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Search results 1 to 100 out of 786 for Osr1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression
Probe: MGI:1791020
Assay Type: RNA in situ
Annotation Date: 2023-08-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640521
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7516533
Age: embryonic day 13.5
Image: 2E Osr1
Note: Expression in partially co-localized with Adamts15 expression.
Specimen Label: 2E Osr1
Detected: true
Specimen Num: 1
Protein
Organism: Mus musculus/domesticus
Length: 25  
Fragment?: true
GXD Expression
Probe: MGI:5811441
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5823676
Age: embryonic day 10.5
Image: 1E - Osr1
Note: This gene exhibits category 3 expression: staining is observed in the posterior-proximal limb bud.
Specimen Label: 1E - Osr1
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5811441
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823676
Age: embryonic day 11.5
Image: S1A - Osr1 - E11.5
Note: This gene exhibits category 3 expression: staining is observed in the posterior-proximal limb bud.
Specimen Label: S1A - Osr1 - E11.5
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:5811441
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5823676
Age: embryonic day 10.5
Image: S1A - Osr1 - E10.5
Note: This gene exhibits category 3 expression: staining is observed in the posterior-proximal limb bud.
Specimen Label: S1A - Osr1 - E10.5
Detected: true
Specimen Num: 2
Publication
First Author: Piechotta K
Year: 2002
Journal: J Biol Chem
Title: Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).
Volume: 277
Issue: 52
Pages: 50812-9
Publication
First Author: Lan Y
Year: 2011
Journal: Genesis
Title: Generation of Osr1 conditional mutant mice.
Volume: 49
Issue: 5
Pages: 419-22
Protein
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
Publication
First Author: Xu J
Year: 2016
Journal: PLoS One
Title: Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis.
Volume: 11
Issue: 7
Pages: e0159597
Publication
First Author: Gao Y
Year: 2009
Journal: Dev Biol
Title: Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development.
Volume: 328
Issue: 2
Pages: 200-9
Publication
First Author: Han L
Year: 2017
Journal: Dev Biol
Title: Osr1 functions downstream of Hedgehog pathway to regulate foregut development.
Volume: 427
Issue: 1
Pages: 72-83
Publication  
First Author: Liu YL
Year: 2016
Journal: Sci Rep
Title: OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis.
Volume: 6
Pages: 37205
Publication
First Author: Gao Y
Year: 2011
Journal: Dev Biol
Title: The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation.
Volume: 352
Issue: 1
Pages: 83-91
Publication
First Author: Stricker S
Year: 2006
Journal: Gene Expr Patterns
Title: Comparative expression pattern of Odd-skipped related genes Osr1 and Osr2 in chick embryonic development.
Volume: 6
Issue: 8
Pages: 826-34
Publication
First Author: Lynch EC
Year: 2022
Journal: PLoS One
Title: Disrupting Osr1 expression promoted hepatic steatosis and inflammation induced by high-fat diet in the mouse model.
Volume: 17
Issue: 6
Pages: e0268344
Publication  
First Author: Lofrano-Porto A
Year: 2023
Journal: J Clin Invest
Title: OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity.
Volume: 133
Issue: 23
Publication
First Author: Vallecillo-García P
Year: 2023
Journal: Immunity
Title: A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation.
Volume: 56
Issue: 6
Pages: 1204-1219.e8
Publication
First Author: Xie J
Year: 2013
Journal: J Biol Chem
Title: WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
Volume: 288
Issue: 12
Pages: 8566-74
Publication  
First Author: Murugapoopathy V
Year: 2021
Journal: Int J Mol Sci
Title: Osr1 Is Required for Mesenchymal Derivatives That Produce Collagen in the Bladder.
Volume: 22
Issue: 22
Publication
First Author: Zhang Z
Year: 2011
Journal: Hum Mol Genet
Title: A variant OSR1 allele which disturbs OSR1 mRNA expression in renal progenitor cells is associated with reduction of newborn kidney size and function.
Volume: 20
Issue: 21
Pages: 4167-74
Publication
First Author: Ferdaus MZ
Year: 2016
Journal: J Physiol
Title: SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule.
Volume: 594
Issue: 17
Pages: 4945-66
Protein
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
Publication  
First Author: Zhou L
Year: 2015
Journal: J Mol Cell Cardiol
Title: Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation.
Volume: 85
Pages: 1-12
Publication
First Author: Xu J
Year: 2014
Journal: Development
Title: Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis.
Volume: 141
Issue: 7
Pages: 1442-52
Publication  
First Author: Hayashi S
Year: 2021
Journal: Dev Biol
Title: The nephric mesenchyme lineage of intermediate mesoderm is derived from Tbx6-expressing derivatives of neuro-mesodermal progenitors via BMP-dependent Osr1 function.
Volume: 478
Pages: 155-162
Publication
First Author: Dbouk HA
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.
Volume: 111
Issue: 45
Pages: 15999-6004
Publication
First Author: Sengupta S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.
Volume: 110
Issue: 47
Pages: 18826-31
Publication
First Author: Mugford JW
Year: 2008
Journal: Dev Biol
Title: Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney.
Volume: 324
Issue: 1
Pages: 88-98
Protein
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: false
Publication
First Author: Gagnon KB
Year: 2012
Journal: Physiol Rev
Title: Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.
Volume: 92
Issue: 4
Pages: 1577-617
Protein Domain
Type: Family
Description: Serine/threonine-protein kinase OSR1 is a member of the germinal centre kinase VI subfamily of the Ste20 (Sterile20)-related protein kinase family []. OSR1 (oxidative stress response 1) regulates downstream kinases in response to environmental stress []. It regulates the solute carrier 12 family of cation-chloride cotransporters which modulate ion homeostasis throughout the body [].
Publication
First Author: So PL
Year: 1999
Journal: Mech Dev
Title: Cloning and expression analysis of a mouse gene related to Drosophila odd-skipped.
Volume: 84
Issue: 1-2
Pages: 157-60
Publication
First Author: Davisson MT
Year: 2015
Journal: Am J Physiol Renal Physiol
Title: Kidney adysplasia and variable hydronephrosis, a new mutation affecting the odd-skipped related 1 gene in the mouse, causes variable defects in kidney development and hydronephrosis.
Volume: 308
Issue: 12
Pages: F1335-42
UniProt Feature
Begin: 2
Description: Serine/threonine-protein kinase OSR1
Type: chain
End: 527
Publication
First Author: Lan Y
Year: 2001
Journal: Mech Dev
Title: Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development.
Volume: 107
Issue: 1-2
Pages: 175-9
Publication
First Author: Fillion ML
Year: 2017
Journal: Am J Physiol Renal Physiol
Title: Heterozygous loss-of-function mutation in Odd-skipped related 1 (Osr1) is associated with vesicoureteric reflux, duplex systems, and hydronephrosis.
Volume: 313
Issue: 5
Pages: F1106-F1115
Publication
First Author: Kawai S
Year: 2007
Journal: J Bone Miner Res
Title: Zinc-finger transcription factor odd-skipped related 2 is one of the regulators in osteoblast proliferation and bone formation.
Volume: 22
Issue: 9
Pages: 1362-72
Publication
First Author: Xie L
Year: 2012
Journal: Dev Cell
Title: Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.
Volume: 23
Issue: 2
Pages: 280-91
Publication
First Author: Vallecillo-García P
Year: 2017
Journal: Nat Commun
Title: Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development.
Volume: 8
Issue: 1
Pages: 1218
Publication
First Author: Kim WK
Year: 2022
Journal: Nat Commun
Title: Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes.
Volume: 13
Issue: 1
Pages: 4364
Publication
First Author: Yamauchi M
Year: 2008
Journal: Gene
Title: Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors.
Volume: 426
Issue: 1-2
Pages: 81-90
Publication
First Author: Richardson C
Year: 2011
Journal: J Cell Sci
Title: Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.
Volume: 124
Issue: Pt 5
Pages: 789-800
Publication
First Author: Chiga M
Year: 2011
Journal: J Cell Sci
Title: Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.
Volume: 124
Issue: Pt 9
Pages: 1391-5
Publication
First Author: O'Brien LL
Year: 2018
Journal: PLoS Genet
Title: Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies.
Volume: 14
Issue: 1
Pages: e1007181
Publication
First Author: Vorontsova I
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
Volume: 56
Issue: 1
Pages: 310-21
Publication
First Author: Liu H
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Odd-skipped related-1 controls neural crest chondrogenesis during tongue development.
Volume: 110
Issue: 46
Pages: 18555-60
Publication
First Author: Lan Y
Year: 2004
Journal: Development
Title: Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis.
Volume: 131
Issue: 13
Pages: 3207-16
Publication
First Author: Di Giovanni V
Year: 2011
Journal: Development
Title: Alk3 controls nephron number and androgen production via lineage-specific effects in intermediate mesoderm.
Volume: 138
Issue: 13
Pages: 2717-27
Publication
First Author: Zhang KK
Year: 2016
Journal: Hum Mol Genet
Title: Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation.
Volume: 25
Issue: 6
Pages: 1140-51
Publication  
First Author: Liu H
Year: 2018
Journal: Development
Title: Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles.
Volume: 145
Issue: 10
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3815971
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160415
Stage: TS05
Assay Id: MGI:3816775
Age: embryonic day 4.5
Specimen Label: E4.5 inner cell mass
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:5810907
Assay Type: RT-PCR
Annotation Date: 2016-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:5812464
Age: embryonic day 10.5
Image: 3
Specimen Label: Wild-type
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5810907
Assay Type: RT-PCR
Annotation Date: 2016-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:5812464
Age: embryonic day 10.5
Image: 3
Specimen Label: Shh-/-;Gli3-/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3815971
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3816775
Age: embryonic day 1.5
Specimen Label: 2-cell embryo
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3815971
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:3816775
Age: embryonic day 2.0
Specimen Label: 4-cell embryo
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:7461729
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:7461772
Age: embryonic day 9.5
Specimen Label: Heart
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2389138
Assay Type: Northern blot
Annotation Date: 2008-04-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3777645
Age: embryonic day 11.5
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3815971
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:3816775
Age: embryonic day 2.5
Specimen Label: 8-cell embryo
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3815971
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3816775
Age: embryonic day 3.0
Specimen Label: Morula
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:3815971
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3816775
Age: embryonic day 3.5
Specimen Label: E3.5 blastocyst
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3815971
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:3816775
Age: embryonic day 4.5
Specimen Label: E4.5 blastocyst
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3815971
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Absent
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3816775
Age: postnatal
Specimen Label: Metaphase II
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:7461729
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3673015
Stage: TS15
Assay Id: MGI:7461754
Age: embryonic day 9.5
Specimen Label: Tbx5+/-
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7461729
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3673015
Stage: TS15
Assay Id: MGI:7461754
Age: embryonic day 9.5
Specimen Label: Osr1+/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7461729
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3673015
Stage: TS15
Assay Id: MGI:7461754
Age: embryonic day 9.5
Specimen Label: Tbx5+/-;Osr1+/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7461729
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3673015
Stage: TS15
Assay Id: MGI:7461754
Age: embryonic day 9.5
Specimen Label: Osr1-/-
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7461729
Assay Type: RT-PCR
Annotation Date: 2023-04-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3673015
Stage: TS15
Assay Id: MGI:7461772
Age: embryonic day 9.5
Specimen Label: pSHF
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:2389138
Assay Type: RNA in situ
Annotation Date: 2002-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:2429511
Age: embryonic day 10.5
Image: 2E
Specimen Label: 2E
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:2389138
Assay Type: RNA in situ
Annotation Date: 2002-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:2429511
Age: embryonic day 11.5
Image: 2I,J,K
Specimen Label: 2I,J,K
Detected: true
Specimen Num: 9
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2019-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6359821
Age: embryonic day 10.5
Image: 2H
Specimen Label: 2H
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:6359803
Assay Type: RNA in situ
Annotation Date: 2019-09-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6359829
Age: embryonic day 10.5
Image: 2G
Specimen Label: 2G
Detected: true
Specimen Num: 2