Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
37
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Shih DQ |
Year: |
2001 |
Journal: |
Nat Genet |
Title: |
Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. |
Volume: |
27 |
Issue: |
4 |
Pages: |
375-82 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179260 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6190938 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Nr1h4 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179260 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
|
Stage: |
TS24 |
Assay Id: |
MGI:6190938 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Nr1h4 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179260 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190938 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Nr1h4 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179260 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190938 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Nr1h4 |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179260 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6190938 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Nr1h4 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179260 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6190938 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Nr1h4 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6179260 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190938 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Nr1h4 |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim DH |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
Src-mediated crosstalk between FXR and YAP protects against renal fibrosis. |
Volume: |
33 |
Issue: |
10 |
Pages: |
11109-11122 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Kovacs P |
Year: |
2008 |
Journal: |
J Hepatol |
Title: |
Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans. |
Volume: |
48 |
Issue: |
1 |
Pages: |
116-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lambert G |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
The farnesoid X-receptor is an essential regulator of cholesterol homeostasis. |
Volume: |
278 |
Issue: |
4 |
Pages: |
2563-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vavassori P |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
The bile acid receptor FXR is a modulator of intestinal innate immunity. |
Volume: |
183 |
Issue: |
10 |
Pages: |
6251-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fu T |
Year: |
2016 |
Journal: |
Mol Endocrinol |
Title: |
FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of β-Klotho. |
Volume: |
30 |
Issue: |
1 |
Pages: |
92-103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duran-Sandoval D |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition. |
Volume: |
280 |
Issue: |
33 |
Pages: |
29971-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Düfer M |
Year: |
2012 |
Journal: |
Diabetes |
Title: |
Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition. |
Volume: |
61 |
Issue: |
6 |
Pages: |
1479-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee FY |
Year: |
2010 |
Journal: |
Mol Endocrinol |
Title: |
Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity. |
Volume: |
24 |
Issue: |
8 |
Pages: |
1626-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maczewsky J |
Year: |
2017 |
Journal: |
Endocrinology |
Title: |
The LXR Ligand T0901317 Acutely Inhibits Insulin Secretion by Affecting Mitochondrial Metabolism. |
Volume: |
158 |
Issue: |
7 |
Pages: |
2145-2154 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cariou B |
Year: |
2005 |
Journal: |
FEBS Lett |
Title: |
Transient impairment of the adaptive response to fasting in FXR-deficient mice. |
Volume: |
579 |
Issue: |
19 |
Pages: |
4076-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li WT |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
Bile acids induce visceral hypersensitivity via mucosal mast cell-to-nociceptor signaling that involves the farnesoid X receptor/nerve growth factor/transient receptor potential vanilloid 1 axis. |
Volume: |
33 |
Issue: |
2 |
Pages: |
2435-2450 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang X |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Farnesoid X receptor (FXR) gene deficiency impairs urine concentration in mice. |
Volume: |
111 |
Issue: |
6 |
Pages: |
2277-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Renga B |
Year: |
2011 |
Journal: |
Biochim Biophys Acta |
Title: |
The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate. |
Volume: |
1812 |
Issue: |
11 |
Pages: |
1522-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sayin SI |
Year: |
2013 |
Journal: |
Cell Metab |
Title: |
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. |
Volume: |
17 |
Issue: |
2 |
Pages: |
225-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang YD |
Year: |
2008 |
Journal: |
Mol Endocrinol |
Title: |
Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo. |
Volume: |
22 |
Issue: |
7 |
Pages: |
1622-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang G |
Year: |
2023 |
Journal: |
Biomark Res |
Title: |
The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study. |
Volume: |
11 |
Issue: |
1 |
Pages: |
20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moraes LA |
Year: |
2016 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets. |
Volume: |
36 |
Issue: |
12 |
Pages: |
2324-2333 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li G |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. |
Volume: |
7 |
Issue: |
4 |
Pages: |
e35895 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee H |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Regulation of the sodium/sulfate co-transporter by farnesoid X receptor alpha. |
Volume: |
282 |
Issue: |
30 |
Pages: |
21653-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu M |
Year: |
2019 |
Journal: |
Br J Pharmacol |
Title: |
Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice. |
Volume: |
176 |
Issue: |
7 |
Pages: |
847-863 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schittenhelm B |
Year: |
2015 |
Journal: |
Endocrinology |
Title: |
Role of FXR in β-cells of lean and obese mice. |
Volume: |
156 |
Issue: |
4 |
Pages: |
1263-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim DH |
Year: |
2021 |
Journal: |
Cell Death Dis |
Title: |
The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD. |
Volume: |
12 |
Issue: |
4 |
Pages: |
320 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ryan KK |
Year: |
2014 |
Journal: |
Nature |
Title: |
FXR is a molecular target for the effects of vertical sleeve gastrectomy. |
Volume: |
509 |
Issue: |
7499 |
Pages: |
183-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng Y |
Year: |
2023 |
Journal: |
Biomed Pharmacother |
Title: |
Hepatoprotective effect of Typhaneoside on non-alcoholic fatty liver disease via farnesoid X receptor in vivo and in vitro. |
Volume: |
164 |
|
Pages: |
114957 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang F |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. |
Volume: |
67 |
Issue: |
3 |
Pages: |
863-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu W |
Year: |
2014 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease. |
Volume: |
443 |
Issue: |
1 |
Pages: |
68-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Houten SM |
Year: |
2007 |
Journal: |
Mol Endocrinol |
Title: |
In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue. |
Volume: |
21 |
Issue: |
6 |
Pages: |
1312-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim I |
Year: |
2007 |
Journal: |
Carcinogenesis |
Title: |
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. |
Volume: |
28 |
Issue: |
5 |
Pages: |
940-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Swennes AG |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Helicobacter hepaticus infection promotes hepatitis and preneoplastic foci in farnesoid X receptor (FXR) deficient mice. |
Volume: |
9 |
Issue: |
9 |
Pages: |
e106764 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cui JY |
Year: |
2012 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice. |
Volume: |
302 |
Issue: |
9 |
Pages: |
G979-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cariou B |
Year: |
2007 |
Journal: |
FEBS Lett |
Title: |
FXR-deficiency confers increased susceptibility to torpor. |
Volume: |
581 |
Issue: |
27 |
Pages: |
5191-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang XX |
Year: |
2010 |
Journal: |
Diabetes |
Title: |
Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model. |
Volume: |
59 |
Issue: |
11 |
Pages: |
2916-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rizzo G |
Year: |
2006 |
Journal: |
Mol Pharmacol |
Title: |
The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo. |
Volume: |
70 |
Issue: |
4 |
Pages: |
1164-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimizu M |
Year: |
2013 |
Journal: |
Biochem J |
Title: |
FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress. |
Volume: |
450 |
Issue: |
1 |
Pages: |
221-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fickert P |
Year: |
2009 |
Journal: |
Am J Pathol |
Title: |
Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts. |
Volume: |
175 |
Issue: |
6 |
Pages: |
2392-405 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nomoto M |
Year: |
2009 |
Journal: |
Biol Pharm Bull |
Title: |
Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor. |
Volume: |
32 |
Issue: |
2 |
Pages: |
172-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh AB |
Year: |
2019 |
Journal: |
Biochim Biophys Acta Mol Cell Biol Lipids |
Title: |
Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor. |
Volume: |
1864 |
Issue: |
3 |
Pages: |
358-371 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie S |
Year: |
2017 |
Journal: |
FEBS Lett |
Title: |
A rapid administration of GW4064 inhibits the NLRP3 inflammasome activation independent of farnesoid X receptor agonism. |
Volume: |
591 |
Issue: |
18 |
Pages: |
2836-2847 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deng Y |
Year: |
2013 |
Journal: |
Endocrinology |
Title: |
Identification of chemerin as a novel FXR target gene down-regulated in the progression of nonalcoholic steatohepatitis. |
Volume: |
154 |
Issue: |
5 |
Pages: |
1794-801 |
|
•
•
•
•
•
|
Publication |
First Author: |
Langhi C |
Year: |
2013 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Regulation of N-Myc downstream regulated gene 2 by bile acids. |
Volume: |
434 |
Issue: |
1 |
Pages: |
102-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shih DM |
Year: |
2006 |
Journal: |
J Lipid Res |
Title: |
A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. |
Volume: |
47 |
Issue: |
2 |
Pages: |
384-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramos Pittol JM |
Year: |
2020 |
Journal: |
Gastroenterology |
Title: |
FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs. |
Volume: |
159 |
Issue: |
5 |
Pages: |
1853-1865.e10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li G |
Year: |
2012 |
Journal: |
Toxicol Appl Pharmacol |
Title: |
A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor. |
Volume: |
258 |
Issue: |
2 |
Pages: |
268-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi S |
Year: |
2017 |
Journal: |
Toxicol Sci |
Title: |
Editor's Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway. |
Volume: |
158 |
Issue: |
2 |
Pages: |
334-346 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marschall HU |
Year: |
2006 |
Journal: |
J Lipid Res |
Title: |
Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids. |
Volume: |
47 |
Issue: |
3 |
Pages: |
582-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jansen PL |
Year: |
2007 |
Journal: |
J Hepatol |
Title: |
Endogenous bile acids as carcinogens. |
Volume: |
47 |
Issue: |
3 |
Pages: |
434-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li H |
Year: |
2023 |
Journal: |
Front Pharmacol |
Title: |
Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo. |
Volume: |
14 |
|
Pages: |
1148737 |
|
•
•
•
•
•
|
Publication |
First Author: |
Degirolamo C |
Year: |
2015 |
Journal: |
Hepatology |
Title: |
Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation. |
Volume: |
61 |
Issue: |
1 |
Pages: |
161-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Erpecum KJ |
Year: |
2006 |
Journal: |
J Lipid Res |
Title: |
Gallbladder histopathology during murine gallstone formation: relation to motility and concentrating function. |
Volume: |
47 |
Issue: |
1 |
Pages: |
32-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ho PP |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis. |
Volume: |
113 |
Issue: |
6 |
Pages: |
1600-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmidt DR |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Regulation of bile acid synthesis by fat-soluble vitamins A and D. |
Volume: |
285 |
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