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Search results 1 to 99 out of 99 for Ormdl3

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
94103 | ORMDL3
Type: gene
Organism: human
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Gene
746120 | ORMDL3
Type: gene
Organism: chimpanzee
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Gene
480530 | ORMDL3
Type: gene
Organism: dog, domestic
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Gene
615368 | ORMDL3
Type: gene
Organism: cattle
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Gene
426131 | ORMDL3
Type: gene
Organism: chicken
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Gene
450067 | ormdl3
Type: gene
Organism: zebrafish
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Gene
699154 | ORMDL3
Type: gene
Organism: macaque, rhesus
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Gene
360618 | Ormdl3
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1913862 | Ormdl3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
34954108 | J:331180
 
First Author: Song Y
Year: 2022
Journal: Mol Metab
Title: Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation.
Volume: 56
Pages: 101423
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Publication
36753412 | J:341336
First Author: James BN
Year: 2023
Journal: FASEB J
Title: Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice.
Volume: 37
Issue: 3
Pages: e22799
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Publication
28747345 | J:251260
First Author: Dang J
Year: 2017
Journal: J Immunol
Title: ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway.
Volume: 199
Issue: 5
Pages: 1647-1659
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Publication
24623133 | J:210226
First Author: Miller M
Year: 2014
Journal: J Immunol
Title: ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.
Volume: 192
Issue: 8
Pages: 3475-87
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Publication
31330218 | J:293260
First Author: Debeuf N
Year: 2019
Journal: J Allergy Clin Immunol
Title: The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice.
Volume: 144
Issue: 6
Pages: 1648-1659.e9
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Publication
27623174 | J:278421
First Author: Löser S
Year: 2017
Journal: J Allergy Clin Immunol
Title: Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.
Volume: 139
Issue: 5
Pages: 1496-1507.e3
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Publication
27645259 | J:268593
First Author: Zhakupova A
Year: 2016
Journal: FASEB J
Title: ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase.
Volume: 30
Issue: 12
Pages: 4289-4300
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Publication
25691431 | J:221146
First Author: Siow D
Year: 2015
Journal: J Lipid Res
Title: ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis.
Volume: 56
Issue: 4
Pages: 898-908
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Publication
28275141 | J:247806
First Author: Miller M
Year: 2017
Journal: J Immunol
Title: Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate.
Volume: 198
Issue: 8
Pages: 3017-3022
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Publication
37124760 | J:342757
 
First Author: Hurley LD
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Ormdl3 regulation of specific ceramides is dispensable for mouse β-cell function and glucose homeostasis under obesogenic conditions.
Volume: 14
Pages: 1170461
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Publication
23011799 | J:190332
First Author: Miller M
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6.
Volume: 109
Issue: 41
Pages: 16648-53
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Publication
31255288 | J:291765
First Author: Wang H
Year: 2019
Journal: Biochem Biophys Res Commun
Title: ORMDL3 knockdown in the lungs alleviates airway inflammation and airway remodeling in asthmatic mice via JNK1/2-MMP-9 pathway.
Volume: 516
Issue: 3
Pages: 739-746
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Publication
31880535 | J:285452
   
First Author: Clarke BA
Year: 2019
Journal: Elife
Title: The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice.
Volume: 8
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Publication
33643282 | J:328837
 
First Author: Bugajev V
Year: 2020
Journal: Front Immunol
Title: ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling.
Volume: 11
Pages: 591975
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Publication
32273303 | J:319509
First Author: Youssef M
Year: 2020
Journal: J Pharmacol Exp Ther
Title: Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (Ormdl3) Expression and Normalizes Ceramide Imbalance.
Volume: 373
Issue: 3
Pages: 476-487
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Publication
31560728 | J:280030
First Author: Chang ML
Year: 2019
Journal: PLoS One
Title: Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock.
Volume: 14
Issue: 9
Pages: e0223212
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Protein Coding Gene
MGP_CAROLIEiJ_G0017089 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019064 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019032 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019002 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019005 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018819 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1913862 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019458 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018373 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018790 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018898 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018887 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018968 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018914 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019498 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018145 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018423 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018218 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017935 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:6164142
Assay Type: RT-PCR
Annotation Date: 2018-07-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6164149
Age: postnatal
Specimen Label: WT Spleen
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6164142
Assay Type: RT-PCR
Annotation Date: 2018-07-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6164149
Age: postnatal
Specimen Label: KO Spleen
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6164142
Assay Type: RT-PCR
Annotation Date: 2018-07-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6164149
Age: postnatal
Specimen Label: WT Lung
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6164142
Assay Type: RT-PCR
Annotation Date: 2018-07-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6164149
Age: postnatal
Specimen Label: KO Lung
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6164142
Assay Type: RT-PCR
Annotation Date: 2018-07-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6164149
Age: postnatal
Specimen Label: WT Liver
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6164142
Assay Type: RT-PCR
Annotation Date: 2018-07-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6164149
Age: postnatal
Specimen Label: KO Liver
Detected: true
Specimen Num: 6
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Publication
12093374 | J:77436
First Author: Hjelmqvist L
Year: 2002
Journal: Genome Biol
Title: ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins.
Volume: 3
Issue: 6
Pages: RESEARCH0027
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Publication
30254094 | J:269933
First Author: Aden K
Year: 2018
Journal: J Exp Med
Title: ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.
Volume: 215
Issue: 11
Pages: 2868-2886
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Publication
29536159 | J:260850
First Author: Kanagaratham C
Year: 2018
Journal: Mamm Genome
Title: Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion.
Volume: 29
Issue: 3-4
Pages: 281-298
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
33661765 | J:308949
 
First Author: Pham AK
Year: 2021
Journal: JCI Insight
Title: ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility.
Volume: 6
Issue: 7
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Publication
28827284 | J:256382
First Author: Song DJ
Year: 2017
Journal: J Immunol
Title: Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation.
Volume: 199
Issue: 7
Pages: 2215-2224
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Publication
23100328 | -
First Author: Carreras-Sureda A
Year: 2013
Journal: Hum Mol Genet
Title: ORMDL3 modulates store-operated calcium entry and lymphocyte activation.
Volume: 22
Issue: 3
Pages: 519-30
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Publication
24204796 | -
First Author: Zhuang LL
Year: 2013
Journal: PLoS One
Title: All-trans retinoic acid modulates ORMDL3 expression via transcriptional regulation.
Volume: 8
Issue: 10
Pages: e77304
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Publication
19819884 | -
First Author: Cantero-Recasens G
Year: 2010
Journal: Hum Mol Genet
Title: The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress.
Volume: 19
Issue: 1
Pages: 111-21
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Allele
Ormdl3<em1Quli> | MGI:6369059
Name: ORM1-like 3 (S. cerevisiae); endonuclease-mediated mutation 1, Qiji Liu
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Ormdl3/Ormdl3
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR029883 | ORML3
Type: Family
Description: ORM1-like protein 3 (ORML3) is involved in the processes of endoplasmic reticulum stress induction [], sphingolipid regulation [, ]and T-lymphocyte activation []. ORMDL3 has been associated with the development of asthma [].
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Allele
Gt(ROSA)26Sor<tm1.1(CAG-Ormdl3)Sspi> | MGI:7572532
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Sarah Spiegel
Allele Type: Targeted
Attribute String: Epitope tag, Inserted expressed sequence
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Allele
Tg(CAG-RFP*,-ORMDL3)#Dhbe | MGI:6284006
Name: transgene insertion, David H Broide
Allele Type: Transgenic
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Strain
MGI:7572536 | B6.Cg-Gt(ROSA)26Sor<tm1.1(CAG-Ormdl3)Sspi>/J
Attribute String: congenic, mutant strain, targeted mutation
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Protein
Q9CPZ6
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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HT Experiment
GSE98513 | Suppression of asthmatic phenotype and altered lipid metabolism in mice lacking zona pellucida binding protein 2
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
23066021 | -
First Author: Siow DL
Year: 2012
Journal: J Biol Chem
Title: Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis.
Volume: 287
Issue: 48
Pages: 40198-204
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Publication
20182505 | -
First Author: Breslow DK
Year: 2010
Journal: Nature
Title: Orm family proteins mediate sphingolipid homeostasis.
Volume: 463
Issue: 7284
Pages: 1048-53
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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