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Search results 1 to 100 out of 426 for Nox4

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Type Details Score
Gene
Type: gene
Organism: human
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Gene
Type: gene
Organism: frog, western clawed
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Gene
Type: gene
Organism: rat
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Gene
Type: gene
Organism: dog, domestic
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Gene
Type: gene
Organism: chimpanzee
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Gene
Type: gene
Organism: cattle
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Gene
Type: gene
Organism: chicken
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Gene
Type: gene
Organism: macaque, rhesus
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Gene
Type: gene
Organism: zebrafish
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Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
Type: gene
Organism: human
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GXD Expression    
Probe: MGI:3828272
Assay Type: RT-PCR
Annotation Date: 2009-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737324
Stage: TS24
Assay Id: MGI:3828277
Age: embryonic day 16.0
Image: 1
Specimen Label: Nox4 K
Detected: true
Specimen Num: 4
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Publication
First Author: Brewer AC
Year: 2011
Journal: Free Radic Biol Med
Title: Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo.
Volume: 51
Issue: 1
Pages: 205-15
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Publication  
First Author: Geis C
Year: 2017
Journal: Exp Neurol
Title: NOX4 is an early initiator of neuropathic pain.
Volume: 288
Pages: 94-103
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Publication
First Author: Vogel J
Year: 2015
Journal: PLoS One
Title: Nox4 Is Dispensable for Exercise Induced Muscle Fibre Switch.
Volume: 10
Issue: 6
Pages: e0130769
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Publication  
First Author: He C
Year: 2019
Journal: JCI Insight
Title: NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis.
Volume: 4
Issue: 16
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Publication  
First Author: Hammers DW
Year: 2022
Journal: JCI Insight
Title: NOX4 inhibition promotes the remodeling of dystrophic muscle.
Volume: 7
Issue: 20
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Publication
First Author: Larson-Casey JL
Year: 2021
Journal: J Biol Chem
Title: NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression.
Volume: 297
Issue: 1
Pages: 100810
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Publication  
First Author: Specht KS
Year: 2021
Journal: Mol Metab
Title: Nox4 mediates skeletal muscle metabolic responses to exercise.
Volume: 45
Pages: 101160
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Publication
First Author: Bouabout G
Year: 2018
Journal: Arch Cardiovasc Dis
Title: Nox4 genetic inhibition in experimental hypertension and metabolic syndrome.
Volume: 111
Issue: 1
Pages: 41-52
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Publication
First Author: Matsushima S
Year: 2016
Journal: J Clin Invest
Title: Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling.
Volume: 126
Issue: 9
Pages: 3403-16
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Publication
First Author: Babelova A
Year: 2012
Journal: Free Radic Biol Med
Title: Role of Nox4 in murine models of kidney disease.
Volume: 53
Issue: 4
Pages: 842-53
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Publication
First Author: Choi SA
Year: 2019
Journal: Cell Death Differ
Title: Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis.
Volume: 26
Issue: 9
Pages: 1582-1599
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Publication
First Author: Demircan MB
Year: 2022
Journal: J Cancer Res Clin Oncol
Title: Context-specific effects of NOX4 inactivation in acute myeloid leukemia (AML).
Volume: 148
Issue: 8
Pages: 1983-1990
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Publication
First Author: Beretta M
Year: 2020
Journal: EMBO J
Title: Nox4 regulates InsP(3) receptor-dependent Ca(2+) release into mitochondria to promote cell survival.
Volume: 39
Issue: 19
Pages: e103530
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Publication  
First Author: Helfinger V
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors.
Volume: 118
Issue: 11
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Publication  
First Author: Bond JM
Year: 2025
Journal: Redox Biol
Title: Sex-specific metabolic responses to high-fat diet in mice with NOX4 deficiency.
Volume: 85
Pages: 103698
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Publication
First Author: Tang X
Year: 2021
Journal: Angiogenesis
Title: Endothelium-specific deletion of Nox4 delays retinal vascular development and mitigates pathological angiogenesis.
Volume: 24
Issue: 2
Pages: 363-377
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Publication
First Author: Jha JC
Year: 2016
Journal: Diabetologia
Title: Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy.
Volume: 59
Issue: 2
Pages: 379-89
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Publication  
First Author: Vendrov AE
Year: 2023
Journal: Redox Biol
Title: Cardiomyocyte NOX4 regulates resident macrophage-mediated inflammation and diastolic dysfunction in stress cardiomyopathy.
Volume: 67
Pages: 102937
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Publication
First Author: Xirouchaki CE
Year: 2021
Journal: Sci Adv
Title: Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance.
Volume: 7
Issue: 51
Pages: eabl4988
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Publication
First Author: Kodama R
Year: 2013
Journal: Genes Cells
Title: ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence.
Volume: 18
Issue: 1
Pages: 32-41
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Publication  
First Author: Lee HY
Year: 2020
Journal: Redox Biol
Title: The correlation of IRE1? oxidation with Nox4 activation in aging-associated vascular dysfunction.
Volume: 37
Pages: 101727
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Publication
First Author: Anea CB
Year: 2013
Journal: PLoS One
Title: Circadian clock control of Nox4 and reactive oxygen species in the vasculature.
Volume: 8
Issue: 10
Pages: e78626
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Publication
First Author: Mittal M
Year: 2007
Journal: Circ Res
Title: Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature.
Volume: 101
Issue: 3
Pages: 258-67
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Publication  
First Author: Yuan S
Year: 2021
Journal: Redox Biol
Title: Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation.
Volume: 47
Pages: 102166
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Publication  
First Author: Rezende F
Year: 2017
Journal: Redox Biol
Title: Knock out of the NADPH oxidase Nox4 has no impact on life span in mice.
Volume: 11
Pages: 312-314
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Publication
First Author: Khayrullina G
Year: 2023
Journal: PLoS One
Title: Differential effects of NOX2 and NOX4 inhibition after rodent spinal cord injury.
Volume: 18
Issue: 3
Pages: e0281045
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Publication
First Author: Schr?der K
Year: 2012
Journal: Circ Res
Title: Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase.
Volume: 110
Issue: 9
Pages: 1217-25
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Publication
First Author: Zhang M
Year: 2018
Journal: Cardiovasc Res
Title: Both cardiomyocyte and endothelial cell Nox4 mediate protection against hemodynamic overload-induced remodelling.
Volume: 114
Issue: 3
Pages: 401-408
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Publication  
First Author: Sasaki Y
Year: 2017
Journal: Sci Rep
Title: NOX4 Regulates CCR2 and CCL2 mRNA Stability in Alcoholic Liver Disease.
Volume: 7
Pages: 46144
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Publication
First Author: Wang X
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Hv1-deficiency protects ? cells from glucotoxicity through regulation of NOX4 level.
Volume: 513
Issue: 2
Pages: 434-438
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Publication
First Author: Carnesecchi S
Year: 2011
Journal: Antioxid Redox Signal
Title: A key role for NOX4 in epithelial cell death during development of lung fibrosis.
Volume: 15
Issue: 3
Pages: 607-19
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Publication
First Author: Ray R
Year: 2011
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo.
Volume: 31
Issue: 6
Pages: 1368-76
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Publication  
First Author: Yu W
Year: 2021
Journal: Free Radic Biol Med
Title: Endothelial Nox4 dysfunction aggravates atherosclerosis by inducing endoplasmic reticulum stress and soluble epoxide hydrolase.
Volume: 164
Pages: 44-57
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Publication
First Author: Ago T
Year: 2010
Journal: Circ Res
Title: Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes.
Volume: 106
Issue: 7
Pages: 1253-64
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Publication
First Author: Chen JR
Year: 2020
Journal: JBMR Plus
Title: Nox4 Expression Is Not Required for OVX-Induced Osteoblast Senescence and Bone Loss in Mice.
Volume: 4
Issue: 8
Pages: e10376
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Publication  
First Author: Cully TR
Year: 2020
Journal: Redox Biol
Title: Nox4 - RyR1 - Nox2: Regulators of micro-domain signaling in skeletal muscle.
Volume: 36
Pages: 101557
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Publication  
First Author: Han C
Year: 2022
Journal: Int Immunopharmacol
Title: NOX4 promotes mucosal barrier injury in inflammatory bowel disease by mediating macrophages M1 polarization through ROS.
Volume: 104
Pages: 108361
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Publication
First Author: Prior KK
Year: 2016
Journal: J Biol Chem
Title: The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein.
Volume: 291
Issue: 13
Pages: 7045-59
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Publication
First Author: Pendyala S
Year: 2011
Journal: Free Radic Biol Med
Title: Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter.
Volume: 50
Issue: 12
Pages: 1749-59
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Publication
First Author: Xue B
Year: 2012
Journal: Am J Physiol Heart Circ Physiol
Title: PVN adenovirus-siRNA injections silencing either NOX2 or NOX4 attenuate aldosterone/NaCl-induced hypertension in mice.
Volume: 302
Issue: 3
Pages: H733-41
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Publication
First Author: Ford BM
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice.
Volume: 305
Issue: 3
Pages: F323-32
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Publication
First Author: Mandal CC
Year: 2011
Journal: Biochem J
Title: Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation.
Volume: 433
Issue: 2
Pages: 393-402
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Publication  
First Author: Rajaram RD
Year: 2019
Journal: Redox Biol
Title: Tubular NOX4 expression decreases in chronic kidney disease but does not modify fibrosis evolution.
Volume: 26
Pages: 101234
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Publication  
First Author: Jiranugrom P
Year: 2020
Journal: Genes (Basel)
Title: NOX4 Deficiency Exacerbates the Impairment of Cystatin C-Dependent Hippocampal Neurogenesis by a Chronic High Fat Diet.
Volume: 11
Issue: 5
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Publication  
First Author: Qi J
Year: 2020
Journal: J Diabetes Res
Title: Swimming Exercise Protects against Insulin Resistance via Regulating Oxidative Stress through Nox4 and AKT Signaling in High-Fat Diet-Fed Mice.
Volume: 2020
Pages: 2521590
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Publication
First Author: He C
Year: 2013
Journal: Am J Pathol
Title: 7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B.
Volume: 183
Issue: 2
Pages: 626-37
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Publication
First Author: Wang J
Year: 2024
Journal: PLoS One
Title: Effects of Nox4 upregulation on PECAM-1 expression in a mouse model of diabetic retinopathy.
Volume: 19
Issue: 5
Pages: e0303010
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Publication  
First Author: Qu Z
Year: 2025
Journal: Free Radic Biol Med
Title: USP38 stabilizes NOX4 and activates CaMKII to enhance ventricular arrhythmias susceptibility in CKD mice.
Volume: 237
Pages: 344-356
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Publication
First Author: Chen L
Year: 2014
Journal: Biochim Biophys Acta
Title: Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines.
Volume: 1842
Issue: 12 Pt A
Pages: 2489-99
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Publication
First Author: Nadworny AS
Year: 2013
Journal: Am J Physiol Heart Circ Physiol
Title: Nox2 and Nox4 influence neonatal c-kit(+) cardiac precursor cell status and differentiation.
Volume: 305
Issue: 6
Pages: H829-42
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Publication
First Author: Li X
Year: 2017
Journal: Sci Rep
Title: Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes.
Volume: 7
Issue: 1
Pages: 14603
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Publication
First Author: Sancho P
Year: 2012
Journal: PLoS One
Title: NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development.
Volume: 7
Issue: 9
Pages: e45285
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Publication
First Author: Matsushima S
Year: 2013
Journal: Circ Res
Title: Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy.
Volume: 112
Issue: 4
Pages: 651-63
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Publication
First Author: Das R
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Upregulation of mitochondrial Nox4 mediates TGF-?-induced apoptosis in cultured mouse podocytes.
Volume: 306
Issue: 2
Pages: F155-67
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Publication  
First Author: Jim?nez-Altay? F
Year: 2018
Journal: Free Radic Biol Med
Title: Redox stress in Marfan syndrome: Dissecting the role of the NADPH oxidase NOX4 in aortic aneurysm.
Volume: 118
Pages: 44-58
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Publication  
First Author: Park MW
Year: 2021
Journal: Redox Biol
Title: NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases.
Volume: 41
Pages: 101947
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Publication
First Author: Spurney CF
Year: 2008
Journal: Neuromuscul Disord
Title: Dystrophin-deficient cardiomyopathy in mouse: expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart.
Volume: 18
Issue: 5
Pages: 371-81
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Publication  
First Author: Yoshikawa Y
Year: 2019
Journal: Neuroscience
Title: Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury.
Volume: 398
Pages: 193-205
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Publication
First Author: Santos CX
Year: 2016
Journal: EMBO J
Title: Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2?-mediated stress signaling.
Volume: 35
Issue: 3
Pages: 319-34
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Publication
First Author: Lan T
Year: 2015
Journal: PLoS One
Title: Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation.
Volume: 10
Issue: 7
Pages: e0129743
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Publication
First Author: Mahadev K
Year: 2004
Journal: Mol Cell Biol
Title: The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction.
Volume: 24
Issue: 5
Pages: 1844-54
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Publication  
First Author: Jiang J
Year: 2020
Journal: Redox Biol
Title: Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction.
Volume: 36
Pages: 101638
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Publication  
First Author: Boonpraman N
Year: 2023
Journal: Redox Biol
Title: NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease.
Volume: 62
Pages: 102698
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Publication
First Author: Zhang J
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Enhanced expression and activity of Nox2 and Nox4 in the macula densa in ANG II-induced hypertensive mice.
Volume: 306
Issue: 3
Pages: F344-50
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Publication  
First Author: Siu KL
Year: 2015
Journal: J Mol Cell Cardiol
Title: Netrin-1 abrogates ischemia/reperfusion-induced cardiac mitochondrial dysfunction via nitric oxide-dependent attenuation of NOX4 activation and recoupling of NOS.
Volume: 78
Pages: 174-85
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Publication
First Author: Wu X
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: NOX4 pathway as a source of selective insulin resistance and responsiveness.
Volume: 32
Issue: 5
Pages: 1236-45
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Publication  
First Author: Braunersreuther V
Year: 2013
Journal: J Mol Cell Cardiol
Title: Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury.
Volume: 64
Pages: 99-107
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Publication  
First Author: Kumar RA
Year: 2023
Journal: Free Radic Biol Med
Title: Skeletal muscle Nox4 knockout prevents and Nox2 knockout blunts loss of maximal diaphragm force in mice with heart failure with reduced ejection fraction.
Volume: 194
Pages: 23-32
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Publication
First Author: Li J
Year: 2006
Journal: Mol Biol Cell
Title: The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation.
Volume: 17
Issue: 9
Pages: 3978-88
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Publication
First Author: Yu JH
Year: 2012
Journal: Hepatology
Title: The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice.
Volume: 56
Issue: 6
Pages: 2375-86
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Publication  
First Author: Murray TV
Year: 2015
Journal: J Mol Cell Cardiol
Title: Redox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcription.
Volume: 79
Pages: 54-68
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Publication
First Author: Zhang M
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis.
Volume: 107
Issue: 42
Pages: 18121-6
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Publication
First Author: Kallenborn-Gerhardt W
Year: 2012
Journal: J Neurosci
Title: NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury.
Volume: 32
Issue: 30
Pages: 10136-45
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Publication    
First Author: Chanda D
Year: 2021
Journal: Elife
Title: Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells.
Volume: 10
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Publication
First Author: Lee SR
Year: 2024
Journal: iScience
Title: Nox4-SH3YL1 complex is involved in diabetic nephropathy.
Volume: 27
Issue: 2
Pages: 108868
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Publication
First Author: Yoo JY
Year: 2020
Journal: Cell Rep
Title: LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1.
Volume: 33
Issue: 3
Pages: 108245
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Publication
First Author: Anilkumar N
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells.
Volume: 33
Issue: 4
Pages: e104-12
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Publication
First Author: Casas AI
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage.
Volume: 114
Issue: 46
Pages: 12315-12320
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Publication
First Author: Kuroda J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart.
Volume: 107
Issue: 35
Pages: 15565-70
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Publication
First Author: Khazim K
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo.
Volume: 305
Issue: 5
Pages: F691-700
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Publication  
First Author: Canugovi C
Year: 2019
Journal: Redox Biol
Title: Increased mitochondrial NADPH oxidase 4 (NOX4) expression in aging is a causative factor in aortic stiffening.
Volume: 26
Pages: 101288
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Publication
First Author: Den Hartigh LJ
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in Obesity.
Volume: 37
Issue: 3
Pages: 466-475
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Publication
First Author: Singh A
Year: 2017
Journal: Sci Rep
Title: NADPH oxidase 4 modulates hepatic responses to lipopolysaccharide mediated by Toll-like receptor-4.
Volume: 7
Issue: 1
Pages: 14346
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Publication  
First Author: Stenke E
Year: 2020
Journal: Redox Biol
Title: NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation.
Volume: 37
Pages: 101752
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Publication  
First Author: Siedlar AM
Year: 2023
Journal: Redox Biol
Title: NADPH oxidase 4 is dispensable for skin myofibroblast differentiation and wound healing.
Volume: 60
Pages: 102609
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Publication  
First Author: Zhao S
Year: 2021
Journal: Free Radic Biol Med
Title: Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage.
Volume: 173
Pages: 81-96
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Publication
First Author: Stevenson MD
Year: 2019
Journal: Antioxid Redox Signal
Title: NADPH Oxidase 4 Regulates Inflammation in Ischemic Heart Failure: Role of Soluble Epoxide Hydrolase.
Volume: 31
Issue: 1
Pages: 39-58
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Publication
First Author: Kim JY
Year: 2024
Journal: Sci Rep
Title: NADPH oxidase 4 deficiency promotes hepatocellular carcinoma arising from hepatic fibrosis by inducing M2-macrophages in the tumor microenvironment.
Volume: 14
Issue: 1
Pages: 22358
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