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Search results 1 to 100 out of 122 for Orc2

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: This entry represents subunit 2, which binds the origin of replication. It plays a role in chromosome replication and mating type transcriptional silencing.The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding complex encoded in yeast by ORC1-6 []. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle []. ORC directs DNA replication throughout the genome and is required for its initiation [, , ]. ORC bound at replication origins serves as the foundation for assembly of the pre-replicative complex (pre-RC), which includes Cdc6, Tah11 (aka Cdt1), and the Mcm2-7 complex [, , ]. Pre-RC assembly during G1 is required for replication licensing of chromosomes prior to DNA synthesis during S phase [, , ]. Cell cycle-regulated phosphorylation of ORC2, ORC6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates initiation of DNA replication, including blocking reinitiation in G2/M phase [, , , ]. In yeast, ORC also plays a role in the establishment of silencing at the mating-type loci Hidden MAT Left (HML) and Hidden MAT Right (HMR) [, , ]. ORC participates in the assembly of transcriptionally silent chromatin at HML and HMR by recruiting the Sir1 silencing protein to the HML and HMR silencers [, , ]. Both ORC1 and ORC5 bind ATP, although only ORC1 has ATPase activity []. The binding of ATP by ORC1 is required for ORC binding to DNA and is essential for cell viability []. The ATPase activity of ORC1 is involved in formation of the pre-RC [, , ]. ATP binding by ORC5 is crucial for the stability of ORC as a whole. Only the ORC1-5 subunits are required for origin binding; ORC6 is essential for maintenance of pre-RCs once formed []. Interactions within ORC suggest that ORC2-3-6 may form a core complex []. ORC homologues have been found in various eukaryotes, including fission yeast, insects, amphibians, and humans [].
Publication
First Author: Ortega MA
Year: 2012
Journal: Biol Reprod
Title: Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
Volume: 87
Issue: 3
Pages: 62
Publication
First Author: Takahara K
Year: 1996
Journal: Genomics
Title: Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L.
Volume: 31
Issue: 1
Pages: 119-22
Protein
Organism: Mus musculus
Length: 576  
Fragment?: false
Protein
Organism: Mus musculus
Length: 576  
Fragment?: false
Protein
Organism: Mus musculus
Length: 528  
Fragment?: false
Publication  
First Author: Chesnokov IN
Year: 2007
Journal: Int Rev Cytol
Title: Multiple functions of the origin recognition complex.
Volume: 256
Pages: 69-109
Publication
First Author: Matsuda K
Year: 2007
Journal: FEMS Yeast Res
Title: Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.
Volume: 7
Issue: 8
Pages: 1263-9
Publication
First Author: Bell SP
Year: 1992
Journal: Nature
Title: ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex.
Volume: 357
Issue: 6374
Pages: 128-34
Publication
First Author: Bell SP
Year: 1995
Journal: Cell
Title: The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing.
Volume: 83
Issue: 4
Pages: 563-8
Publication
First Author: Gibson DG
Year: 2006
Journal: Genes Cells
Title: Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.
Volume: 11
Issue: 6
Pages: 557-73
Publication
First Author: Rao H
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators.
Volume: 92
Issue: 6
Pages: 2224-8
Publication
First Author: Rowley A
Year: 1995
Journal: EMBO J
Title: Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.
Volume: 14
Issue: 11
Pages: 2631-41
Publication
First Author: Speck C
Year: 2005
Journal: Nat Struct Mol Biol
Title: ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.
Volume: 12
Issue: 11
Pages: 965-71
Publication  
First Author: Kelly TJ
Year: 2000
Journal: Annu Rev Biochem
Title: Regulation of chromosome replication.
Volume: 69
Pages: 829-80
Publication  
First Author: Bell SP
Year: 2002
Journal: Annu Rev Biochem
Title: DNA replication in eukaryotic cells.
Volume: 71
Pages: 333-74
Publication
First Author: Stillman B
Year: 2005
Journal: FEBS Lett
Title: Origin recognition and the chromosome cycle.
Volume: 579
Issue: 4
Pages: 877-84
Publication
First Author: Weinreich M
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle.
Volume: 98
Issue: 20
Pages: 11211-7
Publication
First Author: Nguyen VQ
Year: 2001
Journal: Nature
Title: Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms.
Volume: 411
Issue: 6841
Pages: 1068-73
Publication
First Author: Archambault V
Year: 2005
Journal: Mol Cell Biol
Title: Disruption of mechanisms that prevent rereplication triggers a DNA damage response.
Volume: 25
Issue: 15
Pages: 6707-21
Publication
First Author: Triolo T
Year: 1996
Journal: Nature
Title: Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.
Volume: 381
Issue: 6579
Pages: 251-3
Publication
First Author: Fox CA
Year: 1997
Journal: Science
Title: The origin recognition complex, SIR1, and the S phase requirement for silencing.
Volume: 276
Issue: 5318
Pages: 1547-51
Publication
First Author: Klemm RD
Year: 1997
Journal: Cell
Title: Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex.
Volume: 88
Issue: 4
Pages: 493-502
Publication
First Author: Klemm RD
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: ATP bound to the origin recognition complex is important for preRC formation.
Volume: 98
Issue: 15
Pages: 8361-7
Publication
First Author: Bowers JL
Year: 2004
Journal: Mol Cell
Title: ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.
Volume: 16
Issue: 6
Pages: 967-78
Publication
First Author: Randell JC
Year: 2006
Journal: Mol Cell
Title: Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.
Volume: 21
Issue: 1
Pages: 29-39
Publication
First Author: Semple JW
Year: 2006
Journal: EMBO J
Title: An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes.
Volume: 25
Issue: 21
Pages: 5150-8
Publication  
First Author: Dutta A
Year: 1997
Journal: Annu Rev Cell Dev Biol
Title: Initiation of DNA replication in eukaryotic cells.
Volume: 13
Pages: 293-332
Publication
First Author: Natale DA
Year: 2000
Journal: EMBO J
Title: Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals.
Volume: 19
Issue: 11
Pages: 2728-38
Publication
First Author: Chan KM
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Diverse factors are involved in maintaining X chromosome inactivation.
Volume: 108
Issue: 40
Pages: 16699-704
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2652188
Age: embryonic day 7.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2652188
Age: embryonic day 11.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2652188
Age: embryonic day 15.0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2652188
Age: embryonic day 17.0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6388636
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6388688
Age: embryonic day 17.5
Image: 6
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6388636
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388688
Age: postnatal week 1
Image: 6
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6388636
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388688
Age: postnatal week 2
Image: 6
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6388636
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388688
Age: postnatal week 3
Image: 6
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6388636
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388688
Age: postnatal week 6
Image: 6
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6388636
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388688
Age: postnatal week 9
Image: 6
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4844660
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848545
Age: embryonic day 11.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844660
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1680017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848545
Age: embryonic day 10.5
Note: Staining is present in the olfactory placode.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844660
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848545
Age: embryonic day 11.5
Note: Staining is present in the progress zone.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4844660
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848545
Age: embryonic day 10.5
Note: Staining is present in the otic pit.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4844660
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1638817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848545
Age: embryonic day 10.5
Note: Staining is present in the maxillary process.
Detected: true
Specimen Num: 1
Publication
First Author: Craig JM
Year: 2003
Journal: Hum Mol Genet
Title: Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.
Volume: 12
Issue: 23
Pages: 3109-21
Publication
First Author: Dannenberg JH
Year: 2005
Journal: Genes Dev
Title: mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival.
Volume: 19
Issue: 13
Pages: 1581-95
Publication
First Author: Kneissl M
Year: 2003
Journal: J Mol Biol
Title: Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.
Volume: 327
Issue: 1
Pages: 111-28
Publication
First Author: Okano-Uchida T
Year: 2018
Journal: Genes Dev
Title: Endoreduplication of the mouse genome in the absence of ORC1.
Volume: 32
Issue: 13-14
Pages: 978-990
Publication
First Author: Geng Y
Year: 2003
Journal: Cell
Title: Cyclin E ablation in the mouse.
Volume: 114
Issue: 4
Pages: 431-43
Publication
First Author: Ishii H
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis.
Volume: 102
Issue: 27
Pages: 9655-60
Publication
First Author: Campbell GR
Year: 2011
Journal: Mol Cell Neurosci
Title: Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.
Volume: 46
Issue: 2
Pages: 548-61
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS