Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase (OGT; ) is a heterotrimer of one 78kDa subunit and two 110kDa subunits. OGT catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in a protein. Substrate proteins include histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. The consequences of this form of glycosylation are diverse, including insulin resistance in muscle and adipocyte cells (brought about by inhibiting the 'Thr-308' phosphorylation of AKT1) []; regulation of glycolysis by inhibiting PFKL activity []; in the cell cycle O-glycosylation stabilizes ARNTL/BMAL1 and CLOCK, preventing their ubiquitination and subsequent degradation []; glycosylation of HCFC1 and interaction with TET proteins promotes binding of the SET1/COMPASS methyltransferase SETD1A to chromatin []; and H2B GlcNAcylation is a histone modification that facilitates H2BK120 monoubiquitination []. It is a component of several complexes, including MLL5-L, NSL []and THAP1/THAP3-HCFC1-OGT [].This entry represents the 110kDa subunit which has thirteen tetratricopeptide (TPR) repeats that are required for substrate binding and oligomerization [].The NSL complex is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. The complex is composed of at least MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Li MD |
Year: |
2013 |
Journal: |
Cell Metab |
Title: |
O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. |
Volume: |
17 |
Issue: |
2 |
Pages: |
303-10 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
171
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Deplus R |
Year: |
2013 |
Journal: |
EMBO J |
Title: |
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS. |
Volume: |
32 |
Issue: |
5 |
Pages: |
645-55 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1046
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Li MD |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Adipocyte OGT governs diet-induced hyperphagia and obesity. |
Volume: |
9 |
Issue: |
1 |
Pages: |
5103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watson LJ |
Year: |
2014 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Cardiomyocyte Ogt is essential for postnatal viability. |
Volume: |
306 |
Issue: |
1 |
Pages: |
H142-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lagerlöf O |
Year: |
2016 |
Journal: |
Science |
Title: |
The nutrient sensor OGT in PVN neurons regulates feeding. |
Volume: |
351 |
Issue: |
6279 |
Pages: |
1293-6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354374 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-08-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3270422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:4354798 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Table S5 - Ogt |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354374 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-08-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4354798 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression is present in the upper and lower cortical plate. |
Specimen Label: |
Table S5 - Ogt |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354374 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-08-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4354798 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Table S5 - Ogt |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murakami K |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy. |
Volume: |
34 |
Issue: |
1 |
Pages: |
108579 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Q |
Year: |
2022 |
Journal: |
Sci Adv |
Title: |
Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity. |
Volume: |
8 |
Issue: |
35 |
Pages: |
eabn8092 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang Y |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance. |
Volume: |
117 |
Issue: |
28 |
Pages: |
16616-16625 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ito R |
Year: |
2014 |
Journal: |
Genes Cells |
Title: |
TET3-OGT interaction increases the stability and the presence of OGT in chromatin. |
Volume: |
19 |
Issue: |
1 |
Pages: |
52-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling. |
Volume: |
34 |
Issue: |
13 |
Pages: |
108905 |
|
•
•
•
•
•
|
Publication |
First Author: |
Formichetti S |
Year: |
2025 |
Journal: |
PLoS Genet |
Title: |
Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo. |
Volume: |
21 |
Issue: |
1 |
Pages: |
e1011507 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burén S |
Year: |
2016 |
Journal: |
Cancer Cell |
Title: |
Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms. |
Volume: |
30 |
Issue: |
2 |
Pages: |
290-307 |
|
•
•
•
•
•
|
Publication |
First Author: |
Howerton CL |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction. |
Volume: |
111 |
Issue: |
26 |
Pages: |
9639-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vella P |
Year: |
2013 |
Journal: |
Mol Cell |
Title: |
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. |
Volume: |
49 |
Issue: |
4 |
Pages: |
645-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2017 |
Journal: |
J Exp Med |
Title: |
Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation. |
Volume: |
214 |
Issue: |
4 |
Pages: |
1093-1109 |
|
•
•
•
•
•
|
Publication |
First Author: |
JÃnek M |
Year: |
2004 |
Journal: |
Nat Struct Mol Biol |
Title: |
The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha. |
Volume: |
11 |
Issue: |
10 |
Pages: |
1001-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Whelan SA |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes. |
Volume: |
285 |
Issue: |
8 |
Pages: |
5204-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yi W |
Year: |
2012 |
Journal: |
Science |
Title: |
Phosphofructokinase 1 glycosylation regulates cell growth and metabolism. |
Volume: |
337 |
Issue: |
6097 |
Pages: |
975-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujiki R |
Year: |
2011 |
Journal: |
Nature |
Title: |
GlcNAcylation of histone H2B facilitates its monoubiquitination. |
Volume: |
480 |
Issue: |
7378 |
Pages: |
557-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mazars R |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias. |
Volume: |
285 |
Issue: |
18 |
Pages: |
13364-71 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
182
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Cai Y |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. |
Volume: |
285 |
Issue: |
7 |
Pages: |
4268-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Authier F |
Year: |
2024 |
Journal: |
Dis Model Mech |
Title: |
Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability. |
Volume: |
17 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Vágó J |
Year: |
2021 |
Journal: |
Cells |
Title: |
Analysis of Gene Expression Patterns of Epigenetic Enzymes Dnmt3a, Tet1 and Ogt in Murine Chondrogenic Models. |
Volume: |
10 |
Issue: |
10 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Q |
Year: |
2013 |
Journal: |
Nature |
Title: |
TET2 promotes histone O-GlcNAcylation during gene transcription. |
Volume: |
493 |
Issue: |
7433 |
Pages: |
561-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dong X |
Year: |
2023 |
Journal: |
J Neuroinflammation |
Title: |
Ogt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-κB signaling pathway. |
Volume: |
20 |
Issue: |
1 |
Pages: |
146 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mizuguchi-Hata C |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
Quantitative regulation of nuclear pore complex proteins by O-GlcNAcylation. |
Volume: |
1833 |
Issue: |
12 |
Pages: |
2682-2689 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng J |
Year: |
2020 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Loss of O-GlcNAc transferase in neural stem cells impairs corticogenesis. |
Volume: |
532 |
Issue: |
4 |
Pages: |
541-547 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao M |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells. |
Volume: |
32 |
Issue: |
6 |
Pages: |
108013 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sodi VL |
Year: |
2018 |
Journal: |
Oncogene |
Title: |
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation. |
Volume: |
37 |
Issue: |
7 |
Pages: |
924-934 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang Y |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity. |
Volume: |
11 |
Issue: |
1 |
Pages: |
181 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lagerlöf O |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
O-GlcNAc transferase regulates excitatory synapse maturity. |
Volume: |
114 |
Issue: |
7 |
Pages: |
1684-1689 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kreppel LK |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats. |
Volume: |
272 |
Issue: |
14 |
Pages: |
9308-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu JL |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
O-GlcNAcylation is required for B cell homeostasis and antibody responses. |
Volume: |
8 |
Issue: |
1 |
Pages: |
1854 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi Q |
Year: |
2022 |
Journal: |
Cancer Cell |
Title: |
Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance. |
Volume: |
40 |
Issue: |
10 |
Pages: |
1207-1222.e10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Whisenhunt TR |
Year: |
2006 |
Journal: |
Glycobiology |
Title: |
Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development. |
Volume: |
16 |
Issue: |
6 |
Pages: |
551-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanover JA |
Year: |
2003 |
Journal: |
Arch Biochem Biophys |
Title: |
Mitochondrial and nucleocytoplasmic isoforms of O-linked GlcNAc transferase encoded by a single mammalian gene. |
Volume: |
409 |
Issue: |
2 |
Pages: |
287-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Donnell N |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. |
Volume: |
24 |
Issue: |
4 |
Pages: |
1680-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shafi R |
Year: |
2000 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny. |
Volume: |
97 |
Issue: |
11 |
Pages: |
5735-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang B |
Year: |
2019 |
Journal: |
JCI Insight |
Title: |
O-GlcNAc transferase suppresses necroptosis and liver fibrosis. |
Volume: |
4 |
Issue: |
21 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Fan J |
Year: |
2023 |
Journal: |
J Clin Invest |
Title: |
O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission. |
Volume: |
133 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wheatley EG |
Year: |
2019 |
Journal: |
Curr Biol |
Title: |
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. |
Volume: |
29 |
Issue: |
20 |
Pages: |
3359-3369.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohashi N |
Year: |
2017 |
Journal: |
Diabetes |
Title: |
Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis. |
Volume: |
66 |
Issue: |
9 |
Pages: |
2351-2362 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dai CL |
Year: |
2018 |
Journal: |
Neurobiol Aging |
Title: |
Neuronal O-GlcNAc transferase regulates appetite, body weight, and peripheral insulin resistance. |
Volume: |
70 |
|
Pages: |
40-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tan EP |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism. |
Volume: |
292 |
Issue: |
36 |
Pages: |
14940-14962 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen E |
Year: |
2024 |
Journal: |
Sci Rep |
Title: |
Paternal DDT exposure induces sex-specific programming of fetal growth, placenta development and offspring's health phenotypes in a mouse model. |
Volume: |
14 |
Issue: |
1 |
Pages: |
7567 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaasik K |
Year: |
2013 |
Journal: |
Cell Metab |
Title: |
Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. |
Volume: |
17 |
Issue: |
2 |
Pages: |
291-302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2022 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
O-GlcNAcylation promotes cerebellum development and medulloblastoma oncogenesis via SHH signaling. |
Volume: |
119 |
Issue: |
34 |
Pages: |
e2202821119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alejandro EU |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure. |
Volume: |
13 |
Issue: |
11 |
Pages: |
2527-2538 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lockridge A |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
Islet O-GlcNAcylation Is Required for Lipid Potentiation of Insulin Secretion through SERCA2. |
Volume: |
31 |
Issue: |
5 |
Pages: |
107609 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu H |
Year: |
2020 |
Journal: |
Oxid Med Cell Longev |
Title: |
O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes. |
Volume: |
2020 |
|
Pages: |
5602396 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao Y |
Year: |
2022 |
Journal: |
Int J Mol Sci |
Title: |
O-GlcNAcylation of SIRT1 Protects against Cold Stress-Induced Skeletal Muscle Damage via Amelioration of Mitochondrial Homeostasis. |
Volume: |
23 |
Issue: |
23 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Latorre-Muro P |
Year: |
2021 |
Journal: |
Cell Metab |
Title: |
A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation. |
Volume: |
33 |
Issue: |
3 |
Pages: |
598-614.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim S |
Year: |
2016 |
Journal: |
J Neurosci |
Title: |
Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity. |
Volume: |
36 |
Issue: |
37 |
Pages: |
9633-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moore M |
Year: |
2021 |
Journal: |
Int J Mol Sci |
Title: |
Disruption of O-Linked N-Acetylglucosamine Signaling in Placenta Induces Insulin Sensitivity in Female Offspring. |
Volume: |
22 |
Issue: |
13 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Su C |
Year: |
2017 |
Journal: |
J Neurosci |
Title: |
O-GlcNAc Transferase Is Essential for Sensory Neuron Survival and Maintenance. |
Volume: |
37 |
Issue: |
8 |
Pages: |
2125-2136 |
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Publication |
First Author: |
Ruan HB |
Year: |
2014 |
Journal: |
Cell |
Title: |
O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat. |
Volume: |
159 |
Issue: |
2 |
Pages: |
306-17 |
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Publication |
First Author: |
Zhang Z |
Year: |
2022 |
Journal: |
Front Immunol |
Title: |
An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism. |
Volume: |
13 |
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Pages: |
874863 |
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Publication |
First Author: |
Nugent BM |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Placental H3K27me3 establishes female resilience to prenatal insults. |
Volume: |
9 |
Issue: |
1 |
Pages: |
2555 |
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Publication |
First Author: |
Murata K |
Year: |
2018 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Lack of O-GlcNAcylation enhances exercise-dependent glucose utilization potentially through AMP-activated protein kinase activation in skeletal muscle. |
Volume: |
495 |
Issue: |
2 |
Pages: |
2098-2104 |
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Publication |
First Author: |
Essawy A |
Year: |
2021 |
Journal: |
J Biol Chem |
Title: |
O-linked N-Acetylglucosamine Transferase (OGT) regulates pancreatic α-cell function in mice. |
|
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Pages: |
100297 |
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Publication |
First Author: |
Zumbaugh MD |
Year: |
2021 |
Journal: |
Front Physiol |
Title: |
Skeletal Muscle O-GlcNAc Transferase Action on Global Metabolism Is Partially Mediated Through Interleukin-15. |
Volume: |
12 |
|
Pages: |
682052 |
|
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Publication |
First Author: |
Yang YR |
Year: |
2012 |
Journal: |
Aging Cell |
Title: |
O-GlcNAcase is essential for embryonic development and maintenance of genomic stability. |
Volume: |
11 |
Issue: |
3 |
Pages: |
439-48 |
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Publication |
First Author: |
Pantaleon M |
Year: |
2010 |
Journal: |
Biol Reprod |
Title: |
Toxic effects of hyperglycemia are mediated by the hexosamine signaling pathway and o-linked glycosylation in early mouse embryos. |
Volume: |
82 |
Issue: |
4 |
Pages: |
751-8 |
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•
•
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•
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Publication |
First Author: |
Khanal S |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
Deletion of Smooth Muscle O-GlcNAc Transferase Prevents Development of Atherosclerosis in Western Diet-Fed Hyperglycemic ApoE(-/-) Mice In Vivo. |
Volume: |
24 |
Issue: |
9 |
|
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•
•
•
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Publication |
First Author: |
Kim S |
Year: |
2018 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN. |
Volume: |
115 |
Issue: |
31 |
Pages: |
8019-8024 |
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•
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•
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Publication |
First Author: |
Watson LJ |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
O-linked β-N-acetylglucosamine transferase is indispensable in the failing heart. |
Volume: |
107 |
Issue: |
41 |
Pages: |
17797-802 |
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•
•
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Publication |
First Author: |
Ida S |
Year: |
2017 |
Journal: |
Diabetologia |
Title: |
Diverse metabolic effects of O-GlcNAcylation in the pancreas but limited effects in insulin-sensitive organs in mice. |
Volume: |
60 |
Issue: |
9 |
Pages: |
1761-1769 |
|
•
•
•
•
•
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Publication |
First Author: |
Nishimura K |
Year: |
2022 |
Journal: |
Mol Metab |
Title: |
Glycaemia and body weight are regulated by sodium-glucose cotransporter 1 (SGLT1) expression via O-GlcNAcylation in the intestine. |
Volume: |
59 |
|
Pages: |
101458 |
|
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•
•
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Publication |
First Author: |
Toleman C |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities. |
Volume: |
279 |
Issue: |
51 |
Pages: |
53665-73 |
|
•
•
•
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•
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Publication |
First Author: |
Howerton CL |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
O-GlcNAc transferase (OGT) as a placental biomarker of maternal stress and reprogramming of CNS gene transcription in development. |
Volume: |
110 |
Issue: |
13 |
Pages: |
5169-74 |
|
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•
•
•
•
|
Publication |
First Author: |
Dey A |
Year: |
2012 |
Journal: |
Science |
Title: |
Loss of the tumor suppressor BAP1 causes myeloid transformation. |
Volume: |
337 |
Issue: |
6101 |
Pages: |
1541-6 |
|
•
•
•
•
•
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Publication |
First Author: |
Wong A |
Year: |
2023 |
Journal: |
J Biol Chem |
Title: |
Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion. |
Volume: |
299 |
Issue: |
2 |
Pages: |
102878 |
|
•
•
•
•
•
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Publication |
First Author: |
Jo S |
Year: |
2019 |
Journal: |
J Biol Chem |
Title: |
eIF4G1 and carboxypeptidase E axis dysregulation in O-GlcNAc transferase-deficient pancreatic β-cells contributes to hyperproinsulinemia in mice. |
Volume: |
294 |
Issue: |
35 |
Pages: |
13040-13050 |
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•
•
•
•
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Publication |
First Author: |
Mu Y |
Year: |
2020 |
Journal: |
PLoS Genet |
Title: |
O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1. |
Volume: |
16 |
Issue: |
4 |
Pages: |
e1008730 |
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•
•
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•
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Publication |
First Author: |
Guinez C |
Year: |
2011 |
Journal: |
Diabetes |
Title: |
O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver. |
Volume: |
60 |
Issue: |
5 |
Pages: |
1399-413 |
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•
•
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Publication |
First Author: |
Baumann D |
Year: |
2020 |
Journal: |
Development |
Title: |
Role of nutrient-driven O-GlcNAc-post-translational modification in pancreatic exocrine and endocrine islet development. |
Volume: |
147 |
Issue: |
7 |
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Publication |
First Author: |
Streubel G |
Year: |
2017 |
Journal: |
EMBO J |
Title: |
Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. |
Volume: |
36 |
Issue: |
15 |
Pages: |
2216-2232 |
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•
•
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•
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Publication |
First Author: |
Soma S |
Year: |
2024 |
Journal: |
Stem Cells |
Title: |
O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation. |
Volume: |
42 |
Issue: |
1 |
Pages: |
55-63 |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
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•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
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