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Search results 1 to 100 out of 766 for Nfat5

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
10725 | NFAT5
Type: gene
Organism: human
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Gene
538523 | NFAT5
Type: gene
Organism: cattle
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Gene
415866 | NFAT5
Type: gene
Organism: chicken
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Gene
705518 | NFAT5
Type: gene
Organism: macaque, rhesus
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Gene
100495532 | nfat5
Type: gene
Organism: frog, western clawed
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Gene
key_48660 | NFAT5
Type: gene
Organism: pig, domestic
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Gene
307820 | Nfat5
Type: gene
Organism: rat
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Gene
489734 | NFAT5
Type: gene
Organism: dog, domestic
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Gene
454203 | NFAT5
Type: gene
Organism: chimpanzee
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Protein Domain
IPR015646 | NFAT5
Type: Family
Description: Nuclear factor of activated T-cells 5 (NFAT5) is a member of the nuclear factors of activated T cells (NFAT) of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. NFAT5, regulated by DDX5/DDX17, plays a role in the migratory capacity of breast cancer cells []. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Five transcript variants encoding three different isoforms have been identified for this gene [].NFAT proteins appear to be regulated primarily at the level of their subcellular localisation []. They are found exclusively in the cytoplasm of resting T cells, and consist of 2 components: a pre-existing cytoplasmic component that translocates into the nucleus on calcium mobilisation, and an inducible nuclear component comprising members of the activating protein-1 (AP-1) family of transcription factors. In response to antigen receptor signalling, the calcium-regulated phosphatase calcineurin acts directly to dephosphorylate NFAT proteins, causing their rapid translocation from the cytoplasm to the nucleus, where they cooperatively bind their target.
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Protein Coding Gene
MGI:1859333 | Nfat5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12438710 | J:80792
First Author: Dalski A
Year: 2002
Journal: Cytogenet Genome Res
Title: Complete cDNA sequence, expression, alternative splicing, and genomic organization of the mouse Nfat5 gene.
Volume: 97
Issue: 3-4
Pages: 179-82
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Publication
11060450 | J:65211
First Author: Hebinck A
Year: 2000
Journal: Cytogenet Cell Genet
Title: Assignment of transcription factor NFAT5 to human chromosome 16q22.1, murine chromosome 8D and porcine chromosome 6p1.4 and comparison of the polyglutamine domains.
Volume: 90
Issue: 1-2
Pages: 68-70
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Protein
Q8VHJ6
Organism: Mus musculus/domesticus
Length: 1458  
Fragment?: false
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Publication
23045390 | J:192726
First Author: Jang EJ
Year: 2012
Journal: Mol Cell Biol
Title: TAZ suppresses NFAT5 activity through tyrosine phosphorylation.
Volume: 32
Issue: 24
Pages: 4925-32
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Publication
12421923 | J:80066
First Author: Trama J
Year: 2002
Journal: J Immunol
Title: The osmoprotective function of the NFAT5 transcription factor in T cell development and activation.
Volume: 169
Issue: 10
Pages: 5477-88
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Protein
Q9WV30
Organism: Mus musculus/domesticus
Length: 1534  
Fragment?: false
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Publication
28192374 | J:242926
First Author: Choi S
Year: 2017
Journal: J Clin Invest
Title: Transcription factor NFAT5 promotes macrophage survival in rheumatoid arthritis.
Volume: 127
Issue: 3
Pages: 954-969
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Publication
22266867 | -
First Author: Germann S
Year: 2012
Journal: Oncogene
Title: Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor.
Volume: 31
Issue: 42
Pages: 4536-49
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Publication
31816635 | J:289860
 
First Author: Huerga Encabo H
Year: 2020
Journal: J Exp Med
Title: The transcription factor NFAT5 limits infection-induced type I interferon responses.
Volume: 217
Issue: 3
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Publication
33806698 | J:305523
 
First Author: Gwon DH
Year: 2021
Journal: Int J Mol Sci
Title: NFAT5 Deficiency Alleviates Formalin-Induced Inflammatory Pain Through mTOR.
Volume: 22
Issue: 5
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Publication
20937271 | J:167777
First Author: Fujiki T
Year: 2010
Journal: Exp Cell Res
Title: NFAT5 regulates transcription of the mouse telomerase reverse transcriptase gene.
Volume: 316
Issue: 20
Pages: 3342-50
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Publication
11528118 | -
First Author: Dalski A
Year: 2001
Journal: Cytogenet Cell Genet
Title: Genomic organization of the human NFAT5 gene: exon-intron structure of the 14-kb transcript and CpG-island analysis of the promoter region.
Volume: 93
Issue: 3-4
Pages: 239-41
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Publication
34383982 | J:310455
First Author: Kappert L
Year: 2021
Journal: FASEB J
Title: Loss of Nfat5 promotes lipid accumulation in vascular smooth muscle cells.
Volume: 35
Issue: 9
Pages: e21831
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Publication
22934063 | J:290910
 
First Author: Halterman JA
Year: 2012
Journal: Front Physiol
Title: NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration.
Volume: 3
Pages: 313
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Publication
14983020 | J:88636
First Author: López-Rodríguez C
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression.
Volume: 101
Issue: 8
Pages: 2392-7
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Publication
17164296 | J:117463
First Author: O'Connor RS
Year: 2007
Journal: J Cell Sci
Title: A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis.
Volume: 120
Issue: Pt 1
Pages: 149-59
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Publication
25601839 | J:232839
 
First Author: Küper C
Year: 2014
Journal: Front Physiol
Title: Generation of a conditional knockout allele for the NFAT5 gene in mice.
Volume: 5
Pages: 507
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Publication
29794013 | J:264065
First Author: Lee S
Year: 2018
Journal: J Immunol
Title: Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2.
Volume: 201
Issue: 2
Pages: 359-370
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Publication
19369291 | J:148695
First Author: Hao S
Year: 2009
Journal: Am J Physiol Renal Physiol
Title: Expression and function of NFAT5 in medullary thick ascending limb (mTAL) cells.
Volume: 296
Issue: 6
Pages: F1494-503
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Publication
21037089 | J:166144
First Author: Berga-Bolaños R
Year: 2010
Journal: J Immunol
Title: NFAT5 regulates T lymphocyte homeostasis and CD24-dependent T cell expansion under pathologic hypernatremia.
Volume: 185
Issue: 11
Pages: 6624-35
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Publication
34031145 | J:320464
First Author: Lunazzi G
Year: 2021
Journal: J Immunol
Title: NFAT5 Amplifies Antipathogen Responses by Enhancing Chromatin Accessibility, H3K27 Demethylation, and Transcription Factor Recruitment.
Volume: 206
Issue: 11
Pages: 2652-2667
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Publication
21228109 | J:170644
First Author: Hao S
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Differential regulation of NFAT5 by NKCC2 isoforms in medullary thick ascending limb (mTAL) cells.
Volume: 300
Issue: 4
Pages: F966-75
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Publication
23269645 | J:193276
First Author: Hao S
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: NKCC2A and NFAT5 regulate renal TNF production induced by hypertonic NaCl intake.
Volume: 304
Issue: 5
Pages: F533-42
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Publication
30413537 | J:274742
First Author: Maeoka Y
Year: 2019
Journal: J Biol Chem
Title: NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells.
Volume: 294
Issue: 1
Pages: 101-115
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190870
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Nfat5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190870
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Nfat5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190870
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Nfat5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190870
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Nfat5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190870
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Nfat5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190870
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Nfat5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6178958
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190870
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Nfat5
Detected: true
Specimen Num: 7
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Publication
24389345 | J:210024
First Author: Luo Y
Year: 2014
Journal: Biochim Biophys Acta
Title: Sfmbt2 10th intron-hosted miR-466(a/e)-3p are important epigenetic regulators of Nfat5 signaling, osmoregulation and urine concentration in mice.
Volume: 1839
Issue: 2
Pages: 97-106
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Publication
19381288 | J:148271
First Author: Drews-Elger K
Year: 2009
Journal: PLoS One
Title: The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress.
Volume: 4
Issue: 4
Pages: e5245
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Publication
31970899 | J:305682
First Author: Madonna R
Year: 2020
Journal: J Cell Mol Med
Title: Co-expression of glycosylated aquaporin-1 and transcription factor NFAT5 contributes to aortic stiffness in diabetic and atherosclerosis-prone mice.
Volume: 24
Issue: 5
Pages: 2857-2865
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Publication
31067085 | J:276943
First Author: Serman Y
Year: 2019
Journal: Am J Physiol Cell Physiol
Title: Emerging new role of NFAT5 in inducible nitric oxide synthase in response to hypoxia in mouse embryonic fibroblast cells.
Volume: 317
Issue: 1
Pages: C31-C38
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Publication
23324178 | J:194347
First Author: Zhou X
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Inhibitory phosphorylation of GSK-3β by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP).
Volume: 304
Issue: 7
Pages: F908-17
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Protein
Q80TR0
Organism: Mus musculus/domesticus
Length: 1033  
Fragment?: true
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Protein
A0A1U6URG8
Organism: Mus musculus/domesticus
Length: 1458  
Fragment?: false
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Protein
Q9JIH4
Organism: Mus musculus/domesticus
Length: 669  
Fragment?: false
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Protein
Q9JIH5
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
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Protein
Q3UZ77
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: false
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Protein
F6VCW7
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: true
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Protein
Q8C778
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
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Protein
Q3UW17
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
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Protein
Q9QXF1
Organism: Mus musculus/domesticus
Length: 688  
Fragment?: true
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Protein
F6ZRF0
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Protein
D6RH40
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: false
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Publication
10652349 | -
First Author: Porter CM
Year: 2000
Journal: J Biol Chem
Title: Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization.
Volume: 275
Issue: 5
Pages: 3543-51
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Publication
30383452 | J:287994
First Author: Arnold C
Year: 2019
Journal: FASEB J
Title: Genetic ablation of NFAT5/TonEBP in smooth muscle cells impairs flow- and pressure-induced arterial remodeling in mice.
Volume: 33
Issue: 3
Pages: 3364-3377
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Publication
15247420 | J:91482
First Author: Go WY
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment.
Volume: 101
Issue: 29
Pages: 10673-8
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Publication
21757659 | J:191847
First Author: Halterman JA
Year: 2011
Journal: Arterioscler Thromb Vasc Biol
Title: Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation.
Volume: 31
Issue: 10
Pages: 2287-96
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Publication
36197017 | J:330062
First Author: Petrillo F
Year: 2022
Journal: FASEB J
Title: Genetic deletion of the nuclear factor of activated T cells 5 in collecting duct principal cells causes nephrogenic diabetes insipidus.
Volume: 36
Issue: 11
Pages: e22583
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Publication
30327417 | J:269768
First Author: Buxadé M
Year: 2018
Journal: J Exp Med
Title: Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.
Volume: 215
Issue: 11
Pages: 2901-2918
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Publication
23172129 | J:317821
First Author: Mak KM
Year: 2012
Journal: Neurosignals
Title: Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury.
Volume: 20
Issue: 4
Pages: 237-51
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Publication
31801906 | J:287896
 
First Author: Schröder A
Year: 2019
Journal: JCI Insight
Title: Osteoprotective action of low-salt diet requires myeloid cell-derived NFAT5.
Volume: 4
Issue: 23
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Publication
31053298 | J:291079
First Author: Maeoka Y
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5.
Volume: 514
Issue: 2
Pages: 436-442
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Publication
23233732 | J:194299
First Author: Ueno M
Year: 2013
Journal: J Lipid Res
Title: Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress.
Volume: 54
Issue: 3
Pages: 734-43
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Publication
29150563 | J:253410
First Author: Tellechea M
Year: 2018
Journal: J Immunol
Title: NFAT5-Regulated Macrophage Polarization Supports the Proinflammatory Function of Macrophages and T Lymphocytes.
Volume: 200
Issue: 1
Pages: 305-315
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Publication
36433977 | J:334717
First Author: Chernyakov D
Year: 2022
Journal: Sci Rep
Title: The nuclear factor of activated T cells 5 (NFAT5) contributes to the renal corticomedullary differences in gene expression.
Volume: 12
Issue: 1
Pages: 20304
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Publication
22312110 | J:181691
First Author: Buxadé M
Year: 2012
Journal: J Exp Med
Title: Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5.
Volume: 209
Issue: 2
Pages: 379-93
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Publication
27080132 | J:251174
First Author: Chua OW
Year: 2016
Journal: Biochim Biophys Acta
Title: Role of nuclear factor of activated T-cells 5 in regulating hypertonic-mediated secretin receptor expression in kidney collecting duct cells.
Volume: 1859
Issue: 7
Pages: 922-32
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Publication
19211510 | J:181088
First Author: Kino T
Year: 2009
Journal: Sci Signal
Title: Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.
Volume: 2
Issue: 57
Pages: ra5
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Publication
24733925 | J:208837
First Author: Dmitrieva NI
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Secretion of von Willebrand factor by endothelial cells links sodium to hypercoagulability and thrombosis.
Volume: 111
Issue: 17
Pages: 6485-90
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Publication
29298866 | J:254437
 
First Author: Serr I
Year: 2018
Journal: Sci Transl Med
Title: A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes.
Volume: 10
Issue: 422
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Publication
21765887 | J:175527
First Author: Mak MC
Year: 2011
Journal: PLoS One
Title: Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function.
Volume: 6
Issue: 7
Pages: e19186
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Publication
31301300 | J:282363
First Author: Tessier S
Year: 2019
Journal: Dev Biol
Title: NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis.
Volume: 455
Issue: 2
Pages: 369-381
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Protein Coding Gene
MGP_CAROLIEiJ_G0031534 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034099 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034079 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034005 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034072 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033784 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1859333 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034592 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033111 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033757 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033857 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034003 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033902 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034610 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032813 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033226 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023134 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032652 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11934689 | J:79939
First Author: Maouyo D
Year: 2002
Journal: Am J Physiol Renal Physiol
Title: Mouse TonEBP-NFAT5: expression in early development and alternative splicing.
Volume: 282
Issue: 5
Pages: F802-9
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Publication
10860829 | J:62794
First Author: Pan S
Year: 2000
Journal: Biochem Biophys Res Commun
Title: NFATz: a novel rel similarity domain containing protein.
Volume: 272
Issue: 3
Pages: 765-76
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Publication
37998347 | J:342945
 
First Author: Lee JY
Year: 2023
Journal: Cells
Title: TonEBP Haploinsufficiency Attenuates Microglial Activation and Memory Deficits in Middle-Aged and Amyloid β Oligomer-Treated Mice.
Volume: 12
Issue: 22
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Publication
31707045 | J:298041
 
First Author: Tessier S
Year: 2020
Journal: Matrix Biol
Title: TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression.
Volume: 87
Pages: 94-111
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