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Search results 1 to 100 out of 390 for Nfe2l1

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Hits by Category

Hits by Strain

Type Details Score
Gene
4779 | NFE2L1
Type: gene
Organism: human
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Gene
100151700 | nfe2l1
Type: gene
Organism: frog, western clawed
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Gene
360610 | Nfe2l1
Type: gene
Organism: rat
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Gene
403692 | NFE2L1
Type: gene
Organism: dog, domestic
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Gene
455185 | NFE2L1
Type: gene
Organism: chimpanzee
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Gene
534582 | NFE2L1
Type: gene
Organism: cattle
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Gene
417987 | NFE2L1
Type: gene
Organism: chicken
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Gene
695404 | NFE2L1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR029847 | NFE2L1
Type: Family
Description: NFE2L1 is an endoplasmic reticulum membrane sensor which, in response to various stresses, it is released from the ER membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 []. In conditions of excess cholesterol, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, this allows the expression of genes promoting cholesterol removal []. In response to oxidative stress, Nrf1 up-regulates expression of antioxidant genes by binding to the antioxidant response elements (AREs) present in the promoter of these genes []. In humans Nrf1 exists in two forms, p120 and p110. p120 is embedded in the ER membrane, while p110 is soluble and can enter the nucleus [, ].
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Protein Coding Gene
MGI:99421 | Nfe2l1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
10601325 | J:276393
First Author: Kwong M
Year: 1999
Journal: J Biol Chem
Title: The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts.
Volume: 274
Issue: 52
Pages: 37491-8
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Publication
23144760 | J:192355
First Author: Kwong EK
Year: 2012
Journal: PLoS One
Title: Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes.
Volume: 7
Issue: 10
Pages: e48404
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Publication
29149604 | J:250015
First Author: Widenmaier SB
Year: 2017
Journal: Cell
Title: NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.
Volume: 171
Issue: 5
Pages: 1094-1109.e15
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Gene
116435298 | NFE2L1-DT
Type: gene
Organism: human
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Protein
A2A6D0
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Protein
A2A6D1
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: true
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Protein
Q3U4L3
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
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Protein
Q3U5L0
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
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Protein
Q3V3M1
Organism: Mus musculus/domesticus
Length: 453  
Fragment?: false
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Protein
Q6KAM4
Organism: Mus musculus/domesticus
Length: 767  
Fragment?: true
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Protein
Q9CW60
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: true
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Protein
A2A6D2
Organism: Mus musculus/domesticus
Length: 742  
Fragment?: false
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Protein
Q3UFI8
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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Protein
Q9Z2E8
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
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Protein
Q6GTN8
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
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Protein
Q61985
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
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Publication
19665035 | -
First Author: Biswas M
Year: 2010
Journal: Toxicol Appl Pharmacol
Title: Role of Nrf1 in antioxidant response element-mediated gene expression and beyond.
Volume: 244
Issue: 1
Pages: 16-20
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Publication
8903741 | J:30849
First Author: McKie J
Year: 1996
Journal: Mamm Genome
Title: The Nfe2l1 gene maps to distal mouse chromosome 11.
Volume: 7
Issue: 1
Pages: 89
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Publication
29935181 | J:273421
First Author: Hou Y
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice.
Volume: 503
Issue: 1
Pages: 264-270
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Publication
37450596 | J:338613
First Author: Wang Y
Year: 2023
Journal: Sci Adv
Title: Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness.
Volume: 9
Issue: 28
Pages: eadd5479
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Publication
24451648 | J:329721
First Author: Furuya N
Year: 2014
Journal: Autophagy
Title: PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.
Volume: 10
Issue: 4
Pages: 631-41
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GXD Expression
GXD Expression
   
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190874
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Nfe2l1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190874
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Nfe2l1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190874
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Nfe2l1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190874
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Nfe2l1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190874
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Nfe2l1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190874
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Nfe2l1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6178967
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190874
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Nfe2l1
Detected: true
Specimen Num: 7
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Publication
7759107 | J:23248
First Author: McKie J
Year: 1995
Journal: Genomics
Title: Cloning and mapping of murine Nfe2l1.
Volume: 25
Issue: 3
Pages: 716-9
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Publication
25041126 | J:230118
First Author: Hirotsu Y
Year: 2014
Journal: Genes Cells
Title: Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.
Volume: 19
Issue: 8
Pages: 650-65
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Publication
9501099 | J:46990
First Author: Chan JY
Year: 1998
Journal: EMBO J
Title: Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice.
Volume: 17
Issue: 6
Pages: 1779-87
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Publication
15738389 | J:97188
First Author: Xu Z
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia.
Volume: 102
Issue: 11
Pages: 4120-5
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Publication
9087432 | J:39447
First Author: Farmer SC
Year: 1997
Journal: Genes Dev
Title: The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development.
Volume: 11
Issue: 6
Pages: 786-98
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Publication
11342101 | J:252061
First Author: Myhrstad MC
Year: 2001
Journal: Biochim Biophys Acta
Title: TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter.
Volume: 1517
Issue: 2
Pages: 212-9
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Publication
12808106 | J:83958
First Author: Chen L
Year: 2003
Journal: Mol Cell Biol
Title: Nrf1 is critical for redox balance and survival of liver cells during development.
Volume: 23
Issue: 13
Pages: 4673-86
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Publication
17705787 | J:128023
First Author: Zhang Y
Year: 2007
Journal: Biochem J
Title: The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation.
Volume: 408
Issue: 2
Pages: 161-72
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Publication
20385086 | J:162949
First Author: Radhakrishnan SK
Year: 2010
Journal: Mol Cell
Title: Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells.
Volume: 38
Issue: 1
Pages: 17-28
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Publication
21554501 | J:186943
First Author: Kobayashi A
Year: 2011
Journal: Genes Cells
Title: Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.
Volume: 16
Issue: 6
Pages: 692-703
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Publication
21536885 | J:171912
First Author: Lee CS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration.
Volume: 108
Issue: 20
Pages: 8408-13
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Publication
16872277 | J:116009
First Author: Zhang Y
Year: 2006
Journal: Biochem J
Title: Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum.
Volume: 399
Issue: 3
Pages: 373-85
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Publication
18826952 | J:143468
First Author: Ohtsuji M
Year: 2008
Journal: J Biol Chem
Title: Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes.
Volume: 283
Issue: 48
Pages: 33554-62
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Publication
17510056 | J:124618
First Author: Xing W
Year: 2007
Journal: J Biol Chem
Title: Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells.
Volume: 282
Issue: 30
Pages: 22052-61
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Publication
22586274 | J:186656
First Author: Hirotsu Y
Year: 2012
Journal: Mol Cell Biol
Title: NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
Volume: 32
Issue: 14
Pages: 2760-70
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Publication
12968018 | J:86725
First Author: Leung L
Year: 2003
Journal: J Biol Chem
Title: Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress.
Volume: 278
Issue: 48
Pages: 48021-9
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Publication
21953459 | J:252001
First Author: Biswas M
Year: 2011
Journal: J Biol Chem
Title: The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.
Volume: 286
Issue: 45
Pages: 39282-9
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Publication
21911472 | J:178646
First Author: Tsuchiya Y
Year: 2011
Journal: Mol Cell Biol
Title: Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms.
Volume: 31
Issue: 22
Pages: 4500-12
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Publication
23840004 | J:199442
First Author: Molofsky AV
Year: 2013
Journal: Glia
Title: Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions.
Volume: 61
Issue: 9
Pages: 1518-32
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Publication
19887580 | J:157962
First Author: Kim J
Year: 2010
Journal: Physiol Genomics
Title: Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice.
Volume: 40
Issue: 2
Pages: 100-10
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Publication
37716088 | J:340809
 
First Author: Shen W
Year: 2023
Journal: Redox Biol
Title: Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice.
Volume: 67
Pages: 102879
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Publication
27354364 | J:356635
First Author: Villaescusa JC
Year: 2016
Journal: EMBO J
Title: A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease.
Volume: 35
Issue: 18
Pages: 1963-78
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Publication
29400713 | J:265034
First Author: Bartelt A
Year: 2018
Journal: Nat Med
Title: Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.
Volume: 24
Issue: 3
Pages: 292-303
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Publication
27060105 | J:239484
First Author: Zhang Y
Year: 2016
Journal: Biochem J
Title: Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity.
Volume: 473
Issue: 8
Pages: 961-1000
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Protein Coding Gene
MGP_CAROLIEiJ_G0017037 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019013 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018981 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018951 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018954 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018768 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_99421 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019406 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018321 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018739 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018847 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018836 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018917 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018863 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019446 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018093 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018371 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018167 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017883 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
23702335 | J:214539
First Author: Lee CS
Year: 2013
Journal: FEBS J
Title: Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice.
Volume: 280
Issue: 15
Pages: 3609-20
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Publication
32973791 | J:302762
 
First Author: Gbotosho OT
Year: 2020
Journal: Front Immunol
Title: Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice.
Volume: 11
Pages: 1910
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Publication
27920251 | J:244981
 
First Author: Baird L
Year: 2017
Journal: Mol Cell Biol
Title: A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways.
Volume: 37
Issue: 4
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Publication
31931283 | J:309119
 
First Author: Xue P
Year: 2020
Journal: Redox Biol
Title: Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPARγ expression.
Volume: 30
Pages: 101414
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Publication
22971132 | J:203246
First Author: Oh DH
Year: 2012
Journal: FEBS J
Title: Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability.
Volume: 279
Issue: 22
Pages: 4121-30
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Publication
25290918 | J:223104
First Author: Zhang Y
Year: 2014
Journal: PLoS One
Title: The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression.
Volume: 9
Issue: 10
Pages: e109159
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Publication
24448410 | J:283204
 
First Author: Radhakrishnan SK
Year: 2014
Journal: Elife
Title: p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition.
Volume: 3
Pages: e01856
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Publication
8932385 | J:276498
First Author: Johnsen O
Year: 1996
Journal: Nucleic Acids Res
Title: Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1.
Volume: 24
Issue: 21
Pages: 4289-97
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GXD Expression
GXD Expression
   
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3033182
Age: embryonic day 7.5
Image: 2
Specimen Label: 7.5 dpc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3033182
Age: embryonic day 7.5
Image: 2
Specimen Label: 7.5 dpc
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3033182
Age: embryonic day 7.5
Image: 2
Specimen Label: 7.5 dpc
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3033182
Age: embryonic day 10.5
Image: 2
Specimen Label: 10.5 dpc
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3033182
Age: embryonic day 10.5
Image: 2
Specimen Label: 10.5 dpc
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3033182
Age: embryonic day 10.5
Image: 2
Specimen Label: 10.5 dpc
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Stage: TS21
Assay Id: MGI:3033182
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Stage: TS21
Assay Id: MGI:3033182
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Stage: TS21
Assay Id: MGI:3033182
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:3033182
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3033157
Assay Type: RT-PCR
Annotation Date: 2004-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:3033182
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5 dpc
Detected: true
Specimen Num: 12
•
•
•
•
•




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