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Search results 1 to 100 out of 339 for Opa1

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Type Details Score
Gene
4976 | OPA1
Type: gene
Organism: human
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Gene
698540 | OPA1
Type: gene
Organism: macaque, rhesus
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Gene
471042 | OPA1
Type: gene
Organism: chimpanzee
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Gene
524142 | OPA1
Type: gene
Organism: cattle
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Gene
492332 | opa1
Type: gene
Organism: zebrafish
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Gene
477129 | OPA1
Type: gene
Organism: dog, domestic
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Gene
424900 | OPA1
Type: gene
Organism: chicken
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Gene
100145638 | opa1
Type: gene
Organism: frog, western clawed
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Gene
171116 | Opa1
Type: gene
Organism: rat
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Protein Domain
IPR033047 | Opa1
Type: Family
Description: Opa1 is a dynamin-like guanosine triphosphatase required for mitochondrial fusion and regulation of apoptosis. Its activity is controlled by proteolytic cleavage. Stress conditions that cause loss of mitochondrial membrane potential can induce the cleavage of Opa1 at S1 position by OMA1 (an ATP-independent peptidase), and this triggers mitochondrial fragmentation []. It is also involved in mitochondrial cristae remodeling during apoptosis [].
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Protein Coding Gene
MGI:1921393 | Opa1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16839885 | J:116016
First Author: Frezza C
Year: 2006
Journal: Cell
Title: OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion.
Volume: 126
Issue: 1
Pages: 177-89
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Publication
24616225 | J:215813
First Author: Anand R
Year: 2014
Journal: J Cell Biol
Title: The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.
Volume: 204
Issue: 6
Pages: 919-29
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Gene
100873941 | OPA1-AS1
Type: gene
Organism: human
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Publication
23906536 | J:211383
First Author: Fülöp L
Year: 2013
Journal: Mol Cell Endocrinol
Title: Extramitochondrial OPA1 and adrenocortical function.
Volume: 381
Issue: 1-2
Pages: 70-9
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Publication
20652258 | J:162916
First Author: Moore BA
Year: 2010
Journal: Mamm Genome
Title: Mitochondrial retention of Opa1 is required for mouse embryogenesis.
Volume: 21
Issue: 7-8
Pages: 350-60
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Publication
26039449 | J:226126
First Author: Civiletto G
Year: 2015
Journal: Cell Metab
Title: Opa1 overexpression ameliorates the phenotype of two mitochondrial disease mouse models.
Volume: 21
Issue: 6
Pages: 845-54
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Publication
34133045 | J:309047
First Author: Robert P
Year: 2021
Journal: FASEB J
Title: Protective role of the mitochondrial fusion protein OPA1 in hypertension.
Volume: 35
Issue: 7
Pages: e21678
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Publication
19477917 | J:164489
First Author: Song Z
Year: 2009
Journal: Mol Biol Cell
Title: Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion.
Volume: 20
Issue: 15
Pages: 3525-32
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Publication
15509649 | J:94742
First Author: Cipolat S
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: OPA1 requires mitofusin 1 to promote mitochondrial fusion.
Volume: 101
Issue: 45
Pages: 15927-32
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Publication
27587279 | J:237945
First Author: Barrera M
Year: 2016
Journal: FEBS Lett
Title: OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation.
Volume: 590
Issue: 19
Pages: 3309-3322
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Publication
26785494 | J:229455
First Author: Wai T
Year: 2015
Journal: Science
Title: Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice.
Volume: 350
Issue: 6265
Pages: aad0116
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Publication
33944779 | J:327582
   
First Author: Pereira RO
Year: 2021
Journal: Elife
Title: OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21.
Volume: 10
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Publication
31208084 | J:289420
 
First Author: Romanello V
Year: 2019
Journal: Cells
Title: Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles.
Volume: 8
Issue: 6
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Publication
34343501 | J:309736
First Author: Gómez-Valadés AG
Year: 2021
Journal: Cell Metab
Title: Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis.
Volume: 33
Issue: 9
Pages: 1820-1835.e9
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Publication
33237841 | J:309720
First Author: Wang R
Year: 2021
Journal: Mol Biol Cell
Title: Identification of new OPA1 cleavage site reveals that short isoforms regulate mitochondrial fusion.
Volume: 32
Issue: 2
Pages: 157-168
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Publication
24703695 | J:213150
First Author: Mishra P
Year: 2014
Journal: Cell Metab
Title: Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.
Volume: 19
Issue: 4
Pages: 630-41
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Publication
21551073 | J:183074
First Author: Zhang Z
Year: 2011
Journal: Mol Biol Cell
Title: The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells.
Volume: 22
Issue: 13
Pages: 2235-45
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Publication
28607005 | J:244364
First Author: Pereira RO
Year: 2017
Journal: EMBO J
Title: OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.
Volume: 36
Issue: 14
Pages: 2126-2145
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Publication
28552492 | J:256769
First Author: Tezze C
Year: 2017
Journal: Cell Metab
Title: Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.
Volume: 25
Issue: 6
Pages: 1374-1389.e6
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Publication
26783299 | J:230824
First Author: Korwitz A
Year: 2016
Journal: J Cell Biol
Title: Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
Volume: 212
Issue: 2
Pages: 157-66
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Publication
37874273 | J:346781
First Author: Yang Q
Year: 2023
Journal: FASEB J
Title: Loss of UCP2 causes mitochondrial fragmentation by OMA1-dependent proteolytic processing of OPA1 in podocytes.
Volume: 37
Issue: 11
Pages: e23265
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Protein
P58281
Organism: Mus musculus/domesticus
Length: 960  
Fragment?: false
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Protein
Q80TX7
Organism: Mus musculus/domesticus
Length: 953  
Fragment?: true
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Protein
E0CXD1
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
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Protein
H7BX01
Organism: Mus musculus/domesticus
Length: 978  
Fragment?: false
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Publication
26218912 | J:230952
First Author: González-Menéndez I
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Influence of Opa1 Mutation on Survival and Function of Retinal Ganglion Cells.
Volume: 56
Issue: 8
Pages: 4835-45
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Publication
24671334 | J:210969
First Author: Xiao X
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury.
Volume: 306
Issue: 11
Pages: F1318-26
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Publication
19815013 | J:154865
First Author: Alavi MV
Year: 2009
Journal: Exp Neurol
Title: Subtle neurological and metabolic abnormalities in an Opa1 mouse model of autosomal dominant optic atrophy.
Volume: 220
Issue: 2
Pages: 404-9
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Publication
27260406 | J:237307
First Author: Sarzi E
Year: 2016
Journal: Hum Mol Genet
Title: Increased steroidogenesis promotes early-onset and severe vision loss in females with OPA1 dominant optic atrophy.
Volume: 25
Issue: 12
Pages: 2539-2551
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Publication
34072974 | J:314507
 
First Author: Kim D
Year: 2021
Journal: Int J Mol Sci
Title: Opa1 Deficiency Promotes Development of Retinal Vascular Lesions in Diabetic Retinopathy.
Volume: 22
Issue: 11
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Publication
27468686 | J:315851
 
First Author: Kushnareva Y
Year: 2016
Journal: Cell Death Dis
Title: Mitochondrial dysfunction in an Opa1(Q285STOP) mouse model of dominant optic atrophy results from Opa1 haploinsufficiency.
Volume: 7
Pages: e2309
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Publication
37736113 | J:340796
 
First Author: Atamena D
Year: 2023
Journal: Front Mol Neurosci
Title: Genetic background modulates phenotypic expressivity in OPA1 mutated mice, relevance to DOA pathogenesis.
Volume: 16
Pages: 1241222
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Publication
22406748 | J:200812
First Author: Piquereau J
Year: 2012
Journal: Cardiovasc Res
Title: Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload.
Volume: 94
Issue: 3
Pages: 408-17
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Publication
12735796 | J:83833
 
First Author: Delettre C
Year: 2003
Journal: BMC Genet
Title: Gene structure and chromosomal localization of mouse Opa1 : its exclusion from the Bst locus.
Volume: 4
Pages: 8
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Protein
F6U775
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: true
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Publication
17003040 | J:117614
First Author: Duvezin-Caubet S
Year: 2006
Journal: J Biol Chem
Title: Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology.
Volume: 281
Issue: 49
Pages: 37972-9
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Publication
27861891 | J:239178
First Author: Moulis MF
Year: 2017
Journal: J Neurochem
Title: OPA1 haploinsufficiency induces a BNIP3-dependent decrease in mitophagy in neurons: relevance to Dominant Optic Atrophy.
Volume: 140
Issue: 3
Pages: 485-494
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Protein
Q8BK99
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
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Publication
36516772 | J:332395
First Author: Sessions DT
Year: 2022
Journal: Cell Rep
Title: Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD(+) regeneration in KRas-mutant lung adenocarcinoma.
Volume: 41
Issue: 11
Pages: 111818
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Publication
17314202 | J:154966
First Author: Alavi MV
Year: 2007
Journal: Brain
Title: A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy.
Volume: 130
Issue: Pt 4
Pages: 1029-42
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Publication
20038678 | J:156874
First Author: Ehses S
Year: 2009
Journal: J Cell Biol
Title: Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1.
Volume: 187
Issue: 7
Pages: 1023-36
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Publication
28637784 | J:267446
First Author: Nan J
Year: 2017
Journal: Circ Res
Title: TNFR2 Stimulation Promotes Mitochondrial Fusion via Stat3- and NF-kB-Dependent Activation of OPA1 Expression.
Volume: 121
Issue: 4
Pages: 392-410
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Publication
22433842 | J:184716
First Author: Quirós PM
Year: 2012
Journal: EMBO J
Title: Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice.
Volume: 31
Issue: 9
Pages: 2117-33
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Publication
19234344 | J:154570
First Author: White KE
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: OPA1 deficiency associated with increased autophagy in retinal ganglion cells in a murine model of dominant optic atrophy.
Volume: 50
Issue: 6
Pages: 2567-71
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Publication
23714779 | J:199106
First Author: Santo-Domingo J
Year: 2013
Journal: EMBO J
Title: OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange.
Volume: 32
Issue: 13
Pages: 1927-40
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Publication
17428816 | J:121779
First Author: Davies VJ
Year: 2007
Journal: Hum Mol Genet
Title: Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function.
Volume: 16
Issue: 11
Pages: 1307-18
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Publication
25352671 | J:216764
First Author: Sood A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.
Volume: 111
Issue: 45
Pages: 16017-22
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Publication
15161824 | J:92284
First Author: Aijaz S
Year: 2004
Journal: Invest Ophthalmol Vis Sci
Title: Developmental expression profile of the optic atrophy gene product: OPA1 is not localized exclusively in the mammalian retinal ganglion cell layer.
Volume: 45
Issue: 6
Pages: 1667-73
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Publication
30143614 | J:266490
First Author: Quintana-Cabrera R
Year: 2018
Journal: Nat Commun
Title: The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function.
Volume: 9
Issue: 1
Pages: 3399
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Publication
26039448 | J:344143
First Author: Varanita T
Year: 2015
Journal: Cell Metab
Title: The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage.
Volume: 21
Issue: 6
Pages: 834-44
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DO Term
DOID:0111441 | optic atrophy 1
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Publication
24055366 | J:214492
First Author: Cogliati S
Year: 2013
Journal: Cell
Title: Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency.
Volume: 155
Issue: 1
Pages: 160-71
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Publication
11847212 | J:76355
First Author: Misaka T
Year: 2002
Journal: J Biol Chem
Title: Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology.
Volume: 277
Issue: 18
Pages: 15834-42
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Publication
32315597 | J:296538
First Author: Herkenne S
Year: 2020
Journal: Cell Metab
Title: Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1.
Volume: 31
Issue: 5
Pages: 987-1003.e8
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Publication
23250881 | J:237963
First Author: Sarzi E
Year: 2012
Journal: Brain
Title: The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.
Volume: 135
Issue: Pt 12
Pages: 3599-613
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Publication
22658590 | J:199508
First Author: Wasilewski M
Year: 2012
Journal: Curr Biol
Title: Optic atrophy 1-dependent mitochondrial remodeling controls steroidogenesis in trophoblasts.
Volume: 22
Issue: 13
Pages: 1228-34
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Publication
27974214 | J:241706
First Author: Glytsou C
Year: 2016
Journal: Cell Rep
Title: Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control.
Volume: 17
Issue: 11
Pages: 3024-3034
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Publication
22902477 | J:198403
First Author: Belenguer P
Year: 2013
Journal: Biochim Biophys Acta
Title: The dynamin GTPase OPA1: more than mitochondria?
Volume: 1833
Issue: 1
Pages: 176-83
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Publication
21983901 | J:180083
First Author: Pidoux G
Year: 2011
Journal: EMBO J
Title: Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis.
Volume: 30
Issue: 21
Pages: 4371-86
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Publication
22579715 | J:188075
First Author: Sanjuán Szklarz LK
Year: 2012
Journal: Biochim Biophys Acta
Title: The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock.
Volume: 1817
Issue: 10
Pages: 1886-93
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Publication
28746876 | J:254859
First Author: Huang G
Year: 2017
Journal: Cell Rep
Title: WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for Mitochondrial Fusion.
Volume: 20
Issue: 4
Pages: 923-934
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Publication
21803037 | J:189276
First Author: Barnard AR
Year: 2011
Journal: Exp Eye Res
Title: Specific deficits in visual electrophysiology in a mouse model of dominant optic atrophy.
Volume: 93
Issue: 5
Pages: 771-7
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Publication
27723783 | J:251340
First Author: Le Page S
Year: 2016
Journal: PLoS One
Title: Increase in Cardiac Ischemia-Reperfusion Injuries in Opa1+/- Mouse Model.
Volume: 11
Issue: 10
Pages: e0164066
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Publication
32571921 | J:291523
First Author: Meschede IP
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1.
Volume: 117
Issue: 27
Pages: 15684-15693
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Publication
32756920 | J:293812
First Author: Kim D
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: Effects of Diabetes on Mitochondrial Morphology and Its Implications in Diabetic Retinopathy.
Volume: 61
Issue: 10
Pages: 10
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Publication
19834041 | J:160417
First Author: Heiduschka P
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: Electrophysiological and histologic assessment of retinal ganglion cell fate in a mouse model for OPA1-associated autosomal dominant optic atrophy.
Volume: 51
Issue: 3
Pages: 1424-31
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Publication
22158479 | J:202211
 
First Author: Nguyen D
Year: 2011
Journal: Cell Death Dis
Title: A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics.
Volume: 2
Pages: e240
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Publication
18200046 | J:131413
First Author: Twig G
Year: 2008
Journal: EMBO J
Title: Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.
Volume: 27
Issue: 2
Pages: 433-46
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Publication
21346246 | J:172413
First Author: Makino A
Year: 2011
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Regulation of mitochondrial morphology and function by O-GlcNAcylation in neonatal cardiac myocytes.
Volume: 300
Issue: 6
Pages: R1296-302
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Publication
22858546 | J:205546
First Author: Ramonet D
Year: 2013
Journal: Cell Death Differ
Title: Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency.
Volume: 20
Issue: 1
Pages: 77-85
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Publication
30068998 | J:323712
First Author: Bocca C
Year: 2018
Journal: Sci Rep
Title: The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency.
Volume: 8
Issue: 1
Pages: 11528
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Publication
24550258 | J:208034
First Author: Baker MJ
Year: 2014
Journal: EMBO J
Title: Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics.
Volume: 33
Issue: 6
Pages: 578-93
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Publication
28159969 | J:257139
First Author: Chao de la Barca JM
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1delTTAG/+ Mice.
Volume: 58
Issue: 2
Pages: 812-820
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Publication
24042504 | J:215842
First Author: Caffin F
Year: 2013
Journal: J Physiol
Title: Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice.
Volume: 591
Issue: 23
Pages: 6017-37
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Publication
25298396 | J:216587
First Author: Patten DA
Year: 2014
Journal: EMBO J
Title: OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.
Volume: 33
Issue: 22
Pages: 2676-91
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Publication
19360003 | J:149906
First Author: Tondera D
Year: 2009
Journal: EMBO J
Title: SLP-2 is required for stress-induced mitochondrial hyperfusion.
Volume: 28
Issue: 11
Pages: 1589-600
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Publication
23453807 | J:198144
First Author: Müller-Rischart AK
Year: 2013
Journal: Mol Cell
Title: The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.
Volume: 49
Issue: 5
Pages: 908-21
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Publication
26024391 | J:259867
First Author: Laforge M
Year: 2016
Journal: Cell Death Differ
Title: NF-κB pathway controls mitochondrial dynamics.
Volume: 23
Issue: 1
Pages: 89-98
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Publication
20064504 | J:158842
First Author: Kieper N
Year: 2010
Journal: Exp Cell Res
Title: Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.
Volume: 316
Issue: 7
Pages: 1213-24
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Publication
19443720 | J:154544
First Author: Yu-Wai-Man P
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Secondary mtDNA defects do not cause optic nerve dysfunction in a mouse model of dominant optic atrophy.
Volume: 50
Issue: 10
Pages: 4561-6
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Publication
26820596 | J:231368
 
First Author: Smith TG
Year: 2016
Journal: Neuroscience
Title: A randomized, placebo-controlled trial of the benzoquinone idebenone in a mouse model of OPA1-related dominant optic atrophy reveals a limited therapeutic effect on retinal ganglion cell dendropathy and visual function.
Volume: 319
Pages: 92-106
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Publication
23409176 | J:197201
First Author: Perganta G
Year: 2013
Journal: PLoS One
Title: Non-image-forming light driven functions are preserved in a mouse model of autosomal dominant optic atrophy.
Volume: 8
Issue: 2
Pages: e56350
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Publication
16839884 | J:116017
First Author: Cipolat S
Year: 2006
Journal: Cell
Title: Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.
Volume: 126
Issue: 1
Pages: 163-75
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Publication
18691924 | J:139566
First Author: Yamaguchi R
Year: 2008
Journal: Mol Cell
Title: Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization.
Volume: 31
Issue: 4
Pages: 557-69
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Publication
21642619 | J:181410
First Author: Ganapathy PS
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells.
Volume: 52
Issue: 8
Pages: 5551-8
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Publication
15899901 | J:281198
First Author: Chen H
Year: 2005
Journal: J Biol Chem
Title: Disruption of fusion results in mitochondrial heterogeneity and dysfunction.
Volume: 280
Issue: 28
Pages: 26185-92
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Publication
35222801 | J:321633
 
First Author: Zhu P
Year: 2022
Journal: Oxid Med Cell Longev
Title: NR4A1 Promotes LPS-Induced Acute Lung Injury through Inhibition of Opa1-Mediated Mitochondrial Fusion and Activation of PGAM5-Related Necroptosis.
Volume: 2022
Pages: 6638244
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Publication
21081504 | J:173140
First Author: Darshi M
Year: 2011
Journal: J Biol Chem
Title: ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function.
Volume: 286
Issue: 4
Pages: 2918-32
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Publication
36754021 | J:333326
First Author: Suh J
Year: 2023
Journal: Cell Metab
Title: Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis.
Volume: 35
Issue: 2
Pages: 345-360.e7
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