| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yasunaga S |
| Year: |
2000 |
| Journal: |
Am J Hum Genet |
| Title: |
OTOF encodes multiple long and short isoforms: genetic evidence that the long ones underlie recessive deafness DFNB9. |
| Volume: |
67 |
| Issue: |
3 |
| Pages: |
591-600 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179909 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689419 |
|
| Stage: |
TS19 |
| Assay Id: |
MGI:6191003 |
| Age: |
embryonic day 11.5 |
|
|
| Specimen Label: |
Table S2 - E11.5 - Otof |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179909 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689424 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:6191003 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
Table S2 - E15.5 - Otof |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179909 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6191003 |
| Age: |
postnatal day 4 |
|
|
| Specimen Label: |
Table S2 - P4 - Otof |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179909 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6191003 |
| Age: |
postnatal day 28 |
|
|
| Specimen Label: |
Table S2 - P28 - Otof |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179909 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689421 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:6191003 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
Table S2 - E13.5 - Otof |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179909 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689426 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:6191003 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
Table S2 - E18.5 - Otof |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6179909 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6191003 |
| Age: |
postnatal day 14 |
|
|
| Specimen Label: |
Table S2 - P14 - Otof |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Akil O |
| Year: |
2019 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Strenzke N |
| Year: |
2016 |
| Journal: |
EMBO J |
| Title: |
Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants. |
| Volume: |
35 |
| Issue: |
23 |
| Pages: |
2519-2535 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chakrabarti R |
| Year: |
2018 |
| Journal: |
EMBO Rep |
| Title: |
Vesicle sub-pool organization at inner hair cell ribbon synapses. |
| Volume: |
19 |
| Issue: |
11 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tsuzuki N |
| Year: |
2023 |
| Journal: |
Neurosci Lett |
| Title: |
Apoptosis of type I spiral ganglion neuron cells in Otof-mutant mice. |
| Volume: |
803 |
|
| Pages: |
137178 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stalmann U |
| Year: |
2021 |
| Journal: |
Front Cell Neurosci |
| Title: |
Otoferlin Is Required for Proper Synapse Maturation and for Maintenance of Inner and Outer Hair Cells in Mouse Models for DFNB9. |
| Volume: |
15 |
|
| Pages: |
677543 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sellon JB |
| Year: |
2024 |
| Journal: |
Front Mol Neurosci |
| Title: |
Recovery kinetics of dual AAV-mediated human otoferlin expression. |
| Volume: |
17 |
|
| Pages: |
1376128 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takago H |
| Year: |
2018 |
| Journal: |
Front Mol Neurosci |
| Title: |
Disruption of Otoferlin Alters the Mode of Exocytosis at the Mouse Inner Hair Cell Ribbon Synapse. |
| Volume: |
11 |
|
| Pages: |
492 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tertrais M |
| Year: |
2019 |
| Journal: |
J Neurosci |
| Title: |
Viral Transfer of Mini-Otoferlins Partially Restores the Fast Component of Exocytosis and Uncovers Ultrafast Endocytosis in Auditory Hair Cells of Otoferlin Knock-Out Mice. |
| Volume: |
39 |
| Issue: |
18 |
| Pages: |
3394-3411 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reisinger E |
| Year: |
2011 |
| Journal: |
J Neurosci |
| Title: |
Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis. |
| Volume: |
31 |
| Issue: |
13 |
| Pages: |
4886-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Longo-Guess C |
| Year: |
2007 |
| Journal: |
Hear Res |
| Title: |
A missense mutation in the conserved C2B domain of otoferlin causes deafness in a new mouse model of DFNB9. |
| Volume: |
234 |
| Issue: |
1-2 |
| Pages: |
21-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ramakrishnan NA |
| Year: |
2009 |
| Journal: |
J Biol Chem |
| Title: |
Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3. |
| Volume: |
284 |
| Issue: |
3 |
| Pages: |
1364-72 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Beurg M |
| Year: |
2008 |
| Journal: |
J Neurosci |
| Title: |
Calcium- and otoferlin-dependent exocytosis by immature outer hair cells. |
| Volume: |
28 |
| Issue: |
8 |
| Pages: |
1798-803 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vincent PF |
| Year: |
2014 |
| Journal: |
J Neurosci |
| Title: |
Exocytotic machineries of vestibular type I and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ channels. |
| Volume: |
34 |
| Issue: |
33 |
| Pages: |
10853-69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Revelo NH |
| Year: |
2014 |
| Journal: |
J Cell Biol |
| Title: |
A new probe for super-resolution imaging of membranes elucidates trafficking pathways. |
| Volume: |
205 |
| Issue: |
4 |
| Pages: |
591-606 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dulon D |
| Year: |
2009 |
| Journal: |
J Neurosci |
| Title: |
Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses. |
| Volume: |
29 |
| Issue: |
34 |
| Pages: |
10474-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Calhoun G |
| Year: |
2023 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of the mouse auditory cortex. |
| Volume: |
120 |
| Issue: |
30 |
| Pages: |
e2219340120 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vincent PFY |
| Year: |
2018 |
| Journal: |
Cell Rep |
| Title: |
Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses. |
| Volume: |
25 |
| Issue: |
12 |
| Pages: |
3451-3464.e3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wright S |
| Year: |
2014 |
| Journal: |
J Neurophysiol |
| Title: |
Synaptic transmission between end bulbs of Held and bushy cells in the cochlear nucleus of mice with a mutation in Otoferlin. |
| Volume: |
112 |
| Issue: |
12 |
| Pages: |
3173-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mukherjee D |
| Year: |
2022 |
| Journal: |
Cereb Cortex |
| Title: |
Impaired Hearing and Altered Subplate Circuits During the First and Second Postnatal Weeks of Otoferlin-Deficient Mice. |
| Volume: |
32 |
| Issue: |
13 |
| Pages: |
2816-2830 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pangrsic T |
| Year: |
2010 |
| Journal: |
Nat Neurosci |
| Title: |
Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells. |
| Volume: |
13 |
| Issue: |
7 |
| Pages: |
869-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hintze A |
| Year: |
2024 |
| Journal: |
iScience |
| Title: |
Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus. |
| Volume: |
27 |
| Issue: |
1 |
| Pages: |
108700 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xue B |
| Year: |
2022 |
| Journal: |
J Neurosci |
| Title: |
Transient Coupling between Infragranular and Subplate Layers to Layer 1 Neurons Before Ear Opening and throughout the Critical Period Depends on Peripheral Activity. |
| Volume: |
42 |
| Issue: |
9 |
| Pages: |
1702-1718 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Michalski N |
| Year: |
2017 |
| Journal: |
Elife |
| Title: |
Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses. |
| Volume: |
6 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kirst C |
| Year: |
2020 |
| Journal: |
Cell |
| Title: |
Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature. |
| Volume: |
180 |
| Issue: |
4 |
| Pages: |
780-795.e25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen H |
| Year: |
2023 |
| Journal: |
Protein Cell |
| Title: |
Ca2+-binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen H |
| Year: |
2023 |
| Journal: |
Front Mol Neurosci |
| Title: |
Probing the role of the C(2)F domain of otoferlin. |
| Volume: |
16 |
|
| Pages: |
1299509 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ramakrishnan NA |
| Year: |
2014 |
| Journal: |
J Biol Chem |
| Title: |
Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis. |
| Volume: |
289 |
| Issue: |
13 |
| Pages: |
8750-66 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756423 |
| Pattern: |
Single cells |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_07 |
|
| Specimen Label: |
euxassay_007676_07 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756423 |
| Pattern: |
Single cells |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_08 |
|
| Specimen Label: |
euxassay_007676_08 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756423 |
| Pattern: |
Single cells |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_10 |
|
| Specimen Label: |
euxassay_007676_10 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756423 |
| Pattern: |
Single cells |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_11 |
|
| Specimen Label: |
euxassay_007676_11 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756423 |
| Pattern: |
Single cells |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_13 |
|
| Specimen Label: |
euxassay_007676_13 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756423 |
| Pattern: |
Single cells |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_14 |
|
| Specimen Label: |
euxassay_007676_14 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756423 |
| Pattern: |
Single cells |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_15 |
|
| Specimen Label: |
euxassay_007676_15 |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756423 |
| Pattern: |
Single cells |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_16 |
|
| Specimen Label: |
euxassay_007676_16 |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756423 |
| Pattern: |
Single cells |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_17 |
|
| Specimen Label: |
euxassay_007676_17 |
| Detected: |
true |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756423 |
| Pattern: |
Single cells |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_18 |
|
| Specimen Label: |
euxassay_007676_18 |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1856223 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_04 |
|
| Specimen Label: |
euxassay_007676_04 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1856223 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_05 |
|
| Specimen Label: |
euxassay_007676_05 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1856223 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_19 |
|
| Specimen Label: |
euxassay_007676_19 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1856223 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_20 |
|
| Specimen Label: |
euxassay_007676_20 |
| Detected: |
true |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4423741 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1856223 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4827002 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_007676_21 |
|
| Specimen Label: |
euxassay_007676_21 |
| Detected: |
true |
| Specimen Num: |
15 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1977
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Johnson SL |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity. |
| Volume: |
110 |
| Issue: |
21 |
| Pages: |
8720-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Conrad LJ |
| Year: |
2024 |
| Journal: |
J Physiol |
| Title: |
The upregulation of K(+) and HCN channels in developing spiral ganglion neurons is mediated by cochlear inner hair cells. |
| Volume: |
602 |
| Issue: |
20 |
| Pages: |
5329-5351 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Noh J |
| Year: |
2010 |
| Journal: |
Nat Neurosci |
| Title: |
Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map. |
| Volume: |
13 |
| Issue: |
2 |
| Pages: |
232-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Żak M |
| Year: |
2012 |
| Journal: |
Cell Physiol Biochem |
| Title: |
Ergic2, a brain specific interacting partner of Otoferlin. |
| Volume: |
29 |
| Issue: |
5-6 |
| Pages: |
941-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Karagulyan N |
| Year: |
2023 |
| Journal: |
Front Mol Neurosci |
| Title: |
Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses. |
| Volume: |
16 |
|
| Pages: |
1248941 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Heidrych P |
| Year: |
2009 |
| Journal: |
Hum Mol Genet |
| Title: |
Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell. |
| Volume: |
18 |
| Issue: |
15 |
| Pages: |
2779-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eitelmann S |
| Year: |
2020 |
| Journal: |
Int J Mol Sci |
| Title: |
Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness. |
| Volume: |
21 |
| Issue: |
19 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vincent PF |
| Year: |
2017 |
| Journal: |
J Neurosci |
| Title: |
Different CaV1.3 Channel Isoforms Control Distinct Components of the Synaptic Vesicle Cycle in Auditory Inner Hair Cells. |
| Volume: |
37 |
| Issue: |
11 |
| Pages: |
2960-2975 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Neef J |
| Year: |
2014 |
| Journal: |
J Neurosci |
| Title: |
Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells. |
| Volume: |
34 |
| Issue: |
3 |
| Pages: |
705-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vincent PF |
| Year: |
2015 |
| Journal: |
Elife |
| Title: |
A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells. |
| Volume: |
4 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vogl C |
| Year: |
2016 |
| Journal: |
EMBO J |
| Title: |
Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. |
| Volume: |
35 |
| Issue: |
23 |
| Pages: |
2536-2552 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Johnson CP |
| Year: |
2010 |
| Journal: |
J Cell Biol |
| Title: |
Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion. |
| Volume: |
191 |
| Issue: |
1 |
| Pages: |
187-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Roux I |
| Year: |
2006 |
| Journal: |
Cell |
| Title: |
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. |
| Volume: |
127 |
| Issue: |
2 |
| Pages: |
277-89 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Beurg M |
| Year: |
2010 |
| Journal: |
J Neurosci |
| Title: |
Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells. |
| Volume: |
30 |
| Issue: |
40 |
| Pages: |
13281-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
O'Connor AP |
| Year: |
2024 |
| Journal: |
JCI Insight |
| Title: |
In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic efferent innervation in inner hair cells. |
| Volume: |
9 |
| Issue: |
23 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Duncker SV |
| Year: |
2013 |
| Journal: |
J Neurosci |
| Title: |
Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. |
| Volume: |
33 |
| Issue: |
22 |
| Pages: |
9508-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kazmierczak M |
| Year: |
2017 |
| Journal: |
J Neurosci |
| Title: |
Pejvakin, a Candidate Stereociliary Rootlet Protein, Regulates Hair Cell Function in a Cell-Autonomous Manner. |
| Volume: |
37 |
| Issue: |
13 |
| Pages: |
3447-3464 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wilson L |
| Year: |
2005 |
| Journal: |
Genome Res |
| Title: |
Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations. |
| Volume: |
15 |
| Issue: |
8 |
| Pages: |
1095-105 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vogl C |
| Year: |
2015 |
| Journal: |
J Cell Sci |
| Title: |
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells. |
| Volume: |
128 |
| Issue: |
4 |
| Pages: |
638-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ching YH |
| Year: |
2010 |
| Journal: |
BMC Genet |
| Title: |
High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5. |
| Volume: |
11 |
|
| Pages: |
106 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stone JS |
| Year: |
2018 |
| Journal: |
J Assoc Res Otolaryngol |
| Title: |
Characterization of Adult Vestibular Organs in 11 CreER Mouse Lines. |
| Volume: |
19 |
| Issue: |
4 |
| Pages: |
381-399 |
|
•
•
•
•
•
|