Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Vladimer GI |
Year: |
2012 |
Journal: |
Immunity |
Title: |
The NLRP12 inflammasome recognizes Yersinia pestis. |
Volume: |
37 |
Issue: |
1 |
Pages: |
96-107 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zaki MH |
Year: |
2011 |
Journal: |
Cancer Cell |
Title: |
The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. |
Volume: |
20 |
Issue: |
5 |
Pages: |
649-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin Q |
Year: |
2020 |
Journal: |
JCI Insight |
Title: |
Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function. |
Volume: |
5 |
Issue: |
10 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hornick EE |
Year: |
2018 |
Journal: |
J Immunol |
Title: |
Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection. |
Volume: |
200 |
Issue: |
3 |
Pages: |
1188-1197 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen ST |
Year: |
2019 |
Journal: |
Cell Host Microbe |
Title: |
NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25. |
Volume: |
25 |
Issue: |
4 |
Pages: |
602-616.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ulland TK |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. |
Volume: |
7 |
|
Pages: |
13180 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee EJ |
Year: |
2022 |
Journal: |
J Neuroinflammation |
Title: |
The innate immune receptor Nlrp12 suppresses autoimmunity to the retina. |
Volume: |
19 |
Issue: |
1 |
Pages: |
69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krauss JL |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
NLRP12 provides a critical checkpoint for osteoclast differentiation. |
Volume: |
112 |
Issue: |
33 |
Pages: |
10455-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Allen IC |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Characterization of NLRP12 during the development of allergic airway disease in mice. |
Volume: |
7 |
Issue: |
1 |
Pages: |
e30612 |
|
•
•
•
•
•
|
Publication |
First Author: |
Linz BM |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis. |
Volume: |
198 |
Issue: |
6 |
Pages: |
2426-2433 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2017 |
Journal: |
Nat Immunol |
Title: |
NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth. |
Volume: |
18 |
Issue: |
5 |
Pages: |
541-551 |
|
•
•
•
•
•
|
Publication |
First Author: |
Truax AD |
Year: |
2018 |
Journal: |
Cell Host Microbe |
Title: |
The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis. |
Volume: |
24 |
Issue: |
3 |
Pages: |
364-378.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Prado DS |
Year: |
2020 |
Journal: |
FASEB J |
Title: |
NLRP12 controls arthritis severity by acting as a checkpoint inhibitor of Th17 cell differentiation. |
Volume: |
34 |
Issue: |
8 |
Pages: |
10907-10919 |
|
•
•
•
•
•
|
Publication |
First Author: |
Allen IC |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Characterization of NLRP12 during the in vivo host immune response to Klebsiella pneumoniae and Mycobacterium tuberculosis. |
Volume: |
8 |
Issue: |
4 |
Pages: |
e60842 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khan S |
Year: |
2023 |
Journal: |
J Clin Invest |
Title: |
NLRP12 downregulates the Wnt/β-catenin pathway via interaction with STK38 to suppress colorectal cancer. |
Volume: |
133 |
Issue: |
19 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Arthur JC |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. |
Volume: |
185 |
Issue: |
8 |
Pages: |
4515-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Udden SN |
Year: |
2019 |
Journal: |
Elife |
Title: |
NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte. |
Volume: |
8 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Normand S |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens. |
Volume: |
9 |
Issue: |
1 |
Pages: |
5338 |
|
•
•
•
•
•
|
Publication |
First Author: |
Allen IC |
Year: |
2012 |
Journal: |
Immunity |
Title: |
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. |
Volume: |
36 |
Issue: |
5 |
Pages: |
742-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lukens JR |
Year: |
2015 |
Journal: |
Immunity |
Title: |
The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells. |
Volume: |
42 |
Issue: |
4 |
Pages: |
654-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abdelhamid L |
Year: |
2023 |
Journal: |
Front Immunol |
Title: |
Nlrp12 deficiency alters gut microbiota and ameliorates Fas(lpr) -mediated systemic autoimmunity in male mice. |
Volume: |
14 |
|
Pages: |
1120958 |
|
•
•
•
•
•
|
Publication |
First Author: |
Silveira TN |
Year: |
2017 |
Journal: |
Eur J Immunol |
Title: |
NLRP12 negatively regulates proinflammatory cytokine production and host defense against Brucella abortus. |
Volume: |
47 |
Issue: |
1 |
Pages: |
51-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zaki MH |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection. |
Volume: |
111 |
Issue: |
1 |
Pages: |
385-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moustaqil M |
Year: |
2021 |
Journal: |
Emerg Microbes Infect |
Title: |
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species. |
Volume: |
10 |
Issue: |
1 |
Pages: |
178-195 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ataide MA |
Year: |
2014 |
Journal: |
PLoS Pathog |
Title: |
Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. |
Volume: |
10 |
Issue: |
1 |
Pages: |
e1003885 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Simon MM |
Year: |
2013 |
Journal: |
Genome Biol |
Title: |
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. |
Volume: |
14 |
Issue: |
7 |
Pages: |
R82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Joly S |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans. |
Volume: |
189 |
Issue: |
10 |
Pages: |
4713-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clay GM |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis. |
Volume: |
199 |
Issue: |
8 |
Pages: |
2823-2833 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hornung V |
Year: |
2009 |
Journal: |
Nature |
Title: |
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. |
Volume: |
458 |
Issue: |
7237 |
Pages: |
514-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Janowski AM |
Year: |
2016 |
Journal: |
J Clin Invest |
Title: |
NLRC4 suppresses melanoma tumor progression independently of inflammasome activation. |
Volume: |
126 |
Issue: |
10 |
Pages: |
3917-3928 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang D |
Year: |
2015 |
Journal: |
Immunity |
Title: |
Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock. |
Volume: |
43 |
Issue: |
5 |
Pages: |
923-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weng D |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. |
Volume: |
111 |
Issue: |
20 |
Pages: |
7391-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Madissoon E |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Differences in gene expression between mouse and human for dynamically regulated genes in early embryo. |
Volume: |
9 |
Issue: |
8 |
Pages: |
e102949 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elinav E |
Year: |
2011 |
Journal: |
Cell |
Title: |
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. |
Volume: |
145 |
Issue: |
5 |
Pages: |
745-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Henao-Mejia J |
Year: |
2012 |
Journal: |
Nature |
Title: |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. |
Volume: |
482 |
Issue: |
7384 |
Pages: |
179-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
|
Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gaudet P |
Year: |
2011 |
Journal: |
Brief Bioinform |
Title: |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Volume: |
12 |
Issue: |
5 |
Pages: |
449-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
706
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
741
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Pinheiro AS |
Year: |
2011 |
Journal: |
J Mol Biol |
Title: |
The NLRP12 pyrin domain: structure, dynamics, and functional insights. |
Volume: |
413 |
Issue: |
4 |
Pages: |
790-803 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25. |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Allele |
Name: |
NLR family, pyrin domain containing 12; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Stein C |
Year: |
2007 |
Journal: |
Genome Biol |
Title: |
Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish. |
Volume: |
8 |
Issue: |
11 |
Pages: |
R251 |
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Publication |
First Author: |
Manji GA |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B. |
Volume: |
277 |
Issue: |
13 |
Pages: |
11570-5 |
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Protein Domain |
Type: |
Domain |
Description: |
This domain is frequently found associated with the NACHT domain () in fish and other vertebrates []. Proteins containing this domain include NACHT, LRR and PYD domains-containing protein 3/12 (NLRP3/12). In humans, NLRP3 (also known as PYPAF1) may function as an inducer of apoptosis []. NLRP12 is a non-inflammasome NLR (nucleotide-binding domain and leucine-rich repeat-containing receptors) that has been implicated in the regulation of Toll-like receptor-dependent nuclear factor-kappaB activation []. |
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Allele |
Name: |
transgene insertion 1, Lionel Larue |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Recombinase |
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Strain |
Attribute String: |
transgenic, mutant strain, congenic |
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Publication |
First Author: |
Bernardazzi C |
Year: |
2022 |
Journal: |
Int J Mol Sci |
Title: |
The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome. |
Volume: |
23 |
Issue: |
9 |
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Publication |
First Author: |
Lord CA |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1. |
Volume: |
182 |
Issue: |
5 |
Pages: |
2948-58 |
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•
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Publication |
First Author: |
Pedersen M |
Year: |
2013 |
Journal: |
Cancer Discov |
Title: |
Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes. |
Volume: |
3 |
Issue: |
4 |
Pages: |
458-469 |
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