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Search results 1 to 100 out of 107 for Orc3

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Type Details Score
Gene
23595 | ORC3
Type: gene
Organism: human
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Gene
523714 | ORC3
Type: gene
Organism: cattle
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Gene
421822 | ORC3
Type: gene
Organism: chicken
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Gene
334315 | orc3
Type: gene
Organism: zebrafish
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Gene
700773 | ORC3
Type: gene
Organism: macaque, rhesus
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Gene
100125181 | orc3
Type: gene
Organism: frog, western clawed
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Gene
313138 | Orc3
Type: gene
Organism: rat
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Gene
474991 | ORC3
Type: gene
Organism: dog, domestic
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Gene
462876 | ORC3
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1354944 | Orc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR020795 | ORC3
Type: Family
Description: The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding complex encoded in yeast by ORC1-6 []. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle []. ORC directs DNA replication throughout the genome and is required for its initiation [, , ]. ORC bound at replication origins serves as the foundation for assembly of the pre-replicative complex (pre-RC), which includes Cdc6, Tah11 (aka Cdt1), and the Mcm2-7 complex [, , ]. Pre-RC assembly during G1 is required for replication licensing of chromosomes prior to DNA synthesis during S phase [, , ]. Cell cycle-regulated phosphorylation of ORC2, ORC6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates initiation of DNA replication, including blocking reinitiation in G2/M phase [, , , ]. In yeast, ORC also plays a role in the establishment of silencing at the mating-type loci Hidden MAT Left (HML) and Hidden MAT Right (HMR) [, , ]. ORC participates in the assembly of transcriptionally silent chromatin at HML and HMR by recruiting the Sir1 silencing protein to the HML and HMR silencers [, , ]. Both ORC1 and ORC5 bind ATP, although only ORC1 has ATPase activity []. The binding of ATP by ORC1 is required for ORC binding to DNA and is essential for cell viability []. The ATPase activity of ORC1 is involved in formation of the pre-RC [, , ]. ATP binding by ORC5 is crucial for the stability of ORC as a whole. Only the ORC1-5 subunits are required for origin binding; ORC6 is essential for maintenance of pre-RCs once formed []. Interactions within ORC suggest that ORC2-3-6 may form a core complex []. ORC homologues have been found in various eukaryotes, including fission yeast, insects, amphibians, and humans [].
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Publication
10702681 | J:60868
First Author: Springer J
Year: 1999
Journal: Cytogenet Cell Genet
Title: Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex.
Volume: 87
Issue: 3-4
Pages: 245-51
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Protein
Q9JK30
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: false
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Protein
Q3ULT0
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: false
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Protein
A2AT40
Organism: Mus musculus/domesticus
Length: 277  
Fragment?: true
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Publication
17241905 | -
 
First Author: Chesnokov IN
Year: 2007
Journal: Int Rev Cytol
Title: Multiple functions of the origin recognition complex.
Volume: 256
Pages: 69-109
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Publication
17825065 | -
First Author: Matsuda K
Year: 2007
Journal: FEMS Yeast Res
Title: Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.
Volume: 7
Issue: 8
Pages: 1263-9
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Publication
1579162 | -
First Author: Bell SP
Year: 1992
Journal: Nature
Title: ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex.
Volume: 357
Issue: 6374
Pages: 128-34
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Publication
7585959 | -
First Author: Bell SP
Year: 1995
Journal: Cell
Title: The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing.
Volume: 83
Issue: 4
Pages: 563-8
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Publication
16716188 | -
First Author: Gibson DG
Year: 2006
Journal: Genes Cells
Title: Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.
Volume: 11
Issue: 6
Pages: 557-73
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Publication
7892251 | -
First Author: Rao H
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators.
Volume: 92
Issue: 6
Pages: 2224-8
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Publication
7781615 | -
First Author: Rowley A
Year: 1995
Journal: EMBO J
Title: Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.
Volume: 14
Issue: 11
Pages: 2631-41
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Publication
16228006 | -
First Author: Speck C
Year: 2005
Journal: Nat Struct Mol Biol
Title: ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.
Volume: 12
Issue: 11
Pages: 965-71
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Publication
10966477 | -
 
First Author: Kelly TJ
Year: 2000
Journal: Annu Rev Biochem
Title: Regulation of chromosome replication.
Volume: 69
Pages: 829-80
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Publication
12045100 | -
 
First Author: Bell SP
Year: 2002
Journal: Annu Rev Biochem
Title: DNA replication in eukaryotic cells.
Volume: 71
Pages: 333-74
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Publication
15680967 | -
First Author: Stillman B
Year: 2005
Journal: FEBS Lett
Title: Origin recognition and the chromosome cycle.
Volume: 579
Issue: 4
Pages: 877-84
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Publication
11572976 | -
First Author: Weinreich M
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle.
Volume: 98
Issue: 20
Pages: 11211-7
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Publication
11429609 | -
First Author: Nguyen VQ
Year: 2001
Journal: Nature
Title: Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms.
Volume: 411
Issue: 6841
Pages: 1068-73
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Publication
16024805 | -
First Author: Archambault V
Year: 2005
Journal: Mol Cell Biol
Title: Disruption of mechanisms that prevent rereplication triggers a DNA damage response.
Volume: 25
Issue: 15
Pages: 6707-21
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Publication
8622770 | -
First Author: Triolo T
Year: 1996
Journal: Nature
Title: Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.
Volume: 381
Issue: 6579
Pages: 251-3
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Publication
9171055 | -
First Author: Fox CA
Year: 1997
Journal: Science
Title: The origin recognition complex, SIR1, and the S phase requirement for silencing.
Volume: 276
Issue: 5318
Pages: 1547-51
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Publication
9038340 | -
First Author: Klemm RD
Year: 1997
Journal: Cell
Title: Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex.
Volume: 88
Issue: 4
Pages: 493-502
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Publication
11459976 | -
First Author: Klemm RD
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: ATP bound to the origin recognition complex is important for preRC formation.
Volume: 98
Issue: 15
Pages: 8361-7
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Publication
15610739 | -
First Author: Bowers JL
Year: 2004
Journal: Mol Cell
Title: ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.
Volume: 16
Issue: 6
Pages: 967-78
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Publication
16387651 | -
First Author: Randell JC
Year: 2006
Journal: Mol Cell
Title: Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.
Volume: 21
Issue: 1
Pages: 29-39
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Publication
17053779 | -
First Author: Semple JW
Year: 2006
Journal: EMBO J
Title: An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes.
Volume: 25
Issue: 21
Pages: 5150-8
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Publication
9442876 | -
 
First Author: Dutta A
Year: 1997
Journal: Annu Rev Cell Dev Biol
Title: Initiation of DNA replication in eukaryotic cells.
Volume: 13
Pages: 293-332
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Protein Coding Gene
MGP_CAROLIEiJ_G0025879 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028127 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028085 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028048 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027825 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1354944 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028538 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027280 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027797 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027941 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027907 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028049 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027940 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028597 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026999 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027356 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024002 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026828 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6281160
Assay Type: Western blot
Annotation Date: 2019-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:6281178
Age: embryonic day 13.5
Image: S4
Specimen Label: mt
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6281160
Assay Type: Western blot
Annotation Date: 2019-03-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:6281178
Age: embryonic day 13.5
Image: S4
Specimen Label: ctrl
Detected: true
Specimen Num: 1
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Publication
32808929 | J:339148
   
First Author: Jaremko MJ
Year: 2020
Journal: Elife
Title: The dynamic nature of the human origin recognition complex revealed through five cryoEM structures.
Volume: 9
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Publication
21185282 | J:170581
First Author: Kwon HJ
Year: 2011
Journal: Dev Biol
Title: Radial glia regulate Cajal-Retzius cell positioning in the early embryonic cerebral cortex.
Volume: 351
Issue: 1
Pages: 25-34
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Publication
23349620 | J:194480
First Author: Ma S
Year: 2013
Journal: PLoS Biol
Title: Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling.
Volume: 11
Issue: 1
Pages: e1001469
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Publication
22898775 | J:187715
First Author: Xie L
Year: 2012
Journal: Dev Cell
Title: Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.
Volume: 23
Issue: 2
Pages: 280-91
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q9D019
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Publication
31160578 | -
First Author: Coulombe P
Year: 2019
Journal: Nat Commun
Title: The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing.
Volume: 10
Issue: 1
Pages: 2426
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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