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Search results 1 to 100 out of 129 for Orc2

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Type Details Score
Gene
4999 | ORC2
Type: gene
Organism: human
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Gene
511281 | ORC2
Type: gene
Organism: cattle
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Gene
424077 | ORC2
Type: gene
Organism: chicken
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Gene
768161 | orc2
Type: gene
Organism: zebrafish
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Gene
700691 | ORC2
Type: gene
Organism: macaque, rhesus
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Gene
780267 | orc2
Type: gene
Organism: frog, western clawed
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Gene
key_47294 | ORC2
Type: gene
Organism: hamster, Chinese
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Gene
301430 | Orc2
Type: gene
Organism: rat
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Gene
478868 | ORC2
Type: gene
Organism: dog, domestic
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Gene
459868 | ORC2
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1328306 | Orc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR007220 | ORC2
Type: Family
Description: The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding complex encoded in yeast by ORC1-6 []. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle []. ORC directs DNA replication throughout the genome and is required for its initiation [, , ]. ORC bound at replication origins serves as the foundation for assembly of the pre-replicative complex (pre-RC), which includes Cdc6, Tah11 (aka Cdt1), and the Mcm2-7 complex [, , ]. Pre-RC assembly during G1 is required for replication licensing of chromosomes prior to DNA synthesis during S phase [, , ]. Cell cycle-regulated phosphorylation of ORC2, ORC6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates initiation of DNA replication, including blocking reinitiation in G2/M phase [, , , ]. In yeast, ORC also plays a role in the establishment of silencing at the mating-type loci Hidden MAT Left (HML) and Hidden MAT Right (HMR) [, , ]. ORC participates in the assembly of transcriptionally silent chromatin at HML and HMR by recruiting the Sir1 silencing protein to the HML and HMR silencers [, , ]. Both ORC1 and ORC5 bind ATP, although only ORC1 has ATPase activity []. The binding of ATP by ORC1 is required for ORC binding to DNA and is essential for cell viability []. The ATPase activity of ORC1 is involved in formation of the pre-RC [, , ]. ATP binding by ORC5 is crucial for the stability of ORC as a whole. Only the ORC1-5 subunits are required for origin binding; ORC6 is essential for maintenance of pre-RCs once formed []. Interactions within ORC suggest that ORC2-3-6 may form a core complex []. ORC homologues have been found in various eukaryotes, including fission yeast, insects, amphibians, and humans []. This entry represents subunit 2, which binds the origin of replication. It plays a role in chromosome replication and mating type transcriptional silencing.
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Publication
22674395 | J:192413
First Author: Ortega MA
Year: 2012
Journal: Biol Reprod
Title: Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
Volume: 87
Issue: 3
Pages: 62
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Publication
8808289 | J:30882
First Author: Takahara K
Year: 1996
Journal: Genomics
Title: Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L.
Volume: 31
Issue: 1
Pages: 119-22
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Protein
Q60862
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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Protein
Q543F8
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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Protein
Q59IX1
Organism: Mus musculus/domesticus
Length: 528  
Fragment?: false
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Publication
17241905 | -
 
First Author: Chesnokov IN
Year: 2007
Journal: Int Rev Cytol
Title: Multiple functions of the origin recognition complex.
Volume: 256
Pages: 69-109
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Publication
17825065 | -
First Author: Matsuda K
Year: 2007
Journal: FEMS Yeast Res
Title: Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.
Volume: 7
Issue: 8
Pages: 1263-9
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Publication
1579162 | -
First Author: Bell SP
Year: 1992
Journal: Nature
Title: ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex.
Volume: 357
Issue: 6374
Pages: 128-34
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Publication
7585959 | -
First Author: Bell SP
Year: 1995
Journal: Cell
Title: The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing.
Volume: 83
Issue: 4
Pages: 563-8
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Publication
16716188 | -
First Author: Gibson DG
Year: 2006
Journal: Genes Cells
Title: Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.
Volume: 11
Issue: 6
Pages: 557-73
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Publication
7892251 | -
First Author: Rao H
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators.
Volume: 92
Issue: 6
Pages: 2224-8
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Publication
7781615 | -
First Author: Rowley A
Year: 1995
Journal: EMBO J
Title: Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.
Volume: 14
Issue: 11
Pages: 2631-41
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Publication
16228006 | -
First Author: Speck C
Year: 2005
Journal: Nat Struct Mol Biol
Title: ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.
Volume: 12
Issue: 11
Pages: 965-71
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Publication
10966477 | -
 
First Author: Kelly TJ
Year: 2000
Journal: Annu Rev Biochem
Title: Regulation of chromosome replication.
Volume: 69
Pages: 829-80
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Publication
12045100 | -
 
First Author: Bell SP
Year: 2002
Journal: Annu Rev Biochem
Title: DNA replication in eukaryotic cells.
Volume: 71
Pages: 333-74
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Publication
15680967 | -
First Author: Stillman B
Year: 2005
Journal: FEBS Lett
Title: Origin recognition and the chromosome cycle.
Volume: 579
Issue: 4
Pages: 877-84
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Publication
11572976 | -
First Author: Weinreich M
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle.
Volume: 98
Issue: 20
Pages: 11211-7
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Publication
11429609 | -
First Author: Nguyen VQ
Year: 2001
Journal: Nature
Title: Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms.
Volume: 411
Issue: 6841
Pages: 1068-73
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Publication
16024805 | -
First Author: Archambault V
Year: 2005
Journal: Mol Cell Biol
Title: Disruption of mechanisms that prevent rereplication triggers a DNA damage response.
Volume: 25
Issue: 15
Pages: 6707-21
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Publication
8622770 | -
First Author: Triolo T
Year: 1996
Journal: Nature
Title: Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.
Volume: 381
Issue: 6579
Pages: 251-3
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Publication
9171055 | -
First Author: Fox CA
Year: 1997
Journal: Science
Title: The origin recognition complex, SIR1, and the S phase requirement for silencing.
Volume: 276
Issue: 5318
Pages: 1547-51
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Publication
9038340 | -
First Author: Klemm RD
Year: 1997
Journal: Cell
Title: Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex.
Volume: 88
Issue: 4
Pages: 493-502
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Publication
11459976 | -
First Author: Klemm RD
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: ATP bound to the origin recognition complex is important for preRC formation.
Volume: 98
Issue: 15
Pages: 8361-7
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Publication
15610739 | -
First Author: Bowers JL
Year: 2004
Journal: Mol Cell
Title: ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.
Volume: 16
Issue: 6
Pages: 967-78
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Publication
16387651 | -
First Author: Randell JC
Year: 2006
Journal: Mol Cell
Title: Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.
Volume: 21
Issue: 1
Pages: 29-39
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Publication
17053779 | -
First Author: Semple JW
Year: 2006
Journal: EMBO J
Title: An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes.
Volume: 25
Issue: 21
Pages: 5150-8
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Publication
9442876 | -
 
First Author: Dutta A
Year: 1997
Journal: Annu Rev Cell Dev Biol
Title: Initiation of DNA replication in eukaryotic cells.
Volume: 13
Pages: 293-332
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Publication
10835370 | J:62706
First Author: Natale DA
Year: 2000
Journal: EMBO J
Title: Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals.
Volume: 19
Issue: 11
Pages: 2728-38
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Publication
21940502 | J:177353
First Author: Chan KM
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Diverse factors are involved in maintaining X chromosome inactivation.
Volume: 108
Issue: 40
Pages: 16699-704
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Publication
32808929 | J:339148
   
First Author: Jaremko MJ
Year: 2020
Journal: Elife
Title: The dynamic nature of the human origin recognition complex revealed through five cryoEM structures.
Volume: 9
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Protein Coding Gene
MGP_CAROLIEiJ_G0014166 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016053 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016036 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0015992 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0015991 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0015823 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1328306 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016444 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015405 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0015795 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0015896 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0015898 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0015968 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0015918 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016491 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015191 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015468 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027404 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0014972 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Specimen Label: 1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Specimen Label: 2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Specimen Label: 3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Specimen Label: 4
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Specimen Label: 5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Specimen Label: 6
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Specimen Label: 7
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2652185
Age: postnatal adult
Specimen Label: 8
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2652188
Age: embryonic day 7.0
Specimen Label: 7
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2652188
Age: embryonic day 11.0
Specimen Label: 11
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2652188
Age: embryonic day 15.0
Specimen Label: 15
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:28158
Assay Type: Northern blot
Annotation Date: 2003-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2652188
Age: embryonic day 17.0
Specimen Label: 17
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6388636
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6388688
Age: embryonic day 17.5
Image: 6
Specimen Label: E17.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6388636
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388688
Age: postnatal week 1
Image: 6
Specimen Label: 1wk
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6388636
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388688
Age: postnatal week 2
Image: 6
Specimen Label: 2wk
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6388636
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388688
Age: postnatal week 3
Image: 6
Specimen Label: 3wk
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6388636
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388688
Age: postnatal week 6
Image: 6
Specimen Label: 6wk
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6388636
Assay Type: RT-PCR
Annotation Date: 2020-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6388688
Age: postnatal week 9
Image: 6
Specimen Label: 9wk
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:4844660
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848545
Age: embryonic day 11.5
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4844660
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1680017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848545
Age: embryonic day 10.5
Note: Staining is present in the olfactory placode.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4844660
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848545
Age: embryonic day 11.5
Note: Staining is present in the progress zone.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4844660
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848545
Age: embryonic day 10.5
Note: Staining is present in the otic pit.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4844660
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1638817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848545
Age: embryonic day 10.5
Note: Staining is present in the maxillary process.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 1
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Publication
14519686 | J:86777
First Author: Craig JM
Year: 2003
Journal: Hum Mol Genet
Title: Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.
Volume: 12
Issue: 23
Pages: 3109-21
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Publication
15998811 | J:99406
First Author: Dannenberg JH
Year: 2005
Journal: Genes Dev
Title: mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival.
Volume: 19
Issue: 13
Pages: 1581-95
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Publication
12614612 | J:82383
First Author: Kneissl M
Year: 2003
Journal: J Mol Biol
Title: Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.
Volume: 327
Issue: 1
Pages: 111-28
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Publication
12941272 | J:85224
First Author: Geng Y
Year: 2003
Journal: Cell
Title: Cyclin E ablation in the mouse.
Volume: 114
Issue: 4
Pages: 431-43
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Publication
29967292 | J:272584
First Author: Okano-Uchida T
Year: 2018
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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