Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
DeNicola GM |
Year: |
2022 |
Journal: |
MGI Direct Data Submission |
Title: |
Direct Data Submission for Nfe2l2 Allele. |
|
|
|
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178969 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190875 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Nfe2l2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178969 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190875 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Nfe2l2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178969 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190875 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Nfe2l2 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178969 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190875 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Nfe2l2 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178969 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190875 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Nfe2l2 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178969 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190875 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Nfe2l2 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178969 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190875 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Nfe2l2 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
467
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Santos LR |
Year: |
2019 |
Journal: |
Thyroid |
Title: |
Interaction of Genetic Variations in NFE2L2 and SELENOS Modulates the Risk of Hashimoto's Thyroiditis. |
Volume: |
29 |
Issue: |
9 |
Pages: |
1302-1315 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang W |
Year: |
2014 |
Journal: |
J Mol Cell Cardiol |
Title: |
Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins. |
Volume: |
72 |
|
Pages: |
305-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hamad SH |
Year: |
2022 |
Journal: |
Oncogene |
Title: |
TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice. |
Volume: |
41 |
Issue: |
25 |
Pages: |
3423-3432 |
|
•
•
•
•
•
|
Publication |
First Author: |
Witherspoon JG |
Year: |
2024 |
Journal: |
Redox Biol |
Title: |
Mutant Nrf2(E79Q) enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors. |
Volume: |
75 |
|
Pages: |
103261 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bowman BM |
Year: |
2020 |
Journal: |
J Pathol |
Title: |
A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue. |
Volume: |
252 |
Issue: |
2 |
Pages: |
125-137 |
|
•
•
•
•
•
|
Publication |
First Author: |
Calkins MJ |
Year: |
2010 |
Journal: |
Toxicol Sci |
Title: |
Astrocyte-specific overexpression of Nrf2 protects striatal neurons from mitochondrial complex II inhibition. |
Volume: |
115 |
Issue: |
2 |
Pages: |
557-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Satoh H |
Year: |
2016 |
Journal: |
Cancer Res |
Title: |
NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth. |
Volume: |
76 |
Issue: |
10 |
Pages: |
3088-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Slocum SL |
Year: |
2016 |
Journal: |
Arch Biochem Biophys |
Title: |
Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet. |
Volume: |
591 |
|
Pages: |
57-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gan L |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model. |
Volume: |
32 |
Issue: |
49 |
Pages: |
17775-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao W |
Year: |
2022 |
Journal: |
J Neuroinflammation |
Title: |
Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model. |
Volume: |
19 |
Issue: |
1 |
Pages: |
134 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen PC |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte. |
Volume: |
106 |
Issue: |
8 |
Pages: |
2933-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Satoh H |
Year: |
2022 |
Journal: |
Carcinogenesis |
Title: |
Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels. |
Volume: |
43 |
Issue: |
7 |
Pages: |
613-623 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eba S |
Year: |
2013 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice. |
Volume: |
49 |
Issue: |
2 |
Pages: |
324-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Knatko EV |
Year: |
2020 |
Journal: |
iScience |
Title: |
Downregulation of Keap1 Confers Features of a Fasted Metabolic State. |
Volume: |
23 |
Issue: |
10 |
Pages: |
101638 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quinti L |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients. |
Volume: |
114 |
Issue: |
23 |
Pages: |
E4676-E4685 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ludtmann MH |
Year: |
2014 |
Journal: |
Biochem J |
Title: |
Nrf2 affects the efficiency of mitochondrial fatty acid oxidation. |
Volume: |
457 |
Issue: |
3 |
Pages: |
415-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Satoh H |
Year: |
2010 |
Journal: |
Carcinogenesis |
Title: |
Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung. |
Volume: |
31 |
Issue: |
10 |
Pages: |
1833-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu J |
Year: |
2012 |
Journal: |
Diabetes |
Title: |
Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice. |
Volume: |
61 |
Issue: |
12 |
Pages: |
3208-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okada K |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems. |
Volume: |
389 |
Issue: |
3 |
Pages: |
431-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schäfer M |
Year: |
2012 |
Journal: |
EMBO Mol Med |
Title: |
Nrf2 links epidermal barrier function with antioxidant defense. |
Volume: |
4 |
Issue: |
5 |
Pages: |
364-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bronisz-Budzyńska I |
Year: |
2022 |
Journal: |
Cells |
Title: |
NRF2 Regulates Viability, Proliferation, Resistance to Oxidative Stress, and Differentiation of Murine Myoblasts and Muscle Satellite Cells. |
Volume: |
11 |
Issue: |
20 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shimoyama S |
Year: |
2021 |
Journal: |
Eur J Immunol |
Title: |
Ursodeoxycholic acid impairs liver-infiltrating T-cell chemotaxis through IFN-γ and CX3CL1 production in primary biliary cholangitis. |
Volume: |
51 |
Issue: |
6 |
Pages: |
1519-1530 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rowan S |
Year: |
2021 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Aged Nrf2-Null Mice Develop All Major Types of Age-Related Cataracts. |
Volume: |
62 |
Issue: |
15 |
Pages: |
10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao Z |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Age-related retinopathy in NRF2-deficient mice. |
Volume: |
6 |
Issue: |
4 |
Pages: |
e19456 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho HY |
Year: |
2002 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene. |
Volume: |
26 |
Issue: |
1 |
Pages: |
42-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pajares M |
Year: |
2016 |
Journal: |
Autophagy |
Title: |
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. |
Volume: |
12 |
Issue: |
10 |
Pages: |
1902-1916 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shinkai Y |
Year: |
2016 |
Journal: |
Toxicol Appl Pharmacol |
Title: |
Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells. |
Volume: |
295 |
|
Pages: |
37-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang YK |
Year: |
2012 |
Journal: |
Toxicol Appl Pharmacol |
Title: |
Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet. |
Volume: |
264 |
Issue: |
3 |
Pages: |
305-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Joshi N |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Nrf2 is highly expressed in neutrophils, but myeloid cell-derived Nrf2 is dispensable for wound healing in mice. |
Volume: |
12 |
Issue: |
10 |
Pages: |
e0187162 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murakami S |
Year: |
2014 |
Journal: |
Genes Cells |
Title: |
Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells. |
Volume: |
19 |
Issue: |
3 |
Pages: |
239-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reisman SA |
Year: |
2009 |
Journal: |
Toxicol Sci |
Title: |
Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity. |
Volume: |
109 |
Issue: |
1 |
Pages: |
24-30 |
|
•
•
•
•
•
|