Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
NADPH oxidase activator 1 (NOXA1), also known as p51-nox or p67phox-like factor, functions as an activator of NOX1 and NOX2, members of the Nox family of superoxide-producing NADPH oxidases []. It is homologous to the component p67-phox of the phagocytic oxidase, the prototypical Nox [, ]. NOXA1 and NOXO1 support superoxide generation by NOX1 and are expressed predominantly in colon epithelium with NOX1 []. NOXA1 is also coexpressed with NOX2 in some cells, such as endothelial cells, vascular smooth muscle cells, and hematopoietic stem cells []. |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1681637 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-15 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3564922 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:3826126 |
Age: |
embryonic day 14.5 |
Image: |
Additional file 4 Noxa1 |
|
Specimen Label: |
Additional file 4 Noxa1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bánfi B |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. |
Volume: |
278 |
Issue: |
6 |
Pages: |
3510-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Valente AJ |
Year: |
2007 |
Journal: |
Free Radic Biol Med |
Title: |
NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain. |
Volume: |
43 |
Issue: |
3 |
Pages: |
384-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawano M |
Year: |
2012 |
Journal: |
Arch Biochem Biophys |
Title: |
Noxa1 as a moderate activator of Nox2-based NADPH oxidase. |
Volume: |
519 |
Issue: |
1 |
Pages: |
1-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ambasta RK |
Year: |
2006 |
Journal: |
Free Radic Biol Med |
Title: |
Noxa1 is a central component of the smooth muscle NADPH oxidase in mice. |
Volume: |
41 |
Issue: |
2 |
Pages: |
193-201 |
|
•
•
•
•
•
|
Publication |
First Author: |
Geiszt M |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. |
Volume: |
278 |
Issue: |
22 |
Pages: |
20006-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takeya R |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. |
Volume: |
278 |
Issue: |
27 |
Pages: |
25234-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedard K |
Year: |
2007 |
Journal: |
Physiol Rev |
Title: |
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. |
Volume: |
87 |
Issue: |
1 |
Pages: |
245-313 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
444
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Vendrov AE |
Year: |
2019 |
Journal: |
Redox Biol |
Title: |
NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis. |
Volume: |
21 |
|
Pages: |
101063 |
|
•
•
•
•
•
|
Publication |
First Author: |
Flaherty JP |
Year: |
2010 |
Journal: |
Genesis |
Title: |
Generation of a conditional null allele of NADPH oxidase activator 1 (NOXA1). |
Volume: |
48 |
Issue: |
9 |
Pages: |
568-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Niu XL |
Year: |
2010 |
Journal: |
Circulation |
Title: |
Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries. |
Volume: |
121 |
Issue: |
4 |
Pages: |
549-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dutta S |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1. |
Volume: |
5 |
Issue: |
5 |
Pages: |
e10478 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1681637 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826756 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_002004_07 |
|
Specimen Label: |
euxassay_002004_07 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1681637 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826756 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_002004_08 |
|
Specimen Label: |
euxassay_002004_08 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1681637 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826756 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_002004_09 |
|
Specimen Label: |
euxassay_002004_09 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1681637 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826756 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_002004_10 |
|
Specimen Label: |
euxassay_002004_10 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1681637 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826756 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_002004_12 |
|
Specimen Label: |
euxassay_002004_12 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1681637 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826756 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_002004_13 |
|
Specimen Label: |
euxassay_002004_13 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1681637 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826756 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_002004_14 |
|
Specimen Label: |
euxassay_002004_14 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1681637 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826756 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_002004_15 |
|
Specimen Label: |
euxassay_002004_15 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Janus P |
Year: |
2020 |
Journal: |
Cell Death Differ |
Title: |
Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells. |
Volume: |
27 |
Issue: |
7 |
Pages: |
2280-2292 |
|
•
•
•
•
•
|
Publication |
First Author: |
Flodby P |
Year: |
2016 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. |
Volume: |
55 |
Issue: |
1 |
Pages: |
135-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoffman BG |
Year: |
2008 |
Journal: |
Genome Biol |
Title: |
Identification of transcripts with enriched expression in the developing and adult pancreas. |
Volume: |
9 |
Issue: |
6 |
Pages: |
R99 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Streeter J |
Year: |
2014 |
Journal: |
Circ Res |
Title: |
Phosphorylation of Nox1 regulates association with NoxA1 activation domain. |
Volume: |
115 |
Issue: |
11 |
Pages: |
911-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
75
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
BelAiba RS |
Year: |
2007 |
Journal: |
Free Radic Biol Med |
Title: |
NOX5 variants are functionally active in endothelial cells. |
Volume: |
42 |
Issue: |
4 |
Pages: |
446-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaito Y |
Year: |
2014 |
Journal: |
FEBS Lett |
Title: |
Nox1 activation by βPix and the role of Ser-340 phosphorylation. |
Volume: |
588 |
Issue: |
11 |
Pages: |
1997-2002 |
|
•
•
•
•
•
|
Publication |
First Author: |
Debbabi M |
Year: |
2013 |
Journal: |
FASEB J |
Title: |
NOXO1 phosphorylation on serine 154 is critical for optimal NADPH oxidase 1 assembly and activation. |
Volume: |
27 |
Issue: |
4 |
Pages: |
1733-48 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
ADPH oxidase 1 (NOX1) is a NADPH oxidase that generates superoxide []. It is involved in several cell functions such as proliferation, vascular contraction, host defence, and cytoskeletal remodelling []. It requires small GTPase Rac, Noxa1 and Noxo1 for its activation []. It can be regulated by betaPix through Rac activation []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakano Y |
Year: |
2007 |
Journal: |
Biochem J |
Title: |
Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. |
Volume: |
403 |
Issue: |
1 |
Pages: |
97-108 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
591
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
526
|
Fragment?: |
false |
|
•
•
•
•
•
|