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Search results 1 to 100 out of 315 for Orc1

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Type Details Score
Gene
4998 | ORC1
Type: gene
Organism: human
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Gene
513523 | ORC1
Type: gene
Organism: cattle
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Gene
100855917 | ORC1
Type: gene
Organism: dog, domestic
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Gene
424640 | ORC1
Type: gene
Organism: chicken
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Gene
554509 | orc1
Type: gene
Organism: zebrafish
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Gene
713271 | ORC1
Type: gene
Organism: macaque, rhesus
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Gene
734048 | orc1
Type: gene
Organism: frog, western clawed
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Gene
key_47293 | ORC1
Type: gene
Organism: hamster, Chinese
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Gene
313479 | Orc1
Type: gene
Organism: rat
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Gene
456857 | ORC1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1328337 | Orc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR020793 | ORC1
Type: Family
Description: The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding complex encoded in yeast by ORC1-6 []. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle []. ORC directs DNA replication throughout the genome and is required for its initiation [, , ]. ORC bound at replication origins serves as the foundation for assembly of the pre-replicative complex (pre-RC), which includes Cdc6, Tah11 (aka Cdt1), and the Mcm2-7 complex [, , ]. Pre-RC assembly during G1 is required for replication licensing of chromosomes prior to DNA synthesis during S phase [, , ]. Cell cycle-regulated phosphorylation of ORC2, ORC6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates initiation of DNA replication, including blocking reinitiation in G2/M phase [, , , ]. In yeast, ORC also plays a role in the establishment of silencing at the mating-type loci Hidden MAT Left (HML) and Hidden MAT Right (HMR) [, , ]. ORC participates in the assembly of transcriptionally silent chromatin at HML and HMR by recruiting the Sir1 silencing protein to the HML and HMR silencers [, , ]. Both ORC1 and ORC5 bind ATP, although only ORC1 has ATPase activity []. The binding of ATP by ORC1 is required for ORC binding to DNA and is essential for cell viability []. The ATPase activity of ORC1 is involved in formation of the pre-RC [, , ]. ATP binding by ORC5 is crucial for the stability of ORC as a whole. Only the ORC1-5 subunits are required for origin binding; ORC6 is essential for maintenance of pre-RCs once formed []. Interactions within ORC suggest that ORC2-3-6 may form a core complex []. ORC homologues have been found in various eukaryotes, including fission yeast, insects, amphibians, and humans []. This entry represents the largest subunit of the origin recognition complex, subunit 1, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity [, ]. Sir3 is the homologue in Saccharomyces cerevisiae [].
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Gene
340569 | ORC1P1
Type: gene
Organism: human
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Publication
9862484 | J:51511
First Author: Zisimopoulou P
Year: 1998
Journal: Mol Gen Genet
Title: Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1.
Volume: 260
Issue: 2-3
Pages: 295-9
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Publication
10835370 | J:62706
First Author: Natale DA
Year: 2000
Journal: EMBO J
Title: Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals.
Volume: 19
Issue: 11
Pages: 2728-38
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Protein
Q9Z1N2
Organism: Mus musculus/domesticus
Length: 840  
Fragment?: false
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Publication
17241905 | -
 
First Author: Chesnokov IN
Year: 2007
Journal: Int Rev Cytol
Title: Multiple functions of the origin recognition complex.
Volume: 256
Pages: 69-109
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Publication
17825065 | -
First Author: Matsuda K
Year: 2007
Journal: FEMS Yeast Res
Title: Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.
Volume: 7
Issue: 8
Pages: 1263-9
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Publication
1579162 | -
First Author: Bell SP
Year: 1992
Journal: Nature
Title: ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex.
Volume: 357
Issue: 6374
Pages: 128-34
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Publication
7585959 | -
First Author: Bell SP
Year: 1995
Journal: Cell
Title: The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing.
Volume: 83
Issue: 4
Pages: 563-8
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Publication
16716188 | -
First Author: Gibson DG
Year: 2006
Journal: Genes Cells
Title: Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.
Volume: 11
Issue: 6
Pages: 557-73
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Publication
7892251 | -
First Author: Rao H
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators.
Volume: 92
Issue: 6
Pages: 2224-8
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Publication
7781615 | -
First Author: Rowley A
Year: 1995
Journal: EMBO J
Title: Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.
Volume: 14
Issue: 11
Pages: 2631-41
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Publication
16228006 | -
First Author: Speck C
Year: 2005
Journal: Nat Struct Mol Biol
Title: ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.
Volume: 12
Issue: 11
Pages: 965-71
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Publication
10966477 | -
 
First Author: Kelly TJ
Year: 2000
Journal: Annu Rev Biochem
Title: Regulation of chromosome replication.
Volume: 69
Pages: 829-80
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Publication
12045100 | -
 
First Author: Bell SP
Year: 2002
Journal: Annu Rev Biochem
Title: DNA replication in eukaryotic cells.
Volume: 71
Pages: 333-74
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Publication
15680967 | -
First Author: Stillman B
Year: 2005
Journal: FEBS Lett
Title: Origin recognition and the chromosome cycle.
Volume: 579
Issue: 4
Pages: 877-84
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Publication
11572976 | -
First Author: Weinreich M
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle.
Volume: 98
Issue: 20
Pages: 11211-7
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Publication
11429609 | -
First Author: Nguyen VQ
Year: 2001
Journal: Nature
Title: Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms.
Volume: 411
Issue: 6841
Pages: 1068-73
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Publication
16024805 | -
First Author: Archambault V
Year: 2005
Journal: Mol Cell Biol
Title: Disruption of mechanisms that prevent rereplication triggers a DNA damage response.
Volume: 25
Issue: 15
Pages: 6707-21
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Publication
9038340 | -
First Author: Klemm RD
Year: 1997
Journal: Cell
Title: Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex.
Volume: 88
Issue: 4
Pages: 493-502
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Publication
11459976 | -
First Author: Klemm RD
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: ATP bound to the origin recognition complex is important for preRC formation.
Volume: 98
Issue: 15
Pages: 8361-7
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Publication
15610739 | -
First Author: Bowers JL
Year: 2004
Journal: Mol Cell
Title: ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.
Volume: 16
Issue: 6
Pages: 967-78
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Publication
16387651 | -
First Author: Randell JC
Year: 2006
Journal: Mol Cell
Title: Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.
Volume: 21
Issue: 1
Pages: 29-39
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Publication
17053779 | -
First Author: Semple JW
Year: 2006
Journal: EMBO J
Title: An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes.
Volume: 25
Issue: 21
Pages: 5150-8
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Publication
11914271 | -
First Author: Bell SP
Year: 2002
Journal: Genes Dev
Title: The origin recognition complex: from simple origins to complex functions.
Volume: 16
Issue: 6
Pages: 659-72
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Publication
8622770 | -
First Author: Triolo T
Year: 1996
Journal: Nature
Title: Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.
Volume: 381
Issue: 6579
Pages: 251-3
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Publication
9171055 | -
First Author: Fox CA
Year: 1997
Journal: Science
Title: The origin recognition complex, SIR1, and the S phase requirement for silencing.
Volume: 276
Issue: 5318
Pages: 1547-51
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Publication
9442876 | -
 
First Author: Dutta A
Year: 1997
Journal: Annu Rev Cell Dev Biol
Title: Initiation of DNA replication in eukaryotic cells.
Volume: 13
Pages: 293-332
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Publication
24018145 | -
First Author: Varunan SM
Year: 2013
Journal: Mol Biochem Parasitol
Title: Plasmodium falciparum origin recognition complex subunit 1 (PfOrc1) functionally complements Δsir3 mutant of Saccharomyces cerevisiae.
Volume: 191
Issue: 1
Pages: 28-35
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Protein
Q3UR71
Organism: Mus musculus/domesticus
Length: 811  
Fragment?: false
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Protein
Q3TPY7
Organism: Mus musculus/domesticus
Length: 811  
Fragment?: false
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Protein
Q59IX2
Organism: Mus musculus/domesticus
Length: 805  
Fragment?: false
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Protein
Q8C9G3
Organism: Mus musculus/domesticus
Length: 840  
Fragment?: false
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Protein
Q8CFY7
Organism: Mus musculus/domesticus
Length: 840  
Fragment?: true
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Publication
32808929 | J:339148
   
First Author: Jaremko MJ
Year: 2020
Journal: Elife
Title: The dynamic nature of the human origin recognition complex revealed through five cryoEM structures.
Volume: 9
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Publication
29967292 | J:272584
First Author: Okano-Uchida T
Year: 2018
Journal: Genes Dev
Title: Endoreduplication of the mouse genome in the absence of ORC1.
Volume: 32
Issue: 13-14
Pages: 978-990
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Publication
12614612 | J:82383
First Author: Kneissl M
Year: 2003
Journal: J Mol Biol
Title: Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.
Volume: 327
Issue: 1
Pages: 111-28
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Protein Coding Gene
MGP_CAROLIEiJ_G0026270 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028557 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028520 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028467 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028539 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028253 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1328337 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028979 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027689 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028222 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028370 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028338 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028471 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028364 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0029015 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027415 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028603 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027239 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6388633
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6388687
Age: embryonic day 17.5
Image: 6
Specimen Label: E17.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6388633
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388687
Age: postnatal week 1
Image: 6
Specimen Label: 1wk
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6388633
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388687
Age: postnatal week 2
Image: 6
Specimen Label: 2wk
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6388633
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388687
Age: postnatal week 3
Image: 6
Specimen Label: 3wk
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6388633
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388687
Age: postnatal week 6
Image: 6
Specimen Label: 6wk
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6388633
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388687
Age: postnatal week 9
Image: 6
Specimen Label: 9wk
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6388625
Assay Type: Western blot
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6388696
Age: embryonic day 17.5
Image: S5
Specimen Label: E17.5 liver
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6388625
Assay Type: Western blot
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388696
Age: postnatal week 6
Image: S5
Specimen Label: 6wk liver
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6691344
Age: postnatal adult
Image: JAX_1122931
Specimen Label: JAX_1122931
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:6691344
Age: postnatal adult
Image: JAX_1122933
Specimen Label: JAX_1122933
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691344
Age: postnatal adult
Image: JAX_1122929
Specimen Label: JAX_1122929
Detected: true
Specimen Num: 2
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Publication
28700664 | J:246066
First Author: Sundberg JP
Year: 2017
Journal: PLoS One
Title: Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Volume: 12
Issue: 7
Pages: e0180682
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:345476
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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