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Search results 1 to 100 out of 363 for Ogt

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0.042s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: The UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase (OGT; ) is a heterotrimer of one 78kDa subunit and two 110kDa subunits. OGT catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in a protein. Substrate proteins include histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. The consequences of this form of glycosylation are diverse, including insulin resistance in muscle and adipocyte cells (brought about by inhibiting the 'Thr-308' phosphorylation of AKT1) []; regulation of glycolysis by inhibiting PFKL activity []; in the cell cycle O-glycosylation stabilizes ARNTL/BMAL1 and CLOCK, preventing their ubiquitination and subsequent degradation []; glycosylation of HCFC1 and interaction with TET proteins promotes binding of the SET1/COMPASS methyltransferase SETD1A to chromatin []; and H2B GlcNAcylation is a histone modification that facilitates H2BK120 monoubiquitination []. It is a component of several complexes, including MLL5-L, NSL []and THAP1/THAP3-HCFC1-OGT [].This entry represents the 110kDa subunit which has thirteen tetratricopeptide (TPR) repeats that are required for substrate binding and oligomerization [].The NSL complex is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. The complex is composed of at least MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Li MD
Year: 2013
Journal: Cell Metab
Title: O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination.
Volume: 17
Issue: 2
Pages: 303-10
Protein
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
Publication
First Author: Deplus R
Year: 2013
Journal: EMBO J
Title: TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.
Volume: 32
Issue: 5
Pages: 645-55
Protein
Organism: Mus musculus/domesticus
Length: 1046  
Fragment?: false
Publication
First Author: Li MD
Year: 2018
Journal: Nat Commun
Title: Adipocyte OGT governs diet-induced hyperphagia and obesity.
Volume: 9
Issue: 1
Pages: 5103
Publication
First Author: Watson LJ
Year: 2014
Journal: Am J Physiol Heart Circ Physiol
Title: Cardiomyocyte Ogt is essential for postnatal viability.
Volume: 306
Issue: 1
Pages: H142-53
Publication
First Author: Lagerlöf O
Year: 2016
Journal: Science
Title: The nutrient sensor OGT in PVN neurons regulates feeding.
Volume: 351
Issue: 6279
Pages: 1293-6
GXD Expression      
Probe: MGI:4354374
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354798
Age: embryonic day 14.5
Specimen Label: Table S5 - Ogt
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4354374
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354798
Age: embryonic day 14.5
Note: Expression is present in the upper and lower cortical plate.
Specimen Label: Table S5 - Ogt
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4354374
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354798
Age: embryonic day 14.5
Specimen Label: Table S5 - Ogt
Detected: true
Specimen Num: 1
Publication
First Author: Wang Q
Year: 2022
Journal: Sci Adv
Title: Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity.
Volume: 8
Issue: 35
Pages: eabn8092
Publication
First Author: Murakami K
Year: 2021
Journal: Cell Rep
Title: OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy.
Volume: 34
Issue: 1
Pages: 108579
Publication
First Author: Yang Y
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance.
Volume: 117
Issue: 28
Pages: 16616-16625
Publication
First Author: Ito R
Year: 2014
Journal: Genes Cells
Title: TET3-OGT interaction increases the stability and the presence of OGT in chromatin.
Volume: 19
Issue: 1
Pages: 52-65
Publication
First Author: Chen J
Year: 2021
Journal: Cell Rep
Title: Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling.
Volume: 34
Issue: 13
Pages: 108905
Publication
First Author: Burén S
Year: 2016
Journal: Cancer Cell
Title: Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms.
Volume: 30
Issue: 2
Pages: 290-307
Publication
First Author: Howerton CL
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction.
Volume: 111
Issue: 26
Pages: 9639-44
Publication
First Author: Vella P
Year: 2013
Journal: Mol Cell
Title: Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.
Volume: 49
Issue: 4
Pages: 645-56
Publication
First Author: Li X
Year: 2017
Journal: J Exp Med
Title: Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation.
Volume: 214
Issue: 4
Pages: 1093-1109
Publication
First Author: Jínek M
Year: 2004
Journal: Nat Struct Mol Biol
Title: The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha.
Volume: 11
Issue: 10
Pages: 1001-7
Publication
First Author: Whelan SA
Year: 2010
Journal: J Biol Chem
Title: Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes.
Volume: 285
Issue: 8
Pages: 5204-11
Publication
First Author: Yi W
Year: 2012
Journal: Science
Title: Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.
Volume: 337
Issue: 6097
Pages: 975-80
Publication
First Author: Fujiki R
Year: 2011
Journal: Nature
Title: GlcNAcylation of histone H2B facilitates its monoubiquitination.
Volume: 480
Issue: 7378
Pages: 557-60
Publication
First Author: Mazars R
Year: 2010
Journal: J Biol Chem
Title: The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias.
Volume: 285
Issue: 18
Pages: 13364-71
Protein
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: false
Publication
First Author: Cai Y
Year: 2010
Journal: J Biol Chem
Title: Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.
Volume: 285
Issue: 7
Pages: 4268-72
Publication  
First Author: Vágó J
Year: 2021
Journal: Cells
Title: Analysis of Gene Expression Patterns of Epigenetic Enzymes Dnmt3a, Tet1 and Ogt in Murine Chondrogenic Models.
Volume: 10
Issue: 10
Publication
First Author: Chen Q
Year: 2013
Journal: Nature
Title: TET2 promotes histone O-GlcNAcylation during gene transcription.
Volume: 493
Issue: 7433
Pages: 561-4
Publication
First Author: Yang Y
Year: 2020
Journal: Nat Commun
Title: O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity.
Volume: 11
Issue: 1
Pages: 181
Publication
First Author: Mizuguchi-Hata C
Year: 2013
Journal: Biochim Biophys Acta
Title: Quantitative regulation of nuclear pore complex proteins by O-GlcNAcylation.
Volume: 1833
Issue: 12
Pages: 2682-2689
Publication
First Author: Zhao M
Year: 2020
Journal: Cell Rep
Title: Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells.
Volume: 32
Issue: 6
Pages: 108013
Publication
First Author: Cheng J
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Loss of O-GlcNAc transferase in neural stem cells impairs corticogenesis.
Volume: 532
Issue: 4
Pages: 541-547
Publication
First Author: Sodi VL
Year: 2018
Journal: Oncogene
Title: Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation.
Volume: 37
Issue: 7
Pages: 924-934
Publication
First Author: Lagerlöf O
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: O-GlcNAc transferase regulates excitatory synapse maturity.
Volume: 114
Issue: 7
Pages: 1684-1689
Publication
First Author: Kreppel LK
Year: 1997
Journal: J Biol Chem
Title: Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats.
Volume: 272
Issue: 14
Pages: 9308-15
Publication
First Author: Whisenhunt TR
Year: 2006
Journal: Glycobiology
Title: Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development.
Volume: 16
Issue: 6
Pages: 551-63
Publication
First Author: Alejandro EU
Year: 2015
Journal: Cell Rep
Title: Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure.
Volume: 13
Issue: 11
Pages: 2527-2538
Publication
First Author: Wu JL
Year: 2017
Journal: Nat Commun
Title: O-GlcNAcylation is required for B cell homeostasis and antibody responses.
Volume: 8
Issue: 1
Pages: 1854
Publication
First Author: Shi Q
Year: 2022
Journal: Cancer Cell
Title: Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance.
Volume: 40
Issue: 10
Pages: 1207-1222.e10
Publication
First Author: Hanover JA
Year: 2003
Journal: Arch Biochem Biophys
Title: Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian gene.
Volume: 409
Issue: 2
Pages: 287-97
Publication
First Author: O'Donnell N
Year: 2004
Journal: Mol Cell Biol
Title: Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability.
Volume: 24
Issue: 4
Pages: 1680-90
Publication  
First Author: Fan J
Year: 2023
Journal: J Clin Invest
Title: O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission.
Volume: 133
Issue: 7
Publication
First Author: Ohashi N
Year: 2017
Journal: Diabetes
Title: Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis.
Volume: 66
Issue: 9
Pages: 2351-2362
Publication  
First Author: Dai CL
Year: 2018
Journal: Neurobiol Aging
Title: Neuronal O-GlcNAc transferase regulates appetite, body weight, and peripheral insulin resistance.
Volume: 70
Pages: 40-50
Publication
First Author: Wheatley EG
Year: 2019
Journal: Curr Biol
Title: Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain.
Volume: 29
Issue: 20
Pages: 3359-3369.e4
Publication
First Author: Shafi R
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.
Volume: 97
Issue: 11
Pages: 5735-9
Publication  
First Author: Zhang B
Year: 2019
Journal: JCI Insight
Title: O-GlcNAc transferase suppresses necroptosis and liver fibrosis.
Volume: 4
Issue: 21
Publication
First Author: Tan EP
Year: 2017
Journal: J Biol Chem
Title: Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism.
Volume: 292
Issue: 36
Pages: 14940-14962
Publication
First Author: Chen L
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: O-GlcNAcylation promotes cerebellum development and medulloblastoma oncogenesis via SHH signaling.
Volume: 119
Issue: 34
Pages: e2202821119
Publication
First Author: Latorre-Muro P
Year: 2021
Journal: Cell Metab
Title: A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation.
Volume: 33
Issue: 3
Pages: 598-614.e7
Publication
First Author: Kaasik K
Year: 2013
Journal: Cell Metab
Title: Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock.
Volume: 17
Issue: 2
Pages: 291-302
Publication
First Author: Lockridge A
Year: 2020
Journal: Cell Rep
Title: Islet O-GlcNAcylation Is Required for Lipid Potentiation of Insulin Secretion through SERCA2.
Volume: 31
Issue: 5
Pages: 107609
Publication  
First Author: Yu H
Year: 2020
Journal: Oxid Med Cell Longev
Title: O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes.
Volume: 2020
Pages: 5602396
Publication  
First Author: Cao Y
Year: 2022
Journal: Int J Mol Sci
Title: O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis.
Volume: 23
Issue: 23
Publication
First Author: Su C
Year: 2017
Journal: J Neurosci
Title: O-GlcNAc Transferase Is Essential for Sensory Neuron Survival and Maintenance.
Volume: 37
Issue: 8
Pages: 2125-2136
Publication  
First Author: Moore M
Year: 2021
Journal: Int J Mol Sci
Title: Disruption of O-Linked N-Acetylglucosamine Signaling in Placenta Induces Insulin Sensitivity in Female Offspring.
Volume: 22
Issue: 13
Publication
First Author: Kim S
Year: 2016
Journal: J Neurosci
Title: Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity.
Volume: 36
Issue: 37
Pages: 9633-46
Publication
First Author: Nugent BM
Year: 2018
Journal: Nat Commun
Title: Placental H3K27me3 establishes female resilience to prenatal insults.
Volume: 9
Issue: 1
Pages: 2555
Publication
First Author: Ruan HB
Year: 2014
Journal: Cell
Title: O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat.
Volume: 159
Issue: 2
Pages: 306-17
Publication  
First Author: Zhang Z
Year: 2022
Journal: Front Immunol
Title: An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism.
Volume: 13
Pages: 874863
Publication  
First Author: Zumbaugh MD
Year: 2021
Journal: Front Physiol
Title: Skeletal Muscle O-GlcNAc Transferase Action on Global Metabolism Is Partially Mediated Through Interleukin-15.
Volume: 12
Pages: 682052
Publication    
First Author: Essawy A
Year: 2021
Journal: J Biol Chem
Title: O-linked N-Acetylglucosamine Transferase (OGT) regulates pancreatic α-cell function in mice.
Pages: 100297
Publication
First Author: Murata K
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Lack of O-GlcNAcylation enhances exercise-dependent glucose utilization potentially through AMP-activated protein kinase activation in skeletal muscle.
Volume: 495
Issue: 2
Pages: 2098-2104
Publication
First Author: Pantaleon M
Year: 2010
Journal: Biol Reprod
Title: Toxic effects of hyperglycemia are mediated by the hexosamine signaling pathway and o-linked glycosylation in early mouse embryos.
Volume: 82
Issue: 4
Pages: 751-8
Publication
First Author: Kim S
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN.
Volume: 115
Issue: 31
Pages: 8019-8024
Publication  
First Author: Khanal S
Year: 2023
Journal: Int J Mol Sci
Title: Deletion of Smooth Muscle O-GlcNAc Transferase Prevents Development of Atherosclerosis in Western Diet-Fed Hyperglycemic ApoE(-/-) Mice In Vivo.
Volume: 24
Issue: 9
Publication
First Author: Watson LJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: O-linked β-N-acetylglucosamine transferase is indispensable in the failing heart.
Volume: 107
Issue: 41
Pages: 17797-802
Publication
First Author: Ida S
Year: 2017
Journal: Diabetologia
Title: Diverse metabolic effects of O-GlcNAcylation in the pancreas but limited effects in insulin-sensitive organs in mice.
Volume: 60
Issue: 9
Pages: 1761-1769
Publication  
First Author: Nishimura K
Year: 2022
Journal: Mol Metab
Title: Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine.
Volume: 59
Pages: 101458
Publication
First Author: Howerton CL
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: O-GlcNAc transferase (OGT) as a placental biomarker of maternal stress and reprogramming of CNS gene transcription in development.
Volume: 110
Issue: 13
Pages: 5169-74
Publication
First Author: Toleman C
Year: 2004
Journal: J Biol Chem
Title: Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities.
Volume: 279
Issue: 51
Pages: 53665-73
Publication
First Author: Dey A
Year: 2012
Journal: Science
Title: Loss of the tumor suppressor BAP1 causes myeloid transformation.
Volume: 337
Issue: 6101
Pages: 1541-6
Publication
First Author: Wong A
Year: 2023
Journal: J Biol Chem
Title: Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion.
Volume: 299
Issue: 2
Pages: 102878
Publication
First Author: Jo S
Year: 2019
Journal: J Biol Chem
Title: eIF4G1 and carboxypeptidase E axis dysregulation in O-GlcNAc transferase-deficient pancreatic β-cells contributes to hyperproinsulinemia in mice.
Volume: 294
Issue: 35
Pages: 13040-13050
Publication
First Author: Mu Y
Year: 2020
Journal: PLoS Genet
Title: O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1.
Volume: 16
Issue: 4
Pages: e1008730
Publication
First Author: Guinez C
Year: 2011
Journal: Diabetes
Title: O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver.
Volume: 60
Issue: 5
Pages: 1399-413
Publication  
First Author: Baumann D
Year: 2020
Journal: Development
Title: Role of nutrient-driven O-GlcNAc-post-translational modification in pancreatic exocrine and endocrine islet development.
Volume: 147
Issue: 7
Publication
First Author: Streubel G
Year: 2017
Journal: EMBO J
Title: Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.
Volume: 36
Issue: 15
Pages: 2216-2232
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory