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Search results 1 to 100 out of 289 for Nr1i2

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0.048s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rabbit, European
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression    
Probe: MGI:6179264
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190940
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Nr1i2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6179264
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190940
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Nr1i2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6179264
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190940
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Nr1i2
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6179264
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190940
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Nr1i2
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6179264
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190940
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Nr1i2
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6179264
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190940
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Nr1i2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6179264
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190940
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Nr1i2
Detected: true
Specimen Num: 6
Publication
First Author: Gong H
Year: 2006
Journal: Mol Endocrinol
Title: Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells.
Volume: 20
Issue: 2
Pages: 279-90
Publication
First Author: Xie W
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.
Volume: 98
Issue: 6
Pages: 3375-80
Publication
First Author: Cheng J
Year: 2012
Journal: Toxicol Sci
Title: Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice.
Volume: 129
Issue: 2
Pages: 456-68
Publication
First Author: Dou W
Year: 2012
Journal: PLoS One
Title: Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis.
Volume: 7
Issue: 7
Pages: e36075
Publication  
First Author: Brewer CT
Year: 2020
Journal: Cells
Title: Toxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid.
Volume: 9
Issue: 7
Publication
First Author: Xie W
Year: 2000
Journal: Nature
Title: Humanized xenobiotic response in mice expressing nuclear receptor SXR.
Volume: 406
Issue: 6794
Pages: 435-9
Publication
First Author: Xie W
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.
Volume: 100
Issue: 7
Pages: 4150-5
Publication
First Author: Zhai Y
Year: 2007
Journal: Mol Endocrinol
Title: Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis.
Volume: 21
Issue: 1
Pages: 138-47
Publication
First Author: Zhou J
Year: 2008
Journal: Gastroenterology
Title: Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis.
Volume: 134
Issue: 2
Pages: 556-67
Publication
First Author: He J
Year: 2013
Journal: Diabetes
Title: PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice.
Volume: 62
Issue: 6
Pages: 1876-87
Publication  
First Author: Zhang Y
Year: 2015
Journal: Nat Commun
Title: Maternal bile acid transporter deficiency promotes neonatal demise.
Volume: 6
Pages: 8186
Publication
First Author: Zhou J
Year: 2006
Journal: J Biol Chem
Title: A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway.
Volume: 281
Issue: 21
Pages: 15013-20
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kliewer SA
Year: 1998
Journal: Cell
Title: An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.
Volume: 92
Issue: 1
Pages: 73-82
Publication
First Author: Dussault I
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance.
Volume: 100
Issue: 3
Pages: 833-8
Publication
First Author: Ma X
Year: 2007
Journal: Drug Metab Dispos
Title: The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.
Volume: 35
Issue: 2
Pages: 194-200
Publication
First Author: Pang X
Year: 2011
Journal: Xenobiotica
Title: Pregnane X receptor-mediated induction of Cyp3a by black cohosh.
Volume: 41
Issue: 2
Pages: 112-23
Publication
First Author: Spruiell K
Year: 2015
Journal: J Pharmacol Exp Ther
Title: Pregnane X Receptor-Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity.
Volume: 354
Issue: 3
Pages: 459-70
Publication
First Author: Spruiell K
Year: 2014
Journal: J Biol Chem
Title: Role of pregnane X receptor in obesity and glucose homeostasis in male mice.
Volume: 289
Issue: 6
Pages: 3244-61
Publication
First Author: Li F
Year: 2013
Journal: Nat Med
Title: Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy.
Volume: 19
Issue: 4
Pages: 418-20
Publication
First Author: Poulton EJ
Year: 2013
Journal: Toxicol Appl Pharmacol
Title: Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo.
Volume: 266
Issue: 1
Pages: 122-31
Publication
First Author: Sui Y
Year: 2021
Journal: Environ Health Perspect
Title: Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice.
Volume: 129
Issue: 12
Pages: 127001
Publication
First Author: Johnson CH
Year: 2013
Journal: Drug Metab Dispos
Title: Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice.
Volume: 41
Issue: 2
Pages: 406-13
Publication
First Author: Cho JY
Year: 2009
Journal: J Lipid Res
Title: Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation.
Volume: 50
Issue: 5
Pages: 924-37
Publication
First Author: Gwag T
Year: 2019
Journal: J Hepatol
Title: Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis.
Volume: 70
Issue: 5
Pages: 930-940
Publication
First Author: Igarashi K
Year: 2012
Journal: J Toxicol Sci
Title: Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence.
Volume: 37
Issue: 2
Pages: 373-80
Publication
First Author: Staudinger J
Year: 2001
Journal: Drug Metab Dispos
Title: Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.
Volume: 29
Issue: 11
Pages: 1467-72
Publication
First Author: Hagedorn KA
Year: 2007
Journal: Hypertension
Title: Regulation of vascular tone during pregnancy: a novel role for the pregnane X receptor.
Volume: 49
Issue: 2
Pages: 328-33
Publication
First Author: Staudinger JL
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
Volume: 98
Issue: 6
Pages: 3369-74
Publication
First Author: Guo GL
Year: 2004
Journal: Toxicol Sci
Title: Enhanced acetaminophen toxicity by activation of the pregnane X receptor.
Volume: 82
Issue: 2
Pages: 374-80
Publication
First Author: Choi S
Year: 2018
Journal: J Biol Chem
Title: Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice.
Volume: 293
Issue: 1
Pages: 1-17
Publication
First Author: Mota LC
Year: 2011
Journal: Toxicol Appl Pharmacol
Title: Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment.
Volume: 252
Issue: 3
Pages: 259-67
Publication
First Author: Erickson SL
Year: 2020
Journal: FASEB J
Title: The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins.
Volume: 34
Issue: 2
Pages: 2198-2212
Publication  
First Author: Hu H
Year: 2020
Journal: Biochem Pharmacol
Title: PXR phosphorylated at Ser350 transduces a glucose signal to repress the estrogen sulfotransferase gene in human liver cells and fasting signal in mouse livers.
Volume: 180
Pages: 114197
Publication
First Author: Shah YM
Year: 2007
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression.
Volume: 292
Issue: 4
Pages: G1114-22
Publication
First Author: Nakamura K
Year: 2007
Journal: J Biol Chem
Title: Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver.
Volume: 282
Issue: 13
Pages: 9768-76
Publication
First Author: Dubrac S
Year: 2010
Journal: J Immunol
Title: Modulation of T lymphocyte function by the pregnane X receptor.
Volume: 184
Issue: 6
Pages: 2949-57
Publication
First Author: Wallace K
Year: 2010
Journal: J Steroid Biochem Mol Biol
Title: The PXR is a drug target for chronic inflammatory liver disease.
Volume: 120
Issue: 2-3
Pages: 137-48
Publication
First Author: Pulakazhi Venu VK
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation.
Volume: 317
Issue: 2
Pages: E350-E361
Publication
First Author: Scheer N
Year: 2010
Journal: Drug Metab Dispos
Title: In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice.
Volume: 38
Issue: 7
Pages: 1046-53
Publication    
First Author: Selloum M
Year: 2012
Journal: MGI Direct Data Submission
Title: Direct Data Submission
Volume: v
Publication  
First Author: Meng Z
Year: 2019
Journal: JCI Insight
Title: The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling.
Volume: 4
Issue: 3
Publication      
First Author: Selloum M
Year: 2012
Journal: MGI Direct Data Submission
Title: Direct Data Submission
Publication  
First Author: Boussadia B
Year: 2018
Journal: Neuroscience
Title: Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity.
Volume: 370
Pages: 130-138
Publication
First Author: Hassani-Nezhad-Gashti F
Year: 2019
Journal: Sci Rep
Title: Nutritional status modifies pregnane X receptor regulated transcriptome.
Volume: 9
Issue: 1
Pages: 16728
Publication
First Author: Azuma K
Year: 2015
Journal: PLoS One
Title: Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.
Volume: 10
Issue: 3
Pages: e0119177
Publication
First Author: Sonoda J
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites.
Volume: 102
Issue: 6
Pages: 2198-203
Publication
First Author: Sui Y
Year: 2015
Journal: Mol Endocrinol
Title: Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.
Volume: 29
Issue: 5
Pages: 765-76
Publication
First Author: LeCluyse EL
Year: 2001
Journal: Chem Biol Interact
Title: Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics.
Volume: 134
Issue: 3
Pages: 283-9
Publication
First Author: Reed MR
Year: 2001
Journal: Genomics
Title: A complex duplication created by gene targeting at the imprinted H19 locus results in two classes of methylation and correlated Igf2 expression phenotypes.
Volume: 74
Issue: 2
Pages: 186-96
Publication
First Author: Jones SA
Year: 2000
Journal: Mol Endocrinol
Title: The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
Volume: 14
Issue: 1
Pages: 27-39
Publication
First Author: Lehmann JM
Year: 1998
Journal: J Clin Invest
Title: The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
Volume: 102
Issue: 5
Pages: 1016-23
Publication
First Author: Bertilsson G
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.
Volume: 95
Issue: 21
Pages: 12208-13
Publication
First Author: Blumberg B
Year: 1998
Journal: Genes Dev
Title: SXR, a novel steroid and xenobiotic-sensing nuclear receptor.
Volume: 12
Issue: 20
Pages: 3195-205
Publication
First Author: Zhang H
Year: 1999
Journal: Arch Biochem Biophys
Title: Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation.
Volume: 368
Issue: 1
Pages: 14-22
Publication
First Author: Kliewer SA
Year: 2002
Journal: J Lipid Res
Title: Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor.
Volume: 43
Issue: 3
Pages: 359-64
Publication
First Author: Hurst CH
Year: 2004
Journal: Toxicol Appl Pharmacol
Title: Environmental phthalate monoesters activate pregnane X receptor-mediated transcription.
Volume: 199
Issue: 3
Pages: 266-74
Publication
First Author: Saradhi M
Year: 2005
Journal: Biochim Biophys Acta
Title: Pregnane and Xenobiotic Receptor (PXR/SXR) resides predominantly in the nuclear compartment of the interphase cell and associates with the condensed chromosomes during mitosis.
Volume: 1746
Issue: 2
Pages: 85-94
Publication
First Author: Zhou C
Year: 2006
Journal: J Clin Invest
Title: Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation.
Volume: 116
Issue: 8
Pages: 2280-2289
Publication
First Author: Cui JY
Year: 2010
Journal: Nucleic Acids Res
Title: ChIPing the cistrome of PXR in mouse liver.
Volume: 38
Issue: 22
Pages: 7943-63
Publication
First Author: Krausova L
Year: 2011
Journal: Biochem Pharmacol
Title: Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.
Volume: 82
Issue: 11
Pages: 1771-80
Publication
First Author: Wang X
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Shear stress activation of nuclear receptor PXR in endothelial detoxification.
Volume: 110
Issue: 32
Pages: 13174-9
Publication
First Author: Egusquiza RJ
Year: 2020
Journal: Environ Health Perspect
Title: Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice.
Volume: 128
Issue: 4
Pages: 47011
Publication  
First Author: Xia J
Year: 2018
Journal: J Nutr Biochem
Title: Atrazine-induced environmental nephrosis was mitigated by lycopene via modulating nuclear xenobiotic receptors-mediated response.
Volume: 51
Pages: 80-90
Publication
First Author: Saeki N
Year: 2022
Journal: Exp Cell Res
Title: Pregnane X receptor (PXR) represses osteoblast differentiation through repression of the Hedgehog signaling pathway.
Volume: 416
Issue: 1
Pages: 113156