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Search results 1 to 100 out of 220 for Nlgn1

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
22871 | NLGN1
Type: gene
Organism: human
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Gene
470999 | NLGN1
Type: gene
Organism: chimpanzee
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Gene
530042 | NLGN1
Type: gene
Organism: cattle
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Gene
424980 | NLGN1
Type: gene
Organism: chicken
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Gene
100002610 | nlgn1
Type: gene
Organism: zebrafish
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Gene
693541 | NLGN1
Type: gene
Organism: macaque, rhesus
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Gene
100329186 | nlgn1
Type: gene
Organism: frog, western clawed
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Gene
116647 | Nlgn1
Type: gene
Organism: rat
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Gene
488173 | NLGN1
Type: gene
Organism: dog, domestic
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Protein Domain
IPR030022 | NLGN1
Type: Family
Description: Neuroligin-1 (NLGN1) belongs to the neuroligins (NLGNs) family, whose members interact with the neurexin family members and are involved in the modulation of synaptic transmission. NLGN1 is a cell adhesion protein that is essential for the formation and consolidation of synaptic connectivity and is involved in vascular development []. It is localised on excitatory (glutamatergic) synapses []. It has been linked to memory formation []and autism [].
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Protein Coding Gene
MGI:2179435 | Nlgn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24860089 | J:244384
First Author: Samarelli AV
Year: 2014
Journal: J Biol Chem
Title: Neuroligin 1 induces blood vessel maturation by cooperating with the α6 integrin.
Volume: 289
Issue: 28
Pages: 19466-76
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Publication
20147539 | J:157848
First Author: Blundell J
Year: 2010
Journal: J Neurosci
Title: Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior.
Volume: 30
Issue: 6
Pages: 2115-29
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Protein
Q4KMN5
Organism: Mus musculus/domesticus
Length: 814  
Fragment?: false
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Gene
100874010 | NLGN1-AS1
Type: gene
Organism: human
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Publication
35992071 | J:336976
First Author: Ramirez MA
Year: 2022
Journal: iScience
Title: Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3.
Volume: 25
Issue: 8
Pages: 104803
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Publication
31138690 | J:276565
First Author: Jeong J
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: PSD-95 binding dynamically regulates NLGN1 trafficking and function.
Volume: 116
Issue: 24
Pages: 12035-12044
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Protein
Q3TY84
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Publication
9927700 | -
First Author: Song JY
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses.
Volume: 96
Issue: 3
Pages: 1100-5
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Protein
Q3UUJ1
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: false
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Publication
25149987 | -
First Author: Maćkowiak M
Year: 2014
Journal: Pharmacol Rep
Title: Neuroligins, synapse balance and neuropsychiatric disorders.
Volume: 66
Issue: 5
Pages: 830-5
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Protein
Q3UUP2
Organism: Mus musculus/domesticus
Length: 554  
Fragment?: true
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Protein
Q99K10
Organism: Mus musculus/domesticus
Length: 843  
Fragment?: false
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Protein
E9QK34
Organism: Mus musculus/domesticus
Length: 814  
Fragment?: false
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Publication
24441681 | J:207977
First Author: Bie B
Year: 2014
Journal: Nat Neurosci
Title: Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency.
Volume: 17
Issue: 2
Pages: 223-31
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Publication
32324534 | J:292696
   
First Author: Letellier M
Year: 2020
Journal: Elife
Title: Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation.
Volume: 9
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Publication
28841651 | J:247060
First Author: Nakanishi M
Year: 2017
Journal: PLoS Genet
Title: Functional significance of rare neuroligin 1 variants found in autism.
Volume: 13
Issue: 8
Pages: e1006940
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Publication
30046996 | J:332035
First Author: Nozawa K
Year: 2018
Journal: Cerebellum
Title: Cellular and Subcellular Localization of Endogenous Neuroligin-1 in the Cerebellum.
Volume: 17
Issue: 6
Pages: 709-721
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Publication
25595979 | J:221434
 
First Author: Belanger-Nelson E
Year: 2015
Journal: Neuroscience
Title: Brain hemodynamic response to somatosensory stimulation in Neuroligin-1 knockout mice.
Volume: 289
Pages: 242-50
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Publication
34690694 | J:312690
 
First Author: Luo JK
Year: 2021
Journal: Front Mol Neurosci
Title: Postsynaptic Neuroligin-1 Mediates Presynaptic Endocytosis During Neuronal Activity.
Volume: 14
Pages: 744845
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Publication
26440732 | J:243525
First Author: Tristán-Clavijo E
Year: 2015
Journal: Neurobiol Aging
Title: A truncating mutation in Alzheimer's disease inactivates neuroligin-1 synaptic function.
Volume: 36
Issue: 12
Pages: 3171-3175
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Publication
30049666 | J:266960
 
First Author: Zhao JY
Year: 2018
Journal: Neuroscience
Title: Activity-dependent Synaptic Recruitment of Neuroligin 1 in Spinal Dorsal Horn Contributed to Inflammatory Pain.
Volume: 388
Pages: 1-10
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Publication
37293130 | J:346335
 
First Author: Chalkiadaki K
Year: 2023
Journal: Front Cell Dev Biol
Title: Reversal of memory and autism-related phenotypes in Tsc2(+/-) mice via inhibition of Nlgn1.
Volume: 11
Pages: 1205112
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Publication
31801062 | J:298861
First Author: Paskus JD
Year: 2019
Journal: Cell Rep
Title: Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.
Volume: 29
Issue: 10
Pages: 2944-2952.e5
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Publication
32332783 | J:289785
First Author: Dufort-Gervais J
Year: 2020
Journal: Sci Rep
Title: Neuroligin-1 is altered in the hippocampus of Alzheimer's disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers.
Volume: 10
Issue: 1
Pages: 6956
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Publication
27217145 | J:326179
First Author: Jiang M
Year: 2017
Journal: Mol Psychiatry
Title: Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism.
Volume: 22
Issue: 3
Pages: 375-383
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Publication
28607166 | J:243282
First Author: Chanda S
Year: 2017
Journal: J Neurosci
Title: Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.
Volume: 37
Issue: 29
Pages: 6816-6836
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Publication
35704570 | J:326980
First Author: Han Y
Year: 2022
Journal: Sci Adv
Title: Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses.
Volume: 8
Issue: 24
Pages: eabo4173
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Publication
30056576 | J:272678
     
First Author: Chmielewska JJ
Year: 2018
Journal: Mol Neurobiol
Title: Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage.
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Publication
26291161 | J:227671
First Author: Zhang B
Year: 2015
Journal: Neuron
Title: Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses.
Volume: 87
Issue: 4
Pages: 781-96
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Publication
29100073 | J:252787
First Author: Südhof TC
Year: 2017
Journal: Cell
Title: Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits.
Volume: 171
Issue: 4
Pages: 745-769
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Publication
27581450 | J:235211
First Author: Zhang B
Year: 2016
Journal: J Neurosci
Title: Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons.
Volume: 36
Issue: 35
Pages: 9070-83
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Publication
37865312 | J:343246
First Author: Benner O
Year: 2023
Journal: J Biol Chem
Title: Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.
Volume: 299
Issue: 12
Pages: 105361
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Publication
29724786 | J:264052
First Author: Zhang B
Year: 2018
Journal: J Exp Med
Title: Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.
Volume: 215
Issue: 6
Pages: 1543-1553
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Publication
34616037 | J:326180
First Author: Wu X
Year: 2021
Journal: Nature
Title: 5-HT modulation of a medial septal circuit tunes social memory stability.
Volume: 599
Issue: 7883
Pages: 96-101
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Publication
34848499 | J:320476
First Author: Chen P
Year: 2022
Journal: J Neurosci
Title: DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.
Volume: 42
Issue: 4
Pages: 532-551
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Publication
30871858 | J:276060
First Author: Wu X
Year: 2019
Journal: Neuron
Title: Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.
Volume: 102
Issue: 3
Pages: 621-635.e3
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Publication
- | J:138689
     
First Author: Sudhof TC
Year: 2008
Journal: MGI Direct Data Submission
Title: Generation of a Nlgn1 null allele
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Publication
32973045 | J:296694
First Author: Gan KJ
Year: 2020
Journal: J Neurosci
Title: SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.
Volume: 40
Issue: 42
Pages: 8088-8102
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Protein Coding Gene
MGP_CAROLIEiJ_G0024885 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027106 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027066 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027035 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027078 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026819 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2179435 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027523 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026274 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026797 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026931 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026899 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027043 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026920 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027583 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026007 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026347 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026330 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025817 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10892652 | J:116404
First Author: Scheiffele P
Year: 2000
Journal: Cell
Title: Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons.
Volume: 101
Issue: 6
Pages: 657-69
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Publication
23716671 | J:197398
First Author: El Helou J
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Neuroligin-1 links neuronal activity to sleep-wake regulation.
Volume: 110
Issue: 24
Pages: 9974-9
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Publication
22860111 | J:189673
First Author: Zeidan A
Year: 2012
Journal: PLoS One
Title: Neuroligin-1 loss is associated with reduced tenacity of excitatory synapses.
Volume: 7
Issue: 7
Pages: e42314
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Publication
21940442 | J:184102
First Author: Mondin M
Year: 2011
Journal: J Neurosci
Title: Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds.
Volume: 31
Issue: 38
Pages: 13500-15
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Publication
21953696 | J:177461
First Author: Soler-Llavina GJ
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo.
Volume: 108
Issue: 40
Pages: 16502-9
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Publication
20176955 | J:158770
First Author: Jung SY
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors.
Volume: 107
Issue: 10
Pages: 4710-5
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Publication
23143522 | J:197488
First Author: Kwon HB
Year: 2012
Journal: Nat Neurosci
Title: Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number.
Volume: 15
Issue: 12
Pages: 1667-74
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Publication
23269831 | J:193528
First Author: Budreck EC
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling.
Volume: 110
Issue: 2
Pages: 725-30
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Publication
23719805 | J:198660
First Author: Hoy JL
Year: 2013
Journal: J Neurosci
Title: Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions.
Volume: 33
Issue: 22
Pages: 9364-84
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Publication
30266599 | J:295598
 
First Author: Dang R
Year: 2018
Journal: Neuropharmacology
Title: Regulation of hippocampal long term depression by Neuroligin 1.
Volume: 143
Pages: 205-216
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GXD Expression
GXD Expression
     
Probe: MGI:6450884
Assay Type: Western blot
Annotation Date: 2020-08-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267826
Stage: TS26
Assay Id: MGI:6450907
Age: embryonic day 18.5
Specimen Label: wild type
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6450884
Assay Type: Western blot
Annotation Date: 2020-08-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267826
Stage: TS26
Assay Id: MGI:6450907
Age: embryonic day 18.5
Specimen Label: knock-out
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7506556
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7506644
Age: postnatal day 4
Image: 4
Specimen Label: Igsf21+/+ (1)
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7506556
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7506644
Age: postnatal day 4
Image: 4
Specimen Label: Igsf21+/+ (2)
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7506556
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7506644
Age: postnatal day 4
Image: 4
Specimen Label: Igsf21+/+ (3)
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7506556
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7506644
Age: postnatal day 4
Image: 4
Specimen Label: Igsf21-/- (1)
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7506556
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7506644
Age: postnatal day 4
Image: 4
Specimen Label: Igsf21-/- (2)
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7506556
Assay Type: Western blot
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7506644
Age: postnatal day 4
Image: 4
Specimen Label: Igsf21-/- (3)
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:5502781
Assay Type: RNA in situ
Annotation Date: 2013-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5502647
Age: embryonic day 15.5
Image: 4I,I'
Specimen Label: 4I,I'
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:5502781
Assay Type: RNA in situ
Annotation Date: 2013-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271123
Pattern: Non-Uniform
Stage: TS23
Assay Id: MGI:5502647
Age: embryonic day 15.5
Image: 4J,J'
Note: Caudal expression was similar between wild type and mutant, but rostral expression levels were reduced in the cortical plate.
Specimen Label: 4J,J'
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5484521
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-10
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5484666
Age: postnatal adult
Image: S5 A
Specimen Label: S5 A
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5484521
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-10
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5484666
Age: postnatal adult
Image: S5 A
Specimen Label: S5 A
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5484521
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5484666
Age: postnatal adult
Image: S5 E
Specimen Label: S5 E
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:5484521
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-10
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5484666
Age: postnatal adult
Image: S5 A
Specimen Label: S5 A
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:5502781
Assay Type: RNA in situ
Annotation Date: 2013-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5502647
Age: embryonic day 13.5
Image: 3B
Note: Expression was down-regulated in cortical progenitors in the ventricular zone.
Specimen Label: 3B
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5502781
Assay Type: RNA in situ
Annotation Date: 2013-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5502647
Age: embryonic day 13.5
Image: 3C
Note: Expression was down-regulated in cortical progenitors in the ventricular zone.
Specimen Label: 3C
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5502781
Assay Type: RNA in situ
Annotation Date: 2013-08-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691021
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5502647
Age: embryonic day 13.5
Note: Expression was detected in dorsal telencephalon.
Specimen Label: Supp. Table 1
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5484521
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5484666
Age: postnatal adult
Image: S5 D
Specimen Label: S5 D
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5484521
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-10
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5484666
Age: postnatal adult
Image: S5 A
Specimen Label: S5 A
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5484521
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274323
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5484666
Age: embryonic day 15.0
Image: S3 Bc
Specimen Label: S3 Bc
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5484521
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5484666
Age: postnatal adult
Image: S5 B
Specimen Label: S5 B
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5484521
Assay Type: Immunohistochemistry
Annotation Date: 2013-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5484666
Age: postnatal adult
Image: S5 C
Specimen Label: S5 C
Detected: true
Specimen Num: 5
•
•
•
•
•




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