Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Otoraplin, also known as MIAL (MIA-like), is specifically expressed in the cochlea and the vestibule of the inner ear and may contribute to inner ear dysfunction in humans []. It is a member of the MIA family. MIA (melanoma inhibitory activity) family members include MIA, MIAL, MIA2, and MIA3 (also called TANGO). MIA was found to be strongly expressed and secreted by malignant melanomas. It contains a domain that adopts a Src Homology 3 (SH3) domain-like fold; however, it contains an additional antiparallel beta sheet and two disulfide bonds compared to classical SH3 domains. Unlike classical SH3 domains, MIA does not bind proline-rich ligands [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Rendtorff ND |
Year: |
2001 |
Journal: |
Genomics |
Title: |
Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation. |
Volume: |
71 |
Issue: |
1 |
Pages: |
40-52 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
128
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
128
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Stoll R |
Year: |
2008 |
Journal: |
Curr Protein Pept Sci |
Title: |
Extracellular SH3 domain containing proteins--features of a new protein family. |
Volume: |
9 |
Issue: |
3 |
Pages: |
221-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stoll R |
Year: |
2003 |
Journal: |
Protein Sci |
Title: |
Backbone dynamics of the human MIA protein studied by (15)N NMR relaxation: implications for extended interactions of SH3 domains. |
Volume: |
12 |
Issue: |
3 |
Pages: |
510-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Robertson NG |
Year: |
2000 |
Journal: |
Genomics |
Title: |
A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping. |
Volume: |
66 |
Issue: |
3 |
Pages: |
242-8 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3510759 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-12-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:3510796 |
Age: |
embryonic day 10.5 |
Image: |
2 |
|
Specimen Label: |
None |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3510759 |
Assay Type: |
RT-PCR |
Annotation Date: |
2004-12-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1619421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3510796 |
Age: |
embryonic day 13.5 |
Image: |
2 |
|
Specimen Label: |
None |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3797251 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-07-15 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672820 |
|
Stage: |
TS20 |
Assay Id: |
MGI:3797257 |
Age: |
embryonic day 12.5 |
|
|
Specimen Label: |
Not shown |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6111888 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-01-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603926 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6111913 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6111888 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-01-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603926 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6111913 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
+/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6111888 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-01-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603926 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6111913 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
-/- |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3510888 |
Assay Type: |
RNA in situ |
Annotation Date: |
2004-12-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1759621 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3510889 |
Age: |
embryonic day 13.5 |
|
Note: |
Transcript is weak/absent. |
Specimen Label: |
Table 1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cohen-Salmon M |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
Fdp, a new fibrocyte-derived protein related to MIA/CD-RAP, has an in vitro effect on the early differentiation of the inner ear mesenchyme. |
Volume: |
275 |
Issue: |
51 |
Pages: |
40036-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin S |
Year: |
2008 |
Journal: |
Dev Biol |
Title: |
Misexpression of MIA disrupts lung morphogenesis and causes neonatal death. |
Volume: |
316 |
Issue: |
2 |
Pages: |
441-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moser M |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice. |
Volume: |
22 |
Issue: |
5 |
Pages: |
1438-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Monks DC |
Year: |
2012 |
Journal: |
Dev Dyn |
Title: |
Identification of putative retinoic acid target genes downstream of mesenchymal Tbx1 during inner ear development. |
Volume: |
241 |
Issue: |
3 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ficker M |
Year: |
2004 |
Journal: |
Dev Biol |
Title: |
Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. |
Volume: |
268 |
Issue: |
1 |
Pages: |
7-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bohnenpoll T |
Year: |
2014 |
Journal: |
Dev Biol |
Title: |
Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear. |
Volume: |
391 |
Issue: |
1 |
Pages: |
54-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Desai J |
Year: |
2006 |
Journal: |
Hum Mol Genet |
Title: |
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. |
Volume: |
15 |
Issue: |
8 |
Pages: |
1329-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang T |
Year: |
2010 |
Journal: |
Nat Biotechnol |
Title: |
A mouse knockout library for secreted and transmembrane proteins. |
Volume: |
28 |
Issue: |
7 |
Pages: |
749-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lexicon Genetics, Inc |
Year: |
2011 |
Journal: |
Database Download |
Title: |
MGI download of Lexicon knockout data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
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|
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•
•
•
•
•
|
Allele |
Name: |
otoraplin; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Bosserhoff AK |
Year: |
2004 |
Journal: |
Gene Expr Patterns |
Title: |
Characterization and expression pattern of the novel MIA homolog TANGO. |
Volume: |
4 |
Issue: |
4 |
Pages: |
473-9 |
|
•
•
•
•
•
|