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Search results 1 to 100 out of 384 for Npr2

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0.057s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: This family of regulators are involved in post-translational control of nitrogen permease. In mammals, it may act as a tumor suppressor that suppresses cell growth and enhances sensitivity to various anticancer drugs [, ]. This entry also includes the GATOR complex protein NPRL2. The GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway. The mTORC1 pathway promotes cell growth in response to various factors including amino acids. Rag guanosine triphosphatases promote translocation of mTORC1 to the lysosomal membrane, where it is activated [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication    
First Author: Shuhaibar LC
Year: 2017
Journal: Elife
Title: Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor.
Volume: 6
Gene
Type: gene
Organism: human
Publication
First Author: Sogawa-Fujiwara C
Year: 2020
Journal: Sci Rep
Title: Defective development and microcirculation of intestine in Npr2 mutant mice.
Volume: 10
Issue: 1
Pages: 14761
Publication
First Author: Sogawa C
Year: 2007
Journal: J Hered
Title: Short-limbed dwarfism: slw is a new allele of Npr2 causing chondrodysplasia.
Volume: 98
Issue: 6
Pages: 575-80
Publication
First Author: Zhang M
Year: 2010
Journal: Science
Title: Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes.
Volume: 330
Issue: 6002
Pages: 366-9
Publication
First Author: Lu CC
Year: 2014
Journal: PLoS Genet
Title: Mutation of Npr2 leads to blurred tonotopic organization of central auditory circuits in mice.
Volume: 10
Issue: 12
Pages: e1004823
Publication
First Author: Schmidt H
Year: 2007
Journal: J Cell Biol
Title: The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.
Volume: 179
Issue: 2
Pages: 331-40
Publication
First Author: Shuhaibar LC
Year: 2016
Journal: Dev Biol
Title: Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.
Volume: 409
Issue: 1
Pages: 194-201
Protein
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
Publication
First Author: Neklesa TK
Year: 2009
Journal: PLoS Genet
Title: A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex.
Volume: 5
Issue: 6
Pages: e1000515
Publication
First Author: Bar-Peled L
Year: 2013
Journal: Science
Title: A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Volume: 340
Issue: 6136
Pages: 1100-6
Publication
First Author: Kurata A
Year: 2008
Journal: Cancer Sci
Title: TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.
Volume: 99
Issue: 9
Pages: 1827-34
Publication
First Author: Geister KA
Year: 2013
Journal: Hum Mol Genet
Title: A novel loss-of-function mutation in Npr2 clarifies primary role in female reproduction and reveals a potential therapy for acromesomelic dysplasia, Maroteaux type.
Volume: 22
Issue: 2
Pages: 345-57
Publication
First Author: Wagner BM
Year: 2022
Journal: Calcif Tissue Int
Title: Guanylyl Cyclase-B Dependent Bone Formation in Mice is Associated with Youth, Increased Osteoblasts, and Decreased Osteoclasts.
Volume: 111
Issue: 5
Pages: 506-518
Publication  
First Author: Robinson JW
Year: 2020
Journal: Bone
Title: Male mice with elevated C-type natriuretic peptide-dependent guanylyl cyclase-B activity have increased osteoblasts, bone mass and bone strength.
Volume: 135
Pages: 115320
Publication
First Author: Egbert JR
Year: 2018
Journal: Dev Biol
Title: Luteinizing hormone signaling phosphorylates and activates the cyclic GMP phosphodiesterase PDE5 in mouse ovarian follicles, contributing an additional component to the hormonally induced decrease in cyclic GMP that reinitiates meiosis.
Volume: 435
Issue: 1
Pages: 6-14
Publication  
First Author: Wolter S
Year: 2018
Journal: Front Neural Circuits
Title: GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing.
Volume: 12
Pages: 65
Publication
First Author: Ter-Avetisyan G
Year: 2014
Journal: J Neurosci
Title: Bifurcation of axons from cranial sensory neurons is disabled in the absence of Npr2-induced cGMP signaling.
Volume: 34
Issue: 3
Pages: 737-47
Publication
First Author: Schmidt H
Year: 2018
Journal: J Neurosci
Title: Regulation of the Natriuretic Peptide Receptor 2 (Npr2) by Phosphorylation of Juxtamembrane Serine and Threonine Residues Is Essential for Bifurcation of Sensory Axons.
Volume: 38
Issue: 45
Pages: 9768-9780
Publication  
First Author: Tröster P
Year: 2018
Journal: Front Mol Neurosci
Title: The Absence of Sensory Axon Bifurcation Affects Nociception and Termination Fields of Afferents in the Spinal Cord.
Volume: 11
Pages: 19
Publication  
First Author: Wagner BM
Year: 2021
Journal: JCI Insight
Title: Prevention of guanylyl cyclase-B dephosphorylation rescues achondroplastic dwarfism.
Volume: 6
Issue: 9
Publication  
First Author: Ter-Avetisyan G
Year: 2018
Journal: Front Cell Neurosci
Title: Loss of Axon Bifurcation in Mesencephalic Trigeminal Neurons Impairs the Maximal Biting Force in Npr2-Deficient Mice.
Volume: 12
Pages: 153
Publication
First Author: Sogawa C
Year: 2010
Journal: Am J Pathol
Title: Gastrointestinal tract disorder in natriuretic peptide receptor B gene mutant mice.
Volume: 177
Issue: 2
Pages: 822-8
Publication
First Author: Tsuji T
Year: 2005
Journal: J Biol Chem
Title: A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse.
Volume: 280
Issue: 14
Pages: 14288-92
Publication
First Author: Dugbartey GJ
Year: 2019
Journal: Am J Pathol
Title: The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.
Volume: 189
Issue: 9
Pages: 1721-1731
Publication
First Author: Korshunov VA
Year: 2020
Journal: J Am Heart Assoc
Title: Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling.
Volume: 9
Issue: 10
Pages: e014257
Publication  
First Author: Kong N
Year: 2017
Journal: Sci Rep
Title: Natriuretic peptide type C induces sperm attraction for fertilization in mouse.
Volume: 7
Pages: 39711
Publication  
First Author: Baena V
Year: 2020
Journal: Endocrinology
Title: Cellular Heterogeneity of the Luteinizing Hormone Receptor and Its Significance for Cyclic GMP Signaling in Mouse Preovulatory Follicles.
Volume: 161
Issue: 7
Publication
First Author: Kiyosu C
Year: 2012
Journal: Reproduction
Title: NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation during follicular development in the mouse ovary.
Volume: 144
Issue: 2
Pages: 187-93
Publication
First Author: Tsuji T
Year: 2012
Journal: Mol Reprod Dev
Title: CNP/NPR2 signaling maintains oocyte meiotic arrest in early antral follicles and is suppressed by EGFR-mediated signaling in preovulatory follicles.
Volume: 79
Issue: 11
Pages: 795-802
Publication
First Author: Zhang Y
Year: 2014
Journal: Mol Reprod Dev
Title: Porcine natriuretic peptide type B (pNPPB) maintains mouse oocyte meiotic arrest via natriuretic peptide receptor 2 (NPR2) in cumulus cells.
Volume: 81
Issue: 5
Pages: 462-9
Publication  
First Author: Ma Q
Year: 2018
Journal: Exp Neurol
Title: C-type natriuretic peptide functions as an innate neuroprotectant in neonatal hypoxic-ischemic brain injury in mouse via natriuretic peptide receptor 2.
Volume: 304
Pages: 58-66
Publication
First Author: Schmidt H
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons.
Volume: 106
Issue: 39
Pages: 16847-52
Publication
First Author: Schmidt H
Year: 2016
Journal: Eur J Neurosci
Title: Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3.
Volume: 44
Issue: 12
Pages: 2991-3000
Publication
First Author: Liu W
Year: 2017
Journal: Cell Death Dis
Title: Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals.
Volume: 8
Issue: 3
Pages: e2662
Publication  
First Author: Chen Y
Year: 2022
Journal: Front Mol Neurosci
Title: Retinal degeneration protein 3 controls membrane guanylate cyclase activities in brain tissue.
Volume: 15
Pages: 1076430
Publication
First Author: Blaser MC
Year: 2018
Journal: Circ Res
Title: Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice.
Volume: 122
Issue: 3
Pages: 405-416
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Tamura N
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs.
Volume: 101
Issue: 49
Pages: 17300-5
Publication
First Author: Å piranec K
Year: 2018
Journal: Circulation
Title: Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure.
Volume: 138
Issue: 5
Pages: 494-508
Publication      
First Author: Karst SY
Year: 2011
Journal: MGI Direct Data Submission
Title: A remutation to achondroplasia in the MRL/MpJ inbred background: Npr2cn-3J
Publication  
First Author: Sogawa C
Year: 2014
Journal: Reprod Biol Endocrinol
Title: Mutant phenotype analysis suggests potential roles for C-type natriuretic peptide receptor (NPR-B) in male mouse fertility.
Volume: 12
Pages: 64
Publication      
First Author: Harris BS
Year: 2001
Journal: MGI Direct Data Submission
Title: A remutation at the achondroplasia locus in mouse: cn2J. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine
Publication
First Author: Konyukhov BV
Year: 1967
Journal: Acta Biol Acad Sci Hung
Title: Experimental study of the achondroplasia gene effects in the mouse.
Volume: 18
Issue: 3
Pages: 285-94
Publication
First Author: Kleinman HK
Year: 1977
Journal: Growth
Title: Proteoglycan and collagen of "achondroplastic" (cn/cn) neonatal mouse cartilage.
Volume: 41
Issue: 3
Pages: 171-7
Publication  
First Author: Bonucci E
Year: 1977
Journal: J Submicrosc Cytol
Title: An electron microscope investigation of cartilage and bone in achondroplastic (cn/cn) mice
Volume: 9
Pages: 299-306
Publication  
First Author: Dickie MM
Year: 1961
Journal: Mouse News Lett
Title: Disproportionate dwarfing (achondroplasia)
Volume: 25
Pages: 36
Publication
First Author: Konyukhov BV
Year: 1970
Journal: Acta Biol Acad Sci Hung
Title: Abnormal growth of the body, internal organs and skeleton in the achondroplastic mice.
Volume: 21
Issue: 4
Pages: 347-54
Publication  
First Author: Thurston MN
Year: 1985
Journal: J Anat
Title: Cell kinetics of growth cartilage of achondroplastic (cn) mice.
Volume: 140 ( Pt 3)
Pages: 425-34
Publication  
First Author: Brewer AK
Year: 1977
Journal: J Embryol Exp Morphol
Title: Further studies on skull growth in achondroplasic (cn) mice.
Volume: 39
Pages: 59-70
GXD Expression    
Probe: MGI:3823124
Assay Type: RT-PCR
Annotation Date: 2009-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757720
Stage: TS20
Assay Id: MGI:3823267
Age: embryonic day 12.0
Image: 2
Specimen Label: S
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3823124
Assay Type: RT-PCR
Annotation Date: 2009-01-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666820
Stage: TS20
Assay Id: MGI:3823267
Age: embryonic day 12.0
Image: 2
Specimen Label: D
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1755629
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1870523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826771
Age: embryonic day 14.5
Image: euxassay_005611_04
Specimen Label: euxassay_005611_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1755629
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1870523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826771
Age: embryonic day 14.5
Image: euxassay_005611_05
Specimen Label: euxassay_005611_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1755629
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1870523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826771
Age: embryonic day 14.5
Image: euxassay_005611_06
Specimen Label: euxassay_005611_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1755629
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1870523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826771
Age: embryonic day 14.5
Image: euxassay_005611_16
Specimen Label: euxassay_005611_16
Detected: true
Specimen Num: 16
GXD Expression  
Probe: MGI:1755629
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1870523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826771
Age: embryonic day 14.5
Image: euxassay_005611_17
Specimen Label: euxassay_005611_17
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:5310177
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3516422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423501
Age: embryonic day 14.5
Image: EG1047; Specimen G0397
Specimen Label: EG1047; Specimen G0397
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:4355919
Assay Type: RNA in situ
Annotation Date: 2009-09-03
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1665817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4355921
Age: embryonic day 10.5
Image: 1A,B
Note: Expression is in several ganglia.
Specimen Label: 1A,B
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5310177
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1716122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423501
Age: embryonic day 14.5
Image: EG1047; Specimen G0397
Specimen Label: EG1047; Specimen G0397
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5310177
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1691622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423501
Age: embryonic day 14.5
Image: EG1047; Specimen G0397
Specimen Label: EG1047; Specimen G0397
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5310177
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423501
Age: embryonic day 14.5
Image: EG1047; Specimen G0397
Specimen Label: EG1047; Specimen G0397
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5310177
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1737322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423501
Age: embryonic day 14.5
Image: EG1047; Specimen G0397
Specimen Label: EG1047; Specimen G0397
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5310177
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3284222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423501
Age: embryonic day 14.5
Image: EG1047; Specimen G0397
Specimen Label: EG1047; Specimen G0397
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5310177
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1666522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423501
Age: embryonic day 14.5
Image: EG1047; Specimen G0397
Specimen Label: EG1047; Specimen G0397
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5310177
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423501
Age: embryonic day 14.5
Image: EG1047; Specimen G0397
Specimen Label: EG1047; Specimen G0397
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:1755629
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1914323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826771
Age: embryonic day 14.5
Image: euxassay_005611_01
Specimen Label: euxassay_005611_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:1755629
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1914323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826771
Age: embryonic day 14.5
Image: euxassay_005611_02
Specimen Label: euxassay_005611_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1755629
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1914323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826771
Age: embryonic day 14.5
Image: euxassay_005611_03
Specimen Label: euxassay_005611_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1755629
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1914323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826771
Age: embryonic day 14.5
Image: euxassay_005611_20
Specimen Label: euxassay_005611_20
Detected: true
Specimen Num: 20