| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
Not Specified |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
354
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
130
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou X |
| Year: |
1993 |
| Journal: |
Nature |
| Title: |
Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. |
| Volume: |
361 |
| Issue: |
6412 |
| Pages: |
543-7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3654020 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2006-09-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603925 |
|
| Stage: |
TS25 |
| Assay Id: |
MGI:3654469 |
| Age: |
embryonic day 17.5 |
| Image: |
2 |
|
| Specimen Label: |
nodal |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3654020 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2006-09-13 |
| Strength: |
Not Specified |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1737319 |
|
| Stage: |
TS19 |
| Assay Id: |
MGI:3654522 |
| Age: |
embryonic day 11.5 |
| Image: |
2 |
|
| Specimen Label: |
nodal |
|
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7465189 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-04-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1797220 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:7466255 |
| Age: |
embryonic day 12.5 |
| Image: |
S4 |
|
| Specimen Label: |
Nodal +/+ |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7465189 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-04-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1797220 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:7466255 |
| Age: |
embryonic day 12.5 |
| Image: |
S4 |
|
| Specimen Label: |
Nodal fl/+ |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7465189 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-04-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1797220 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:7466255 |
| Age: |
embryonic day 12.5 |
| Image: |
S4 |
|
| Specimen Label: |
Nodal fl/fl |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schier AF |
| Year: |
2000 |
| Journal: |
Nature |
| Title: |
Nodal signalling in vertebrate development. |
| Volume: |
403 |
| Issue: |
6768 |
| Pages: |
385-9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7464576 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-04-21 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:160508 |
| Pattern: |
Widespread |
| Stage: |
TS08 |
| Assay Id: |
MGI:7464815 |
| Age: |
embryonic day 6.0 |
|
| Note: |
Expression in entire epiblast. |
| Specimen Label: |
4 Nodal E6.0 WT |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7464576 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-04-21 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:160508 |
| Pattern: |
Not Specified |
| Stage: |
TS08 |
| Assay Id: |
MGI:7464815 |
| Age: |
embryonic day 6.0 |
|
| Note: |
Expression in epiblast and overlying visceral endoderm. |
| Specimen Label: |
4 Nodal E6.0 -/- |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7464576 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-04-21 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:160518 |
| Pattern: |
Not Specified |
| Stage: |
TS08 |
| Assay Id: |
MGI:7464815 |
| Age: |
embryonic day 6.0 |
|
| Note: |
Expression in epiblast and overlying visceral endoderm. |
| Specimen Label: |
4 Nodal E6.0 -/- |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu W |
| Year: |
2012 |
| Journal: |
Biol Open |
| Title: |
Nodal mutant eXtraembryonic ENdoderm (XEN) stem cells upregulate markers for the anterior visceral endoderm and impact the timing of cardiac differentiation in mouse embryoid bodies. |
| Volume: |
1 |
| Issue: |
3 |
| Pages: |
208-19 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
245 |
| Description: |
Nodal |
| Type: |
chain |
| End: |
354 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5817956 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-01-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1607512 |
| Pattern: |
Uniform |
| Stage: |
TS12 |
| Assay Id: |
MGI:5817984 |
| Age: |
embryonic day 8.0-8.5 |
|
| Note: |
Symmetrical nodal expression. |
| Specimen Label: |
3B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5817956 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-01-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1607512 |
| Pattern: |
Uniform |
| Stage: |
TS12 |
| Assay Id: |
MGI:5817984 |
| Age: |
embryonic day 8.0-8.5 |
|
| Note: |
Symmetrical nodal expression. |
| Specimen Label: |
S1D |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5817956 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-01-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1607512 |
| Pattern: |
Uniform |
| Stage: |
TS12 |
| Assay Id: |
MGI:5817984 |
| Age: |
embryonic day 8.0-8.5 |
|
| Note: |
Symmetrical nodal expression. |
| Specimen Label: |
S1B |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5817956 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-01-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1607512 |
| Pattern: |
Uniform |
| Stage: |
TS12 |
| Assay Id: |
MGI:5817984 |
| Age: |
embryonic day 8.0-8.5 |
|
| Note: |
Symmetrical nodal expression. |
| Specimen Label: |
S1C |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Norris DP |
| Year: |
1999 |
| Journal: |
Genes Dev |
| Title: |
Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements. |
| Volume: |
13 |
| Issue: |
12 |
| Pages: |
1575-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma GT |
| Year: |
2001 |
| Journal: |
Dev Biol |
| Title: |
Nodal regulates trophoblast differentiation and placental development. |
| Volume: |
236 |
| Issue: |
1 |
| Pages: |
124-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hueng DY |
| Year: |
2011 |
| Journal: |
J Neurooncol |
| Title: |
Inhibition of Nodal suppresses angiogenesis and growth of human gliomas. |
| Volume: |
104 |
| Issue: |
1 |
| Pages: |
21-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lowe LA |
| Year: |
2001 |
| Journal: |
Development |
| Title: |
Genetic dissection of nodal function in patterning the mouse embryo. |
| Volume: |
128 |
| Issue: |
10 |
| Pages: |
1831-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brennan J |
| Year: |
2002 |
| Journal: |
Genes Dev |
| Title: |
Nodal activity in the node governs left-right asymmetry. |
| Volume: |
16 |
| Issue: |
18 |
| Pages: |
2339-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yull S |
| Year: |
2023 |
| Journal: |
Front Immunol |
| Title: |
Uterine Nodal expression supports maternal immunotolerance and establishment of the FOXP3(+) regulatory T cell population during the preimplantation period. |
| Volume: |
14 |
|
| Pages: |
1276979 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ware SM |
| Year: |
2006 |
| Journal: |
Dev Dyn |
| Title: |
Heart defects in X-linked heterotaxy: evidence for a genetic interaction of Zic3 with the nodal signaling pathway. |
| Volume: |
235 |
| Issue: |
6 |
| Pages: |
1631-7 |
|
•
•
•
•
•
|
| CL Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Varlet I |
| Year: |
1997 |
| Journal: |
Development |
| Title: |
nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. |
| Volume: |
124 |
| Issue: |
5 |
| Pages: |
1033-44 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179155 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689419 |
|
| Stage: |
TS19 |
| Assay Id: |
MGI:6190911 |
| Age: |
embryonic day 11.5 |
|
|
| Specimen Label: |
Table S2 - E11.5 - Nodal |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179155 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689421 |
|
| Stage: |
TS21 |
| Assay Id: |
MGI:6190911 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
Table S2 - E13.5 - Nodal |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179155 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1689424 |
|
| Stage: |
TS24 |
| Assay Id: |
MGI:6190911 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
Table S2 - E15.5 - Nodal |
| Detected: |
false |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179155 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1689426 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6190911 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
Table S2 - E18.5 - Nodal |
| Detected: |
false |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179155 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:6190911 |
| Age: |
postnatal day 4 |
|
|
| Specimen Label: |
Table S2 - P4 - Nodal |
| Detected: |
false |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179155 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:6190911 |
| Age: |
postnatal day 14 |
|
|
| Specimen Label: |
Table S2 - P14 - Nodal |
| Detected: |
false |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179155 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:6190911 |
| Age: |
postnatal day 28 |
|
|
| Specimen Label: |
Table S2 - P28 - Nodal |
| Detected: |
false |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang XF |
| Year: |
2014 |
| Journal: |
Eur J Immunol |
| Title: |
Nodal promotes the generation of M2-like macrophages and downregulates the expression of IL-12. |
| Volume: |
44 |
| Issue: |
1 |
| Pages: |
173-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sauer S |
| Year: |
2012 |
| Journal: |
Front Oncol |
| Title: |
Left-right symmetry breaking in mice by left-right dynein may occur via a biased chromatid segregation mechanism, without directly involving the Nodal gene. |
| Volume: |
2 |
|
| Pages: |
166 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Varlet I |
| Year: |
1997 |
| Journal: |
Cold Spring Harb Symp Quant Biol |
| Title: |
Nodal signaling and axis formation in the mouse. |
| Volume: |
62 |
|
| Pages: |
105-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pfendler KC |
| Year: |
2000 |
| Journal: |
Genesis |
| Title: |
Nodal and bone morphogenetic protein 5 interact in murine mesoderm formation and implantation. |
| Volume: |
28 |
| Issue: |
1 |
| Pages: |
1-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Arai D |
| Year: |
2015 |
| Journal: |
Mech Dev |
| Title: |
An epigenetic regulatory element of the Nodal gene in the mouse and human genomes. |
| Volume: |
136 |
|
| Pages: |
143-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ayash TA |
| Year: |
2020 |
| Journal: |
Biol Reprod |
| Title: |
Nodal is required to maintain the uterine environment in an anti-inflammatory state during pregnancy†. |
| Volume: |
102 |
| Issue: |
6 |
| Pages: |
1340-1350 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Camus A |
| Year: |
2006 |
| Journal: |
Dev Biol |
| Title: |
Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo. |
| Volume: |
295 |
| Issue: |
2 |
| Pages: |
743-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brennan J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Nodal signalling in the epiblast patterns the early mouse embryo. |
| Volume: |
411 |
| Issue: |
6840 |
| Pages: |
965-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Conlon FL |
| Year: |
1994 |
| Journal: |
Development |
| Title: |
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. |
| Volume: |
120 |
| Issue: |
7 |
| Pages: |
1919-28 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marques S |
| Year: |
2004 |
| Journal: |
Genes Dev |
| Title: |
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. |
| Volume: |
18 |
| Issue: |
19 |
| Pages: |
2342-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Collignon J |
| Year: |
1996 |
| Journal: |
Nature |
| Title: |
Relationship between asymmetric nodal expression and the direction of embryonic turning. |
| Volume: |
381 |
| Issue: |
6578 |
| Pages: |
155-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang YQ |
| Year: |
2008 |
| Journal: |
Dev Dyn |
| Title: |
Nodal and lefty signaling regulates the growth of pancreatic cells. |
| Volume: |
237 |
| Issue: |
5 |
| Pages: |
1255-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Blanchet MH |
| Year: |
2008 |
| Journal: |
Sci Signal |
| Title: |
Cripto localizes Nodal at the limiting membrane of early endosomes. |
| Volume: |
1 |
| Issue: |
45 |
| Pages: |
ra13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanaka Y |
| Year: |
2023 |
| Journal: |
Dev Cell |
| Title: |
Nodal flow transfers polycystin to determine mouse left-right asymmetry. |
| Volume: |
58 |
| Issue: |
16 |
| Pages: |
1447-1461.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meno C |
| Year: |
2001 |
| Journal: |
Dev Cell |
| Title: |
Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2. |
| Volume: |
1 |
| Issue: |
1 |
| Pages: |
127-38 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Perea-Gomez A |
| Year: |
2002 |
| Journal: |
Dev Cell |
| Title: |
Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. |
| Volume: |
3 |
| Issue: |
5 |
| Pages: |
745-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen C |
| Year: |
2004 |
| Journal: |
Curr Biol |
| Title: |
Two modes by which Lefty proteins inhibit nodal signaling. |
| Volume: |
14 |
| Issue: |
7 |
| Pages: |
618-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Houtmeyers R |
| Year: |
2016 |
| Journal: |
Hum Mol Genet |
| Title: |
Zic2 mutation causes holoprosencephaly via disruption of NODAL signalling. |
| Volume: |
25 |
| Issue: |
18 |
| Pages: |
3946-3959 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saijoh Y |
| Year: |
2003 |
| Journal: |
Dev Biol |
| Title: |
Left-right patterning of the mouse lateral plate requires nodal produced in the node. |
| Volume: |
256 |
| Issue: |
1 |
| Pages: |
160-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamamoto M |
| Year: |
2004 |
| Journal: |
Nature |
| Title: |
Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo. |
| Volume: |
428 |
| Issue: |
6981 |
| Pages: |
387-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Andersson O |
| Year: |
2006 |
| Journal: |
Dev Biol |
| Title: |
Synergistic interaction between Gdf1 and Nodal during anterior axis development. |
| Volume: |
293 |
| Issue: |
2 |
| Pages: |
370-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanaka C |
| Year: |
2007 |
| Journal: |
Genes Dev |
| Title: |
Long-range action of Nodal requires interaction with GDF1. |
| Volume: |
21 |
| Issue: |
24 |
| Pages: |
3272-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kumar A |
| Year: |
2008 |
| Journal: |
Dev Dyn |
| Title: |
Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. |
| Volume: |
237 |
| Issue: |
12 |
| Pages: |
3591-601 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hadjantonakis AK |
| Year: |
2008 |
| Journal: |
PLoS One |
| Title: |
Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. |
| Volume: |
3 |
| Issue: |
6 |
| Pages: |
e2511 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liguori GL |
| Year: |
2008 |
| Journal: |
Dev Biol |
| Title: |
Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo. |
| Volume: |
315 |
| Issue: |
2 |
| Pages: |
280-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vincent SD |
| Year: |
2004 |
| Journal: |
Mech Dev |
| Title: |
Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements. |
| Volume: |
121 |
| Issue: |
11 |
| Pages: |
1403-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mesnard D |
| Year: |
2006 |
| Journal: |
Development |
| Title: |
Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning. |
| Volume: |
133 |
| Issue: |
13 |
| Pages: |
2497-505 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iratni R |
| Year: |
2002 |
| Journal: |
Science |
| Title: |
Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. |
| Volume: |
298 |
| Issue: |
5600 |
| Pages: |
1996-9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1343263 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
1999-09-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1617912 |
| Pattern: |
Regionally restricted |
| Stage: |
TS12 |
| Assay Id: |
MGI:1343319 |
| Age: |
embryonic day 8.0 |
| Image: |
5A |
| Note: |
Nodal is expressed on the left side of normal embryos. |
| Specimen Label: |
5A |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park CB |
| Year: |
2012 |
| Journal: |
Biol Reprod |
| Title: |
NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy. |
| Volume: |
86 |
| Issue: |
6 |
| Pages: |
194 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kruithof-de Julio M |
| Year: |
2011 |
| Journal: |
Development |
| Title: |
Regulation of extra-embryonic endoderm stem cell differentiation by Nodal and Cripto signaling. |
| Volume: |
138 |
| Issue: |
18 |
| Pages: |
3885-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Trichas G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
Nodal dependent differential localisation of dishevelled-2 demarcates regions of differing cell behaviour in the visceral endoderm. |
| Volume: |
9 |
| Issue: |
2 |
| Pages: |
e1001019 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meno C |
| Year: |
1999 |
| Journal: |
Mol Cell |
| Title: |
Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. |
| Volume: |
4 |
| Issue: |
3 |
| Pages: |
287-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ishimura A |
| Year: |
2008 |
| Journal: |
Dev Dyn |
| Title: |
Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner. |
| Volume: |
237 |
| Issue: |
12 |
| Pages: |
3565-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Beck S |
| Year: |
2002 |
| Journal: |
Nat Cell Biol |
| Title: |
Extraembryonic proteases regulate Nodal signalling during gastrulation. |
| Volume: |
4 |
| Issue: |
12 |
| Pages: |
981-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dahle Ø |
| Year: |
2010 |
| Journal: |
Sci Signal |
| Title: |
Nodal signaling recruits the histone demethylase Jmjd3 to counteract polycomb-mediated repression at target genes. |
| Volume: |
3 |
| Issue: |
127 |
| Pages: |
ra48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pereira PN |
| Year: |
2012 |
| Journal: |
Development |
| Title: |
Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion. |
| Volume: |
139 |
| Issue: |
18 |
| Pages: |
3343-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Blanchet MH |
| Year: |
2008 |
| Journal: |
EMBO J |
| Title: |
Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation. |
| Volume: |
27 |
| Issue: |
19 |
| Pages: |
2580-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adachi H |
| Year: |
1999 |
| Journal: |
Genes Dev |
| Title: |
Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer. |
| Volume: |
13 |
| Issue: |
12 |
| Pages: |
1589-600 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao F |
| Year: |
2012 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells. |
| Volume: |
303 |
| Issue: |
1 |
| Pages: |
E132-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Spiller CM |
| Year: |
2012 |
| Journal: |
Development |
| Title: |
Endogenous Nodal signaling regulates germ cell potency during mammalian testis development. |
| Volume: |
139 |
| Issue: |
22 |
| Pages: |
4123-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lowe LA |
| Year: |
1996 |
| Journal: |
Nature |
| Title: |
Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. |
| Volume: |
381 |
| Issue: |
6578 |
| Pages: |
158-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamamoto M |
| Year: |
2003 |
| Journal: |
Development |
| Title: |
Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. |
| Volume: |
130 |
| Issue: |
9 |
| Pages: |
1795-804 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee GH |
| Year: |
2016 |
| Journal: |
J Cell Biol |
| Title: |
A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO. |
| Volume: |
215 |
| Issue: |
5 |
| Pages: |
705-718 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Norris DP |
| Year: |
2002 |
| Journal: |
Development |
| Title: |
The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo. |
| Volume: |
129 |
| Issue: |
14 |
| Pages: |
3455-68 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guzman-Ayala M |
| Year: |
2004 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment. |
| Volume: |
101 |
| Issue: |
44 |
| Pages: |
15656-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Larkins CE |
| Year: |
2012 |
| Journal: |
Dev Biol |
| Title: |
Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia. |
| Volume: |
367 |
| Issue: |
1 |
| Pages: |
15-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tavares AT |
| Year: |
2007 |
| Journal: |
Development |
| Title: |
Cerberus is a feedback inhibitor of Nodal asymmetric signaling in the chick embryo. |
| Volume: |
134 |
| Issue: |
11 |
| Pages: |
2051-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Krebs LT |
| Year: |
2003 |
| Journal: |
Genes Dev |
| Title: |
Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. |
| Volume: |
17 |
| Issue: |
10 |
| Pages: |
1207-12 |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Powers SE |
| Year: |
2010 |
| Journal: |
Development |
| Title: |
Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. |
| Volume: |
137 |
| Issue: |
2 |
| Pages: |
249-59 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim YY |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Meteorin regulates mesendoderm development by enhancing nodal expression. |
| Volume: |
9 |
| Issue: |
2 |
| Pages: |
e88811 |
|
•
•
•
•
•
|