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Search results 1 to 100 out of 424 for Nrl

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
4901 | NRL
Type: gene
Organism: human
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Gene
452806 | NRL
Type: gene
Organism: chimpanzee
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Gene
521544 | NRL
Type: gene
Organism: cattle
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Gene
554169 | nrl
Type: gene
Organism: zebrafish
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Gene
714967 | NRL
Type: gene
Organism: macaque, rhesus
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Gene
613052 | nrl
Type: gene
Organism: frog, western clawed
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Gene
290221 | Nrl
Type: gene
Organism: rat
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Gene
490620 | NRL
Type: gene
Organism: dog, domestic
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Protein Domain
IPR028575 | Nrl
Type: Family
Description: Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors. The Maf family is divided into two subclasses, large Mafs (c-maf, mafB, and mafA/L-maf, Nrl) and small Mafs (MafF, MafK and MafG). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. In contrast to the small Mafs, the large Maf proteins contain a transactivator domain in their amino terminus.Neural retina-specific leucine zipper protein (Nrl) is a member of the Maf family of transcription factors that regulates the expression of rod-specific genes, including rhodopsin [, , ]. Mutations in Nrl cause retinitis pigmentosa 27 (RP27), which is a retinal dystrophy belonging to the group of pigmentary retinopathies [, ], and retinal degeneration autosomal recessive clumped pigment type (RDCP), which is a retinopathy characterised by night blindness since early childhood, consistent with a severe reduction in rod function [].
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Protein Coding Gene
MGI:102567 | Nrl
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11694879 | J:78692
First Author: Mears AJ
Year: 2001
Journal: Nat Genet
Title: Nrl is required for rod photoreceptor development.
Volume: 29
Issue: 4
Pages: 447-52
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Protein
P54846
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Publication
20551322 | -
First Author: Roger JE
Year: 2010
Journal: J Biol Chem
Title: Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation.
Volume: 285
Issue: 33
Pages: 25637-44
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Publication
10192380 | -
First Author: Bessant DA
Year: 1999
Journal: Nat Genet
Title: A mutation in NRL is associated with autosomal dominant retinitis pigmentosa.
Volume: 21
Issue: 4
Pages: 355-6
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Publication
15591106 | -
First Author: Nishiguchi KM
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Recessive NRL mutations in patients with clumped pigmentary retinal degeneration and relative preservation of blue cone function.
Volume: 101
Issue: 51
Pages: 17819-24
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Publication
28291770 | J:244487
 
First Author: Yu W
Year: 2017
Journal: Nat Commun
Title: Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice.
Volume: 8
Pages: 14716
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Publication
11477108 | J:71808
First Author: Swain PK
Year: 2001
Journal: J Biol Chem
Title: Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors.
Volume: 276
Issue: 39
Pages: 36824-30
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Publication
16505381 | J:107155
First Author: Akimoto M
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors.
Volume: 103
Issue: 10
Pages: 3890-5
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Publication
8552394 | J:31299
First Author: Liu Q
Year: 1996
Journal: Oncogene
Title: Expression of the bZIP transcription factor gene Nrl in the developing nervous system.
Volume: 12
Issue: 1
Pages: 207-11
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Publication
27878762 | J:310309
First Author: Sreekanth S
Year: 2017
Journal: Mol Neurobiol
Title: miR Cluster 143/145 Directly Targets Nrl and Regulates Rod Photoreceptor Development.
Volume: 54
Issue: 10
Pages: 8033-8049
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Publication
15914637 | J:99413
First Author: Daniele LL
Year: 2005
Journal: Invest Ophthalmol Vis Sci
Title: Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse.
Volume: 46
Issue: 6
Pages: 2156-67
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Publication
15738050 | J:112480
First Author: Nikonov SS
Year: 2005
Journal: J Gen Physiol
Title: Photoreceptors of Nrl -/- mice coexpress functional S- and M-cone opsins having distinct inactivation mechanisms.
Volume: 125
Issue: 3
Pages: 287-304
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Publication
22445942 | -
 
First Author: Jayaram H
Year: 2012
Journal: Exp Eye Res
Title: Focus on molecules: neural retina leucine zipper (NRL).
Volume: 104
Pages: 99-100
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Publication
22334370 | -
First Author: Neveling K
Year: 2012
Journal: Hum Mutat
Title: Next-generation genetic testing for retinitis pigmentosa.
Volume: 33
Issue: 6
Pages: 963-72
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Protein
A0A2I3BQU2
Organism: Mus musculus/domesticus
Length: 62  
Fragment?: true
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Publication
29947801 | J:263912
     
First Author: Kong Y
Year: 2018
Journal: Hum Mol Genet
Title: A FRMD4B variant suppresses dysplastic photoreceptor lesions in models of enhanced S-cone syndrome and of Nrl deficiency.
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Protein
Q543Y0
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Protein
A0A2I3BPV3
Organism: Mus musculus/domesticus
Length: 226  
Fragment?: true
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Protein
Q8C8Y1
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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GXD Expression
GXD Expression
     
Probe: MGI:6179323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190964
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Nrl
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6179323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190964
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Nrl
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6179323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190964
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Nrl
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6179323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190964
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Nrl
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6179323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190964
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Nrl
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6179323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190964
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Nrl
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6179323
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190964
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Nrl
Detected: false
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:6711198
Assay Type: RT-PCR
Annotation Date: 2021-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6711210
Age: postnatal adult
Specimen Label: Nrl
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6711193
Assay Type: RT-PCR
Annotation Date: 2021-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6711211
Age: postnatal adult
Specimen Label: Nrl
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6711197
Assay Type: RT-PCR
Annotation Date: 2021-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6711212
Age: postnatal adult
Specimen Label: Nrl
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6711199
Assay Type: RT-PCR
Annotation Date: 2021-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6711213
Age: postnatal adult
Specimen Label: Nrl
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6711194
Assay Type: RT-PCR
Annotation Date: 2021-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6711214
Age: postnatal adult
Specimen Label: Nrl
Detected: true
Specimen Num: 2
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Publication
27880916 | J:241605
First Author: Kim JW
Year: 2016
Journal: Cell Rep
Title: NRL-Regulated Transcriptome Dynamics of Developing Rod Photoreceptors.
Volume: 17
Issue: 9
Pages: 2460-2473
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Publication
28863214 | J:254618
First Author: Zelinger L
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: Regulation of Noncoding Transcriptome in Developing Photoreceptors by Rod Differentiation Factor NRL.
Volume: 58
Issue: 11
Pages: 4422-4435
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Author
Lind NRL
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Publication
37181654 | J:338794
 
First Author: Thorson MT
Year: 2023
Journal: Front Mol Neurosci
Title: Nrl:CreERT2 mouse model to induce mosaic gene expression in rod photoreceptors.
Volume: 16
Pages: 1161127
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Publication
21813673 | J:174592
First Author: Ng L
Year: 2011
Journal: J Neurosci
Title: Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.
Volume: 31
Issue: 31
Pages: 11118-25
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Publication
15329405 | J:97262
First Author: Strettoi E
Year: 2004
Journal: J Neurosci
Title: Recruitment of the rod pathway by cones in the absence of rods.
Volume: 24
Issue: 34
Pages: 7576-82
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Publication
1729696 | J:19401
First Author: Swaroop A
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: A conserved retina-specific gene encodes a basic motif/leucine zipper domain.
Volume: 89
Issue: 1
Pages: 266-70
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Publication
8288222 | J:15559
First Author: Farjo Q
Year: 1993
Journal: Genomics
Title: Molecular characterization of the murine neural retina leucine zipper gene, Nrl.
Volume: 18
Issue: 2
Pages: 216-22
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Publication
17242361 | J:119504
First Author: Oh EC
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL.
Volume: 104
Issue: 5
Pages: 1679-84
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Publication
22238088 | J:179907
First Author: Roger JE
Year: 2012
Journal: J Neurosci
Title: Preservation of cone photoreceptors after a rapid yet transient degeneration and remodeling in cone-only Nrl-/- mouse retina.
Volume: 32
Issue: 2
Pages: 528-41
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Publication
15292180 | J:118580
First Author: Yu J
Year: 2004
Journal: J Biol Chem
Title: Altered expression of genes of the Bmp/Smad and Wnt/calcium signaling pathways in the cone-only Nrl-/- mouse retina, revealed by gene profiling using custom cDNA microarrays.
Volume: 279
Issue: 40
Pages: 42211-20
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Publication
31915147 | J:293534
 
First Author: Perez-Cervantes C
Year: 2020
Journal: Development
Title: Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.
Volume: 147
Issue: 3
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Publication
24691551 | J:213162
First Author: Hao H
Year: 2014
Journal: Hum Mol Genet
Title: Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL.
Volume: 23
Issue: 16
Pages: 4260-71
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Publication
21813656 | J:176686
First Author: Cheng H
Year: 2011
Journal: Hum Mol Genet
Title: Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursors.
Volume: 20
Issue: 21
Pages: 4102-15
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Publication
12853434 | J:84455
First Author: Zhu X
Year: 2003
Journal: J Neurosci
Title: GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina.
Volume: 23
Issue: 14
Pages: 6152-60
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Publication
23319618 | J:193697
First Author: Montana CL
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Reprogramming of adult rod photoreceptors prevents retinal degeneration.
Volume: 110
Issue: 5
Pages: 1732-7
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Publication
30715780 | J:291310
First Author: Tsai ELS
Year: 2019
Journal: Stem Cells
Title: Modeling of Photoreceptor Donor-Host Interaction Following Transplantation Reveals a Role for Crx, Müller Glia, and Rho/ROCK Signaling in Neurite Outgrowth.
Volume: 37
Issue: 4
Pages: 529-541
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Publication
31819342 | J:284100
 
First Author: Esquerdo-Barragán M
Year: 2019
Journal: Mol Vis
Title: Expression of deubiquitinating enzyme genes in the developing mammal retina.
Volume: 25
Pages: 800-813
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Publication
31469895 | J:279115
First Author: Bush RA
Year: 2019
Journal: Invest Ophthalmol Vis Sci
Title: Cone ERG Changes During Light Adaptation in Two All-Cone Mutant Mice: Implications for Rod-Cone Pathway Interactions.
Volume: 60
Issue: 10
Pages: 3680-3688
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Publication
30713422 | J:282065
 
First Author: Hanke-Gogokhia C
Year: 2018
Journal: Mol Vis
Title: Rescue of cone function in cone-only Nphp5 knockout mouse model with Leber congenital amaurosis phenotype.
Volume: 24
Pages: 834-846
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Publication
24382353 | J:203337
First Author: Roger JE
Year: 2014
Journal: J Clin Invest
Title: OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness.
Volume: 124
Issue: 2
Pages: 631-43
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Publication
22354990 | J:183782
First Author: Kim JW
Year: 2012
Journal: Mol Cell Biol
Title: Transcriptional activity of neural retina leucine zipper (Nrl) is regulated by c-Jun N-terminal kinase and Tip60 during retina development.
Volume: 32
Issue: 9
Pages: 1720-32
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Publication
19838301 | J:154049
First Author: Fischer MD
Year: 2009
Journal: PLoS One
Title: Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography.
Volume: 4
Issue: 10
Pages: e7507
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Publication
37181655 | J:346114
 
First Author: Laird JG
Year: 2023
Journal: Front Mol Neurosci
Title: Mouse all-cone retina models of Cav1.4 synaptopathy.
Volume: 16
Pages: 1155955
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Publication
22570183 | J:194571
First Author: West EL
Year: 2012
Journal: Stem Cells
Title: Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors.
Volume: 30
Issue: 7
Pages: 1424-35
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Publication
34494680 | J:336553
First Author: Ortin-Martinez A
Year: 2021
Journal: EMBO J
Title: Photoreceptor nanotubes mediate the in vivo exchange of intracellular material.
Volume: 40
Issue: 22
Pages: e107264
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Publication
26140606 | J:224847
First Author: Hiler D
Year: 2015
Journal: Cell Stem Cell
Title: Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors.
Volume: 17
Issue: 1
Pages: 101-15
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Publication
19805139 | J:153683
First Author: Jia L
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development.
Volume: 106
Issue: 41
Pages: 17534-9
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Publication
25034607 | J:230121
First Author: Samardzija M
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: A mouse model for studying cone photoreceptor pathologies.
Volume: 55
Issue: 8
Pages: 5304-13
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Publication
25296752 | J:242481
First Author: Fu Y
Year: 2014
Journal: J Biol Chem
Title: Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL.
Volume: 289
Issue: 47
Pages: 32469-80
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Publication
32878923 | J:297080
 
First Author: Javed A
Year: 2020
Journal: Development
Title: Pou2f1 and Pou2f2 cooperate to control the timing of cone photoreceptor production in the developing mouse retina.
Volume: 147
Issue: 18
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Publication
16868010 | J:114905
First Author: Cheng H
Year: 2006
Journal: Hum Mol Genet
Title: In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development.
Volume: 15
Issue: 17
Pages: 2588-602
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Publication
22674725 | J:200207
First Author: Molnar T
Year: 2012
Journal: J Physiol
Title: Store-operated channels regulate intracellular calcium in mammalian rods.
Volume: 590
Issue: 15
Pages: 3465-81
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Publication
33500475 | J:301112
First Author: Maddala R
Year: 2021
Journal: Sci Rep
Title: Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract.
Volume: 11
Issue: 1
Pages: 2203
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Publication
26965927 | J:249375
 
First Author: Smiley S
Year: 2016
Journal: Sci Rep
Title: Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line.
Volume: 6
Pages: 22867
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Publication
15163632 | J:225638
First Author: Yoshida S
Year: 2004
Journal: Hum Mol Genet
Title: Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl.
Volume: 13
Issue: 14
Pages: 1487-503
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Publication
29324782 | J:256730
First Author: Shawki HH
Year: 2018
Journal: PLoS One
Title: MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.
Volume: 13
Issue: 1
Pages: e0190800
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Publication
28288836 | J:242163
 
First Author: Aavani T
Year: 2017
Journal: Gene Expr Patterns
Title: Temporal profiling of photoreceptor lineage gene expression during murine retinal development.
Volume: 23-24
Pages: 32-44
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Protein Coding Gene
MGP_CAROLIEiJ_G0019294 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021346 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021305 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021281 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021309 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021089 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_102567 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021747 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020608 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021056 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021177 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021159 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021251 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021183 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021774 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020355 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020661 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030311 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020183 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
21203345 | J:168341
 
First Author: Krigel A
Year: 2010
Journal: Mol Vis
Title: Circadian-clock driven cone-like photoreceptor phagocytosis in the neural retina leucine zipper gene knockout mouse.
Volume: 16
Pages: 2873-81
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Publication
17620597 | J:123149
First Author: Corbo JC
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: A typology of photoreceptor gene expression patterns in the mouse.
Volume: 104
Issue: 29
Pages: 12069-74
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