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Search results 1 to 100 out of 730 for Nr1h4

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein
Organism: Mus musculus/domesticus
Length: 37  
Fragment?: true
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Shih DQ
Year: 2001
Journal: Nat Genet
Title: Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism.
Volume: 27
Issue: 4
Pages: 375-82
GXD Expression      
Probe: MGI:6179260
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190938
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Nr1h4
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6179260
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190938
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Nr1h4
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6179260
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190938
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Nr1h4
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6179260
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190938
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Nr1h4
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6179260
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190938
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Nr1h4
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6179260
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190938
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Nr1h4
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6179260
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190938
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Nr1h4
Detected: false
Specimen Num: 7
Publication
First Author: Kim DH
Year: 2019
Journal: FASEB J
Title: Src-mediated crosstalk between FXR and YAP protects against renal fibrosis.
Volume: 33
Issue: 10
Pages: 11109-11122
DO Term
Publication
First Author: Kovacs P
Year: 2008
Journal: J Hepatol
Title: Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans.
Volume: 48
Issue: 1
Pages: 116-24
Publication
First Author: Fu T
Year: 2016
Journal: Mol Endocrinol
Title: FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of β-Klotho.
Volume: 30
Issue: 1
Pages: 92-103
Publication
First Author: Lian F
Year: 2011
Journal: Biochem J
Title: Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage.
Volume: 438
Issue: 2
Pages: 315-23
Publication
First Author: Moraes LA
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.
Volume: 36
Issue: 12
Pages: 2324-2333
Publication
First Author: Hubbert ML
Year: 2007
Journal: Mol Endocrinol
Title: Regulation of hepatic Insig-2 by the farnesoid X receptor.
Volume: 21
Issue: 6
Pages: 1359-69
Publication
First Author: Sheng L
Year: 2017
Journal: Sci Rep
Title: Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation.
Volume: 7
Issue: 1
Pages: 1748
Publication
First Author: Nomoto M
Year: 2009
Journal: Biol Pharm Bull
Title: Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor.
Volume: 32
Issue: 2
Pages: 172-8
Publication
First Author: Rizzo G
Year: 2006
Journal: Mol Pharmacol
Title: The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo.
Volume: 70
Issue: 4
Pages: 1164-73
Publication  
First Author: Li H
Year: 2023
Journal: Front Pharmacol
Title: Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo.
Volume: 14
Pages: 1148737
Publication
First Author: Ramos Pittol JM
Year: 2020
Journal: Gastroenterology
Title: FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs.
Volume: 159
Issue: 5
Pages: 1853-1865.e10
Publication  
First Author: Zheng Y
Year: 2023
Journal: Biomed Pharmacother
Title: Hepatoprotective effect of Typhaneoside on non-alcoholic fatty liver disease via farnesoid X receptor in vivo and in vitro.
Volume: 164
Pages: 114957
Publication
First Author: Mencarelli A
Year: 2009
Journal: J Immunol
Title: The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis.
Volume: 183
Issue: 10
Pages: 6657-66
Publication
First Author: Liu HM
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Farnesoid X receptor agonist GW4064 ameliorates lipopolysaccharide-induced ileocolitis through TLR4/MyD88 pathway related mitochondrial dysfunction in mice.
Volume: 490
Issue: 3
Pages: 841-848
Publication
First Author: Jansen PL
Year: 2007
Journal: J Hepatol
Title: Endogenous bile acids as carcinogens.
Volume: 47
Issue: 3
Pages: 434-5
Publication
First Author: Ho PP
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis.
Volume: 113
Issue: 6
Pages: 1600-5
Publication
First Author: Shih DM
Year: 2006
Journal: J Lipid Res
Title: A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids.
Volume: 47
Issue: 2
Pages: 384-92
Publication
First Author: Xu Y
Year: 2021
Journal: Cell Prolif
Title: Farnesoid X receptor promotes renal ischaemia-reperfusion injury by inducing tubular epithelial cell apoptosis.
Volume: 54
Issue: 4
Pages: e13005
Publication
First Author: van Erpecum KJ
Year: 2006
Journal: J Lipid Res
Title: Gallbladder histopathology during murine gallstone formation: relation to motility and concentrating function.
Volume: 47
Issue: 1
Pages: 32-41
Publication
First Author: Swennes AG
Year: 2014
Journal: PLoS One
Title: Helicobacter hepaticus infection promotes hepatitis and preneoplastic foci in farnesoid X receptor (FXR) deficient mice.
Volume: 9
Issue: 9
Pages: e106764
Publication
First Author: Li G
Year: 2013
Journal: Toxicol Appl Pharmacol
Title: Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice.
Volume: 272
Issue: 2
Pages: 299-305
Publication
First Author: Lee FY
Year: 2010
Journal: Mol Endocrinol
Title: Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.
Volume: 24
Issue: 8
Pages: 1626-36
Publication
First Author: Li WT
Year: 2019
Journal: FASEB J
Title: Bile acids induce visceral hypersensitivity via mucosal mast cell-to-nociceptor signaling that involves the farnesoid X receptor/nerve growth factor/transient receptor potential vanilloid 1 axis.
Volume: 33
Issue: 2
Pages: 2435-2450
Publication
First Author: Langhi C
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Regulation of N-Myc downstream regulated gene 2 by bile acids.
Volume: 434
Issue: 1
Pages: 102-9
Publication
First Author: Wang YD
Year: 2008
Journal: Mol Endocrinol
Title: Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo.
Volume: 22
Issue: 7
Pages: 1622-32
Publication
First Author: Renga B
Year: 2011
Journal: Biochim Biophys Acta
Title: The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate.
Volume: 1812
Issue: 11
Pages: 1522-31
Publication
First Author: Takahashi S
Year: 2017
Journal: Toxicol Sci
Title: Editor's Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway.
Volume: 158
Issue: 2
Pages: 334-346
Publication
First Author: Deng Y
Year: 2013
Journal: Endocrinology
Title: Identification of chemerin as a novel FXR target gene down-regulated in the progression of nonalcoholic steatohepatitis.
Volume: 154
Issue: 5
Pages: 1794-801
Publication
First Author: Wang XX
Year: 2010
Journal: Diabetes
Title: Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model.
Volume: 59
Issue: 11
Pages: 2916-27
Publication
First Author: Lee H
Year: 2007
Journal: J Biol Chem
Title: Regulation of the sodium/sulfate co-transporter by farnesoid X receptor alpha.
Volume: 282
Issue: 30
Pages: 21653-61
Publication
First Author: Duran-Sandoval D
Year: 2005
Journal: J Biol Chem
Title: The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition.
Volume: 280
Issue: 33
Pages: 29971-9
Publication
First Author: Shimizu M
Year: 2013
Journal: Biochem J
Title: FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress.
Volume: 450
Issue: 1
Pages: 221-9
Publication
First Author: Yang F
Year: 2007
Journal: Cancer Res
Title: Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor.
Volume: 67
Issue: 3
Pages: 863-7
Publication
First Author: Moschetta A
Year: 2004
Journal: Nat Med
Title: Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.
Volume: 10
Issue: 12
Pages: 1352-8
Publication
First Author: Degirolamo C
Year: 2015
Journal: Hepatology
Title: Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation.
Volume: 61
Issue: 1
Pages: 161-70
Publication
First Author: Singh AB
Year: 2019
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
Title: Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor.
Volume: 1864
Issue: 3
Pages: 358-371
Publication
First Author: Ryan KK
Year: 2014
Journal: Nature
Title: FXR is a molecular target for the effects of vertical sleeve gastrectomy.
Volume: 509
Issue: 7499
Pages: 183-8
Publication
First Author: Li G
Year: 2012
Journal: Toxicol Appl Pharmacol
Title: A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor.
Volume: 258
Issue: 2
Pages: 268-74
Publication  
First Author: Liu HM
Year: 2023
Journal: Int J Mol Sci
Title: Farnesoid X Receptor Agonist GW4064 Protects Lipopolysaccharide-Induced Intestinal Epithelial Barrier Function and Colorectal Tumorigenesis Signaling through the αKlotho/βKlotho/FGFs Pathways in Mice.
Volume: 24
Issue: 23
Publication
First Author: Schmidt DR
Year: 2010
Journal: J Biol Chem
Title: Regulation of bile acid synthesis by fat-soluble vitamins A and D.
Volume: 285
Issue: 19
Pages: 14486-94
Publication
First Author: Miyata M
Year: 2009
Journal: Drug Metab Dispos
Title: Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed farnesoid X receptor (FXR)-null mice: FXR-independent suppression of intestinal bile acid absorption.
Volume: 37
Issue: 2
Pages: 338-44
Publication
First Author: Fickert P
Year: 2009
Journal: Am J Pathol
Title: Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts.
Volume: 175
Issue: 6
Pages: 2392-405
Publication
First Author: Zhang X
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Farnesoid X receptor (FXR) gene deficiency impairs urine concentration in mice.
Volume: 111
Issue: 6
Pages: 2277-82
Publication
First Author: Houten SM
Year: 2007
Journal: Mol Endocrinol
Title: In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.
Volume: 21
Issue: 6
Pages: 1312-23
Publication
First Author: Berrabah W
Year: 2014
Journal: Hepatology
Title: Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR).
Volume: 59
Issue: 5
Pages: 2022-33
Publication
First Author: Lambert G
Year: 2003
Journal: J Biol Chem
Title: The farnesoid X-receptor is an essential regulator of cholesterol homeostasis.
Volume: 278
Issue: 4
Pages: 2563-70
Publication
First Author: Vavassori P
Year: 2009
Journal: J Immunol
Title: The bile acid receptor FXR is a modulator of intestinal innate immunity.
Volume: 183
Issue: 10
Pages: 6251-61
Publication
First Author: Cariou B
Year: 2007
Journal: FEBS Lett
Title: FXR-deficiency confers increased susceptibility to torpor.
Volume: 581
Issue: 27
Pages: 5191-8
Publication
First Author: Cariou B
Year: 2005
Journal: FEBS Lett
Title: Transient impairment of the adaptive response to fasting in FXR-deficient mice.
Volume: 579
Issue: 19
Pages: 4076-80
Publication
First Author: Xie S
Year: 2017
Journal: FEBS Lett
Title: A rapid administration of GW4064 inhibits the NLRP3 inflammasome activation independent of farnesoid X receptor agonism.
Volume: 591
Issue: 18
Pages: 2836-2847
Publication
First Author: Kim I
Year: 2007
Journal: Carcinogenesis
Title: Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice.
Volume: 28
Issue: 5
Pages: 940-6
Publication
First Author: Tang B
Year: 2023
Journal: Nat Commun
Title: Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy.
Volume: 14
Issue: 1
Pages: 1305
Publication
First Author: Marschall HU
Year: 2006
Journal: J Lipid Res
Title: Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids.
Volume: 47
Issue: 3
Pages: 582-92
Publication
First Author: Wu W
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease.
Volume: 443
Issue: 1
Pages: 68-73
Publication
First Author: Düfer M
Year: 2012
Journal: Diabetes
Title: Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition.
Volume: 61
Issue: 6
Pages: 1479-89
Publication
First Author: Sayin SI
Year: 2013
Journal: Cell Metab
Title: Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist.
Volume: 17
Issue: 2
Pages: 225-35
Publication
First Author: Kim DH
Year: 2021
Journal: Cell Death Dis
Title: The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD.
Volume: 12
Issue: 4
Pages: 320
Publication
First Author: Jena PK
Year: 2017
Journal: Am J Pathol
Title: Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment.
Volume: 187
Issue: 8
Pages: 1800-1813
Publication  
First Author: Huang F
Year: 2015
Journal: Front Behav Neurosci
Title: Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior.
Volume: 9
Pages: 70
Publication
First Author: Cho SW
Year: 2013
Journal: J Bone Miner Res
Title: Positive regulation of osteogenesis by bile acid through FXR.
Volume: 28
Issue: 10
Pages: 2109-21
Publication
First Author: Li G
Year: 2012
Journal: PLoS One
Title: Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding.
Volume: 7
Issue: 4
Pages: e35895
Publication
First Author: Cui JY
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice.
Volume: 302
Issue: 9
Pages: G979-96
Publication  
First Author: Shen C
Year: 2021
Journal: J Ethnopharmacol
Title: Emodin palliates high-fat diet-induced nonalcoholic fatty liver disease in mice via activating the farnesoid X receptor pathway.
Volume: 279
Pages: 114340
Publication
First Author: Maczewsky J
Year: 2017
Journal: Endocrinology
Title: The LXR Ligand T0901317 Acutely Inhibits Insulin Secretion by Affecting Mitochondrial Metabolism.
Volume: 158
Issue: 7
Pages: 2145-2154
Publication
First Author: Schittenhelm B
Year: 2015
Journal: Endocrinology
Title: Role of FXR in β-cells of lean and obese mice.
Volume: 156
Issue: 4
Pages: 1263-71
Publication
First Author: Liu ZQ
Year: 2018
Journal: Autophagy
Title: Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo.
Volume: 14
Issue: 6
Pages: 1011-1027
Publication
First Author: Liu X
Year: 2022
Journal: J Lipid Res
Title: Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury.
Volume: 63
Issue: 11
Pages: 100289
Publication
First Author: Wang XX
Year: 2022
Journal: J Biol Chem
Title: The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice.
Volume: 298
Issue: 11
Pages: 102530
Publication
First Author: Deuschle U
Year: 2015
Journal: Int J Cancer
Title: The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein.
Volume: 136
Issue: 11
Pages: 2693-704
Publication
First Author: Peng Z
Year: 2019
Journal: J Biol Chem
Title: Farnesoid X receptor represses matrix metalloproteinase 7 expression, revealing this regulatory axis as a promising therapeutic target in colon cancer.
Volume: 294
Issue: 21
Pages: 8529-8542
Publication
First Author: Fang S
Year: 2015
Journal: Nat Med
Title: Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.
Volume: 21
Issue: 2
Pages: 159-65
Publication
First Author: Peng X
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Activation of farnesoid X receptor induces RECK expression in mouse liver.
Volume: 443
Issue: 1
Pages: 211-6
Publication
First Author: Zollner G
Year: 2005
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver.
Volume: 289
Issue: 5
Pages: G798-805
Publication
First Author: Zhu Y
Year: 2013
Journal: Toxicol Appl Pharmacol
Title: Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver.
Volume: 266
Issue: 2
Pages: 260-6
Publication  
First Author: Weaver BP
Year: 2010
Journal: PLoS One
Title: Zip4 (Slc39a4) expression is activated in hepatocellular carcinomas and functions to repress apoptosis, enhance cell cycle and increase migration.
Volume: 5
Issue: 10
Publication
First Author: Liu X
Year: 2018
Journal: J Biol Chem
Title: Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor-mediated suppression of the estrogen sulfotransferase SULT1E1.
Volume: 293
Issue: 33
Pages: 12759-12769
Publication  
First Author: Manley S
Year: 2014
Journal: Redox Biol
Title: Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity.
Volume: 2
Pages: 991-1002
Publication
First Author: Wang C
Year: 2013
Journal: Mol Cell Biol
Title: Poly(ADP-ribose) polymerase 1 promotes oxidative-stress-induced liver cell death via suppressing farnesoid X receptor α.
Volume: 33
Issue: 22
Pages: 4492-503
Publication
First Author: Cyphert HA
Year: 2012
Journal: J Biol Chem
Title: Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21.
Volume: 287
Issue: 30
Pages: 25123-38
Publication
First Author: Li J
Year: 2005
Journal: J Biol Chem
Title: Regulation of complement C3 expression by the bile acid receptor FXR.
Volume: 280
Issue: 9
Pages: 7427-34