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Publication
30327417 | J:269768
First Author: Buxadé M
Year: 2018
Journal: J Exp Med
Title: Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.
Volume: 215
Issue: 11
Pages: 2901-2918
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Publication
23172129 | J:317821
First Author: Mak KM
Year: 2012
Journal: Neurosignals
Title: Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury.
Volume: 20
Issue: 4
Pages: 237-51
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Publication
31053298 | J:291079
First Author: Maeoka Y
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5.
Volume: 514
Issue: 2
Pages: 436-442
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Publication
23233732 | J:194299
First Author: Ueno M
Year: 2013
Journal: J Lipid Res
Title: Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress.
Volume: 54
Issue: 3
Pages: 734-43
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Publication
22312110 | J:181691
First Author: Buxadé M
Year: 2012
Journal: J Exp Med
Title: Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5.
Volume: 209
Issue: 2
Pages: 379-93
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Publication
29150563 | J:253410
First Author: Tellechea M
Year: 2018
Journal: J Immunol
Title: NFAT5-Regulated Macrophage Polarization Supports the Proinflammatory Function of Macrophages and T Lymphocytes.
Volume: 200
Issue: 1
Pages: 305-315
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Publication
36433977 | J:334717
First Author: Chernyakov D
Year: 2022
Journal: Sci Rep
Title: The nuclear factor of activated T cells 5 (NFAT5) contributes to the renal corticomedullary differences in gene expression.
Volume: 12
Issue: 1
Pages: 20304
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Publication
27080132 | J:251174
First Author: Chua OW
Year: 2016
Journal: Biochim Biophys Acta
Title: Role of nuclear factor of activated T-cells 5 in regulating hypertonic-mediated secretin receptor expression in kidney collecting duct cells.
Volume: 1859
Issue: 7
Pages: 922-32
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Publication
27479742 | J:358497
First Author: Alberdi M
Year: 2017
Journal: Immunol Cell Biol
Title: Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5.
Volume: 95
Issue: 1
Pages: 56-67
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Publication
19211510 | J:181088
First Author: Kino T
Year: 2009
Journal: Sci Signal
Title: Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.
Volume: 2
Issue: 57
Pages: ra5
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Publication
24733925 | J:208837
First Author: Dmitrieva NI
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Secretion of von Willebrand factor by endothelial cells links sodium to hypercoagulability and thrombosis.
Volume: 111
Issue: 17
Pages: 6485-90
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Publication
29298866 | J:254437
 
First Author: Serr I
Year: 2018
Journal: Sci Transl Med
Title: A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes.
Volume: 10
Issue: 422
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Publication
21765887 | J:175527
First Author: Mak MC
Year: 2011
Journal: PLoS One
Title: Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function.
Volume: 6
Issue: 7
Pages: e19186
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Publication
31301300 | J:282363
First Author: Tessier S
Year: 2019
Journal: Dev Biol
Title: NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis.
Volume: 455
Issue: 2
Pages: 369-381
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Protein Coding Gene
MGP_CAROLIEiJ_G0031534 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034099 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034079 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034005 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034072 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033784 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1859333 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034592 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033111 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033757 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033857 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034003 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033902 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
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Protein Coding Gene
MGP_NZOHlLtJ_G0034610 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0032813 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0033226 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0023134 | -
Type: protein_coding_gene
Organism: Mus pahari
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•
•
•
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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