Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Buchmann GK |
Year: |
2020 |
Journal: |
Redox Biol |
Title: |
Deletion of NoxO1 limits atherosclerosis development in female mice. |
Volume: |
37 |
|
Pages: |
101713 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seimetz M |
Year: |
2020 |
Journal: |
Nat Metab |
Title: |
NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD. |
Volume: |
2 |
Issue: |
6 |
Pages: |
532-546 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dutta S |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1. |
Volume: |
5 |
Issue: |
5 |
Pages: |
e10478 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brandes RP |
Year: |
2016 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
The Cytosolic NADPH Oxidase Subunit NoxO1 Promotes an Endothelial Stalk Cell Phenotype. |
Volume: |
36 |
Issue: |
8 |
Pages: |
1558-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oshima H |
Year: |
2014 |
Journal: |
Oncogene |
Title: |
TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells. |
Volume: |
33 |
Issue: |
29 |
Pages: |
3820-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bánfi B |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. |
Volume: |
278 |
Issue: |
6 |
Pages: |
3510-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kiss PJ |
Year: |
2006 |
Journal: |
Curr Biol |
Title: |
Inactivation of NADPH oxidase organizer 1 results in severe imbalance. |
Volume: |
16 |
Issue: |
2 |
Pages: |
208-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakano Y |
Year: |
2007 |
Journal: |
Biochem J |
Title: |
Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. |
Volume: |
403 |
Issue: |
1 |
Pages: |
97-108 |
|
•
•
•
•
•
|
Publication |
First Author: |
DeSantis DA |
Year: |
2013 |
Journal: |
Alcohol Clin Exp Res |
Title: |
Genetic resistance to liver fibrosis on A/J mouse chromosome 17. |
Volume: |
37 |
Issue: |
10 |
Pages: |
1668-79 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Gagnon L |
Year: |
2003 |
Journal: |
MGI Direct Data Submission |
Title: |
A new spontaneous mutation on Chromosome 17 in the mouse named head slant (hslt). Mouse Mutant Resource Web Site, The Jackson Laboratory, Bar Harbor, Maine |
|
|
|
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416583 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1775523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826757 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013661_07 |
|
Specimen Label: |
euxassay_013661_07 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416583 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1775523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826757 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013661_08 |
|
Specimen Label: |
euxassay_013661_08 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416583 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1775523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826757 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013661_09 |
|
Specimen Label: |
euxassay_013661_09 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416583 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1775523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826757 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013661_16 |
|
Specimen Label: |
euxassay_013661_16 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416583 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1775523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826757 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013661_17 |
|
Specimen Label: |
euxassay_013661_17 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416583 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1775523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826757 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013661_18 |
|
Specimen Label: |
euxassay_013661_18 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416583 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1775523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826757 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013661_19 |
|
Specimen Label: |
euxassay_013661_19 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416583 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1728623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826757 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013661_05 |
|
Specimen Label: |
euxassay_013661_05 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416583 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1728623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826757 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013661_06 |
|
Specimen Label: |
euxassay_013661_06 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416583 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1728623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826757 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013661_20 |
|
Specimen Label: |
euxassay_013661_20 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416583 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1728623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826757 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013661_21 |
|
Specimen Label: |
euxassay_013661_21 |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4416583 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1789623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4826757 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_013661_13 |
|
Specimen Label: |
euxassay_013661_13 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Romand R |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
Retinoic acid deficiency impairs the vestibular function. |
Volume: |
33 |
Issue: |
13 |
Pages: |
5856-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Street VA |
Year: |
2014 |
Journal: |
J Assoc Res Otolaryngol |
Title: |
Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions. |
Volume: |
15 |
Issue: |
5 |
Pages: |
721-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
336
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Moll F |
Year: |
2018 |
Journal: |
Front Immunol |
Title: |
NoxO1 Controls Proliferation of Colon Epithelial Cells. |
Volume: |
9 |
|
Pages: |
973 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
106
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Debbabi M |
Year: |
2013 |
Journal: |
FASEB J |
Title: |
NOXO1 phosphorylation on serine 154 is critical for optimal NADPH oxidase 1 assembly and activation. |
Volume: |
27 |
Issue: |
4 |
Pages: |
1733-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Petry A |
Year: |
2010 |
Journal: |
Antioxid Redox Signal |
Title: |
Receptor activation of NADPH oxidases. |
Volume: |
13 |
Issue: |
4 |
Pages: |
467-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng G |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. |
Volume: |
279 |
Issue: |
6 |
Pages: |
4737-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto A |
Year: |
2007 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1). |
Volume: |
352 |
Issue: |
2 |
Pages: |
560-5 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Nox Organizing protein 1 (NoxO1) is a critical regulator of enzyme kinetics of the nonphagocytic NADPH oxidase Nox1, which catalyzes the transfer of electrons from NADPH to molecular oxygen to form superoxide []. NoxO1 is involved in targeting activator subunits (such as NoxA1) to Nox1. It is co-localized with Nox1 in the membranes of resting cells and directs the subcellular localization of Nox1 []. NoxO1 contains an N-terminal Phox homology (PX) domain, tandem SH3 domains (N-SH3 and C-SH3), and a C-terminal proline-rich region (PRR).This entry represents the second SH3 domain (or C-SH3) of NoxO1. The tandem SH3 domains of NoxO1 interact with the PRR of p22phox, which also complexes with Nox1 []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
75
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
BelAiba RS |
Year: |
2007 |
Journal: |
Free Radic Biol Med |
Title: |
NOX5 variants are functionally active in endothelial cells. |
Volume: |
42 |
Issue: |
4 |
Pages: |
446-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaito Y |
Year: |
2014 |
Journal: |
FEBS Lett |
Title: |
Nox1 activation by βPix and the role of Ser-340 phosphorylation. |
Volume: |
588 |
Issue: |
11 |
Pages: |
1997-2002 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
ADPH oxidase 1 (NOX1) is a NADPH oxidase that generates superoxide []. It is involved in several cell functions such as proliferation, vascular contraction, host defence, and cytoskeletal remodelling []. It requires small GTPase Rac, Noxa1 and Noxo1 for its activation []. It can be regulated by betaPix through Rac activation []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Geiszt M |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. |
Volume: |
278 |
Issue: |
22 |
Pages: |
20006-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawano M |
Year: |
2012 |
Journal: |
Arch Biochem Biophys |
Title: |
Noxa1 as a moderate activator of Nox2-based NADPH oxidase. |
Volume: |
519 |
Issue: |
1 |
Pages: |
1-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takeya R |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. |
Volume: |
278 |
Issue: |
27 |
Pages: |
25234-46 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
NADPH oxidase activator 1 (NOXA1), also known as p51-nox or p67phox-like factor, functions as an activator of NOX1 and NOX2, members of the Nox family of superoxide-producing NADPH oxidases []. It is homologous to the component p67-phox of the phagocytic oxidase, the prototypical Nox [, ]. NOXA1 and NOXO1 support superoxide generation by NOX1 and are expressed predominantly in colon epithelium with NOX1 []. NOXA1 is also coexpressed with NOX2 in some cells, such as endothelial cells, vascular smooth muscle cells, and hematopoietic stem cells []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Flaherty JP |
Year: |
2010 |
Journal: |
Genesis |
Title: |
Generation of a conditional null allele of NADPH oxidase activator 1 (NOXA1). |
Volume: |
48 |
Issue: |
9 |
Pages: |
568-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedard K |
Year: |
2007 |
Journal: |
Physiol Rev |
Title: |
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. |
Volume: |
87 |
Issue: |
1 |
Pages: |
245-313 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ambasta RK |
Year: |
2006 |
Journal: |
Free Radic Biol Med |
Title: |
Noxa1 is a central component of the smooth muscle NADPH oxidase in mice. |
Volume: |
41 |
Issue: |
2 |
Pages: |
193-201 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ali MI |
Year: |
2009 |
Journal: |
Circ Res |
Title: |
Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone. |
Volume: |
105 |
Issue: |
10 |
Pages: |
1013-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Valente AJ |
Year: |
2007 |
Journal: |
Free Radic Biol Med |
Title: |
NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain. |
Volume: |
43 |
Issue: |
3 |
Pages: |
384-96 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
349
 |
Fragment?: |
false |
|
•
•
•
•
•
|