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Search results 1 to 100 out of 140 for Otulin

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0.067s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: Otulin (also known as FAM105B) belongs to the ovarian tumour (OTU) deubiquitinases (DUBs) family []. It specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response []. It associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates [].
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Rivkin E
Year: 2013
Journal: Nature
Title: The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Volume: 498
Issue: 7454
Pages: 318-24
Protein
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
Publication
First Author: Keusekotten K
Year: 2013
Journal: Cell
Title: OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin.
Volume: 153
Issue: 6
Pages: 1312-26
Publication
First Author: Damgaard RB
Year: 2016
Journal: Cell
Title: The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Volume: 166
Issue: 5
Pages: 1215-1230.e20
Gene
Type: gene
Organism: human
Publication
First Author: Heger K
Year: 2018
Journal: Nature
Title: OTULIN limits cell death and inflammation by deubiquitinating LUBAC.
Volume: 559
Issue: 7712
Pages: 120-124
Publication
First Author: Mevissen TE
Year: 2013
Journal: Cell
Title: OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
Volume: 154
Issue: 1
Pages: 169-84
Publication
First Author: Verboom L
Year: 2023
Journal: Cell Death Dis
Title: OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection.
Volume: 14
Issue: 8
Pages: 534
Publication
First Author: Damgaard RB
Year: 2020
Journal: Cell Death Differ
Title: OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer.
Volume: 27
Issue: 5
Pages: 1457-1474
Publication
First Author: Schünke H
Year: 2021
Journal: Nat Commun
Title: OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice.
Volume: 12
Issue: 1
Pages: 5912
Publication
First Author: Hoste E
Year: 2021
Journal: Nat Commun
Title: OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity.
Volume: 12
Issue: 1
Pages: 5913
Publication
First Author: Fu Y
Year: 2021
Journal: Mol Cell
Title: OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin.
Volume: 81
Issue: 15
Pages: 3187-3204.e7
Publication
First Author: Doglio MG
Year: 2023
Journal: Sci Immunol
Title: Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion.
Volume: 8
Issue: 89
Pages: eadf4404
Publication
First Author: Verboom L
Year: 2020
Journal: Cell Rep
Title: OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Volume: 30
Issue: 7
Pages: 2237-2247.e6
Publication  
First Author: Almeida SM
Year: 2023
Journal: Dis Model Mech
Title: An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.
Volume: 16
Issue: 8
Publication  
First Author: van Wijk SJL
Year: 2017
Journal: Nat Microbiol
Title: Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.
Volume: 2
Pages: 17066
Publication
First Author: Takiuchi T
Year: 2014
Journal: Genes Cells
Title: Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN.
Volume: 19
Issue: 3
Pages: 254-72
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:5615402
Assay Type: Northern blot
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:5615403
Age: embryonic day 9.0
Specimen Label: E9.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5615402
Assay Type: Northern blot
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5615403
Age: embryonic day 10.5
Specimen Label: E10.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5615402
Assay Type: Northern blot
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:5615403
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5615258
Assay Type: Western blot
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5615404
Age: embryonic day 12.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5615258
Assay Type: Western blot
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5615404
Age: embryonic day 12.5
Specimen Label: Gum/Gum
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5615258
Assay Type: Western blot
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5615405
Age: embryonic day 12.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5615258
Assay Type: Western blot
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5615405
Age: embryonic day 12.5
Specimen Label: Gum/Gum
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Brain
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Lung
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Heart
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Skeletal muscle
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Bone marrow
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Thymus
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Spleen
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Liver
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Kidney
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Stomach
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283428
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Small intestine
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Colon
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Testis
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:5911522
Assay Type: Western blot
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:5911524
Age: postnatal adult
Specimen Label: Skin
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611816
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:5615250
Age: embryonic day 10.0
Specimen Label: S5b
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611819
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5615250
Age: embryonic day 11.5
Note: Expression was detected in distal branchial arches.
Specimen Label: S5c,f
Detected: true
Specimen Num: 4
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752321
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5911519
Age: embryonic day 13.5
Specimen Label: S2C
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610516
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:5615250
Age: embryonic day 10.0
Specimen Label: S5b
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610519
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5615250
Age: embryonic day 11.5
Specimen Label: S5c,f
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5615250
Age: embryonic day 10.5
Note: Expression was detected in neural crest cells.
Specimen Label: 2j,k,l
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Pattern: Regionally restricted
Stage: TS16
Assay Id: MGI:5615250
Age: embryonic day 10.0
Note: Expression was detected in neural crest cells.
Specimen Label: S5b
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5615250
Age: embryonic day 11.5
Note: Expression was detected in neural crest.
Specimen Label: S5c,f
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274317
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5615250
Age: embryonic day 10.5
Specimen Label: 2j,k,l
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5615258
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274317
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5615256
Age: embryonic day 10.5
Note: Expression was detected in a subset of endothelial cells, often located near possible leading regions of vessels.
Specimen Label: 2m,n
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5615258
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274317
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5615256
Age: embryonic day 10.5
Note: Expression was detected in endothelial cells.
Specimen Label: 2o
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5615258
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274317
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5615256
Age: embryonic day 10.5
Note: Expression was detected in a subset of endothelial cells, often located near possible leading regions of vessels.
Specimen Label: 2p
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274315
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5615250
Age: embryonic day 9.5
Note: Expression was in intersomitic vessels.
Specimen Label: S5a,d,e
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1627216
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:5615250
Age: embryonic day 10.0
Specimen Label: S5b
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1627219
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5615250
Age: embryonic day 11.5
Note: Expression was detected in distal branchial arches.
Specimen Label: S5c,f
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620415
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5615250
Age: embryonic day 9.5
Specimen Label: S5a,d,e
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2017-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876521
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5911519
Age: embryonic day 13.5
Note: Expression is in the spleen.
Specimen Label: S2C
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1634615
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5615250
Age: embryonic day 9.5
Specimen Label: S5a,d,e
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1634619
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:5615250
Age: embryonic day 11.5
Specimen Label: S5c,f
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5615248
Assay Type: RNA in situ
Annotation Date: 2015-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5615250
Age: embryonic day 10.5
Specimen Label: 2j,k,l
Detected: true
Specimen Num: 1
Publication      
First Author: Esapa C
Year: 2010
Journal: Unpublished
Title: Information obtained from the Mammalian Genetics Unit, Medical Research Council (MRC), Harwell, UK.
Publication
First Author: Mar L
Year: 2005
Journal: J Neurosci
Title: A genetic screen for mutations that affect cranial nerve development in the mouse.
Volume: 25
Issue: 50
Pages: 11787-95
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use