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Search results 1 to 100 out of 380 for Nfe2l1

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0.045s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: NFE2L1 is an endoplasmic reticulum membrane sensor which, in response to various stresses, it is released from the ER membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 []. In conditions of excess cholesterol, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, this allows the expression of genes promoting cholesterol removal []. In response to oxidative stress, Nrf1 up-regulates expression of antioxidant genes by binding to the antioxidant response elements (AREs) present in the promoter of these genes []. In humans Nrf1 exists in two forms, p120 and p110. p120 is embedded in the ER membrane, while p110 is soluble and can enter the nucleus [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Kwong M
Year: 1999
Journal: J Biol Chem
Title: The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts.
Volume: 274
Issue: 52
Pages: 37491-8
Publication
First Author: Kwong EK
Year: 2012
Journal: PLoS One
Title: Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes.
Volume: 7
Issue: 10
Pages: e48404
Publication
First Author: Widenmaier SB
Year: 2017
Journal: Cell
Title: NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.
Volume: 171
Issue: 5
Pages: 1094-1109.e15
Gene
Type: gene
Organism: human
Protein
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 453  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 767  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 742  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
Publication
First Author: Biswas M
Year: 2010
Journal: Toxicol Appl Pharmacol
Title: Role of Nrf1 in antioxidant response element-mediated gene expression and beyond.
Volume: 244
Issue: 1
Pages: 16-20
Publication
First Author: McKie J
Year: 1996
Journal: Mamm Genome
Title: The Nfe2l1 gene maps to distal mouse chromosome 11.
Volume: 7
Issue: 1
Pages: 89
Publication
First Author: Hou Y
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice.
Volume: 503
Issue: 1
Pages: 264-270
Publication
First Author: Furuya N
Year: 2014
Journal: Autophagy
Title: PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.
Volume: 10
Issue: 4
Pages: 631-41
GXD Expression    
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190874
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Nfe2l1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190874
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Nfe2l1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190874
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Nfe2l1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190874
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Nfe2l1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190874
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Nfe2l1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190874
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Nfe2l1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190874
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Nfe2l1
Detected: true
Specimen Num: 7
Publication
First Author: McKie J
Year: 1995
Journal: Genomics
Title: Cloning and mapping of murine Nfe2l1.
Volume: 25
Issue: 3
Pages: 716-9
Publication
First Author: Hirotsu Y
Year: 2014
Journal: Genes Cells
Title: Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.
Volume: 19
Issue: 8
Pages: 650-65
Publication
First Author: Chan JY
Year: 1998
Journal: EMBO J
Title: Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice.
Volume: 17
Issue: 6
Pages: 1779-87
Publication
First Author: Xu Z
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia.
Volume: 102
Issue: 11
Pages: 4120-5
Publication
First Author: Farmer SC
Year: 1997
Journal: Genes Dev
Title: The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development.
Volume: 11
Issue: 6
Pages: 786-98
Publication
First Author: Myhrstad MC
Year: 2001
Journal: Biochim Biophys Acta
Title: TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter.
Volume: 1517
Issue: 2
Pages: 212-9
Publication
First Author: Chen L
Year: 2003
Journal: Mol Cell Biol
Title: Nrf1 is critical for redox balance and survival of liver cells during development.
Volume: 23
Issue: 13
Pages: 4673-86
Publication
First Author: Zhang Y
Year: 2007
Journal: Biochem J
Title: The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation.
Volume: 408
Issue: 2
Pages: 161-72
Publication
First Author: Radhakrishnan SK
Year: 2010
Journal: Mol Cell
Title: Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells.
Volume: 38
Issue: 1
Pages: 17-28
Publication
First Author: Kobayashi A
Year: 2011
Journal: Genes Cells
Title: Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.
Volume: 16
Issue: 6
Pages: 692-703
Publication
First Author: Lee CS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration.
Volume: 108
Issue: 20
Pages: 8408-13
Publication
First Author: Zhang Y
Year: 2006
Journal: Biochem J
Title: Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum.
Volume: 399
Issue: 3
Pages: 373-85
Publication
First Author: Ohtsuji M
Year: 2008
Journal: J Biol Chem
Title: Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes.
Volume: 283
Issue: 48
Pages: 33554-62
Publication
First Author: Xing W
Year: 2007
Journal: J Biol Chem
Title: Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells.
Volume: 282
Issue: 30
Pages: 22052-61
Publication
First Author: Hirotsu Y
Year: 2012
Journal: Mol Cell Biol
Title: NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
Volume: 32
Issue: 14
Pages: 2760-70
Publication
First Author: Leung L
Year: 2003
Journal: J Biol Chem
Title: Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress.
Volume: 278
Issue: 48
Pages: 48021-9
Publication
First Author: Biswas M
Year: 2011
Journal: J Biol Chem
Title: The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.
Volume: 286
Issue: 45
Pages: 39282-9
Publication
First Author: Tsuchiya Y
Year: 2011
Journal: Mol Cell Biol
Title: Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms.
Volume: 31
Issue: 22
Pages: 4500-12
Publication
First Author: Molofsky AV
Year: 2013
Journal: Glia
Title: Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions.
Volume: 61
Issue: 9
Pages: 1518-32
Publication
First Author: Kim J
Year: 2010
Journal: Physiol Genomics
Title: Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice.
Volume: 40
Issue: 2
Pages: 100-10
Publication  
First Author: Shen W
Year: 2023
Journal: Redox Biol
Title: Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice.
Volume: 67
Pages: 102879
Publication
First Author: Bartelt A
Year: 2018
Journal: Nat Med
Title: Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.
Volume: 24
Issue: 3
Pages: 292-303
Publication
First Author: Zhang Y
Year: 2016
Journal: Biochem J
Title: Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity.
Volume: 473
Issue: 8
Pages: 961-1000
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lee CS
Year: 2013
Journal: FEBS J
Title: Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice.
Volume: 280
Issue: 15
Pages: 3609-20
Publication  
First Author: Xue P
Year: 2020
Journal: Redox Biol
Title: Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPARγ expression.
Volume: 30
Pages: 101414
Publication  
First Author: Gbotosho OT
Year: 2020
Journal: Front Immunol
Title: Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice.
Volume: 11
Pages: 1910
Publication  
First Author: Baird L
Year: 2017
Journal: Mol Cell Biol
Title: A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways.
Volume: 37
Issue: 4
Publication
First Author: Oh DH
Year: 2012
Journal: FEBS J
Title: Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability.
Volume: 279
Issue: 22
Pages: 4121-30
Publication
First Author: Zhang Y
Year: 2014
Journal: PLoS One
Title: The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression.
Volume: 9
Issue: 10
Pages: e109159
Publication  
First Author: Radhakrishnan SK
Year: 2014
Journal: Elife
Title: p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition.
Volume: 3
Pages: e01856
Publication
First Author: Johnsen O
Year: 1996
Journal: Nucleic Acids Res
Title: Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1.
Volume: 24
Issue: 21
Pages: 4289-97
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3033182
Age: embryonic day 7.5
Image: 2
Specimen Label: 7.5 dpc
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3033182
Age: embryonic day 7.5
Image: 2
Specimen Label: 7.5 dpc
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3033182
Age: embryonic day 7.5
Image: 2
Specimen Label: 7.5 dpc
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3033182
Age: embryonic day 10.5
Image: 2
Specimen Label: 10.5 dpc
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3033182
Age: embryonic day 10.5
Image: 2
Specimen Label: 10.5 dpc
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3033182
Age: embryonic day 10.5
Image: 2
Specimen Label: 10.5 dpc
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Stage: TS21
Assay Id: MGI:3033182
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Stage: TS21
Assay Id: MGI:3033182
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Stage: TS21
Assay Id: MGI:3033182
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:3033182
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:3033182
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:3033182
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:3033182
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 14