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Search results 1 to 100 out of 262 for Nlrc4

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0.037s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: NLRC4 is a nucleotide binding/leucine-rich Repeat (NLR) protein and a inflammasome activator. It contains an N-terminal homotypic interaction domain, a central nucleotide binding domain, and a series of C-terminal LRRs. NLRC4 activates CASP1, the primary protease responsible for converting pro-IL-1beta to active, secreted IL-1beta. NLRC4 has been linked to autoinflammation diseases [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Duncan JA
Year: 2018
Journal: Immunol Rev
Title: The NLRC4 Inflammasome.
Volume: 281
Issue: 1
Pages: 115-123
Publication
First Author: Kitamura A
Year: 2014
Journal: J Exp Med
Title: An inherited mutation in NLRC4 causes autoinflammation in human and mice.
Volume: 211
Issue: 12
Pages: 2385-96
Publication
First Author: Qu Y
Year: 2016
Journal: J Exp Med
Title: NLRP3 recruitment by NLRC4 during Salmonella infection.
Volume: 213
Issue: 6
Pages: 877-85
Publication
First Author: Hu Z
Year: 2013
Journal: Science
Title: Crystal structure of NLRC4 reveals its autoinhibition mechanism.
Volume: 341
Issue: 6142
Pages: 172-5
Protein
Organism: Mus musculus
Length: 1024  
Fragment?: false
Publication  
First Author: Kolb R
Year: 2016
Journal: Nat Commun
Title: Obesity-associated NLRC4 inflammasome activation drives breast cancer progression.
Volume: 7
Pages: 13007
Publication
First Author: Qu Y
Year: 2012
Journal: Nature
Title: Phosphorylation of NLRC4 is critical for inflammasome activation.
Volume: 490
Issue: 7421
Pages: 539-42
Publication
First Author: Karki R
Year: 2018
Journal: Cell
Title: IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.
Volume: 173
Issue: 4
Pages: 920-933.e13
Publication
First Author: Lightfield KL
Year: 2011
Journal: Infect Immun
Title: Differential requirements for NAIP5 in activation of the NLRC4 inflammasome.
Volume: 79
Issue: 4
Pages: 1606-14
Publication
First Author: Janowski AM
Year: 2016
Journal: J Clin Invest
Title: NLRC4 suppresses melanoma tumor progression independently of inflammasome activation.
Volume: 126
Issue: 10
Pages: 3917-3928
Publication
First Author: Matusiak M
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5.
Volume: 112
Issue: 5
Pages: 1541-6
Publication
First Author: Zhao Y
Year: 2011
Journal: Nature
Title: The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.
Volume: 477
Issue: 7366
Pages: 596-600
Publication
First Author: Lee BL
Year: 2018
Journal: Sci Rep
Title: ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages.
Volume: 8
Issue: 1
Pages: 3788
Publication
First Author: Vijay-Kumar M
Year: 2010
Journal: Eur J Immunol
Title: TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin.
Volume: 40
Issue: 12
Pages: 3528-34
Publication
First Author: Broz P
Year: 2010
Journal: J Exp Med
Title: Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella.
Volume: 207
Issue: 8
Pages: 1745-55
Publication
First Author: Denes A
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.
Volume: 112
Issue: 13
Pages: 4050-5
Publication
First Author: Silveira TN
Year: 2010
Journal: Infect Immun
Title: Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis.
Volume: 78
Issue: 3
Pages: 1403-13
Publication
First Author: Kupz A
Year: 2012
Journal: Nat Immunol
Title: NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells.
Volume: 13
Issue: 2
Pages: 162-9
Publication
First Author: Malireddi RK
Year: 2010
Journal: J Immunol
Title: Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes.
Volume: 185
Issue: 6
Pages: 3127-30
Publication  
First Author: Pereira MS
Year: 2011
Journal: Front Microbiol
Title: The Nlrc4 Inflammasome Contributes to Restriction of Pulmonary Infection by Flagellated Legionella spp. that Trigger Pyroptosis.
Volume: 2
Pages: 33
Publication
First Author: Tomalka J
Year: 2011
Journal: PLoS Pathog
Title: A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans.
Volume: 7
Issue: 12
Pages: e1002379
Publication
First Author: Cai S
Year: 2012
Journal: J Immunol
Title: NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against gram-negative bacterial infection.
Volume: 188
Issue: 11
Pages: 5623-35
Publication
First Author: Kupz A
Year: 2014
Journal: PLoS One
Title: In vivo IFN-γ secretion by NK cells in response to Salmonella typhimurium requires NLRC4 inflammasomes.
Volume: 9
Issue: 5
Pages: e97418
Publication
First Author: Freeman L
Year: 2017
Journal: J Exp Med
Title: NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
Volume: 214
Issue: 5
Pages: 1351-1370
Publication
First Author: Miao EA
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome.
Volume: 107
Issue: 7
Pages: 3076-80
Publication
First Author: McClellan SA
Year: 2017
Journal: PLoS One
Title: NLRC4 regulates caspase-1 and IL-1beta production in a CD11blowLy6Glow population of cells required for resistance to Pseudomonas aeruginosa keratitis.
Volume: 12
Issue: 9
Pages: e0185718
Publication
First Author: Man SM
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.
Volume: 111
Issue: 20
Pages: 7403-8
Publication
First Author: Suzuki S
Year: 2014
Journal: PLoS Pathog
Title: Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.
Volume: 10
Issue: 2
Pages: e1003926
Publication
First Author: Sauer JD
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity.
Volume: 108
Issue: 30
Pages: 12419-24
Publication  
First Author: Ip WK
Year: 2015
Journal: Nat Commun
Title: Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation.
Volume: 6
Pages: 6931
Publication
First Author: Karmakar M
Year: 2012
Journal: J Immunol
Title: Cutting edge: IL-1β processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1.
Volume: 189
Issue: 9
Pages: 4231-5
Publication
First Author: Pereira MS
Year: 2011
Journal: J Immunol
Title: Activation of NLRC4 by flagellated bacteria triggers caspase-1-dependent and -independent responses to restrict Legionella pneumophila replication in macrophages and in vivo.
Volume: 187
Issue: 12
Pages: 6447-55
Publication
First Author: Fan LC
Year: 2017
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Macrolides protect against Pseudomonas aeruginosa infection via inhibition of inflammasomes.
Volume: 313
Issue: 4
Pages: L677-L686
Publication
First Author: Yuan F
Year: 2016
Journal: PLoS One
Title: Involvement of the NLRC4-Inflammasome in Diabetic Nephropathy.
Volume: 11
Issue: 10
Pages: e0164135
Publication
First Author: Tenthorey JL
Year: 2017
Journal: Science
Title: The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.
Volume: 358
Issue: 6365
Pages: 888-893
Publication
First Author: Franchi L
Year: 2012
Journal: Nat Immunol
Title: NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense.
Volume: 13
Issue: 5
Pages: 449-56
Publication
First Author: Diebolder CA
Year: 2015
Journal: Structure
Title: Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation.
Volume: 23
Issue: 12
Pages: 2349-57
Publication
First Author: Hu Z
Year: 2015
Journal: Science
Title: Structural and biochemical basis for induced self-propagation of NLRC4.
Volume: 350
Issue: 6259
Pages: 399-404
Publication
First Author: Hu B
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.
Volume: 107
Issue: 50
Pages: 21635-40
Publication
First Author: Zhang L
Year: 2015
Journal: Science
Title: Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
Volume: 350
Issue: 6259
Pages: 404-9
Publication
First Author: Nichols RD
Year: 2017
Journal: Nat Commun
Title: NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease.
Volume: 8
Issue: 1
Pages: 2209
Publication
First Author: Schieber AM
Year: 2015
Journal: Science
Title: Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling.
Volume: 350
Issue: 6260
Pages: 558-63
Publication
First Author: Zhao Y
Year: 2016
Journal: J Exp Med
Title: Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice.
Volume: 213
Issue: 5
Pages: 647-56
Publication
First Author: Man SM
Year: 2013
Journal: J Immunol
Title: Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production.
Volume: 191
Issue: 10
Pages: 5239-46
Publication
First Author: Yang J
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation.
Volume: 110
Issue: 35
Pages: 14408-13
Publication
First Author: Cohen TS
Year: 2013
Journal: J Clin Invest
Title: Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia.
Volume: 123
Issue: 4
Pages: 1630-7
Publication
First Author: Liu Z
Year: 2012
Journal: J Biol Chem
Title: Role of inflammasomes in host defense against Citrobacter rodentium infection.
Volume: 287
Issue: 20
Pages: 16955-64
Publication  
First Author: Iannitti RG
Year: 2016
Journal: Nat Commun
Title: IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis.
Volume: 7
Pages: 10791
Publication
First Author: Floyd M
Year: 2016
Journal: PLoS Pathog
Title: Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa.
Volume: 12
Issue: 11
Pages: e1005987
Publication
First Author: Van Opdenbosch N
Year: 2017
Journal: Cell Rep
Title: Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.
Volume: 21
Issue: 12
Pages: 3427-3444
Publication
First Author: Akhter A
Year: 2009
Journal: PLoS Pathog
Title: Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.
Volume: 5
Issue: 4
Pages: e1000361
Publication
First Author: Zhao C
Year: 2014
Journal: J Biol Chem
Title: Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation.
Volume: 289
Issue: 24
Pages: 17020-9
Publication
First Author: Allen IC
Year: 2010
Journal: J Exp Med
Title: The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.
Volume: 207
Issue: 5
Pages: 1045-56
Publication
First Author: McCoy AJ
Year: 2010
Journal: J Immunol
Title: Differential regulation of caspase-1 activation via NLRP3/NLRC4 inflammasomes mediated by aerolysin and type III secretion system during Aeromonas veronii infection.
Volume: 185
Issue: 11
Pages: 7077-84
Publication
First Author: Miao EA
Year: 2010
Journal: Nat Immunol
Title: Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.
Volume: 11
Issue: 12
Pages: 1136-42
Publication
First Author: Maltez VI
Year: 2015
Journal: Immunity
Title: Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.
Volume: 43
Issue: 5
Pages: 987-97
Publication
First Author: Wynosky-Dolfi MA
Year: 2014
Journal: J Exp Med
Title: Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome.
Volume: 211
Issue: 4
Pages: 653-68
Publication
First Author: von Moltke J
Year: 2012
Journal: Nature
Title: Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.
Volume: 490
Issue: 7418
Pages: 107-11
Publication
First Author: Place DE
Year: 2018
Journal: Am J Pathol
Title: ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.
Volume: 188
Issue: 4
Pages: 1021-1030
Publication
First Author: Rauch I
Year: 2017
Journal: Immunity
Title: NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8.
Volume: 46
Issue: 4
Pages: 649-659
Publication
First Author: Kofoed EM
Year: 2011
Journal: Nature
Title: Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity.
Volume: 477
Issue: 7366
Pages: 592-5
Publication
First Author: Shio MT
Year: 2009
Journal: PLoS Pathog
Title: Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.
Volume: 5
Issue: 8
Pages: e1000559
Publication
First Author: Gomes MT
Year: 2013
Journal: J Immunol
Title: Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection.
Volume: 190
Issue: 7
Pages: 3629-38
Publication
First Author: Fortier A
Year: 2009
Journal: Infect Immun
Title: Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.
Volume: 77
Issue: 11
Pages: 4794-805
Publication
First Author: Abdalla H
Year: 2012
Journal: PLoS One
Title: Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis.
Volume: 7
Issue: 7
Pages: e40722
Publication
First Author: Ceballos-Olvera I
Year: 2011
Journal: PLoS Pathog
Title: Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1β is deleterious.
Volume: 7
Issue: 12
Pages: e1002452
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication      
First Author: Shi H
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for inwood
Publication
First Author: Shames SR
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Multiple Legionella pneumophila effector virulence phenotypes revealed through high-throughput analysis of targeted mutant libraries.
Volume: 114
Issue: 48
Pages: E10446-E10454
Publication
First Author: Franchi L
Year: 2006
Journal: Nat Immunol
Title: Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages.
Volume: 7
Issue: 6
Pages: 576-82
Publication  
First Author: Arasaki K
Year: 2017
Journal: Nat Commun
Title: Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.
Volume: 8
Pages: 15406
Publication
First Author: Lamkanfi M
Year: 2007
Journal: J Immunol
Title: The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation.
Volume: 178
Issue: 12
Pages: 8022-7
Publication
First Author: Rayamajhi M
Year: 2013
Journal: J Immunol
Title: Cutting edge: Mouse NAIP1 detects the type III secretion system needle protein.
Volume: 191
Issue: 8
Pages: 3986-9
Publication
First Author: DeSantis DA
Year: 2013
Journal: Alcohol Clin Exp Res
Title: Genetic resistance to liver fibrosis on A/J mouse chromosome 17.
Volume: 37
Issue: 10
Pages: 1668-79
Publication
First Author: Mariathasan S
Year: 2005
Journal: J Exp Med
Title: Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis.
Volume: 202
Issue: 8
Pages: 1043-9
Publication
First Author: Fortier A
Year: 2007
Journal: Cell Microbiol
Title: Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila.
Volume: 9
Issue: 4
Pages: 910-23
Publication
First Author: Lightfield KL
Year: 2008
Journal: Nat Immunol
Title: Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin.
Volume: 9
Issue: 10
Pages: 1171-8
Publication
First Author: Thomas PG
Year: 2009
Journal: Immunity
Title: The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.
Volume: 30
Issue: 4
Pages: 566-75