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Search results 1 to 100 out of 100 for Nudt1

0.019s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
4521 | NUDT1
Type: gene
Organism: human
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Gene
448146 | nudt1
Type: gene
Organism: frog, western clawed
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Gene
117260 | Nudt1
Type: gene
Organism: rat
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Gene
489894 | NUDT1
Type: gene
Organism: dog, domestic
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Gene
463225 | NUDT1
Type: gene
Organism: chimpanzee
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Gene
525496 | NUDT1
Type: gene
Organism: cattle
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Gene
416467 | NUDT1
Type: gene
Organism: chicken
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Gene
406727 | nudt1
Type: gene
Organism: zebrafish
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Gene
713078 | NUDT1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:109280 | Nudt1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
7586133 | J:71789
First Author: Cai JP
Year: 1995
Journal: Carcinogenesis
Title: cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides.
Volume: 16
Issue: 10
Pages: 2343-50
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Protein Coding Gene
MGP_CAROLIEiJ_G0027945 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030296 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030265 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030197 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030282 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029993 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_109280 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030727 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029398 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030113 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030068 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030199 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030099 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030767 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029113 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029472 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024517 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028949 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7592783 | J:29544
First Author: Kakuma T
Year: 1995
Journal: J Biol Chem
Title: Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution.
Volume: 270
Issue: 43
Pages: 25942-8
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Publication
9013634 | J:38676
First Author: Igarashi H
Year: 1997
Journal: J Biol Chem
Title: Organization and expression of the mouse MTH1 gene for preventing transversion mutation.
Volume: 272
Issue: 6
Pages: 3766-72
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Publication
11572992 | J:71836
First Author: Tsuzuki T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase.
Volume: 98
Issue: 20
Pages: 11456-61
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Publication
11376688 | J:69737
First Author: Tsuzuki T
Year: 2001
Journal: Mutat Res
Title: Analysis of MTH1 gene function in mice with targeted mutagenesis.
Volume: 477
Issue: 1-2
Pages: 71-8
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Publication
12483507 | J:81237
First Author: Sekiguchi M
Year: 2002
Journal: Oncogene
Title: Oxidative nucleotide damage: consequences and prevention.
Volume: 21
Issue: 58
Pages: 8895-904
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Publication
16273081 | J:121040
First Author: Yamaguchi H
Year: 2006
Journal: Cell Death Differ
Title: MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Volume: 13
Issue: 4
Pages: 551-63
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Publication
37563135 | J:355460
First Author: Ding Y
Year: 2023
Journal: Nat Commun
Title: MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis.
Volume: 14
Issue: 1
Pages: 4829
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Publication
35809767 | J:332985
 
First Author: Li J
Year: 2022
Journal: Free Radic Biol Med
Title: MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3.
Volume: 188
Pages: 447-458
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Publication
36640852 | J:332814
 
First Author: Li J
Year: 2023
Journal: Free Radic Biol Med
Title: 8-oxo-dGTP curbs tumor development via S phase arrest and AIF-mediated apoptosis.
Volume: 196
Pages: 53-64
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Publication
11376687 | J:69987
First Author: Nakabeppu Y
Year: 2001
Journal: Mutat Res
Title: Molecular genetics and structural biology of human MutT homolog, MTH1.
Volume: 477
Issue: 1-2
Pages: 59-70
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Publication
10954591 | J:64146
First Author: Shimokawa H
Year: 2000
Journal: Nucleic Acids Res
Title: Functional significance of conserved residues in the phosphohydrolase module of Escherichia coli MutT protein.
Volume: 28
Issue: 17
Pages: 3240-9
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Publication
11756418 | J:75150
First Author: Sakai Y
Year: 2002
Journal: J Biol Chem
Title: A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1.
Volume: 277
Issue: 10
Pages: 8579-87
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Publication
12062055 | J:77402
First Author: Colussi C
Year: 2002
Journal: Curr Biol
Title: The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool.
Volume: 12
Issue: 11
Pages: 912-8
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Publication
16621731 | J:112189
First Author: Nakabeppu Y
Year: 2006
Journal: DNA Repair (Amst)
Title: MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.
Volume: 5
Issue: 7
Pages: 761-72
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Publication
28067232 | J:244733
 
First Author: Çağlayan M
Year: 2017
Journal: Nat Commun
Title: Oxidized nucleotide insertion by pol β confounds ligation during base excision repair.
Volume: 8
Pages: 14045
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Publication
12615700 | J:82287
First Author: Sakumi K
Year: 2003
Journal: Cancer Res
Title: Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption.
Volume: 63
Issue: 5
Pages: 902-5
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Publication
12531017 | J:79732
First Author: Egashira A
Year: 2002
Journal: DNA Repair (Amst)
Title: Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes.
Volume: 1
Issue: 11
Pages: 881-93
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Publication
23143307 | J:193978
First Author: Sheng Z
Year: 2012
Journal: J Clin Invest
Title: 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.
Volume: 122
Issue: 12
Pages: 4344-61
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Publication
24732879 | J:210511
 
First Author: Ohno M
Year: 2014
Journal: Sci Rep
Title: 8-oxoguanine causes spontaneous de novo germline mutations in mice.
Volume: 4
Pages: 4689
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Publication
28127763 | J:241301
First Author: Pilati C
Year: 2017
Journal: J Pathol
Title: Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas.
Volume: 242
Issue: 1
Pages: 10-15
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Publication
17425590 | J:123869
First Author: Tsuzuki T
Year: 2007
Journal: Cancer Sci
Title: Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis.
Volume: 98
Issue: 4
Pages: 465-70
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Publication
33758207 | J:304921
First Author: Oka S
Year: 2021
Journal: Sci Rep
Title: MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis.
Volume: 11
Issue: 1
Pages: 5819
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Publication
34838904 | J:324343
 
First Author: Mizuno Y
Year: 2022
Journal: Neurosci Res
Title: Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the AppNL-G-F/NL-G-F knock-in mouse model of Alzheimer's disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior.
Volume: 177
Pages: 118-134
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Publication
21070968 | J:166846
First Author: Song MG
Year: 2010
Journal: Mol Cell
Title: Multiple mRNA decapping enzymes in mammalian cells.
Volume: 40
Issue: 3
Pages: 423-32
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Publication
27581360 | J:239343
First Author: Anjos-Afonso F
Year: 2016
Journal: Blood
Title: Perturbed hematopoiesis in mice lacking ATMIN.
Volume: 128
Issue: 16
Pages: 2017-2021
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Publication
27689697 | J:235644
First Author: Wu Y
Year: 2016
Journal: PLoS Genet
Title: Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Volume: 12
Issue: 9
Pages: e1006355
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
38493213 | J:346385
First Author: Ye M
Year: 2024
Journal: Nat Commun
Title: Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability.
Volume: 15
Issue: 1
Pages: 2377
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Publication
30304478 | -
First Author: Jemth AS
Year: 2018
Journal: Nucleic Acids Res
Title: MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Volume: 46
Issue: 20
Pages: 10888-10904
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Publication
32144205 | J:286825
First Author: Scaletti ER
Year: 2020
Journal: J Biol Chem
Title: MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Volume: 295
Issue: 15
Pages: 4761-4772
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Publication
28679043 | -
First Author: Ellermann M
Year: 2017
Journal: ACS Chem Biol
Title: Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
Volume: 12
Issue: 8
Pages: 1986-1992
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Publication
24695224 | -
First Author: Gad H
Year: 2014
Journal: Nature
Title: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Volume: 508
Issue: 7495
Pages: 215-21
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Publication
27210421 | -
 
First Author: Kawamura T
Year: 2016
Journal: Sci Rep
Title: Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.
Volume: 6
Pages: 26521
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Protein Domain
IPR003563 | 8ODP
Type: Family
Description: This entry represents Oxidized purine nucleoside triphosphate hydrolase (8ODP, also known as 7,8-dihydro-8-oxoguanine triphosphatase and MHT1), and similar Nudix hydrolase domain-containing proteins from bacteria, eukaryots and archaea. This protein has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP and catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA [, , ]. It was originally considered to play an important role as sanitizer of the oxidized nucleotide pool [, ]. However, later studies indicate that NUDT1 plays a redundant role in eliminating oxidized nucleotides and that it is not essential for cancer cell proliferation and survival [, ].
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Protein
P53368
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
A0A0G2JFE5
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
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Protein
D3YWH7
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom