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Search results 1 to 100 out of 129 for Oxsr1

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Hits by Category

Hits by Strain

Type Details Score
Gene
9943 | OXSR1
Type: gene
Organism: human
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Gene
407902 | oxsr1
Type: gene
Organism: frog, western clawed
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Gene
316064 | Oxsr1
Type: gene
Organism: rat
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Gene
607809 | OXSR1
Type: gene
Organism: dog, domestic
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Gene
470791 | OXSR1
Type: gene
Organism: chimpanzee
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Gene
526949 | OXSR1
Type: gene
Organism: cattle
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Gene
420421 | OXSR1
Type: gene
Organism: chicken
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Gene
696362 | OXSR1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028749 | Oxsr1
Type: Family
Description: Serine/threonine-protein kinase OSR1 is a member of the germinal centre kinase VI subfamily of the Ste20 (Sterile20)-related protein kinase family []. OSR1 (oxidative stress response 1) regulates downstream kinases in response to environmental stress []. It regulates the solute carrier 12 family of cation-chloride cotransporters which modulate ion homeostasis throughout the body [].
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Protein Coding Gene
MGI:1917378 | Oxsr1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12386165 | J:80982
First Author: Piechotta K
Year: 2002
Journal: J Biol Chem
Title: Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).
Volume: 277
Issue: 52
Pages: 50812-9
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Protein
Q6P9R2
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
Q6ZPX7
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: true
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Protein
D6RFV0
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: false
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Protein
F7AVI9
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
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Publication
24191005 | -
First Author: Sengupta S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.
Volume: 110
Issue: 47
Pages: 18826-31
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Publication
23073627 | -
First Author: Gagnon KB
Year: 2012
Journal: Physiol Rev
Title: Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.
Volume: 92
Issue: 4
Pages: 1577-617
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Publication
27400149 | J:259583
First Author: Köchl R
Year: 2016
Journal: Nat Immunol
Title: WNK1 kinase balances T cell adhesion versus migration in vivo.
Volume: 17
Issue: 9
Pages: 1075-83
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Publication
36662229 | J:336245
 
First Author: Hayward DA
Year: 2023
Journal: J Exp Med
Title: B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice.
Volume: 220
Issue: 3
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Publication
33051000 | J:303541
   
First Author: Köchl R
Year: 2020
Journal: Elife
Title: Critical role of WNK1 in MYC-dependent early mouse thymocyte development.
Volume: 9
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Publication
23386621 | J:197855
First Author: Xie J
Year: 2013
Journal: J Biol Chem
Title: WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
Volume: 288
Issue: 12
Pages: 8566-74
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Protein Coding Gene
MGP_CAROLIEiJ_G0032797 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035415 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035396 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035329 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035392 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035100 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1917378 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035915 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034403 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035067 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035226 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035173 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035305 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035214 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035934 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034109 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034524 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015664 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033945 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
14707132 | J:88954
First Author: Chen W
Year: 2004
Journal: J Biol Chem
Title: Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.
Volume: 279
Issue: 12
Pages: 11129-36
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Publication
23019198 | J:193656
First Author: Pasham V
Year: 2012
Journal: Am J Physiol Gastrointest Liver Physiol
Title: OSR1-sensitive small intestinal Na+ transport.
Volume: 303
Issue: 11
Pages: G1212-9
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Publication
22648948 | J:191351
First Author: Pasham V
Year: 2012
Journal: Am J Physiol Cell Physiol
Title: OSR1-sensitive regulation of Na+/H+ exchanger activity in dendritic cells.
Volume: 303
Issue: 4
Pages: C416-26
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5472029
Age: postnatal
Specimen Label: Wild Type
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5472029
Age: postnatal
Specimen Label: Wild Type
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5472029
Age: postnatal
Specimen Label: Wild Type
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5472029
Age: postnatal
Specimen Label: NCC Knockout
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5472029
Age: postnatal
Specimen Label: NCC Knockout
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5472029
Age: postnatal
Specimen Label: NCC Knockout
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5472029
Age: postnatal
Specimen Label: NCC Knockout
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473283
Age: postnatal
Specimen Label: Wild Type
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473283
Age: postnatal
Specimen Label: Wild Type
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473283
Age: postnatal
Specimen Label: Wild Type
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473283
Age: postnatal
Specimen Label: NCC Knockout
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473283
Age: postnatal
Specimen Label: NCC Knockout
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5472026
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473283
Age: postnatal
Specimen Label: NCC Knockout
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5473286
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473287
Age: postnatal
Specimen Label: Wild Type
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5473286
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473287
Age: postnatal
Specimen Label: Wild Type
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5473286
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473287
Age: postnatal
Specimen Label: Wild Type
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5473286
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473287
Age: postnatal
Specimen Label: NCC Knockout
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5473286
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473287
Age: postnatal
Specimen Label: NCC Knockout
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5473286
Assay Type: Western blot
Annotation Date: 2013-04-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5473287
Age: postnatal
Specimen Label: NCC Knockout
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:5472026
Assay Type: Immunohistochemistry
Annotation Date: 2013-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3551228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5472074
Age: postnatal
Specimen Label: 6A, Wild Type, merge
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5472026
Assay Type: Immunohistochemistry
Annotation Date: 2013-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3551228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5472074
Age: postnatal
Specimen Label: 6A, Knockout, merge
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5472026
Assay Type: Immunohistochemistry
Annotation Date: 2013-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3551228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5472074
Age: postnatal
Specimen Label: 6B, Wild Type, merge
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5472026
Assay Type: Immunohistochemistry
Annotation Date: 2013-04-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3551228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5472074
Age: postnatal
Specimen Label: 6B, Knockout, merge
Detected: true
Specimen Num: 4
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Publication
20091762 | J:191566
First Author: Rafiqi FH
Year: 2010
Journal: EMBO Mol Med
Title: Role of the WNK-activated SPAK kinase in regulating blood pressure.
Volume: 2
Issue: 2
Pages: 63-75
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Publication
24173353 | J:205045
First Author: Gamba G
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Regulation of NKCC2 activity by SPAK truncated isoforms.
Volume: 306
Issue: 1
Pages: F49-50
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Publication
24393035 | J:211319
First Author: de Los Heros P
Year: 2014
Journal: Biochem J
Title: The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.
Volume: 458
Issue: 3
Pages: 559-73
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Publication
22977235 | J:192476
First Author: Grimm PR
Year: 2012
Journal: J Biol Chem
Title: SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.
Volume: 287
Issue: 45
Pages: 37673-90
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Publication
26861815 | J:264975
First Author: Zhao H
Year: 2017
Journal: J Cereb Blood Flow Metab
Title: Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke.
Volume: 37
Issue: 2
Pages: 550-563
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Publication
27068441 | J:286060
First Author: Ferdaus MZ
Year: 2016
Journal: J Physiol
Title: SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule.
Volume: 594
Issue: 17
Pages: 4945-66
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Publication
24039833 | J:207559
First Author: Chu PY
Year: 2013
Journal: PLoS One
Title: SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.
Volume: 8
Issue: 9
Pages: e72969
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Publication
27853306 | J:250169
 
First Author: Liu YL
Year: 2016
Journal: Sci Rep
Title: OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis.
Volume: 6
Pages: 37205
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Publication
19307180 | J:150513
First Author: Geng Y
Year: 2009
Journal: J Biol Chem
Title: The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons.
Volume: 284
Issue: 21
Pages: 14020-8
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Publication
25515571 | J:230986
First Author: Vorontsova I
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
Volume: 56
Issue: 1
Pages: 310-21
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Publication
20231443 | J:158651
First Author: Hengl T
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Molecular components of signal amplification in olfactory sensory cilia.
Volume: 107
Issue: 13
Pages: 6052-7
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Publication
21907141 | J:176654
First Author: McCormick JA
Year: 2011
Journal: Cell Metab
Title: A SPAK isoform switch modulates renal salt transport and blood pressure.
Volume: 14
Issue: 3
Pages: 352-64
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Publication
25565204 | J:219977
First Author: Terker AS
Year: 2015
Journal: Cell Metab
Title: Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride.
Volume: 21
Issue: 1
Pages: 39-50
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Publication
21972418 | J:177443
First Author: Lin SH
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome.
Volume: 108
Issue: 42
Pages: 17538-43
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Publication
21486947 | J:182953
First Author: Chiga M
Year: 2011
Journal: J Cell Sci
Title: Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.
Volume: 124
Issue: Pt 9
Pages: 1391-5
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Publication
18800028 | J:162717
First Author: Chiga M
Year: 2008
Journal: Kidney Int
Title: Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone.
Volume: 74
Issue: 11
Pages: 1403-9
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Publication
24808538 | J:211041
First Author: Davies M
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK.
Volume: 307
Issue: 1
Pages: F96-F106
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Publication
38057317 | J:359681
First Author: de Boer LL
Year: 2023
Journal: Nat Commun
Title: T cell migration requires ion and water influx to regulate actin polymerization.
Volume: 14
Issue: 1
Pages: 7844
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Publication
27782176 | J:278187
 
First Author: Zhang J
Year: 2016
Journal: Sci Rep
Title: Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.
Volume: 6
Pages: 35986
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Publication
31666509 | J:281596
First Author: Man JCK
Year: 2019
Journal: Nat Commun
Title: An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.
Volume: 10
Issue: 1
Pages: 4943
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Publication
27689697 | J:235644
First Author: Wu Y
Year: 2016
Journal: PLoS Genet
Title: Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Volume: 12
Issue: 9
Pages: e1006355
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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